Recipient Organization
OREGON STATE UNIVERSITY
(N/A)
CORVALLIS,OR 97331
Performing Department
(N/A)
Non Technical Summary
Food and nutrition are fundamental pillars supporting healthy aging. To find solutions for our health challenges, we must change the one-size-fits-all approach to a new approach that understands and leverages the factors that mediate individualized responses to nutrition and disease risk. New evidence indicates that interactions among the microbiota, metabolism and nutrition contribute to age-related dysfunction and chronic disease. These interactive relationships are poorly defined and the tools to understand their meaning are still evolving. Our goal for this conference is to break down barriers and highlight how precision nutrition approaches can help achieve optimal health. This conference grant will support panelists, speakers and sessions that focus on the interaction among food bioactives and the microbiome on precision health outcomes including immune function, cognition, neurodegenerative diseases and obesity. Our objectives are 1) Review the current understanding of precision nutrition with a focus on the microbiome as a factor driving personalized health responses 2) Assess and review the impact of microbiome-targeted interventions on health outcomes and identify opportunities for using artificial intelligence, machine learning and data sciences to advance understanding of nutrition, microbiome and health interactions. 3) Provide opportunities to foster transdisciplinary research discussions among established and young investigators across multiple disciplines and diverse backgrounds. The Linus Pauling Institute's Diet and Optimum Health Conference has been an inclusive venue where people with diverse backgrounds and perspectives can come together to find innovative solutions. This conference will present cutting-edge science and catalyze collaborations at the intersections between nutrition and precision health research.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Goals / Objectives
Now, more than ever before, our nation's people face significant health issues and challenges. About 60% of US adults have a chronic health condition that drives this national crisis. Food and nutrition are fundamental pillars supporting healthy aging and preventing chronic disease. To find solutions for our health challenges, we must change the one-size-fits-all approach for dietary recommendations to a precision health approach that understands and leverages the factors that mediate individualized responses to nutrition and chronic disease risk. Increasing evidence indicates interactions between the gut microbiota, metabolism and nutrition contribute to age-related dysfunction and chronic disease. For example, the gut microbiota are essential for development and homeostasis of immune function throughout life. Furthermore, diet profoundly affects gut microbiota composition, and simultaneously the microbiota significantly impact metabolism and utilization of nutrients. These interactions and their relationships with age-related dysfunction, inflammation and chronic disease are poorly defined and the tools to improve our understanding are still evolving.Goals: Our overall goal for this conference is to break down barriers created by previous reductionist approaches to nutrition and highlight how precision nutrition approaches can help achieve optimal health. This AFRI conference grant will support panelists, speakers and sessions that focus on the microbiome's role in precision health and healthy aging outcomes including immune function, cognition, neurodegenerative diseases and obesity.Objective 1: Review the current understanding of precision nutrition with a focus on the role of the microbiome as a factor driving personalized health responsesObjective 2: Assess and review the impact of microbiome-targeted interventions on health outcomes and identify opportunities for using artificial intelligence, machine learning and data sciences to advance understanding of nutrition, microbiome and health interactions.Objective 3: Provide opportunities to foster transdisciplinary research discussions among established and young investigators across multiple disciplines and diverse backgrounds.
Project Methods
Session 1: Precision Health Keynote Panel - Meets Objectives 1 & 3 Assess and review the current understanding of precision nutritionProvide networking opportunities for young investigatorsHolly Nicastro, PhD, MPH25Program Director, Nutrition for Precision HealthOffice of Nutrition Research, National Institutes of Health, Bethesda MDCindy Davis, PhD26National Program Leader, Nutrition, Food Safety/QualityAgricultural Research Service, US Department of Agriculture, Beltsville MDAndrea Wong, PhD27Senior Vice President, Scientific and Regulatory AffairsCouncil for Responsible Nutrition, Washington DCThis keynote panel including leaders from several federal agencies will provide interactive opportunities for attendees to ask questions about the current state, gaps and opportunities in Precision Nutrition and individualized responses. The session will begin with short 10-minute framing presentations from each of the panelists, followed by facilitated discussion. The interplay among nutrition, food and microbiome will be a key discussion item. We will invite Young Investigators to help co-moderate the session, and encourage them to interact with panelists during and immediately following the session at the coffee break.Session 2: How Big Data Informs Optimal Nutrition - Meets Objective 2Assess and review the impact of microbiome-targeted intervention on health outcomes and identify opportunities for the use of artificial intelligence, machine learning and data sciencesIdentifying multiomic signatures of microbial metabolites for understanding nutrition responses and human diseaseMichael Snyder, PhD28Stanford W. Ascherman Professor of GeneticsStanford University School of MedicineArtificial Intelligence (AI), Big Data, & Other Computer-aided Approaches: Bringing Systems Methods to Precision Nutrition,Bruce Y Lee, MD, MBA29Professor, Health Policy and ManagementSchool of Public Health, City University of New YorkData integration and informatics for accelerating discoveries and advancing human health; Melissa Haendel, PhD30Professor, Biomedical InformaticsSchool of Medicine, University of Colorado AnschutzThis session will outline opportunities and new methods in data sciences to enable microbiome science, precision nutrition and health in the population. We will invite Young Investigators to help co-moderate the session, and encourage them to interact with panelists during and immediately following the session at the coffee break.Session 3: Nutrition and the Microbiome: More Than What You Eat - Meets Objectives 1 & 2 Assess and review the current understanding of precision nutritionAssess and review the impact of microbiome-targeted intervention on health outcomes Ketogenic diets alter host immunity via the gut microbiome,Peter Turnbaugh, PhD31Associate Professor, Microbiology and ImmunologyBiomedical Sciences, University of California San FranciscoThe First 1000 Days: Childhood Obesity, Microbiome, and Brain AxisSharon Donovan, PhD32Professor and Melissa M. Noel Endowed Chair in Nutrition and HealthNutritional Sciences, University of Illinois at Urbana ChampaignMicrobiome drives personalized responses in nutrient-environment-health outcome interactions; Thomas Sharpton, PhD45Associate Professor, MicrobiologyOregon State UniversityThis session will focus on the role of the microbiome in individual health across the lifespan, and provide specific examples of successful dietary interventions. We will invite Young Investigators to help co-moderate the session, and encourage them to interact with panelists during and immediately following the session at the coffee break.Session 7: Fortifying an Aging Immune System - Meets Objective 2Assess and review the impact of microbiome-targeted intervention on health outcomes Postbiotics, Longevity, and Immunosenescence,Heather Zwickey, PhD 39Senior Research Investigator, Helfgott Research InstituteNational University of Natural Medicine Vitamin A Metabolism at the Host-Microbiome Interface,Shipra Vaishnava, PhD 40Assistant Professor, Molecular Microbiology and ImmunologyBrown UniversityAlteration of Zinc Homeostasis in the Gut-Lung Microbiome Axis Adversely Impacts Host Defense Against Bacterial Pneumonia,Daren Knoell, PharmD, FCCP 41Professor and Chair, Pharmacy Practice and ScienceUniversity of Nebraska Medical CenterThis session will focus on the role of the microbiome/dietary factors in immune function, and provide specific examples of successful dietary interventions. We will invite Young Investigators to help co-moderate the session, and encourage them to interact with panelists during and immediately following the session at the coffee break.Session 4: Lightning Talks - Meets Objective 3Provide networking opportunities for young investigatorsApproximately 10-minute presentations from registrants, especially Young Investigators selected from submitted abstracts.Networking Lunches - Meets Objective 3Provide networking opportunities for young investigatorsLunch is an integral part of the meeting and is included in the registration. We will serve a buffet-style lunch in the foyer adjacent to the meeting room and near the poster display location. Participants can sit at large round tables that accommodate 10 persons or they can take advantage of the many informal seating arrangements in the Alumni Center (see Facilities and Resources). Our intention is to encourage casual discussions between participants, especially Young Investigators. Presenters will set-up posters in the morning prior to lunch so that interested parties can also discuss posters during the lunch hour. We will encourage participants to view the posters and meet with the presenters.Networking Reception and Poster Session - Meets Objective 3Provide networking opportunities for young investigatorsThe reception is an integral part of the meeting and is included in the registration. Poster presentations are from submitted abstracts. An abstract booklet is included to facilitate attendees' visit to the posters. The session is designed to encourage both networking and meeting the speakers and young investigators. Name badges are used to help identify participants.Banquet Dinner and Young Investigator Awards - Meets Objective 3Provide networking opportunities for young investigatorsAll attendees are invited; dinner is included in the registration. This is an opportunity for networking and interactions. Young investigators are highlighted and awards are announced at the banquet.