Source: CLEMSON UNIVERSITY submitted to
IMPROVING OIL CONTENT FOR UPLAND COTTON GROWERS: NEW MOLECULAR TOOLS AND GERMPLASM
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
NEW
Funding Source
Reporting Frequency
Annual
Accession No.
1030121
Grant No.
2023-69008-39861
Project No.
SC-2022-10078
Proposal No.
2022-10078
Multistate No.
(N/A)
Program Code
A1701
Project Start Date
May 15, 2023
Project End Date
May 14, 2026
Grant Year
2023
Project Director
Saski, C.
Recipient Organization
CLEMSON UNIVERSITY
(N/A)
CLEMSON,SC 29634
Performing Department
(N/A)
Non Technical Summary
Cotton is primarily grown and harvested for the lint, which has been the focus of cotton research and breeding efforts over many decades, leaving seed traits neglected. Our short to medium term goals are to leverage an existing, unique RIL population segregating for cottonseed oil content, to deliver: 1) A comprehensive understanding of the genetic architecture of cottonseed oil content in important germplasm (QTLs and functional alleles); 2) Applied approaches to track and predict cottonseed oil content in upland cotton germplasm and breeding pipelines; 3) Delivery of unique germplasm with high cottonseed oil content AND genetic resistance to the #1 disease threat to upland cotton (Fusarium oxysporum, vasinfectum race 4) to stakeholders. Our long-term goals are to identify the genetic basis of cottonseed oil content and release new germplasm and DNA markers for improvement of this trait. Our vision is to develop a joint fiber and seed cotton production system to maximize value from both plant components. These outcomes will directly benefit breeders, growers, and allied scientists that transect the public/private/non-profit industries. In the longer term, this project will develop a foundation that can lead to the production of designer cottonseed with improved nutritional benefits and enhanced functional properties that will add more value to this by-product of fiber production. This proposal addresses the AFRI Critical Agricultural Research and Extension (CARE) program. Our project will deliver solutions to cotton stakeholders requests to increase the value of the crop to make farming operations more profitable, resilient, and sustainable.
Animal Health Component
0%
Research Effort Categories
Basic
50%
Applied
30%
Developmental
20%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
20117191080100%
Knowledge Area
201 - Plant Genome, Genetics, and Genetic Mechanisms;

Subject Of Investigation
1719 - Cotton, other;

Field Of Science
1080 - Genetics;
Goals / Objectives
Cotton is primarily grown and harvested for the lint, which has been the focus of cotton research and breeding efforts over many decades, leaving seed traits neglected. Our short to medium term goals are to leverage an existing, unique RIL population segregating for cottonseed oil content, to deliver: 1) A comprehensive understanding of the genetic architecture of cottonseed oil content in important germplasm (QTLs and functional alleles); 2) Applied approaches to track and predict cottonseed oil content in upland cotton germplasm and breeding pipelines; 3) Delivery of unique germplasm with high cottonseed oil content AND genetic resistance to the #1 disease threat to upland cotton (Fusarium oxysporum, vasinfectum race 4) to stakeholders. Our long-term goals are to identify the genetic basis of cottonseed oil content and release new germplasm and DNA markers for improvement of this trait. Our vision is to develop a joint fiber and seed cotton production system to maximize value from both plant components. These outcomes will directly benefit breeders, growers, and allied scientists that transect the public/private/non-profit industries. In the longer term, this project will develop a foundation that can lead to the production of designer cottonseed with improved nutritional benefits and enhanced functional properties that will add more value to this by-product of fiber production.Our objectives are to:1. Collect oil content measurements from a recombinant inbred population (U1 x Siokra 250) in 12 environments (6 each year for 2 years). The population is currently at F7:8.2. Conduct high-resolution genetic mapping using multi-location, multi-year phenotyping with whole genome genotypes collected through a current USDA-NIFA proposal (2021-11395).3. Release inbred lines with high oil content and identify candidate genes and causal alleles underpinning oil content (genetic variation) to translate to DNA biomarkers to track and predict this trait in breeding pipelines. These results will also move to a genome editing pipeline for future genetic tailoring of this trait with biotechnology.
Project Methods
This project builds upon significant population development, breeding, screening, and genetic analysis to understand the genetic basis of FOV4 resistance in the highly resistant parent, U1. The susceptible parent, the elite Australian commercial variety Siokra 250, was crossed to U1, and RILs developed (F7:8) using single seed decent in the Costa Rica winter nursery. A high-resolution genetic map will be constructed for FOV4 under USDA project 2021-11395 using F8 plants to collect genotypes. Genotypes will be whole-genome skim sequences for each RIL (~300). This same population segregates for oil content. Through this project, we will collect cottonseed oil measurements in 6 environments spanning the cotton belt (S.C., GA, AK, MS, TX, and AZ) over 2 years to assemble a high-resolution genetic map of the cottonseed oil trait. We will design and validate molecular markers (SNPs) that can predict FOV4/oil QTLs. We will id and release germplasm with both positive characteristics. We will identify DNA biomarkers that are diagnostic of the discovered QTLs. We will publicly release lines derived from the RIL population verified to contain high oil alleles in the Journal of Plant Registrations. Also, we will publish results in referred journals and communicate to the cotton research community at the annual Beltwide Cotton Conference held each January. Regular outreach/extension to the cotton grower leadership will occur via Cotton Incorporated's Board of Director Meetings held four times each year.

Progress 05/15/23 to 05/14/24

Outputs
Target Audience:The target audiences reached by our efforts for this project include the following: All major cotton seed company representatives.These representatives were engaged during this year of the project at various meetings/conferences/field days (described in other sections). Cotton Incorporated Board of Directors Agricultural Research Committee. This committee consists of 70 U.S. cotton growers and represents all cotton growing regions in the U.S. The audience at the annual Beltwide Cotton Conference. This conference is attended by allied research scientists, cotton breeders, plant pathologists, industry representatives and is considered the primary annual cotton meeting Attendees of field days. These include all major cotton seed companies and cotton growers. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive transdisiplinary training for 1 Ph.D. student (Foster Kangben - a Fullbright Scholar from Ghana and currently in the Plant and Environmental Sciences (PES) department at Clemson University). This student was exposed to hands on field work, quantitative/population genetics, experimental design and statistical analysis, and genetic mapping. This project also provided training for 3 undergraduate students (2 in the PES department and 1 in the Genetics department) at Clemson University. These students were trained in high-throughput phenotyping and statistical analysis methods. How have the results been disseminated to communities of interest?The first-year outcomes and resultshave been communicated to the Board of Directors at Cotton Incorporated.This committee consists of 70 U.S. cotton growers and represents all cotton growing regions in the U.S. A more detailed report will be delivered in Year 2. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period, we will analyze the year 2 data independently and in combination with the Year 1 data to develop a high-resolution genetic map. We anticipate publication of the Year 1 data in addition to another publication of that includes both years analyzed together. We will continue training and mentoring the post-doctoral scholars, graduate and undergraduate students affiliated with the project. We will devleop genetic biomarkers and advance eliate lines through germplasm release for breeders to use for improving trait genetics of interest.

Impacts
What was accomplished under these goals? The F8 RIL population was planted, maintained, and data collected on oil content, protein, yield, seed size in 6 locations during the first year. The phenotype data has been analyzed for year 1 and validated that the population is segregting for the traits of interest. Genotypes with superior trait genetics have been identified for year 1 and will be evaluated again in year 2.This population has been planted in the Spring of 2024 to collect year 2 data during the second reporting period.

Publications