Source: UNIVERSITY OF FLORIDA submitted to NRP
MINIMIZING PESTICIDE CONTAMINATION OF FLOWERS DURING ORNAMENTAL PLANT PRODUCTION
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
ACTIVE
Funding Source
Reporting Frequency
Annual
Accession No.
1029704
Grant No.
2023-67013-38989
Cumulative Award Amt.
$749,982.00
Proposal No.
2022-08495
Multistate No.
(N/A)
Project Start Date
May 15, 2023
Project End Date
May 14, 2027
Grant Year
2023
Program Code
[A1113]- Pollinator Health: Research and Application
Recipient Organization
UNIVERSITY OF FLORIDA
G022 MCCARTY HALL
GAINESVILLE,FL 32611
Performing Department
(N/A)
Non Technical Summary
Pollinator species include a wide range of arthropods and other organisms that are essential for maintenance of many ecological systems and production of agricultural crops. Losses of pollinator species can significantly reduce yields of open-pollinated crops and negatively impact the ecology of desireable agriculturally-allied and natural systems. Pollinator species losses have been well documented and pesticide-use for crop production/landscape maintenance has been identified as one of several factors potentially contributing to the loss. Little research has focused on contamination of floral resources (nectar and pollen) in ornamental plants. A preliminary study conducted by the PIs found that application methods, rates, and timings can greatly influence contamination of nectar using salvia x 'Indigo Spires' as a model species. Concentrations in nectar greatly exceeded reported toxicity thresholds for native bees/honeybees for some treatments, while others were of less concern, indicating that "safe" application windows may exist but need to be identified. This research project will expand on the preliminary study, with goals of 1) characterizing the influence of pesticide application method, rates, and timing on contamination of floral resources in herbaceous and woody ornamental species; 2) evaluating the potential for identifying windows-of-opportunity when systemic pesticides may be applied with little risk of floral resource contamination relative to sell dates for plants; and 3) determining how quickly pesticide contamination in floral resources dissipates once treated plants are transplanted into the landscape.This project will use cyantraniliprole, flupyradifurone, and thiamethoxam as model systemic insecticides and Mysty salvia and Bloomify lantana as model herbaceous and woody ornamentals, respectively. Rooted liners of the each species will be planted in 3-gallon nursery containers. For determining the effects of application method on floral resource contamination, pesticides will be applied as drenches or as sprays. All of these pesticides are labeled for application through both means, though the rates of application differ. Pesticides will be applied at low, medium, and high rates specified on the labels for each pesticide and application method. All plants for each pesticide-plant combination will be purchased and established at the same time. To evaluate the influence of pesticide application timing on contamination, the pesticides will be applied before the plants form flowers (approximately 1 week after potting the liners in 3 gallon pots) to one set of plants, just before the majority of plants begin to form flower buds for another set, and just before flower buds begin to open for the last set. Once all plants are flowering, nectar and pollen samples will be collected for analysis by uHPLC-MS/MS. Nectar samples will be collected using glass capillaries and anthers will be excised and serve as a proxy for pollen. Following sample collection, half of the replicates within each treatment group will be pruned to evaluate the potential effects of this cultural practice on pesticide concentrations in subsequent flowers. Once the plants are all flowering again samples will be collected as previously described. At the end of this study phase, all plants will be transplanted into the landscape with one to two more samplings to evaluate dissipation of residues once the plants are in the landscape.Each plant-pesticide evaluation will require approximately four months in the shade house from the time the rooted liners are received and an additional two months in the field. Key milestones will be completion studies for of each plant-pesticide combination. Results from the aggregate of study results available at the time will be analyzed and packaged for delivery to stakeholders as abstracts, proceedings, refereed journal articles, presentations (poster and oral) at local and professional meetings, and individual interactions with those interested.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
13321992000100%
Goals / Objectives
The over-arching goal of this project is to identify management practices that can minimize exposure of pollinator species to pesticides used in ornamental plant production when the plants are market-ready. To achieve this goal, information is needed aboutpesticide applications (how, when, and how much), pesticide transport dynamics within the plants (based on initial application method and partitioning into different tissues), and pesticide dissipation kinetics once plants are established in the landscape.The objectives of this project are to:1) Characterize the influence of pesticide application method, rates, and timing on contamination of floral resources in an herbaceous and a woody ornamental species.2) Evaluate the feasibility of using predictive regression models for characterizing contamination of pollen and nectar with pesticides based on concentrations in leaves to schedule when pesticide applications can be made to minimize contamination in plants going to market.3) Determine how quickly pesticide contamination in floral resources dissipates once treated plants are transplanted into the landscape.
Project Methods
This project will use cyantraniliprole, flupyradifurone, and thiamethoxam as model systemic insecticides and Mysty salvia and Bloomify lantana as model herbaceous and woody ornamentals, respectively. Rooted liners of the each species will be planted in 3-gallon nursery containers. For determining the effects of application method on floral resource contamination, pesticides will be applied as drenches or as sprays. All of these pesticides are labeled for application through both means, though the rates of application differ. Pesticides will be applied at low, medium, and high rates specified on the labels for each pesticide and application method. Drench applications will be made by adding the appropriate amount of diluted pesticide into each pot volumetrically per label specifications. Foliar pesticide applications will be made using hand-held spray bottles. All three pesticide formulations indicate that pesticides should be sprayed to thoroughly cover plants, but not result in runoff from foliage. Prior to applying sprays to treatment plants, spray bottles will be adjusted to optimize spray pattern and calibrated to thoroughly cover the test plants. The same volume and application sequence (e.g. spray from bottom to top while circling the plant at a constant velocity) will be used for each plant. Studies will be conducted in a screenhouse in order to minimize visitation (and possible cross-contamination) by pollinator species. All plants for each plant-pesticide combination will be purchased and established at the same time. To evaluate the influence of pesticide application timing on contamination, the pesticides will be applied before the plants form flowers (approximately 1 week after potting the liners in 3 gallon pots) to one set of plants, just before the majority of plants begin to form flower buds for another set, and just before flower buds begin to open for the last set. Once all plants are flowering, nectar and pollen samples will be collected for analysis. Nectar samples will preferentially be collected using 1, 5, 10 or 25 µL micropipettes (volumes > 1 µL). Microcapillaries will either be inserted into the throat of individual flowers of the flower corollas will be removed and nectar sampled from the base. Nectar samples will be ejected into microcentrifuge tubes and stored on ice in the field and at -20 C in the lab until analysis. Since these plants are not prolific pollen producers, entire anthers will be used as a proxy for pollen. Furthermore, given the small biomass of anthers, these analyses will be restricted to only one of the plant species (i.e. the one that produces the largest anthers and pollen loads). Anthers will be excised from stamens in florets that are just beginning to open to ensure that all pollen is accounted for. Anthers collected will be placed in 1.5 mL microcentrifuge tubes, which will be kept on ice in the field and transferred to -20 C storage until analysis in the lab. The number of anthers to be collected will be determined in preliminary studies to characterize masses, pollen content, and method detection limits. Leaves will be collected from 6 randomly selected positions on the plants, placed in Whirl-Pak bags, and stored at -20°C until analysis. Samplers will use a new pair of gloves for collecting leaves from each plant to minimize cross-contamination.Following sample collection, half of the replicates within each treatment group will be pruned to evaluate the potential effects of this cultural practice on pesticide concentrations in subsequent flowers. Once the plants are all flowering again samples will be collected as previously described. At the end of this study phase, all plants will be transplanted into the ground at the UF/IFAS Plant Science Research and Education Unit (Citra, FL). Plants will be established and maintained in raised beds. Plants will be deadheaded weekly and floral resources will be sampled 1 to 3 months after transplanting depending on flowering status. If residues are still present at high concentrations in floral resources, those plants will be re-sampled again after 1 to 3 months to identify how long exposure risks are significant.Pesticide concentrations in nectar will preferentially be analyzed by direct injection of diluted samples if sensitivity is adequate. If sensitivity is not adequate nectar samples will be diluted with water and extracted using novel or published methods. For analysis by direct-injection, nectar samples will be diluted with 200 µl of H2O:ACN (9:1) followed by thorough mixing using a vortex genie. Samples will be centrifuged (13,000 RCF, 10 min) prior to uHPLC-MS/MS analysis. QuECHERS methods will be adapted for analysis of each target pesticide in pollen and leaves. This method resulted in very good recoveries for thiamethoxam and clothianidin in our preliminary research and is expected to perform equally well with cyantraniliprole and flupyradifurone. Pesticide concentrations in extracts and diluted nectar samples will be analyzed by ultra high-pressure liquid chromatography with tandem mass spectrometer detection (uHPLC/MS/MS). Pesticides will be chromatographed using an Agilent 1290 Infinity II uHPLC System equipped with a C18 reversed-phase column and coupled to an Agilent 6495 tandem mass spectrometer. The MS/MS will be operated in electrospray ionization (ESI) positive or negative mode with nitrogen used as the source and collision gas. Data will be acquired in multiple-reaction monitoring (MRM) mode. Mobile phase for the LC separation may differ depending on the targeted pesticide. We currently have a robust method for extraction and analysis of thiamethoxam and clothianidin, and a base instrument method that includes cyantraniliprole and flupyradifurone. This instrument method will be optimized for cyantraniliprole and flupyradifurone.Pesticide concentrations in nectar, pollen, and leaves will be analyzed by Analysis of Variance (P = 0.05) to identify differences associated with application method (drench or spray), application rate (low, medium, and high), and application timing (at repotting stage, pre-bloom initiation, and post initiation/pre-opening). If differences are identified, Tukeys HSD post hoc analysis will be used to identify treatments that are different. Specific comparisons that will be made include: 1) foliar spray vs. drench at each respective application rate/application timing (e.g., foliar spray/low rate/at potting compared to media drench/low rate/at potting, etc.); 2) within each application method, rates will be compared within each timing (e.g. within foliar spray application method, concentrations in plant matrix will be compared between the low, medium and high application rates within each application timing separately; 3) within each application method and rate, contamination due to timing of application will be assessed. Linear or non-linear regression will be used to characterize relationships between concentrations in leaves and concentrations in nectar and pollen based on the different application rates. Multivariate principal components analysis will be used to further characterize primary factors (timing, rate, application method) associated with contamination of floral resources.Each plant-pesticide evaluation will require approximately four months in the shade house from the time the rooted liners are received and an additional two months in the field. Key milestones will be completion studies for of each plant-pesticide combination. Results from the aggregate of study results available at the time will be analyzed and packaged for delivery to stakeholders as abstracts, proceedings, refereed journal articles, presentations (poster and oral) at local and professional meetings, and individual interactions with those interested.

Progress 05/15/24 to 05/14/25

Outputs
Target Audience:Researchers working in the areas of pollinator conservation and toxicology, and ornamental plant producers who use systemic pesticides to produce plants destined for the landscape. Changes/Problems:The plant culture/health monitoring efforts that we instituted following the last reporting period are working well and helping to minimize lost time due to plant irrigation, disease, and fertility problems. One unexpected probem that we ran into during the last period was higher-than-normal temperaturesduring the summer. Salvia plants are not as tolerant of heat and as a result flower and nectar production was not as abundant later into the summer after the first sampling. We also underestimated the amount of time and effort needed to extract the pesticides from leaves and to analyze them. We have hired two part-time undergraduate students who are very interested in the project and learning lab methods to help with leaf extractions as well as sampling and other project-related activities. We are planning to not conduct a plant study during the summer and to focus efforts on extracting the hundreds of leaf samples currently stored in the freezer. We will start the second plant study in late summer to allow enough time to complete sampling and manipulations before the onset of cooler temperatures and shorter days. Another change that we made is reducing the pot size from 3-gallons to 1-gallon. We've observed that nurseries more commonly produce these plants in 1-gallon and smaller containers for consumers. Since the pot size impacts the amount of chemical applied by drench we feel that this may bea better representation of nursery production methods. One other change is related to pollen analyses. After close observations of the flowers of both lantana and salvia, it became apparant that neither plant produces enough pollen for pesticide analysis. To gain some information on the influence of pesticide application rates, timing, and methods on possible contamination of pollen, we developed and validated sampling, extraction/preparation , and analyticalmethods (for thiamethoxam only) using Gaillardia spp. as a model plant. This plant produces much pollen and is also popular in the landscape. As mentioned previously, an early freeze killed the plants that were transplanted into the field to monitor pesticide dissipation in nectar once planted in the landscape. Dissipation was observed up until the freeze, but concentrations had not yet reached the method detection limits. After analyzing the data we will decide whether or not to repeat this study. What opportunities for training and professional development has the project provided?The MS and PhD students are gaining extensive experience in designing andconducting research projects, developing and validating sampling/analytical methods, analyzing data, writing abstracts and papers, preparing/delivering presentations for different audiences, organizing and training helpers, and managing their plants. In addition, we have recently hired two part-time students to help with sample preparation, who are keenly interested in research and the project methods and may be excellent prospects for graduate school whenthey graduate. How have the results been disseminated to communities of interest?Research results from various combinations of the plant-pesticide studies have been presented to a variety of audiences including: ornamental plant nursery owners/managers at theInternational Plant Propagators Society meeting (platform presentationand poster); scientific peers at the American Society for Horticultural Sciences,the Society of Environmental Toxicology and Chemistry (platform presentation), and the UF/IFAS Soil, Water, and Ecosystem Sciences Research Forum (Platform presentation);researchers and policy makers at the Hazards of Pesticides to Bees 16th International Symposium of the ICP-PR Bee Protection Group (platform presentation) and the USDA's Pollinator Research Innovation Series Webinar (Teams);and extension professionals at the Center for Landscape Use Efficiency Landscape Summit (platform presentations and posters). In addition our student (V. Rostan) also presented results to the local Bee Club, which included students, backyard enthusiasts, and professionals;and shared her studywith students in rural schools and high schools in Uruguay via Zoom. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period we will continue with the studies evaluating lantana-flupyridifurone and salvia-cyantraniliprole. We have a backlog of leafsamples to analyze from the previous studies, so plan to extract and analyze these. We should submit at least twomanuscripts to peer reviewed journals for possible publication. We will also develop and validate the sample preparation and analyticalmethods for cyantriliprole quantitation in nectar and leaves.

Impacts
What was accomplished under these goals? During the period from May 15,2024 through May 14,2025, we conducted five plant-pesticide studies. We completed the lantana-thiamethoxam study that was just beginning at the time of the last report. We also added two complementary studiesinvestigating the effects of drench volume on contamination of nectar in an annual species of salvia (Salvia coccinia) using thiamethoxam and flupyridifurone,repeated the salvia-flupyridifurone studyfrom the past fall in thesummer, and conducteda fall study looking at lantana-flupyridifurone. We are currently conducting the study with Mysty salvia-flupyridifurone. We also developed pollen sampling and analysis methods using Gaillardia spp. as a model species since neither salvia nor lantana produce enough pollen for analysis. Gaillardia produces much pollen and is a popular ornamental in the landscape. We also conducted a pesticide dissipation study where we treated plants at the high rates for thiamethoxam and flupyridifurone, and then planted in the field and monitored dissipation in nectar on a weekly basis until the plants were killed by an early frost. This study may need to be repeated since concentrations were not below the method detection limits at the time of the frost. However, significant dissipation was observed.

Publications

  • Type: Conference Papers and Presentations Status: Published Year Published: 2024 Citation: Wilson PC, Rostan V, Cabrera M, Wilson SB. 2024. Pesticide management decisions affect contamination of nectar in containerized ornamental plant production. American Society for Horticultural Sciences Annual Conference, September 23  27, Honolulu, HI.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2024 Citation: Rostan V, Wilson PC, Wilson SB. 2025. Nectar contamination in ornamental plants: the role of pesticide application method and their potential impact on pollinators, in: Hazards of Pesticides to Bees, 16th International Symposium of the ICP-PR Bee Protection Group, Proceedings; 15th-17th , 2024; Sevilla (Spain).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2024 Citation: Rostan V, Wilson PC, Wilson SB. 2024. Influence of systemic vs. non-systemic pesticide applications on contamination of nectar in pollinator-friendly Salvia. UF/IFAS Center for Land Use Efficiency (CLUE) Landscape Summit, Gainesville, FL.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2024 Citation: Rostan V, Wilson PC, Wilson SB. 2024. Prediction of nectar contamination with pesticides using leaf tissue measurements. SE-Society of Environmental Toxicology and Chemistry Meeting, Gainesville, FL, April 26 - 27.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2024 Citation: Cabrera, M, Wilson SB, Rostan V, Wilson PC. 2024. Influence of thiamethoxam application method, timing and rate on contamination of floral resources in lantana. Comb. Proc. Intl. Plant Prop. Soc. 74:386-375.


Progress 05/15/23 to 05/14/24

Outputs
Target Audience:Researchers working in the area of pollinator conservation and toxiology. Changes/Problems:We conducted our first study using Mysty Salvia and flupyradifurone during the Fall 2023 semester.One unexpected problem that we encountered was the onset of fusarium root rot in a significant proportion of the Mysty salvia plants during thisstudy. In addition, during sampling we found very high populations of thrips in the flowers.We also determined that the manufacturer's label for the pesticide was defective (after the study was initiated), listing a much lower rate of application than would be effective for controlling pests.We sampled the plants, but deemed the data compromised based on the disease, thrips, and inaccurate label recommendations. The company has since revised the label.In response to these experiences,for subsequent studies we have adopted a more intense pest and irrigation management program. We apply fungicides and insecticides in rotations as needed with active scouting. We also only apply irrigation after the media has dried within the pots. Initially irrigation was applied by timer. One possible change that we want to consider is: instead of transplanting all plants from the study to the field after the second sampling, we might consider conducting a completely separate study where plants are treated (spray and drench at one rate) with all three pesticides while potted in the shadehouse, followed by transplantation into the field a week or two later. The reason for this is that by the end of the second sampling in the shadehouse (as originally proposed), concentrations in the plants are likely to be very low and more variable. By treating all plants before transplantation, we should have more reproducibility and will be gauranteed to have similar measureable concentrations at the onset of field dissipation monitoring. The rate applied and timing of application would be chosen based on concentrations in nectar determined from the individual shadehouse studies. We are currently planning to transplant some of the Lantana plants (high application rates) in the current study to inform our decisions, and will know better the best path foward later this summer. We would also like to note that we may hire another MS student later in the project due to unforseen savings. The PhD student who we recruitedfor the project competed for and was awarded a UF-sponsored Fellowship for her doctoral studies. As a result we are considering hiring another MS student to help with the study as our current MS student finishes. We have also hired a part-time student to help with maintaining the plants. What opportunities for training and professional development has the project provided?Two graduate students (oneMS and one PhDstudent) are gaining extensive training and experience in plant management techniques (fertilization, pest management, irrigation management, scheduling, etc.), sampling techniques (nectar and leaves), and preparative and analytical chemistry techniques. Students werealso sent to professional meetings for professional development (UF Center for Landscape Use Efficiency Research Conference and Society for Environmental Toxicology and Chemistry). How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals?We will complete the currently running lantana-thiamethoxam study, and initiate a new study with Mysty salvia-thiamethoxam in June, followed byflupyradifurone studies with Mysty salvia and lantana.

Impacts
What was accomplished under these goals? We conducted our first study using Mysty Salvia and flupyradifurone during the fall semester, but the data were compromised (see problems encountered section for description). During the spring semester we implemented a lantana study with thiamethoxam. That study is currently in progress. We sampled nectar last week and pruned half of the replicatesthis week. During this period we also validated the thiamethoxam analysis method and developed and validated the analytical method for flupyradifurone in nectar. We also adopted a preventative pest management routine with the plants used in the studies, which include rotations of fungicides and insecticides as needed.

Publications