Source: UNIV OF MASSACHUSETTS submitted to
HEALTH RISKS OF FOODBORNE SILICON DIOXIDE NANOPARTICLES
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
ACTIVE
Funding Source
AFRI COMPETITIVE GRANT
Reporting Frequency
Annual
Accession No.
1028076
Grant No.
2022-67021-37014
Cumulative Award Amt.
$597,845.00
Proposal No.
2021-09045
Multistate No.
(N/A)
Project Start Date
May 15, 2022
Project End Date
May 14, 2026
Grant Year
2022
Program Code
[A1511]- Agriculture Systems and Technology: Nanotechnology for Agricultural and Food Systems
Recipient Organization
UNIV OF MASSACHUSETTS
(N/A)
AMHERST,MA 01003
Performing Department
Dept: Food Sciences
Non Technical Summary
This project addresses an important challenge area of nanotoxicology- a detailed understanding of the mode of actions by which engineered nanoparticles (NPs) induce health risks. A large number of food products contain engineered inorganic NPs, such as silicon dioxide NPs, due to both unintentional and intentional addition. However, a detailed understanding of the potential adverse effects of foodborne silicon dioxide NPs and the molecular mechanism involved is not currently available. Our preliminary studies demonstrated that oral intake of silicon dioxide NPs in mice resulted in accumulation of the NPs in the liver and kidney, adverse effects on liver and kidney, toxicity in reproductive systems, and disruption of gut microbiota. These adverse effects of Silicon dioxide NPs tended to be stronger in the obese mice than non-obese mice. These findings are critically important because they suggested a mode of action by which foodborne silicon dioxide NPs induced adverse health effects, and it also demonstrated that certain populations (such as those who were obese) were more susceptible to the silicon dioxide NPs-induced adverse effects. To address the lack of knowledge on the health risks of foodborne Silicon dioxide NPs, based on our preliminary data, the overall objective of this project is to systematically determine the adverse effects of foodborne silicon dioxide NPs and elucidate the molecular mechanisms involved in different populations including those potentially more susceptible to the adverse effects of silicon dioxide NPs, such as children and obese individuals. The knowledge gained from this project is critically important for ensuring the safety of a wide range of food products that may contain silicon dioxide NPs.
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
72350101150100%
Knowledge Area
723 - Hazards to Human Health and Safety;

Subject Of Investigation
5010 - Food;

Field Of Science
1150 - Toxicology;
Goals / Objectives
The major goal of this project is to systematically determine the adverse effects of foodborne silicon dioxide nanoparticlesand elucidate the molecular mechanisms involved in different populations including those potentially more susceptible to the adverse effects of silicon dioxide nanoparticles, such as children and obese individuals. The knowledge gained from this project is critically important for ensuring the safety of a wide range of food products that may contain silicon dioxide nanoparticles.
Project Methods
TheMain Approaches:Aim 1: Determine the General Adverse Effects of Foodborne SiO2 NPs on Different Sub-populations of Mice. Foodborne SiO2 in different sizes and forms will be subjected to detailed 13-week sub-chronic toxicity studies to determine the general nanotoxicity of SiO2 NPs in different sub-populations such as young vs. adult, male vs. female, and non-obese vs. obese mice.Aim 2: Determine Reproductive Toxicity of Foodborne SiO2 NPs in Different Sub-populations of Mice. The effects of foodborne SiO2 NPs on the development and functions of the reproductive systems will be systematically determined in different sub-populations of mice (youth vs. adults, non-obese vs. obese, and male vs. female).Aim 3: Determine the Impact of Foodborne SiO2 NPs on Gut Microbiota and Its Implication in the Health Risks Induced by SiO2 NPs in Mice. The effects of foodborne SiO2 NPs on the structure of gut microbiota will be determined in different sub-populations of mice (youth vs. adults, non-obese vs. obese, and male vs. female). Microbiota transplant study will be used to demonstrate the direct effects of altered gut microbiota on the health of the mice.

Progress 05/15/23 to 05/14/24

Outputs
Target Audience:Scientists and technologists in food chemistry, nutrition, food safety, and related fields. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive research training for multiple graduate students. How have the results been disseminated to communities of interest?By publications in peer-reviewed journals publications and presentations at conferences. What do you plan to do during the next reporting period to accomplish the goals?Publications in peer-reviewed journals publications and presentations at conferences.

Impacts
What was accomplished under these goals? We have made satisfactory progress in this period by publishing 1 research paper and 3conference papers. See the specific published articles for the details of experimental results achieved in this period.

Publications

  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Wu, Yanyan, et al. "Adverse effects of titanium dioxide nanoparticles on beneficial gut bacteria and host health based on untargeted metabolomics analysis." Environmental Research 228 (2023): 115921.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2023 Citation: Interplay between Food and Gut Microbiome: Critical Roles in Human Health, May. 29-31, 2022, Hang Xiao*. 4th international symposium of food science and nutrition health, Dalian, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2023 Citation: Health Risks of Foodborne Silicon Dioxide Nanoparticles. August. 9-11, 2023, Hang Xiao. USDA/NIFA AFRI nanotechnology for agriculture and food systems grantees conference, Knoxville, Tennessee.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2023 Citation: Diet and Chronic Disease Prevention: Insights and Strategies for a Healthier Life, August. 2-6, 2023, Hang Xiao. 7th International Symposium on Phytochemicals in Medicine and Food (7-ISPMF), Beijing, China.


Progress 05/15/22 to 05/14/23

Outputs
Target Audience:Scientists and technologists in the food, nutrition, and related fields. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive research training for multiple graduate students. How have the results been disseminated to communities of interest?By publications in peer-reviewed journals publications and presentations at conferences. What do you plan to do during the next reporting period to accomplish the goals?Publications in peer-reviewed journal publications and presentations at the conferences

Impacts
What was accomplished under these goals? We have made satisfactory progress in this period by publishing 1 research paper and 6conference papers. See the specific published articles for the details of experimental results achieved in this period.

Publications

  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Wu, Yanyan, et al. "Adverse effects of titanium dioxide nanoparticles on beneficial gut bacteria and host health based on untargeted metabolomics analysis." Environmental Research 228 (2023): 115921.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Applications of gut microbiota technology for agricultural products. Sep. 24, 2022, Hang Xiao. International Symposium on Agricultural Product Processing. Anhui Agricultural University, Hefei, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Frontier in Food for Human Health & Wellness Research, Nov. 19, 2022, Hang Xiao. College of Food Science and Technology, Shanxi Normal University, Xian, Shannxi, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Role of gut microbiota in mediating health effects of food components, Dec. 19, 2022, Hang Xiao. College of Food Science and Technology, South China Agricultural University, Hangzhou, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2023 Citation: The recent advances in food and gut microbiota research, March 25, 2023, Hang Xiao. College of Food and Tea Science, Anhui Agricultural University, Hefei, Anhui, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Interplay between Food and Gut Microbiome: Critical Roles in Human Health, May. 29-31, 2022, Hang Xiao. 4th international symposium of food science and nutrition health, Dalian, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Interplay between Food and Gut Microbiome: Critical Roles in Human Health, May. 29-31, 2022, Hang Xiao*. 4th international symposium of food science and nutrition health, Dalian, China.