Source: MONTANA STATE UNIVERSITY submitted to NRP
BUDGETING FOR CLIMATE CHANGE: CARBON COST OF A HEALTHY ROOT MICROBIOME UNDER ENVIRONMENTAL STRESS
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1028051
Grant No.
2022-67011-36570
Cumulative Award Amt.
$120,000.00
Proposal No.
2021-09461
Multistate No.
(N/A)
Project Start Date
Dec 15, 2021
Project End Date
Dec 14, 2024
Grant Year
2022
Program Code
[A7101]- AFRI Predoctoral Fellowships
Recipient Organization
MONTANA STATE UNIVERSITY
(N/A)
BOZEMAN,MT 59717
Performing Department
Microbiology & Cell Biology
Non Technical Summary
Ensuring plant survival during environmental stress is necessary to feed our growing human population particularly in the face of fluctuating precipitation and temperature regimes linked to climate change. The release of carbon (C)-rich root exudates is a key mechanism by which plants manage the root microbiome to withstand environmental stress, resulting in a "C-cost" diverted from growth and metabolism. The proposed research project will determine how plants and soil microbes adapted to different climate regimes balance the cost-benefit of maintaining the root microbiome under drought and heat stress. I will use a greenhouse experiment to impose four environmental stress treatments on the grass species blue grama: ambient, heat, drought, heat+drought in soils collected across a natural precipitation gradient. I will measure plant C allocation to growth and root exudates using 13CO2-labelling and plant physiology and determine how stress-induced shifts in C allocation alter the active rhizosphere using metagenomics (stable isotope probing, SIP). Deliverables will include one peer-reviewed, first-author publication contributed to my dissertation materials, and three co-authorships. This proposal directly addresses the AFRI Priority Area of Plant Health and Production and Plant Products as it will result in new knowledge regarding the adaptation of plants and microbes to environmental stresses and the consequences of altered plant C allocation for agricultural landscapes. This Predoctoral Fellowship is relevant to the AFRI EWD goal of Advancing Science because it will allow me to pursue my career goal of improving agricultural sustainability by developing climate-smart agricultural practices prioritizing healthy plants and soils.
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
1020110104070%
1021629102030%
Goals / Objectives
The main objective of this proposal is to determine the effect of precipitation legacy on C allocation and microbiome restructuring of blue grama under environmental stress.While my training has prepared me to design and conduct fundamental research in microbialecology, I am most inspired to bridge interactions of the microbial world from soil to plants. I amcurrently transitioning to a NIFA-funded project that focuses directly on the mechanisms thatunderlie above- and belowground interactions between plants and microbes in systemsexperiencing climate stresses such as heat and drought. The goals of that project are focused onunderstanding plant allocation of C belowground under heat and drought stress, the effects ofthose stresses on the soil microbiome, and how plant and microbiome responses are linked.Building on this, here I am proposing to expand our current study to include a range of sitesacross Montana that represent a strong precipitation gradient. By incorporating a broader naturalgradient, I will drastically broaden the scope and robustness of this research to improvepredictability across ecosystems. The interdisciplinary nature of the project, which includes myprimary advisor, Dr. Brent Peyton (environmental bioengineer), and collaborators Dr. RebeccaMueller (microbial ecologist) and Dr. Danielle Ulrich (plant physiologist) will increase myprofessional skillset. In carrying out this project I will achieve my goals of gaining experience in plant physiology andmicrobial -omics approaches and I will learn new laboratory techniques and analyses that willsignificantly benefit my competitiveness as a future career applicant in agricultural sciences.
Project Methods
Approach. Experimental Design. I will collect soil from four additional locations in Montana where blue grama is naturally found representing a 400 mm precipitation gradient. Blue grama seeds will be purchased from a reputable seed dealership (Wind River Seed, WY) and grown in a mix of 10% field-collected soil in pasteurized potting mix. A 10% inoculum is sufficient to allow proliferation of native soil microbiomes while minimizing soil nutrient and texture differences. To ensure establishment, the plants will be allowed to grow for 30 days prior to application of environmental stress treatments.Sample collection. After 30 days, plants will be randomly assigned to one of four treatment conditions for 60 days: Ambient, drought, heat, or heat + drought, n=5 for each. Drought treatments will reflect 50% precipitation reductions from the ambient used to maintain robust plant growth and heat treatments will reflect 3 ?C above ambient. At each time point (20, 40, 60 days), 5L of 99% 13CO2 (Sigma-Aldrich) will be injected into sealed growth chambers for several hours to ensure full uptake by the plants. After 72 hr, root exudate, shoot, and root samples will be collected and analyzed with an isotope ratio mass spectrometer at the Oregon State University Stable Isotope Laboratory. The amount of 13C label allocated to roots and root exudates will be calculated as the 13C atom percent excess as in Karst et al. (2017) to determine the root exudate:root mass ratio. This ratio can be scaled up to estimate root exudation at field scale, informing ecosystem C fluxes. Plant physiology including root and shoot biomass, photosynthesis and respiration will be measured at each time point. Soil samples will be collected by shaking soil off each plant which will then be flash-frozen and transferred to -80 ?C for long-term storage. For plant physiology the total sample count will be 310 (5 sites, 4 treatments, 3 time points, 5 replicates, and ten pretreatment samples). Soil chemistry data including pH, TOC, and total nitrogen and phosphorous will be collected for each of the soil sites. Due to the cost of metagenomics, I will focus microbial sampling on the low-, mid-, and high- precipitation history sites (n=3), and only the ambient, drought, and heat+drought treatments at the final timepoint. I will use soils without plants (no-plant controls) to identify the contribution of C-fixing bacteria relative to plant photosynthates. This brings the total metagenome count to 27 (3 sites, 3 treatments, 1 timepoint with paired no-plant controls, plus 9 background samples (n=3 for each site).Microbiome sequencing. For metagenomics, DNA will be extracted from 2 g of soil, and heavy DNA (13C) will be separated using cesium-chloride gradients as described by Buckley et al.to identify the microbial community actively taking up newly fixed C. Metagenomic library construction and sequencing across one lane of the Illumina NovaSeq6000 will be conducted at the University of Oregon Genomics and Cell Characterization Core Facility. Metagenome-assembled genomes (MAGs) for Bacteria and Archaea will be constructed. High quality MAGs will be classified taxonomically using the Genome Taxonomy Database and functionally annotated using the program RASTand Prokka. As reconstruction genomes of eukaryotic microbes from environmental samples is generally unsuccessful due to the complexity of mixed communities in diverse soil we will classify unassembled sequences against known databases (e.g., community aggregated traits), including Carbohydrate Active Enzymes (CAZyme), Protein Families (PFAM)and UniProt, to gain insights into the functional potential of eukaryotes present across the research sites, with a particular focus on fungi present in soils. All statistical analyses will be performed in R using R Markdown to create runnable, annotated scripts for enhanced reproducibility.Feasibility. Although isotope labeling can greatly advance our understanding of plant C flows to root exudates, pulse labeling does not deliver reliable C balances. However, complementing isotope labeling with additional C allocation measurements including respiration, photosynthesis and root exudate quantitation provides a reliable overall C budget. In addition, the high diversity of microbial communities in soils complicates metagenomic assemblies, but our approach of acquiring higher coverages (n=3) in background soils will improve confidence in our assemblies.The work described above will provide new knowledge of plant-microbe interactions under heat and drought stress that will be used in outreach efforts, by co-mentor Dr. Ulrich in teaching materials, and published in peer-reviewed articles. Evaluation milestones will include peer-reviewed publications and feedback from outreach presentations.

Progress 12/15/21 to 12/14/24

Outputs
Target Audience:The target audience for this project was the broader scientific field of microbial ecologists. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?In completing this experiment I was trained to conduct plant physiology measurements including stomatal conductance and photosynthesis using a LICOR gas analyzer, and water potentials using a pressure chamber. I was also trained to conduct stable isotope labeling which included the use of gas-tight chambers, CO2 probes and navigating gas monitoring software (Campbell Scientific Datalogger PC400). To complete this experiment two undergraduate students were hired by the Ulrich Lab and I have been able to mentor them through sample collection, DNA extraction, sequencing preparation and data analysis.I was also selected to attend a summer school program hosted by the Environmental Molecular Sciences Laboratory (EMSL) focused on visualization tools, analysis, and modeling ofsoil data. This project has provided me the ability to continue in my role as a leader of the Montana State University Graduate Women in Science & Engineering (WISE) student organization. As a WISE leader I have been able to organize and lead an ongoinginterdisciplinary working and writing group, and organize several faculty seminars focused on career opportunities andchallenges for women in STEM. How have the results been disseminated to communities of interest?I presented preliminary results from priorB. gracilisexperiments and experimental design plans for this experiment at a departmental seminar for the Montana State University (MSU)Microbiology & Cell Biology Department in May 2022. I also served as a guest lecturer for an introductory microbiology course at MSU and shared preliminary results in September 2022. This work formed a chapter of my dissertation thesis which was presented to the public (Dec. 2023)and published in the MSU thesis archives, and I presented results from this study at the annual meeting of the Ecological Society of America in August 2024. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? The primary experimentproposed here was successfully conducted from June 2022 to September 2022. In completing this experiment I was trained to conduct plant physiology measurements including stomatal conductance and photosynthesis using a LICOR gas analyzer, and water potentials using a pressure chamber. I was also trained to conduct stable isotope labeling which included the use of gas-tight chambers, CO2 probes and navigating gas monitoring software (Campbell Scientific Datalogger PC400). Amplicon sequencing of the 16S rRNA gene for bacteria and archaea has also been completed and I am currently finalizing manuscript preparation synthesizing microbial community differences across sites and responses to drought and recovery. Concomitantly, I was able to completeextraction oftotal nucleic acids for our previously-awarded NIFA project (2020-07194, PD: Dr. Danielle Ulrich) which will be sent to the Joint Genome Institute for metatranscriptomics as well as used for in-house amplicon sequencing of DNA and cDNA libraries to identify active vs. total microbial community members ofB. gracilisunder drought and heat stress.

Publications


    Progress 12/15/22 to 12/14/23

    Outputs
    Target Audience:I presented results from this work at the Ecological Society of America annual meeting in Portland Oregon and in the public oral defense of my thesis, as well as in writing in my doctoral thesis document which has been successfully submitted and accepted by Montana State University. Changes/Problems:We received the data for our 13C labeled plant tissues and unlabeled controls from Cornell university and it appears that our labeling efforts were not particularly successful. However, we can still make some interesting comparison about label updake in control plants across the different field sites for this experiment. What opportunities for training and professional development has the project provided?In completing this experiment I was trained to conduct plant physiology measurements including stomatal conductance and photosynthesis using a LICOR gas analyzer, and water potentials using a pressure chamber. I was also trained to conduct stable isotope labeling which included the use of gas-tight chambers, CO2 probes and navigating gas monitoring software (Campbell Scientific Datalogger PC400). To complete this experiment two undergraduate students were hired by the Ulrich Lab and I have been able to mentor them through sample collection, DNA extraction, sequencing preparation and data analysis.I am currently involved in the Environmental Molecular Sciences Laboratory's Molecular Observation Network which involves regular workshops to learn about data analysis and interpretation for soil biogeochemical measures including FTICR and XRT. How have the results been disseminated to communities of interest?I presented data from this study in the public oral defense of my dissertation and in my written doctoral thesis document. What do you plan to do during the next reporting period to accomplish the goals?I plan to publish at least2 manuscripts on the data generated from this study.

    Impacts
    What was accomplished under these goals? The primary experimentproposed here was successfully conducted from June 2022 to September 2022. In completing this experiment I was trained to conduct plant physiology measurements including stomatal conductance and photosynthesis using a LICOR gas analyzer, and water potentials using a pressure chamber. I was also trained to conduct stable isotope labeling which included the use of gas-tight chambers, CO2 probes and navigating gas monitoring software (Campbell Scientific Datalogger PC400). Amplicon sequencing of the 16S rRNA gene for bacteria and archaea has also been completed and I am currently finishing manuscript preparation. Concomitantly, I was able to completeextraction oftotal nucleic acids for our previously-awarded NIFA project (2020-07194, PD: Dr. Danielle Ulrich) which were sent to the Joint Genome Institute for metatranscriptomics as well as used for in-house amplicon sequencing of DNA and cDNA libraries to identify active vs. total microbial community members ofB. gracilisunder drought and heat stress. I am currently analyzing these data.

    Publications

    • Type: Journal Articles Status: Accepted Year Published: 2024 Citation: 1. Goemann HM, Ulrich DEM, Peyton BM, Gallegos-Graves LV, Mueller RC. 2024. Severe and mild drought cause distinct phylogenetically linked shifts in the blue grama (Bouteloua gracilis) rhizobiome. Frontiers in Microbiomes 2:1310790. doi: 10.3389/frmbi.2023/1310790


    Progress 12/15/21 to 12/14/22

    Outputs
    Target Audience:Project design and goals were presented to peers within the Montana State University Microbiology & Cell Biology Department in Spring 2022. Changes/Problems:No major changes have been made to the project. A few minor changes included decreasing the proposed field sites from five to four due to logistical challenges of space and time in setting up the greenhouse experiment. What opportunities for training and professional development has the project provided?In completing this experiment I was trained to conduct plant physiology measurements including stomatal conductance and photosynthesis using a LICOR gas analyzer, and water potentials using a pressure chamber. I was also trained to conduct stable isotope labeling which included the use of gas-tight chambers, CO2 probes and navigating gas monitoring software (Campbell Scientific Datalogger PC400). To complete this experiment two undergraduate students were hired by the Ulrich Lab and I have been able to mentor them through sample collection, DNA extraction, sequencing preparation and data analysis.I was also selected to attend a summer school program hosted by the Environmental Molecular Sciences Laboratory (EMSL) focused on visualization tools, analysis, and modeling ofsoil data. This project has provided me the ability to continue in my role as a leader of the Montana State University Graduate Women in Science & Engineering (WISE) student organization. As a WISE leader I have been able to organize and lead an ongoinginterdisciplinary working and writing group, and organize several faculty seminars focused on career opportunities and challenges for women in STEM. How have the results been disseminated to communities of interest?I presented preliminary results from prior B. gracilisexperiments and experimental design plans for this experiment at a departmental seminar for the Montana State University (MSU) Microbiology & Cell Biology Department in May 2022. I also served as a guest lecturer for an introductory microbiology course at MSU and shared preliminary results in September 2022. What do you plan to do during the next reporting period to accomplish the goals?I plan to continue data processing and analysis, and begin manuscript preparation. I will continue to train two undergraduate students in molecular laboratory techniques. I will also continue to be a leader of WISE and organize additional programming for the group through the next year, as well as participate in outreach events such as local Science Saturdays at the Montana Science Center in Bozeman, MT, Skype a Scientist, and MSU-organized elementary student outreach days. I also plan to help prepare and submit a JGI-EMSL FICUS grant in Spring 2023 focused on analyzing the stable isotope-labeled samples for fractionated metagenomics. Further, I plan to submit abstracts for oral and/or poster presentations at several well-established conferences including American Society for Microbiology: Microbe (June 2023) and theEcological Society of America (August 2023).

    Impacts
    What was accomplished under these goals? The primary experimentproposed here was successfully conducted from June 2022 to September 2022. In completing this experiment I was trained to conduct plant physiology measurements including stomatal conductance and photosynthesis using a LICOR gas analyzer, and water potentials using a pressure chamber. I was also trained to conduct stable isotope labeling which included the use of gas-tight chambers, CO2 probes and navigating gas monitoring software (Campbell Scientific Datalogger PC400). Amplicon sequencing of the 16S rRNA gene for bacteria and archaea has also been completed and I am currently analyzing microbial community differences across sites and responses to drought and recovery. Concomitantly, I was able to complete extraction oftotal nucleic acids for our previously-awarded NIFA project (2020-07194, PD: Dr. Danielle Ulrich) which will be sent to the Joint Genome Institute for metatranscriptomics as well as used for in-house amplicon sequencing of DNA and cDNA libraries to identify active vs. total microbial community members of B. gracilisunder drought and heat stress.

    Publications