Source: IOWA STATE UNIVERSITY submitted to NRP
NAHLN LEVEL 1 LABORATORY WORK PLAN
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1027321
Grant No.
2021-37624-35673
Cumulative Award Amt.
$250,000.00
Proposal No.
2021-07354
Multistate No.
(N/A)
Project Start Date
Aug 1, 2021
Project End Date
Jul 31, 2022
Grant Year
2021
Program Code
[AA-G]- Homeland Security
Recipient Organization
IOWA STATE UNIVERSITY
S. AND 16TH ELWOOD
AMES,IA 50011
Performing Department
Vet Diagnostic & Production An
Non Technical Summary
The financial resources provided to the Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) as a core laboratory in the National Animal Health Laboratory Network (NAHLN) are essential in enhancing animal disease monitoring capabilities and capacity, demonstrating competence and compliance of well-defined testing standards, supporting the development and implementation of quality assurance programs that drive the continuous improvement of the laboratory, increasing collaboration and connectivity between state and federal animal health officials and diagnostic laboratories, and improving foreign or emerging animal disease testing, surveillance, and containment capabilities. NAHLN's support of the ISU VDL is essential in driving the continual improvement of the laboratory's ability to adequately serve and protect the health and well-being of US food-animal agriculture and the safety and abundance of our nation's food-supply. Federal support through the NAHLN is a cornerstone of enhancing our laboratory, regional, and national preparedness to effectively monitor and respond to emerging diseases of importance to both animal and human health. These funds have enabled the ISU VDL the ability to maintain a BSL- 3 capable diagnostic laboratory space and proficiency-trained diagnostic technicians that must be prepared when a disease outbreak occurs and utilized on a regular basis for foreign, emerging, and domestic disease surveillance. These funds also support laboratory information technology infrastructure, capabilities, and personnel to develop and use data systems necessary for secure management and transmission of sensitive laboratory data. Similarly, support through the NAHLN has been critical towards enhancing the ISU VDL's quality assurance programs that validate the accuracy and reliability of the test results to reassure decision-makers and foreign trading partners that they can have confidence in the results. In short, funding received through the NAHLN is used as an extremely efficient and effective means of leveraging the capabilities existing at the ISU VDL to enhance the US diagnostic system serving to protect animal health, human health, and the greater than 100 billion dollar US animal agricultural economy.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
31139991160100%
Knowledge Area
311 - Animal Diseases;

Subject Of Investigation
3999 - Animal research, general;

Field Of Science
1160 - Pathology;
Goals / Objectives
The ISU VDL will take the following actions to fulfill the responsibilities of a Level 1 laboratory:Meet all responsibilities of a Level 1 laboratory as outlined in the 2021 Agreement for Participation in the National Animal Health Laboratory Network (NAHLN) As a Level 1 Laboratory.Increase NAHLN capabilities and capacity in addressing an adverse animal health event such as may occur with an emerging disease detection or foreign animal disease outbreak.Some highlights include:1. Accept and rapidly test samples in support of disease investigations, surveillance and outbreak situations.2. Provide diagnostic data per the specified timelines and reporting requirements.3. Maintaining full accreditation by AAVLD or by an accrediting body according to OIE/ISO 17025 standard and provide documentation of such.4. Actively and consistently electronically message diagnostic test results, using HL7 standards, to the Laboratory Messaging System (LMS) or other VS systems for all laboratory approved NAHLN assays able to be messaged.
Project Methods
Moving forward into 2021, the ISU VDL will plan to continue to meet the commitments and expectations associated with being a Level 1 Laboratory in the NAHLN. Such commitments are outlined and detailed more in full in the "2021 Agreement for Participation in the National Animal Health Laboratory Network (NAHLN) as a Level 1 Laboratory".These commitments largely center on maintaining and continuing to increase the NAHLN capabilities and capacity in addressing an adverse animal health event such as may occur with an emerging disease detection or foreign animal disease outbreak.Specific areas of focus center on sustaining and continual advancement of the ISU VDL's veterinary diagnostic information technology capabilities, quality system, and overall diagnostic testing capabilities and testing capacities for diseases of high consequence to US animal agriculture. Such capabilities and continuously improvements are largely brought about through sustaining depth of well-trained and highly competent technical staff, and in maintaining a capable, functional, and well-equipped facility.

Progress 08/01/21 to 07/31/22

Outputs
Target Audience:Veterinarians and producers interested in minimizing the impact of disease and ensuring a high-quality, abundant, affordable, wholesome, and safe food supply. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?We capitalize on the close working relationship between our veterinary diagnosticians and technical staff to facilitate our staff's understanding of the technical aspects of the assays being conducted, pathogens being tested, and the impact of their role in safeguarding US animal agriculture. How have the results been disseminated to communities of interest?All of the USDA associated surveillance test results conducted at the ISU VDL are reported to the NAHLN. What do you plan to do during the next reporting period to accomplish the goals?Moving forward, the ISU VDL will plan to continue to meet the commitments and expectations associated with being a Level 1 Laboratory in the NAHLN. Such commitments are outlined and detailed more in full in the "Agreement for Participation in the National Animal Health Laboratory Network (NAHLN) as a Level 1 Laboratory". These commitments largely center on maintaining and continuing to increase the NAHLN capabilities and capacity in addressing an adverse animal health event such as may occur with an emerging disease detection or foreign animal disease outbreak. Specific areas of focus center on sustaining and continual advancement of the ISU VDL's veterinary diagnostic information technology capabilities, quality system, and overall diagnostic testing capabilities and testing capacities for diseases of high consequence to US animal agriculture. Such capabilities and continuously improvements are largely brought about through sustaining depth of well-trained and highly competent technical staff, and in maintaining a capable, functional, and well-equipped facility

Impacts
What was accomplished under these goals? The ISU VDL effectively executed on the responsibilities and duties as defined in the 2021 Agreement for Participation in the National Animal Health Laboratory Network (NAHLN) as a Level 1 Laboratory and in continuing to expand capabilities and capacities across the lab. Highlights of these responsibilities and accomplishments are outlined below. 1. Provided veterinarians, animal owners, and state and federal animal health officials the diagnostic services needed to support a wide variety of animal health surveillance, suspected disease outbreak investigations, and outbreak response related efforts. 2. Provided the information technology infrastructure (Laboratory Information Management System) and personnel necessary to electronically message diagnostic test results, using HL7 standards, to the USDA's Laboratory Messaging System (LMS) and other VS systems in a timely fashion in accordance with specified timelines and reporting requirements. 3. Provided the quality management personnel, infrastructure, and related practices and quality system necessary for maintaining full accreditation by the AAVLD's Accreditation Committee. 4. The ISU VDL is one of the largest food-animal centered VDLs in North America that processed more than 110,000 case submissions over the course of this project period. The ISU VDL's caseload and testing capacities are ever-expanding and sustained approximately twenty molecular, six serology, and 3 CWD staff proficient in performing the primary NAHLN assays conducted at the ISU VDL.

Publications