Source: UNIVERSITY OF CALIFORNIA, DAVIS submitted to NRP
TRANSGENIC ANIMAL CONFERENCE XIII
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1026980
Grant No.
2021-33522-35338
Cumulative Award Amt.
$5,000.00
Proposal No.
2021-04206
Multistate No.
(N/A)
Project Start Date
Jul 1, 2021
Project End Date
Jun 30, 2022
Grant Year
2021
Program Code
[HX]- Biotechnology Risk Assessment
Recipient Organization
UNIVERSITY OF CALIFORNIA, DAVIS
410 MRAK HALL
DAVIS,CA 95616-8671
Performing Department
Animal Science
Non Technical Summary
This project will support the 13th Transgenic Animal Research Conference hosted by UC Davis. This conference brings together leading researchers from labs around the world working on the genetic engineering and gene editing of agriculturally-important animals including livestock, poultry and fish. The goal of the conference is to convey new knowledge, foster collaborations and move the field of applying genome modifications to domesticated food-animal species forward. The conference also provides an opportunity for interactions with regulators for better understanding and shaping of policy. Due to uncertainties surrounding Covid-19, the conference will be held virtually August 9-12, 2021. The conference will consist of 19 invited oral presentations, short oral presentation by selected students, presentations by representatives of US Federal regulatory agencies (APHIS, FSIS, FDA/CVM) and a discussion panel focused on the regulation of transgenic and gene edited animals. Topics of invited talks include technology, agricultural and biomedical applications and regulation. The day devoted to regulation is with the intent of bringing scientists and regulators together to discuss progress, problems and potential applications of gene biotechnologies as applied to animals. Speaker and student abstracts will be publically available on the conference website and tentatively published in the journal Genes and Genome Editing. Funds are requested to support the virtual management of the conference including the administration of registration, the conference website and Zoom sessions. Overall, the conference will provide a venue for the sharing of scientific information on recent advancements in this field leading to outreach and the education of the public on topics around applying current state of the art biotechnologies for gene modification to benefit animal agriculture. The conference is aligned with the overall purpose of the BRAG Program in that is geared toward disseminating science-based information on genetically engineered animals in order to assist Federal regulatory agencies on making policy/decisions on the use of such animals in agricultural production systems.
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
30339991080100%
Knowledge Area
303 - Genetic Improvement of Animals;

Subject Of Investigation
3999 - Animal research, general;

Field Of Science
1080 - Genetics;
Goals / Objectives
The goal of this project is to host a virtual three day international conference focused on genetic engineering and gene editing in livestock, poultry and fish. The main objective of the conference is to bring together scientists from academia, industry and government labs/agencies from around the world to present and discuss the latest research and developments in the science of using gene biotechnologies in agriculturally important species. The conference is designed to promote the exchange of ideas, foster interactions between participants and provide science-based information for governmental regulators and the general public.
Project Methods
Science-based knowledge will be delivered in the form of oral presentations. There will be a total of 19 invited talks and six short oral presentations of selected students over the duration of the conference. Students will be chosen for presentation based on their submitted abstract. Seven of the invited talks are specifically applicable to the BRAG Program objectives including work on transgene containment (Day 2), technologies around gene editing (Day 1) and regulatory issues (Day 4).Day 1Goetz Laible, Ag Research New Zealand- Optimization of HDR editing in injected zygotesXiaolong Wang, Northwest A&F University China- Base and Prime EditingDay 2Xavier Lauth, Center for Aquaculture Technologies- A solution for providing sterile farmed fishDay 4Mark Cigan, Genus- Towards Commercializing Gene Edited LivestockCassie Edgar, McKee, Voorhees & Sease, PLC- Global Intellectual Property and Regulatory IssuesCharlie Arnot, Center for Food Integrity- Building Trust in TechnologyDavid Ayres, Revivicor- GalSafe pig approval for therapeutic use

Progress 07/01/21 to 06/30/22

Outputs
Target Audience:University, government and industry scientists working in the fields of genetic engineering and gene editing Federal regulators Livestock producers Changes/Problems:The $2,000 budgeted for UC Davis Conference and Events Services was not needed as conference logistics and attendance enabled UC ANR to run registration and the website. What opportunities for training and professional development has the project provided?Graduate students had an opportunity for professional development with respect to presentation skills. Four graduate students participated in a student poster award competition where they submitted an abstract and if chosen, a poster on their work and then gave a 10 minute oral presentation and answered questions from the audience and judges during the plenary session on Day 1 of the conference. Details can be found here: https://ucanr.edu/sites/TARC/StudentPosterAward/. How have the results been disseminated to communities of interest?Video recordings of all presentations are available on the conference website and can be accessed by anyone to extend the reach of the conference. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? A four day international conference focused on genetic engineering and gene editing in livestock, poultry and fish was held online that brought together scientists from academia, industry and government labs/agencies and regulators from around the world to present and discuss the latest research and developments in the science of using gene biotechnologies in agriculturally important species. Over 400 people registered to attend the online conference with the majority of participants from the US (138) with others from India (30), Canada (23), Brazil (21), Nigeria (21), Australia, (20), the UK (19), Germany (18), China (14), Israel (13), Philippines (11), Pakistan (10), Kenya, (8), Bangladesh (7), Columbia (7), France (4), Saudi Arabia (4), Argentina (3), Mali (3), Peru (3),Turkey (3), two people each from Ethiopia, Guatemala, Iraq, Mexico, Spain, Sudan and Uganda and one person each from Belgium, Chile, Costa Rica, Denmark, Egypt, Finland, Ghana, Honduras, Indonesia, Japan, Malaysia, Mozambique, the Netherlands, New Zealand, Norway, Romania, Senegal, Slovenia, South Africa, Switzerland Thailand and Uruguay. Most attendees were from academic institutions (165) with 101 associated with regulatory agencies, 68 from government labs, 64 from biotechnology-related companies and 7 participants from various scientific organizations/commodity groups. Due to the uncertainties of Covid-19, the biannual conference was adapted to an online format. The conference consisted of 19 plenary talks, a panel discussion and 4 student poster presentations, all conducted synchronously on Zoom with recordings of each presentation made for later access. Each day of the conference was dedicated to a specific topic- Technology Development on Day 1 (4 talks), Agricultural Applications on Day 2 (5 talks), Biomedical Applications on Day 3 (6 talks) and Regulatory Considerations on Day 4 (4 talks, presentations from 3 US regulatory agencies (APHIS, FSIS and FDA/CVM) and a panel discussion with members representing academia and regulatory agencies). With respect to risk assessment, the presentations included topics such as transgene containment, assessment of off-target effects of CRISPR/Cas9 and regulatory issues associated with genetic engineering and gene editing in animals. The final program for the conference can be found at https://ucanr.edu/sites/TARC/Agenda/ and the conference website here: https://ucanr.edu/sites/TARC/.

Publications