Source: SOUTHERN UNIV submitted to
CENTER OF EXCELLENCE FOR NUTRITION, HEALTH, WELLNESS, AND QUALITY OF LIFE
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
EXTENDED
Funding Source
Reporting Frequency
Annual
Accession No.
1026396
Grant No.
2021-38427-34836
Project No.
LAX06SUAG-COE21
Proposal No.
2021-01838
Multistate No.
(N/A)
Program Code
COE
Project Start Date
May 1, 2021
Project End Date
Apr 30, 2023
Grant Year
2022
Project Director
Malekian, F.
Recipient Organization
SOUTHERN UNIV
(N/A)
BATON ROUGE,LA 70813
Performing Department
Nutrition, Health & Wellness
Non Technical Summary
African Americans (AAs) remain the least healthy ethnic group in the USA. Diet is a key contributor to disparities in many chronic diseases and conditions. AA communities have trusted the 1890 institutions for more than a century, therefore, they can play important roles in assisting AAs to combat diet-related disparities especially obesity and its related chronic diseases. Establishing an 1890 Center of Excellence (COE) for Nutrition, Health, Wellness, and Quality of Life is very timely and will strengthen 1890 institution's capacities in research, teaching and extension to address diet-related health disparities in AAs. Louisiana, North Carolina, and Alabama are among the top 10 most obese states in non-Hispanic black adults. Southern University and A&M College, North Carolina A&T State University, and Tuskegee University have complementary strengths in research, teaching, and extension, and are in a unique position to work as a team to establish a COE, which is on the tripartite "land-grant" mission of research, teaching, and extension to improve the health and well-being of underserved and minority populations. The primary goal of this COE is to increase the capacities of 1890 institutions to address health disparity through nutrition research, teaching, and extension. The Specific Objectives are: 1) Research: To enhance the research capacity at 1890 institutions focusing on food intake and nutritional/health outcomes, 2) Teaching: To strengthen and advance innovative food and nutrition educational and instructional strategies for students at 1890 institutions, and 3) Extension: To provide training and education to underrepresented communities through multi-state food and innovative nutrition outreach programs.
Animal Health Component
0%
Research Effort Categories
Basic
80%
Applied
10%
Developmental
10%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7036099302060%
7246020101040%
Goals / Objectives
The primary goal of this COE is to increase the capacities of 1890 institutions to address health disparity through nutrition research, teaching, and extensionThe Specific Objectives are:1. Research: To enhance the research capacity at 1890 institutions focusing on food intake and nutritional/health outcomesObjective 1a. Developing methods to quantify bioactive microbial metabolites using targeted metabolomic approaches.Objective 1b. Developing the platform to study the global fecal metabolome using untargeted metabolomic approachesObjective 1c. Determining the association between food intake and gut microbiota profiles2. Teaching: To strengthen and advance innovative food and nutrition educational and instructional strategies for students at 1890 institutionsObjective 2a. Create opportunities for students to be trained at multiple 1890 institutions via an 1890 Center for Research and Extension ScholarsObjective 2b. Create a nutrition disparities symposium that is open to students and faculty at all 1890s via an 1890 Center Symposium Series3. Extension: To provide training and education to underrepresented communities through multi-state food and innovative nutrition outreach programsObjective 3a. Sister's Together: Move More, Eat BetterObjective 3b. Make Fruits and Vegetables Available to AllObjective 3c. Emerging Technologies for Extension ProgramsObjective 4. Establish pilot projects program for faculty at all 1890 institutions
Project Methods
The brief summary on how to accomplish each objective include:Research: Objective 1. Enhance the research capacity at 1890 institutions focusing on food intake and nutritional/health outcomes--Build a metabolomics core facility at North Carolina A&T State University to study diet-related health disparities.Our long-term goals are to 1) use metabolomics as a powerful tool to study food intake and nutritional/health outcomes related to underrepresented minorities and 2) provide a shared metabolomic core to all 1890 institutions.The short-term goal for this one-year project is to use fecal metabolome as the indicator to study the preventive effects of functional foods against chronic diseases especially those where AAs are at high risks.Objective 1a. Developing methods to quantify bioactive microbial metabolites using targeted metabolomic approaches. North Carolina A&T State University has an ongoing USDA project to study the biomarkers of whole grain intake. In this project, baseline stool samples were collected from 54 participants, which include 10 samples from AAs (five males and five females). We will use these 10 samples to develop our LC/MS and/or GC/MS methods to quantify bioactive microbial metabolites. In the meantime, we plan to collect stool samples from 16 healthy lean AA volunteers (eight males and eight females) and 16 obese AA volunteers (eight males and eight females) from each of our partners. Each participant will also be asked to provide a three-day food diary.Objective 1b. Developing the platform to study the global fecal metabolome using untargeted metabolomic approaches. Untargeted metabolomics focus on global detection and relative quantitation of small molecules in a sample and usually involve comparing the metabolome of different groups to identify differences between their metabolite profiles, which is a very useful approach to identify biomarkers for further mechanistic studies. In this one-year project, we plan to use the untargeted metabolomic approach to study the fecal metabolome of AAs, compare the differences between samples collected from lean and obese subjects and the three different regions, and investigate the impact of diet on the fecal metabolome of AAs.Objective 1c. Determining the association between food intake and gut microbiota profilesIn order to determine whether the fecal metabolome can be used as the read out of the gut microbiome, we will correlate the fecal metabolites identified from the targeted and untargeted metabolomics with the bacteria profiles of the gut microbiome of the fecal samples collected from the three geographic regions. We will use the UNC-Chapel Hill's Microbiome core to sequence the microbiota of fecal samples collected from the tree regions for identification, classification and quantitation of microbes. UNC-Chapel Hill's Microbiome core will assist us on the association studies between microbial metabolites and gut microbes.Teaching: Objective 2. Strengthen and advance the food and nutrition educational and instructional strategies for students at 1890 institutionsAcademic institutions must prepare students to resolve issues affecting diet-related disparities through the intellectual exchange of academic excellence, knowledge and leadership. This will be fostered through the development of an 1890 Center for Research and Extension Scholars accompanied by an 1890 Center Symposium Series, which will aid in the development and sustainment of an interdisciplinary Center of Excellence for Nutrition, Health, Wellness and Quality of Life across participating land-grant institutions. Our goals are to 1) establish an interdisciplinary cross collaborative 1890 Research and Extension Scholars exchange program which will provide undergraduates the opportunity to collaborate and participate in innovative research and Extension projects that have a direct impact on diet-related disparities and 2) develop a virtual symposium series open to all 1890's that highlight faculty, Extension specialist, students and community experts conducting work in diet-related disparities.Objective 2a. Create opportunities for students to be trained at multiple 1890 institutions via an 1890 Center for Research and Extension Scholars.The goal of the 1890 Center for Research and Extension Scholars is to provide students at each of the three participating 1890 institutions training to become interdisciplinary researchers and Extension professionals with a focus on diet-related disparities among minority populations. Each university will select approximately three students to participate as 1890 Center Scholars.Objective 2b. Create a nutrition disparities symposium that is open to students and faculty at all 1890s via an 1890 Center Symposium Series.The participating 1890s have created an alliance to deliver an 1890 Center Symposium Series. The goal of this symposium series is to build a collaborative network of 1890 faculty, staff and students by engaging them in a series of discussions, forums and presentations that inform and educate them on the role of diet-related disparities among low-income and historically marginalized populations. This bi-monthly symposium will focus on diet-related disparities and present the work being done by 1890 faculty, staff, students, and community partners. Additionally, this 1890 Center Symposium will provide a forum for bidirectional education and dissemination between the community and researchers through which students, faculty, and community members can learn.Extension: Objective 3. Provide training and education to underrepresented communities through multi-state food and nutrition outreach programsThe Extension goal of this COE is to create the platform and opportunity for Southern University AgriculturalCenter, NCA &T and Tuskegee to work collaboratively to further strengthen the existing nutrition education programs at each institution, identify and test new programs, and develop emerging technologies to help the underserved minority communities to combat diet-related health disparities and live a healthy life. This collaborative effort can accelerate the acquisition and dissemination of knowledge more effectively than a single institution can achieve. At the host and co-host institutions, we will partner with existing nutrition education programs to deliver and continue to build and expand upon the relationships formed, and will continue to train students and community members that will change the underrepresented communities based upon their needs and assessments.Objective 3a. Sister's Together: Move More, Eat BetterSister's Together is a national community-based health awareness program that encourages Black women, 18 years and older, to maintain a healthy weight by being more physically active and eating nutritious foods.?Objective 3b. Make Fruits and Vegetables Available to AllTuskegee University will provide nutrition education via its innovative Make Fruits and Vegetables to All program. This program makes fruits and vegetables available to the Black communities in Alabama.Objective 3c. Emerging Technologies for Extension ProgramsEmerging technology will be used to work directly with programs and communities. With only one-year, we will not have time to conduct any activities using the existing emerging technologies at each institution or develop new technologies. However, we will use this opportunity to share the existing emerging technologies at each institution with other partners through the 1890 Symposium series especially under the topic "Community Engagement and its Impact on Diet-Related Disparities".Pilot Project: Objective 4. Establish pilot projects program for faculty at all 1890 institutionsThe mission of this COE is to benefit the entire 1890 community. Therefore, we will set aside funds for pilot projects that faculty and research staff at all 1890 institutions can apply.