Source: KANSAS STATE UNIV submitted to
FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD)
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
TERMINATED
Funding Source
OTHER GRANTS
Reporting Frequency
Annual
Accession No.
1023913
Grant No.
2020-41480-32497
Project No.
KS80202824
Proposal No.
2020-08541
Multistate No.
(N/A)
Program Code
FARAD
Project Start Date
Sep 1, 2020
Project End Date
Aug 31, 2023
Grant Year
2020
Project Director
Jaberi-Douraki, M.
Recipient Organization
KANSAS STATE UNIV
(N/A)
MANHATTAN,KS 66506
Performing Department
Anatomy & Physiology
Non Technical Summary
The Food Animal Residue Avoidance Databank (FARAD) program is a national food safety program funded since 1982 by USDA and is a collaborative effort with five regional centers: Kansas State University (KSU), North Carolina State University, University of California, Davis, University of Florida, and Virginia-Maryland College of Veterinary Medicine. The goal of FARAD is to provide the most updated information and scientific tools to help the production of safe foods of animal origin. The program accomplishes this goal through its objectives: (1) to identify, extract, assemble, evaluate and distribute reviewed information about residue avoidance and mitigation to people involved in residue avoidance programs; (2) to develop tools that allow people to predict proper withdrawal intervals after extralabel drug use. To continue to fulfill the mission of FARAD, during 2020-2021, the specific objectives at KSU include: (1) to continue developing a Physiological Parameter Database in several food animal species, including goats, sheep, chickens, and turkeys, (2) to develop a generic interactive physiologically based pharmacokinetic (iPBPK) platform for drugs in food animals, (3) to develop PBPK model for specific drugs based on the calls/inquiries we received, (4) to expand FARAD databases to develop global connection, and (5) to develop a HTML webpage and an artificial intelligence system for global FARAD program. The proposed research is important as it will provide tools for FARAD responders to calculate withdrawal intervals after extralabel drug use in different food animal species, which is needed because AMDUCA permits extralabel drug use in food animals by veterinarians.
Animal Health Component
100%
Research Effort Categories
Basic
50%
Applied
50%
Developmental
0%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7115010118010%
7115010115015%
7115010208015%
7113520118010%
7113320118010%
7113440118010%
7113620118010%
7113820118010%
7113260118010%
Knowledge Area
711 - Ensure Food Products Free of Harmful Chemicals, Including Residues from Agricultural and Other Sources;

Subject Of Investigation
3320 - Meat, beef cattle; 3260 - Poultry meat; 3520 - Meat, swine; 3440 - Meat, dairy cattle; 3620 - Meat, sheep; 3820 - Goats, meat, and mohair; 5010 - Food;

Field Of Science
1180 - Pharmacology; 2080 - Mathematics and computer sciences; 1150 - Toxicology;
Goals / Objectives
The goal of the national FARAD program is to protect the American public by promoting the production of safe, animal-derived human food products (milk, eggs, meat, honey, etc.) that are devoid of violative or potentially unsafe chemical residues,including drugs, pesticides, environmental contaminants, natural toxins and other harmful substances.There are six specific objectives of the national FARAD program: (1) extraction and validation of data for incorporation into the system and support for FARAD's approved drug databases for publication in electronic format (VetGRAM) for internet-based delivery, including extraction of relevant data from foreign drug compendia and gFARAD partners, (2) operation of the Regional Access Centers (RAC's) at NCSU, VMCVM and UCD for provision of residue avoidance information, with access through the toll-free hotline and online submission form, (3) data entry, pharmacokinetic analysis, maintenance, and distribution of the FARAD files, (4) preparation of FARAD Digests for publication in the Journal of the AVMA, newsletters and FARAD fact sheets/species information web based pages, (5) education of veterinarians on drug residue avoidance, and (6) continued development and validation of methods to allow extrapolative techniques to be used in providing information and advice insituations where no direct data currently exists, as is typically required for nearly all environmental contaminant exposures.The goal of the KSU component of the FARAD program is to develop web-based interface platforms and databases that allow FARAD responders to calculate drug withdrawal intervals after extralabel use of different drugs in different food animal species real time.There are five specific objectives of the KSU component of the FARAD program: (1) to continue developing a Physiological Parameter Database in several food animal species, including goats, sheep, chickens, and turkeys, (2) to develop a generic interactive physiologically based pharmacokinetic (iPBPK) platform for drugs in food animals, (3) to develop PBPK model for specific drugs based on the calls/inquiries we received, (4) to expand FARAD databases to develop global connection, and (5) to develop a HTML webpage and an artificial intelligence system for global FARAD program.
Project Methods
The proposed PBPK models will be developed based on pharmacokinetic data from the FARAD database using Berkeley Madonna (Version 8, University of California at Berkeley, CA) and/or R language program.The web-based interface will be developed using R Shiny (a web-based visualization platform for R language).The developed PBPK models will be evaluated with independent pharmacokinetic data that were not used in the model development according to the PBPK model evaluation criteria from the World Health Organization.The results of the model-predicted withdrawal interval will be evaluated and interpreted by comparing with the labeled withdrawal period after drug administration at the labeled dose.The proposed 1Data database and the HTML webpage will be connected to the existing FARAD database to develop global connection.A HTML webpage and an artificial intelligent system will be incorporated into the global FARAD database.The efforts of the Principal Director, Co-Principal Director, Postdoctoral Fellows, and Research Assistants will be mainly focused on computational PBPK modeling and database development.

Progress 09/01/20 to 08/31/23

Outputs
Target Audience:FARAD's immediate clients are practicing veterinarians, regulators, extension officers, producers, and researchers, but it ultimately protects the food consuming public and contributes to human Public Health by equipping these professionals with the best science available. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This is a list of estimated FTE. • Two graduate students: 1.0 FTE • Sixpostdocs: 1.0 FTE •Dr. Zhoumeng Lin andDr. Wei-Chun Chou: 1.0 FTE How have the results been disseminated to communities of interest?See data above on call center and internet access which is the primary route for information dissemination for FARAD. We also published our research in peer-reviewed journals (see the Products page) and presented our research findings in local, regional, and national meetings, including the Annual Meeting of Society of Toxicology in 2021 and 2022. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? The national FARAD program aims to safeguard the American public by ensuring the production of safe animal-derived human food products, free from violative or potentially harmful chemical residues. This includes drugs, pesticides, environmental contaminants, natural toxins, and other detrimental substances. The specific goal of the KSU, in collaboration with the subaward to Florida led by Dr. Zhoumeng Lin, within FARAD is to establish web-based interface platforms and databases. These platforms empower FARAD responders to calculate real-time drug withdrawal intervals following the extralabel use of different drugs in diverse food animal species. Key objectives achieved include:? Expanded FARAD databases to establish a global connection. Developed an HTML webpage and an artificial intelligence system for the global FARAD program. Created an Evaluation tool for Precision Livestock Technology. Constructed an Automated Customizable Live Web Crawler for the Curation of Comparative Pharmacokinetic Data, constituting an intelligent compilation of a research-based comprehensive article repository. Employed machine learning algorithms to estimate maximum residue limits for veterinary medicines. Completed a Physiological Parameter Database for PBPK modeling in six food animal species (cattle, swine, sheep, goats, chickens, and turkey), linked to the FARAD website. Constructed new web-based PBPK interfaces for oxytetracycline in sheep and goats, as well as meloxicam in broiler chickens and laying hens. Developed a generic PBPK interface capable of simulating multiple drugs (e.g., penicillin G, flunixin, and florfenicol) in two major food animal species (cattle and swine). Established a generic PBPK interface for multiple per- and polyfluoroalkyl substances (PFAS) in beef cattle and dairy cows. Assisted FARAD colleagues at the Regional Center at the University of California - Davis in completing a pharmacokinetic study for florfenicol in goats, contributing to the development of a new web-based PBPK interface for florfenicol in sheep and goats.

Publications

  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Wu X, Lin Z, Toney E, Clapham MO, Wetzlich SE, Davis JL, Chen Q, Tell LA*. (2023). Pharmacokinetics, Tissue Residue Depletion, and Withdrawal Interval Estimations of Florfenicol in Goats Following Repeated Subcutaneous Administrations. Food and Chemical Toxicology, in press. [PMID: 37838212] https://doi.org/10.1016/j.fct.2023.114098
  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Chou WC, Tell LA, Baynes RE, Davis JL, Cheng YH, Maunsell FP, Riviere JE, Lin Z. (2023). Development and Application of an Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Model for Adult Beef Cattle and Lactating Dairy Cows to Estimate Tissue Distribution and Edible Tissue and Milk Withdrawal Intervals for Per- and Polyfluoroalkyl Substances (PFAS). Food and Chemical Toxicology, 181:114062. [PMID: 37769896]
  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Ampadi Ramachandran, R., Tell, L. A., Rai, S., Millagaha Gedara, N. I., Xu, X., Riviere, J. E., & Jaberi-Douraki, M. (2023). An Automated Customizable Live Web Crawler for Curation of Comparative Pharmacokinetic Data: An Intelligent Compilation of Research-Based Comprehensive Article Repository. Pharmaceutics, 15(5), 1384. https://doi.org/10.3390/pharmaceutics15051384
  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Bortoluzzi, E. M., Goering, M. J., Ochoa, S. J., Holliday, A. J., Mumm, J. M., Nelson, C. E., ... Jaberi-Douraki, M. & Hulbert, L. E. (2023). Evaluation of Precision Livestock Technology and Human Scoring of Nursery Pigs in a Controlled Immune Challenge Experiment. Animals, 13(2), 246. https://doi.org/10.3390/ani13020246
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2023 Citation: Remya Ampadi Ramachandran, Nader Zad, Lisa A. Tell, Xuan Xu, Jim E. Riviere, Ronald Baynes, Zhoumeng Lin, Fiona Maunsell, Jennifer Davis, Majid Jaberi-Douraki. Oct 18, 2023. Harnessing Machine Learning for Veterinary Medicine Maximum Residue Limit (MRL) Estimation. Research Connections, K-State. (Poster Presentation) https://www.k-state.edu/research/faculty/other-resources/connections/
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2023 Citation: Hossein Sholehrasa, Remya Ampadi Ramachandran, Lisa A. Tell, Sidharth Rai, Nuwan Indika Millagaha Gedara, Xuan Xu, Jim E. Riviere, Hande kucuk McGinty�and Majid Jaberi-Douraki. Oct 18, 2023. An Automated Customizable Live Web Crawler for Curation of Comparative Pharmacokinetic Data: An Intelligent Compilation of Research-Based Comprehensive Article Repository. Research Connections, K-State. (Poster Presentation) https://www.k-state.edu/research/faculty/other-resources/connections/
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2023 Citation: Remya Ampadi Ramachandran, Nader Zad, Lisa A. Tell, Xuan Xu, Jim E. Riviere, Ronald Baynes, Zhoumeng Lin, Fiona Maunsell, Jennifer Davis, Majid Jaberi-Douraki. Oct. 16-18, 2023. Harnessing Machine Learning for Veterinary Medicine Maximum Residue Limit (MRL) Estimation. AI Symposium, K-State. (Poster Presentation) https://lib.k-state.edu/technology/ai-and-libraries/ai-symposium/
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2023 Citation: Hossein Sholehrasa, Remya Ampadi Ramachandran, Lisa A. Tell, Sidharth Rai, Nuwan Indika Millagaha Gedara, Xuan Xu, Jim E. Riviere, Hande kucuk McGinty�and Majid Jaberi-Douraki. Oct. 16-18, 2023. An Automated Customizable Live Web Crawler for Curation of Comparative Pharmacokinetic Data: An Intelligent Compilation of Research-Based Comprehensive Article Repository. AI Symposium, K-State. (Poster Presentation) https://lib.k-state.edu/technology/ai-and-libraries/ai-symposium/
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2022 Citation: Sidharth, Lisa Tell, Majid Jaberi-Douraki. April 2022. Automatic Data Curation and Extraction from Scientific Publications. Poster presentation in 2022 Nexus Informatics Conference, Kansas City, MO.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Chou WC, Tell LA, Lin Z. An interactive generic physiologically based pharmacokinetic modeling platform to predict meat and milk residues and withdrawal intervals for perfluorooctanoic acid, perfluorooctane sulfonate and perfluorohexane sulfonate in beef and dairy cattle. Society for Risk Analysis (SRA) Annual Meeting, Tampa, FL. (December 4-8, 2022) (Selected to do a Platform Presentation; Presenter: Lin Z. Section T4-G: Innovative Approaches in Food Safety Risk Management)
  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Zad, N., Tell, L. A., Ramachandran, R. A., Xu, X., Riviere, J. E., Baynes, R., ... & Jaberi-Douraki, M. (2023). Development of machine learning algorithms to estimate maximum residue limits for veterinary medicines. Food and Chemical Toxicology, 179, 113920. https://doi.org/10.1016/j.fct.2023.113920
  • Type: Journal Articles Status: Published Year Published: 2023 Citation: Nelson, C. E., Aramouni, F. M., Goering, M. J., Bortoluzzi, E. M., Knapp, L. A., Herrera-Ibata, D. M., ... Jaberi-Douraki, M. & Hulbert, L. E. (2023). Adult Ossabaw pigs prefer fermented sorghum tea over isocaloric sweetened water. Animals, 13(20), 3253. https://doi.org/10.3390/ani13203253


Progress 09/01/21 to 08/31/22

Outputs
Target Audience:FARAD's immediate clients are practicing veterinarians, regulators, extension officers, producers, and researchers, but it ultimately protects the food consuming public and contributes to human Public Health by equipping these professionals with the best science available. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This is a list of estimated FTE. Two graduate students: 0.5 FTE each Three postdocs: 0.5FTE each Dr. Zhoumeng Lin: 0.1 How have the results been disseminated to communities of interest?See data above on call center and internet access which is the primary route for information dissemination for FARAD. Upon completion of a specific project, we also publish the research findings in peer-reviewed journals. Please refer to the publications listed in the Products page. Also, we present our research findings in local and national conferences, such as the Annual Meeting of Society of Toxicology in 2020, 2021, and 2022 (listed in the Products page). What do you plan to do during the next reporting period to accomplish the goals?In the next reporting period, we plan to complete a new web-based PBPK interface for florfenicol in sheep and goats. We also plan to complete a new web-based PBPK interface for per- and polyfluoroalkyl substances (PFAS) in beef cattle and dairy cows. We also plantoexpand our FARAD databases to extract clearance data from food animals as well as other animals to be able to artificial intelligence system for global FARAD program.

Impacts
What was accomplished under these goals? We have completed the literature review project on physiological parameters for PBPK modeling of drugs in six food animal species, including cattle, swine, sheep, goats, chickens, and turkeys. We have developed a Physiological Parameter Database for these six food animal species. This database has been linked to the FARAD website. We have built a new PBPK model for flunixin in finishing-age swine. We have built a generic PBPK interface that can perform simulations for multiple drugs (i.e., penicillin G, flunixin, and florfenicol) in two major food animal species (cattle and swine). We have expandedFARAD databases to develop global connection using navigation systems from HTML, XML, or pdf files and started developing artificial intelligence system for global FARAD program.

Publications

  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yuan L, Lin Z, Dutch RS, Richards ED, Clapham MO, Burmas N, Wetzlich SE, Tell LA. (2022). Residue depletion profiles and withdrawal interval estimations of meloxicam in eggs and ovarian follicles following intravenous (Meloxicam Solution for Injection) and oral (Meloxidyl�) administration in domestic chickens (Gallus domesticus). Regulatory Toxicology and Pharmacology, 132, 105170. [PMID: 35460801] https://doi.org/10.1016/j.yrtph.2022.105170
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Mercer MA, Davis JL, Riviere JE, Baynes RE, Tell LA, Jaberi-Douraki M, Maunsell FP, Lin Z. (2022). Mechanisms of Toxicity and Residue Considerations of Rodenticide Exposure in Food Animals: a FARAD Perspective. Journal of the American Veterinary Medical Association, 260(5):514-523. [PMID: 35092661] https://doi.org/10.2460/javma.21.08.0364
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Richards ED, Dutch RS, Burmas NC, Davis JL, Lin Z, Clapham MO, Wetzlich SE, Tell LA. (2022). Pharmacokinetic parameters and estimating extra-label tissue withdrawal intervals using three approaches and various matrices for domestic laying chickens following meloxicam administration. Frontiers in Veterinary Science, 9:826367. [PMID: 35310412] [PMCID: PMC8927936] https://doi.org/10.3389/fvets.2022.826367
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Halleran JL, Papich MG, Li M, Lin Z, Davis J, Maunsell P, Riviere J, Baynes R, Foster DM. (2022). Update on Withdrawal Intervals following Extralabel Use of Procaine Penicillin G in Cattle and Swine. Journal of the American Veterinary Medical Association, 260(1):50-55. [PMID: 34793323] https://doi.org/10.2460/javma.21.05.0268
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z*. (2021). Development and application of an interactive physiologically based pharmacokinetic (iPBPK) model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep and goats. Toxicological Sciences, 183(2):253-268. [PMID: 34329480] https://doi.org/10.1093/toxsci/kfab095
  • Type: Conference Papers and Presentations Status: Other Year Published: 2022 Citation: Riad MH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Predicting florfenicol and florfenicol amine tissue distribution and estimating withdrawal intervals in market-age sheep and goats using a physiologically based pharmacokinetic model. The 61st Annual Meeting of Society of Toxicology, San Diego, CA. The Toxicologist, Supplement to Toxicological Sciences, 186, (S1), p. 293, abstract/poster board #: 4001/P699. (March 27-31, 2022)
  • Type: Conference Papers and Presentations Status: Other Year Published: 2022 Citation: Yuan L, Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens. The 61st Annual Meeting of Society of Toxicology, San Diego, CA. The Toxicologist, Supplement to Toxicological Sciences, 186, (S1), p. 292, abstract/poster board #: 3998/P696. (March 27-31, 2022)
  • Type: Conference Papers and Presentations Status: Other Year Published: 2022 Citation: Yuan L, Chou WC, Riad MH, Cheng YH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 201, abstract/poster board #: 2539/P277. (March 12-26, 2021)
  • Type: Conference Papers and Presentations Status: Other Year Published: 2022 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a physiologically based pharmacokinetic model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 158, abstract/poster board #: 2364/P102. (March 12-26, 2021)
  • Type: Conference Papers and Presentations Status: Other Year Published: 2022 Citation: Sidharth, Lisa Tell, Majid Jaberi-Douraki. Automatic Data Curation and Extraction from Scientific Publications. 2022 Nexus Informatics Conference.(Kansas City, MO, April 7-8, 2022).
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Salas JR, Jaberi-Douraki M, Wen X, Volkova VV. (2020). Mathematical modeling of the inoculum effect': six applicable models and the MIC advancement point concept. FEMS Microbiology Letters, 367(5), fnaa012.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Richards ED, Tell LA, Davis JL, Baynes RE, Lin Z, Maunsell FP, Riviere JE, Jaberi-Douraki M, Martin KL, Davidson G. (2021). Honey bee medicine for veterinarians and guidance for avoiding violative chemical residues in honey. Journal of the American Veterinary Medical Association, 259(8):860-873. [PMID: 34609191] https://doi.org/10.2460/javma.259.8.860
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Maunsell, F., Baynes, R., Davis, J., Foster, D., Jaberi-Douraki, M., Riviere, J., & Tell, L. (2021, October). FARAD: How we respond to withdrawal inquiries. In American Association of Bovine Practitioners Conference Proceedings (pp. 9-11).
  • Type: Conference Papers and Presentations Status: Other Year Published: 2022 Citation: Yuan L, Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in domestic chickens. Annual Meeting of Southeastern Society of Toxicology (SESOT), virtual. (November 18-19, 2021).


Progress 09/01/20 to 08/31/21

Outputs
Target Audience:FARAD's immediate clients are practicing veterinarians, regulators, extension officers, producers, and researchers, but it ultimately protects the food consuming public and contributes to human Public Health by equipping these professionals with the best science available. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This is a list of estimated FTE. Two graduate students: 0.25 FTEeach Three postdocs: 0.25 FTE each Dr. Zhoumeng Lin: 0.1 How have the results been disseminated to communities of interest?As we normally do, upon completion of a specific project, we publish the research findings in peer-reviewed journals. Please refer to the publications listed in the Products page. Also, we present our research findings in local and national conferences, such as the Annual Meeting of Society of Toxicology (also listed in the Products page). What do you plan to do during the next reporting period to accomplish the goals?In the next reporting period, Dr. Lin plans to complete a new web-based PBPK interface for florfenicol in sheep and goats, as well as to complete a generic PBPK interface that can be used to estimate withdrawal intervals of multiple drugs in cattle and swine. Dr. Zhoumeng Lin and all his lab members moved from Kansas State University to University of Florida in May 2021. At UF, Dr. Lin and his lab members will continue to complete the project that was originally committed to KSU. Based on the advice from USDA Program Director, Dr. Lin has been working to subaward the PBPK component of this project from KSU to UF. UF sent all subaward documents to KSU Grant Office several months ago. Unfortunately, there is a delay at the KSU Grant Office, and UF has not received this subaward yet. In order not to delay the project, Dr. Lin and his lab members have been continuing working on this project, and Dr. Lin's lab members are now paid by departmental funds with the permission of his departmental chair. Dr. Lin will keep sending reminders to KSU Grant Office to request their help to process the subaward request. Moving forward, Dr Jaberiplans to take advantage and leverage a comprehensive array of AI tools for training machine learning models to analyze the resourceful collected data and understand the underlying patterns defining structure/function properties. From the wealth of alternatives by combining AI/ML and a network of the paired databanks, Dr Jaberi has been working on navigatingADEs in food-producing animals, expanding and makingsense of data-driven patterns to narrow our research, and more efficiently search for and discover mechanisms and effective statistical data analysis.Dr Jaberi-Douraki is also currently working on three manuscripts to be submitted next year: 1. Data extraction: Designing a web crawling/navigating system 2. Prediction of missing/unavailable MRLs for veterinary drugs 3. Global trends in antimicrobial use in food animals

Impacts
What was accomplished under these goals? We have completed a Physiological Parameter Database for PBPK modeling in six food animal species, including cattle, swine, sheep, goats, chickens, and turkey. This database has been linked to the FARAD website. We have built a new web-based PBPK interface for oxytetracycline in sheep and goats. We have finalized a data collecting framework/agreement for the global database of drug's withdrawal time. We are currently working on the development of the HTML webpage and artificial intelligence system for global FARAD program.

Publications

  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z*. (2021). Development and application of an interactive physiologically based pharmacokinetic (iPBPK) model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep and goats. Toxicological Sciences, 183(2):253-268. [PMID: 34329480] https://doi.org/10.1093/toxsci/kfab095
  • Type: Conference Papers and Presentations Status: Other Year Published: 2021 Citation: Yuan L, Chou WC, Riad MH, Cheng YH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological
  • Type: Conference Papers and Presentations Status: Other Year Published: 2021 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a physiologically based pharmacokinetic model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 158, abstract/poster board #: 2364/P102. (March 12-26, 2021)
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Jaberi-Douraki M, Dinani ST, Millagaha Gedara NI, Xu X, Richards E, Maunsell F, Zad N, Tell LA. (2021) Large-scale data mining of rapid residue detection assay data from HTML and PDF documents: improving data access and visualization for veterinarians. Frontiers in veterinary science. 8:787.
  • Type: Conference Papers and Presentations Status: Other Year Published: 2020 Citation: Oct 2020, Majid Jaberi-Douraki, Progress on the Intelligent Medicine Recommender System. CTSA One Health Alliance (COHA) 2020 Data Sharing Workshop. Organized by Tufts, UC Davis and Colorado State.