Progress 09/01/20 to 08/31/22
Outputs
Target Audience:The target audience(s) for the genetic engineering platform isplanting seed companies that develop, produce, sell and market planting seed cultivars and hybrids. The North American wheat planting seed market is highly fragmented, with WestBred (Monsanto, merged by Bayer CropScience) being the dominant "Big Ag" player along with BrettYoung, DuPont/Pioneer (current Corteva Agriscience), and Winfield United (Land O'Lakes). In addition, wheat planting seed is sold by literally dozens of small seed companies, family-owned businesses, and U.S. universities such as Kansas State University and Montana State University that provide foundation seed. Group Limagrain, based in France, is the dominant EU player, while Nuseed and Pioneer are notable players in Australia's wheat-planting seed market. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?
Nothing Reported
How have the results been disseminated to communities of interest?
Nothing Reported
What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
This SBIR Phase I research project performed by Astalake Biosystems generated several DNA plasmid constructs with target promoter and transcription factor genes combinations. The DNA constructs were transformed into a publicly available wheat variety at a plant transformation center. The genetically engineered plantlets were then generated from tissue culture and transferred into the soil after sufficient development. The high-yielding low-lignin lines were selected from the developed lines based on molecular characterization, detailed morphological analysis, and biomass composition analyses in the laboratory environment. This SBIR project's outcome offers high-yielding grains and fast-growing high-quality residue for animal feed, improvement of soil health, and advanced lignocellulosic feedstocks for bioenergy. Commercial economics in the planting seed industry revolves around high-yield planting seeds. The market share of any cultivar is driven by crop performance - i.e., yield and, to a lesser extent, quality - under a given set of environmental conditions. On average, wheat planting seed input cost on a per-acre basis is $15.08. Based on these numbers, the world wheat planting seed market's value was $US 8.03 billion. Although Astalake Biosystems has seen yield increases in other crops of 30% and more in its greenhouse, the company recognizes that actual commercial crop yields will be lower than that achieved in field environments. If the technology were to increase commercial wheat yields by 3-10% in fields, based on royalties for other biotechnology traits, it should receive a royalty of 0.5-2% on net sales. Assuming the licensors of its technology were to use the technology on a combined market share of 35% of wheat acreage in the key targeted geographies (US, Canada, the EU, and Australia), Astalake Biosystems' royalty income at peak market penetration would be $4.57-18.28 million for wheat.
Publications
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Progress 09/01/20 to 08/31/21
Outputs
Target Audience:The target audience(s) for the genetic engineering platform will be planting seed companies who develop, produce, sell and market planting seed cultivars and hybrids. The North American wheat planting seed market is highly fragmented with WestBred (Monsanto, merged by Bayer CropScience) being the dominant "Big Ag" player along with BrettYoung, DuPont/Pioneer and Winfield United (Land O'Lakes). In addition, wheat planting seed is sold by literally dozens of small seed companies, family-owned businesses, and U.S. universities such as Kansas State University and Montana State University that provide foundation seed. Group Limagrain, based in France, is the dominant EU player, while Nuseed and Pioneer are notable players in the wheat planting seed market in Australia. Commercial economics in the planting seed industry revolves around high-yield planting seeds. Market share of any cultivar is driven by crop performance - i.e., yield and to a lesser extent quality - under a given set of environmental conditions. On average, wheat planting seed input cost on a per-acre basis is $15.08. Based on these numbers, the value of the 2013 world wheat planting seed markets was $US 8.03 billion. Although Astalake Biosystems has seen yield increases in other crops of 30% and more in its nurseries, the company recognizes that actual commercial crop yields will be lower than that achieved in a nursery. If the technology were to increase commercial wheat yields by 3-10%, based on royalties for other biotechnology traits, it should be able to receive a royalty of 0.5-2% on net sales. Assuming the licensors of its technology were to use the technology on a combined market share of 35% of wheat acreage in the key targeted geographies (US, Canada, the EU, and Australia), Astalake Biosystems' royalty income at peak market penetration would be $4.57-18.28 million for wheat. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?
Nothing Reported
How have the results been disseminated to communities of interest?
Nothing Reported
What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
Over the duration of the project, Astalake Biosystems has generated several constructs with selection marker cassettes and target cassettes and transformed these constructs into a publically available wheat variety. The transgenic plantlets regenerated from tissue culture were transferred to soil for further analysis. Among the generated lines, the best events will be selected based on molecular characterization, detailed morphological analysis, and biomass composition analyses.
Publications
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