Source: UNIV OF MASSACHUSETTS submitted to NRP
GUT MICROBIOTA-MEDIATED PROTECTIVE EFFECTS OF WHOLE STRAWBERRY AGAINST COLONIC INFLAMMATION
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
AFRI COMPETITIVE GRANT
Reporting Frequency
Annual
Accession No.
1021977
Grant No.
2020-67017-30835
Cumulative Award Amt.
$499,969.00
Proposal No.
2019-08172
Multistate No.
(N/A)
Project Start Date
Apr 1, 2020
Project End Date
Mar 31, 2025
Grant Year
2020
Program Code
[A1343]- Food and Human Health
Recipient Organization
UNIV OF MASSACHUSETTS
(N/A)
AMHERST,MA 01003
Performing Department
Dept: Food Sciences
Non Technical Summary
Colonic inflammation is a significant health threat. Accumulating evidence suggests that colonic inflammation may be prevented by increased consumption of certain fruits and vegetables such as berries. Whole strawberry contains various potential anti-inflammatory components. However, there is no detailed mechanistic information available on the overall protective effects of whole strawberry against colon inflammation. Our metabolomic analysis and fecal transplant study in mice demonstrated that gut microbiota dysbiosis led to colonic inflammation. Moreover, we found that oral consumption of whole strawberry inhibited colonic inflammation in mice, and the protective effects of whole strawberry might be through ameliorating gut microbiota dysbiosis-induced inflammation in the colon. Our findings provided a novel mechanism by which whole strawberry inhibits colonic inflammation, as well as a strong scientific basis to use strawberry to promote colon health. The objective of this project is to utilize two important mouse models (namely high-fat diet-fed mice and IL-10 knockout mice) of colonic inflammation to establish the efficacy of whole strawberry in inhibiting colonic inflammation and elucidate the role of gut microbiota in mediating the anti-inflammatory effects of strawberry in the colon. The findings from this project will help gain new knowledge of how whole food such as berries promote colon health, and how the bioactive components of the berries fight against colonic inflammation. This knowledge will serve as an indispensable basis for the development of effective whole-food-based strategies for promoting colon health, which can be validated by future human trials. The approach used in this study can also be applied to studies on other related food components.
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
70111221010100%
Knowledge Area
701 - Nutrient Composition of Food;

Subject Of Investigation
1122 - Strawberry;

Field Of Science
1010 - Nutrition and metabolism;
Goals / Objectives
Colonic inflammation is a significant health threat. Accumulating evidence suggests that colonic inflammation may be prevented by increased consumption of certain fruits and vegetables such as berries. Whole strawberry contains various potential anti-inflammatory components. However, there is no detailed mechanistic information available on the overall protective effects of whole strawberry against colon inflammation. Our metabolomic analysis and fecal transplant study in mice demonstrated that gut microbiota dysbiosis led to colonic inflammation. Moreover, we found that oral consumption of whole strawberry inhibited colonic inflammation in mice, and the protective effects of whole strawberry might be through ameliorating gut microbiota dysbiosis-induced inflammation in the colon. Our findings provided a novel mechanism by which whole strawberry inhibits colonic inflammation, as well as a strong scientific basis to use strawberry to promote colon health. The objective of this project is to utilize two important mouse models (namely high-fat diet-fed mice and IL-10 knockout mice) of colonic inflammation to establish the efficacy of whole strawberry in inhibiting colonic inflammation and elucidate the role of gut microbiota in mediating the anti-inflammatory effects of strawberry in the colon. The findings from this project will help gain new knowledge of how whole food such as berries promote colon health, and how the bioactive components of the berries fight against colonic inflammation. This knowledge will serve as an indispensable basis for the development of effective whole-food-based strategies for promoting colon health, which can be validated by future human trials. The approach used in this study can also be applied to studies on other related food components.
Project Methods
Specific aims and approachesDetermine the efficacy of whole strawberry at low doses in inhibiting chemically induced, genetically induced, as well as hyperuricemia-exacerbated colitis in mice. Multiple mouse models of colitis will be utilized to determine the efficacy of oral intake of whole strawberry at human-relevant doses in inhibiting colonic inflammation. These different mouse models will provide the platform to determine the effects of whole strawberry on gut microbiota as well as colonic hyperuricemia.Establish the role of gut microbiota in mediating anti-colitis effects of whole strawberry through lowering colonic levels of uric acid. A fecal microbiota transplant study will be used to determine the direct effects of whole strawberry in ameliorating microbiota dysbiosis and subsequent colonic hyperuricemia. A potential uric acid-degrading bacterial strain whose fecal abundance was greatly increased by dietary whole strawberry will be utilized to establish its role in suppressing colonic inflammation through lowering the colonic level of uric acid.

Progress 04/01/20 to 03/31/24

Outputs
Target Audience:The project's dissemination efforts targeted a diverse range of audiences, including academic and research communities, healthcare professionals, industry stakeholders, policymakers, and the general public. Researchers, university students, and early-career scientists were engaged through peer-reviewed publications and conference presentations. Healthcare professionals, such as dietitians, nutritionists, and medical practitioners, were informed about clinical applications. Industry stakeholders, including food, beverage, pharmaceutical, and nutraceutical companies, were considered for potential product development. Policy makers and public health officials were targeted for the integration of findings into public health policies. Finally, the general public, especially health-conscious consumers and patient advocacy groups, was reached through public lectures, outreach events, and social media to raise awareness about the health benefits of whole strawberries. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?We have provided ample research training and practice opportunities for multiple undergraduate and graduate students. Specifically, the project has provided extensive opportunities for training and professional development, including hands-on research experience in experimental design, laboratory techniques, and data analysis. Participants gained skills in bioinformatics, statistical analysis, scientific writing, and grant proposal preparation. The project facilitated presentation skills through conference presentations and poster sessions and fostered interdisciplinary collaboration and networking. Additionally, it offered mentorship and supervision experience, as well as participation in technical workshops and seminars, contributing to the professional growth of all team members and enhancing overall research capabilities. How have the results been disseminated to communities of interest?Research findings (18papers) have been published in peer-reviewed journals, ensuring scientific rigor and broad academic reach. The team has presented at national and international conferences 6times, sharing insights with fellow researchers and practitioners. Additionally, results have been communicated through poster sessions and seminars, facilitating direct engagement and feedback. Public lectures and outreach events have been organized to inform broader communities, including health professionals and the general public, about the potential health benefits of strawberries. Social media and institutional websites have also been used to share updates and engage with a wider audience. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? 1. Efficacy of Whole Strawberry in Inhibiting Colonic Inflammation High-Fat Diet-Fed Mice Model: Conducted experiments where high-fat diet-fed mice were supplemented with whole strawberries. Monitored biomarkers of colonic inflammation, such as cytokine levels and histological markers. Found a significant reduction in markers of colonic inflammation in strawberry-supplemented mice compared to controls. Demonstrated that strawberry consumption led to improvements in gut barrier function and a reduction in inflammatory cytokines. IL-10 Knockout Mice Model: Used IL-10 knockout mice, which are prone to spontaneous colonic inflammation, to test the anti-inflammatory effects of whole strawberry. Observed a marked decrease in colonic inflammation in IL-10 knockout mice fed with whole strawberry. Histological analysis revealed reduced tissue damage and inflammatory cell infiltration in the strawberry-supplemented group. 2. Role of Gut Microbiota in Mediating Anti-Inflammatory Effects Metabolomic Analysis: Performed comprehensive metabolomic profiling on fecal samples from both mouse models. Identified changes in the composition of gut microbiota associated with strawberry supplementation. Noted an increase in beneficial bacteria and a decrease in harmful bacterial strains linked to inflammation. Fecal Transplant Study: Conducted fecal transplants from strawberry-fed mice to antibiotic-treated mice. Antibiotic-treated mice that received fecal transplants showed reduced colonic inflammation compared to control mice. This provided strong evidence that the anti-inflammatory effects of strawberries are mediated through the modulation of gut microbiota. 3. Mechanistic Insights into Anti-Inflammatory Effects of Strawberry Bioactive Components: Isolated and characterized key bioactive components in whole strawberries that contribute to its anti-inflammatory effects. Conducted in vitro studies to understand the molecular pathways affected by these components. Found that specific polyphenols in strawberries can inhibit pro-inflammatory pathways and promote anti-inflammatory responses in colon cells. 4. Application to Other Foods: The approach and findings of this study can be applied to investigate other fruits and vegetables with potential anti-inflammatory properties. This project has laid the groundwork for broader research into whole-food-based strategies for preventing and managing colonic inflammation. Research Publications: 18papers have been published in peer-reviewed journals, contributing to the scientific understanding of strawberry's health benefits. Presentations and Conferences: Presenting results 6times at scientific conferences and symposia to share knowledge and gather feedback. Overall, the project successfully demonstrated the protective effects of whole strawberry against colonic inflammation, elucidated the role of gut microbiota in mediating these effects, and provided mechanistic insights into how strawberry components contribute to these benefits. These findings contribute significantly to the field of nutrition and health, offering promising avenues for future research and dietary recommendations.

Publications

  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Han, Yanhui, et al. "Guidelines for inflammation models in mice for food components." eFood 3.3 (2022): e16.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Huang, Meigui, et al. "Protective effects of non-extractable phenolics from strawberry against inflammation and colon cancer in vitro." Food Chemistry 374 (2022): 131759.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Luo, Haiyan, et al. "Impact of excipient emulsions made from different types of oils on the bioavailability and metabolism of curcumin in gastrointestinal tract." Food Chemistry 370 (2022): 130980.
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Wu, Xian, et al. "Identification of xanthomicrol as a major metabolite of 5-demethyltangeretin in mouse gastrointestinal tract and its inhibitory effects on colon cancer cells." Frontiers in Nutrition 7 (2020): 103.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Li, Fang, et al. "Gut microbiota-derived resveratrol metabolites, dihydroresveratrol and lunularin, significantly contribute to the biological activities of resveratrol." Frontiers in Nutrition 9 (2022): 912591.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Guo, Shanshan, et al. "Anti-Inflammatory Property of 5-Demethylnobiletin (5-Hydroxy-6, 7, 8, 3?, 4?-pentamethoxyflavone) and Its Metabolites in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells." Biology 11.12 (2022): 1820.
  • Type: Journal Articles Status: Published Year Published: 2024 Citation: Du, Hengjun, et al. "Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis." Food Research International 184 (2024): 114228.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Ma, Gaoxing, et al. "Inhibitory effects of ?-type glycosidic polysaccharide from Pleurotus eryngii on dextran sodium sulfate-induced colitis in mice." Food & function 12.9 (2021): 3831-3841.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Luo, Haiyan, et al. "Black pepper and vegetable oil-based emulsion synergistically enhance carotenoid bioavailability of raw vegetables in humans." Food Chemistry 373 (2022): 131277.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yi, Lingxiao, et al. "Inhibitory effects of polyphenols-rich components from three edible seaweeds on inflammation and colon cancer in vitro." Frontiers in Nutrition 9 (2022): 856273.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Li, Fang, et al. "Dietary pterostilbene inhibited colonic inflammation in dextran-sodium-sulfate-treated mice: a perspective of gut microbiota." Infectious Microbes & Diseases 3.1 (2021): 22-29.
  • Type: Journal Articles Status: Published Year Published: 2024 Citation: Sun, Yukun, et al. "The anti-inflammatory potential of a strain of probiotic Bifidobacterium pseudocatenulatum G7: in vitro and in vivo evidence." Journal of Agricultural and Food Chemistry 72.18 (2024): 10355-10365.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Guo, Shanshan, et al. "Identification of 4?-demethyltangeretin as a Major urinary metabolite of tangeretin in mice and its anti-inflammatory activities." Journal of Agricultural and Food Chemistry 69.15 (2021): 4381-4391.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yi, Lingxiao, et al. "Bioactive components from Gracilaria rubra with growth inhibition on HCT116 colon cancer cells and anti-inflammatory capacity in RAW 264.7 macrophages." Frontiers in Nutrition 9 (2022): 856282.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Ma, Gaoxing, et al. "Health benefits of edible mushroom polysaccharides and associated gut microbiota regulation." Critical reviews in food science and nutrition 62.24 (2021): 6646-6663.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Zhu, Zhenjun, et al. "Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota." Comprehensive Reviews in Food Science and Food Safety 20.3 (2021): 2882-2913.
  • Type: Journal Articles Status: Published Year Published: 2024 Citation: Qiu, Zhichang, et al. "Physicochemical, structural, and functional properties of fructans from single-clove garlic and multiclove garlic: A comparison." Journal of Agricultural and Food Chemistry 72.14 (2024): 7818-7831.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Ahnan?Winarno, Amadeus Driando, et al. "Tempeh: A semicentennial review on its health benefits, fermentation, safety, processing, sustainability, and affordability." Comprehensive Reviews in Food Science and Food Safety 20.2 (2021): 1717-1767.
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Role of gut microbiota in food bioactives, Dec. 21, 2020, Hang Xiao. 6th South Lake International Young Scientists Spring Forum, Huazhong Agricultural University, Wuhan, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Interaction of food bioactives and gut microbiota, Sep. 10, 2020, Hang Xiao. Anhui Academy of Agricultural Sciences, Anhui, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: The role of gut microbiota on the biotransformation and biofunction of nobiletin, a major citrus flavonoid, August 25, 2021, Hang Xiao. ACS Fall 2021 Meetings & Expos, Aug. 22-26, Atlanta, GA
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Role of gut microbiota in mediating health effects of food components, Nov 23-25, 2022. Hang Xiao, The 4th global forum for Tea Research. Hangzhou, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Gut Microbiota-mediated Biotransformation and Biofunctions of Food Components. Hang Xiao. 2022-Dec 10-11. International Conference on food biotechnology and precision nutrition. University of Shanghai for science and Technology, Shanghai, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Applications of gut microbiota technology for agricultural products. Sep. 24, 2022, Hang Xiao. International Symposium on Agricultural Product Processing. Anhui Agricultural University, Hefei, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2023 Citation: Interplay between Food and Gut Microbiome: Critical Roles in Human Health, May. 29-31, 2023, Hang Xiao. 4th international symposium of food science and nutrition health, Dalian, China.


Progress 04/01/23 to 03/31/24

Outputs
Target Audience:Scientists and technologists in the food, nutrition and related fields Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive research training for multiple graduate students. How have the results been disseminated to communities of interest?By publications in the peer-reviewed journal publications and presentations in the conferences. What do you plan to do during the next reporting period to accomplish the goals?Publications in peer-reviewed journals publications and presentations at conferences.

Impacts
What was accomplished under these goals? We have made satisfactory progress in this period by publishing 3peer-reviewed journal publications in quality journals and 3Ph.D. dissertation theses. See the specific published articles for the details of experimental results achieved in this period

Publications

  • Type: Journal Articles Status: Published Year Published: 2024 Citation: Du, Hengjun, et al. "Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis." Food Research International 184 (2024): 114228.
  • Type: Journal Articles Status: Published Year Published: 2024 Citation: Qiu, Zhichang, et al. "Physicochemical, structural, and functional properties of fructans from single-clove garlic and multiclove garlic: A comparison." Journal of Agricultural and Food Chemistry 72.14 (2024): 7818-7831.
  • Type: Journal Articles Status: Published Year Published: 2024 Citation: Sun, Yukun, et al. "The Anti-inflammatory Potential of a Strain of Probiotic Bifidobacterium pseudocatenulatum G7: In Vitro and In Vivo Evidence." Journal of Agricultural and Food Chemistry (2024).


Progress 04/01/22 to 03/31/23

Outputs
Target Audience:Scientists and technologists in the food, nutrition and related fields Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive research training for multiple graduate students. How have the results been disseminated to communities of interest?By publications in the peer-reviewed journal publications and presentations in the conferences. What do you plan to do during the next reporting period to accomplish the goals?Publications in the peer-reviewed journal publications and presentations in the conferences.

Impacts
What was accomplished under these goals? We have made satisfactory progress in this period by publishing 7peer-reviewed journal publications in quality journals and 2 Ph.D. dissertation thesises. See the specific published articles for the details of experimental results achieved in this period.

Publications

  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Han, Yanhui, Sasha A. Itenberg, Xian Wu, and Hang Xiao. "Guidelines for inflammation models in mice for food components." eFood 3, no. 3 (2022): e16.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Luo, H., Li, Z., Straight, C. R., Wang, Q., Zhou, J., Sun, Y., ... & Xiao, H. (2022). Black pepper and vegetable oil-based emulsion synergistically enhance carotenoid bioavailability of raw vegetables in humans. Food Chemistry, 373, 131277.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yi, Lingxiao, Qi Wang, Haiyan Luo, Daqing Lei, Zhonghai Tang, Sijia Lei, and Hang Xiao. "Inhibitory effects of polyphenols-rich components from three edible seaweeds on inflammation and colon cancer in vitro." Frontiers in Nutrition 9 (2022).
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Luo, H., Li, Z., Yao, M., McClements, D. J., & Xiao, H. (2022). Impact of excipient emulsions made from different types of oils on the bioavailability and metabolism of curcumin in gastrointestinal tract. Food Chemistry, 370, 130980.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Guo, S., Wu, X., Zheng, J., Song, M., Dong, P., & Xiao, H. (2022). Anti-Inflammatory Property of 5-Demethylnobiletin (5-Hydroxy-6, 7, 8, 3?, 4?-pentamethoxyflavone) and Its Metabolites in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells. Biology, 11(12), 1820.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yi, L., Wang, Q., Luo, H., Lei, D., Tang, Z., Lei, S., & Xiao, H. (2022). Bioactive Components From Gracilaria rubra With Growth Inhibition on HCT116 Colon Cancer Cells and Anti-inflammatory Capacity in RAW 264.7 Macrophages. Frontiers in Nutrition, 9.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Huang, M., Han, Y., Li, L., Rakariyatham, K., Wu, X., Gao, Z., & Xiao, H. (2022). Protective effects of non-extractable phenolics from strawberry against inflammation and colon cancer in vitro. Food Chemistry, 374, 131759.
  • Type: Theses/Dissertations Status: Other Year Published: 2023 Citation: Dissertation title: Inhibition of colonic inflammation by edible seaweeds. Author?Lingxiao Yi Advisor: Dr. Hang Xiao
  • Type: Theses/Dissertations Status: Other Year Published: 2022 Citation: Title: Food nanoemulsions enhance bioavailability of lipophilic nutraceuticals. Author?Haiyan Luo Advisor: Dr. Hang Xiao


Progress 04/01/21 to 03/31/22

Outputs
Target Audience:Scientists and technologists in the food, nutrition and related fields Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive research training for multiple graduate students. How have the results been disseminated to communities of interest?By publications in peer-reviewed journal publications and presentations at conferences. What do you plan to do during the next reporting period to accomplish the goals?Publications in the peer-reviewed journal publications and presentations in the conferences.

Impacts
What was accomplished under these goals? We have made satisfactory progress in this period by publishing 14 peer-reviewed journal publications in quality journals and showed the outcome at international conferences 4 times. See the specific published articles for the details of experimental results achieved in this period.

Publications

  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Huang, Meigui, et al. "Protective effects of non-extractable phenolics from strawberry against inflammation and colon cancer in vitro." Food Chemistry 374 (2022): 131759.
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Wu, Xian, et al. "Identification of Xanthomicrol as a major metabolite of 5-demethyltangeretin in mouse gastrointestinal tract and its inhibitory effects on colon cancer cells." Frontiers in Nutrition 7 (2020): 103.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Luo, Haiyan, et al. "Black pepper and vegetable oil-based emulsion synergistically enhance carotenoid bioavailability of raw vegetables in humans." Food Chemistry 373 (2022): 131277.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Han, Yanhui, et al. "Guidelines for inflammation models in mice for food components." eFood 3.3 (2022): e16.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Luo, Haiyan, et al. "Impact of excipient emulsions made from different types of oils on the bioavailability and metabolism of curcumin in gastrointestinal tract." Food Chemistry 370 (2022): 130980.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Ma, Gaoxing, et al. "Inhibitory effects of ?-type glycosidic polysaccharide from Pleurotus eryngii on dextran sodium sulfate-induced colitis in mice." Food & function 12.9 (2021): 3831-3841.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yi, Lingxiao, et al. "Bioactive Components From Gracilaria rubra With Growth Inhibition on HCT116 Colon Cancer Cells and Anti-inflammatory Capacity in RAW 264.7 Macrophages." Frontiers in nutrition 9 (2022).
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Ma, Gaoxing, et al. "Health benefits of edible mushroom polysaccharides and associated gut microbiota regulation." Critical Reviews in Food Science and Nutrition (2021): 1-18.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Guo, Shanshan, et al. "Identification of 4?-Demethyltangeretin as a Major Urinary Metabolite of Tangeretin in Mice and Its Anti-inflammatory Activities." Journal of Agricultural and Food Chemistry 69.15 (2021): 4381-4391.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Zhu, Zhenjun, et al. "Health effects of dietary sulfated polysaccharides from seafoods and their interaction with gut microbiota." Comprehensive Reviews in Food Science and Food Safety 20.3 (2021): 2882-2913.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Li, Fang, et al. "Dietary Pterostilbene Inhibited Colonic Inflammation in Dextran-Sodium-Sulfate-Treated Mice: A Perspective of Gut Microbiota." Infectious Microbes & Diseases 3.1 (2021): 22-29.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Ahnan?Winarno, Amadeus Driando, et al. "Tempeh: A semicentennial review on its health benefits, fermentation, safety, processing, sustainability, and affordability." Comprehensive Reviews in Food Science and Food Safety 20.2 (2021): 1717-1767.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yi, Lingxiao, et al. "Inhibitory Effects of Polyphenols-Rich Components From Three Edible Seaweeds on Inflammation and Colon Cancer in vitro." Frontiers in Nutrition 9 (2022).
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Li, Fang, et al. "Gut Microbiota-Derived Resveratrol Metabolites, Dihydroresveratrol and Lunularin, Significantly Contribute to the Biological Activities of Resveratrol." Frontiers in Nutrition 9 (2022).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: The role of gut microbiota on the biotransformation and biofunction of nobiletin, a major citrus flavonoid, August 25, 2021, Hang Xiao. ACS Fall 2021 Meetings & Expos, Aug. 22-26, Atlanta, GA.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Vegetable oil excipient emulsion for food bioactives, Jan. 15, 2021, Hang Xiao. The Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Vegetable oil excipient emulsion for food bioactives, Feb. 2, 2021, Hang Xiao. College of food science and engineering, Ocean University of China, Qingdao, China.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Role of gut microbiota in food bioactives, Dec. 21, 2020, Hang Xiao. 6th South Lake International Young Scientists Spring Forum, Huazhong Agricultural University, Wuhan, China.
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2022 Citation: Impact of egg white addition on freeze-drying kinetics of foamed whole strawberry puree. Zhihao Zhou, Jiakai Lu and Hang Xiao*. 15th Conference of Food Engineering, Sep. 18-21, 2022, Raleigh, NC, USA.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Gut microbiota-mediated biotransformation of selected polyphenols, August 25, 2021, Ermin Zhao, Min Gu, Yukun Sun, Fang Li, Zhengze Li, William Dixon, Hang Xiao*. ACS Fall 2021 Meetings & Expos, Aug. 22-26, Atlanta, GA.


Progress 04/01/20 to 03/31/21

Outputs
Target Audience:Scientists and technologists in the food, nutrition and related fields Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?This project has provided extensive research training for multiple graduate students. How have the results been disseminated to communities of interest?By publications in the peer-reviewed journal publications and presentations in the conferences. What do you plan to do during the next reporting period to accomplish the goals?Publications in the peer-reviewed journal publications and presentations in the conferences.

Impacts
What was accomplished under these goals? We have made satisfactory progress in this period by publishing 4 peer-reviewed journal publications in quality journals. See the specific published articles for the details of experimental results achieved in this period.

Publications

  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Han, Yanhui, and Hang Xiao. "Whole foodbased approaches to modulating gut microbiota and associated diseases." Annual Review of Food Science and Technology 11 (2020): 119-143.
  • Type: Journal Articles Status: Accepted Year Published: 2022 Citation: Huang, Meigui, et al. "Protective effects of non-extractable phenolics from strawberry against inflammation and colon cancer in vitro." Food Chemistry 374 (2022): 131759.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Cui, Jiefen, et al. "Pectins from fruits: Relationships between extraction methods, structural characteristics, and functional properties." Trends in Food Science & Technology 110 (2021): 39-54.
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Catalkaya, Gizem, et al. "Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health." Food Frontiers 1.2 (2020): 109-133.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Role of gut microbiota in food bioactives, Dec. 21, 2020, Hang Xiao. 6th South Lake International Young Scientists Spring Forum, Huazhong Agricultural University, Wuhan, China.