Source: UNIVERSITY OF CALIFORNIA, DAVIS submitted to NRP
FARAD, AKA FOOD ANIMAL RESIDUE AVOIDANCE DATABANK
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
OTHER GRANTS
Reporting Frequency
Annual
Accession No.
1020547
Grant No.
2019-41480-30294
Cumulative Award Amt.
$825,000.00
Proposal No.
2019-05321
Multistate No.
(N/A)
Project Start Date
Sep 1, 2019
Project End Date
Aug 31, 2022
Grant Year
2019
Program Code
[FARAD]- Food An. Res. Avoidance Database,FARAD
Recipient Organization
UNIVERSITY OF CALIFORNIA, DAVIS
410 MRAK HALL
DAVIS,CA 95616-8671
Performing Department
Vm: Medicine & Epidemiology
Non Technical Summary
The Food Animal Residue Avoidance Databank (FARAD) is a collaborative university-based food safety program that is coordinated and delivered by veterinary faculty and staff at several US colleges of veterinary medicine. Throughout its 37 year existence, FARAD has continued to evolve to meet the ever changing demands of providing accurate, timely and reliable service to both the veterinary profession and food animal industry stakeholders. At present, the program is managed through a very close collaboration of personnel at the University of California-Davis (UCD), University of Florida (UF), North Carolina State University (NCSU), Kansas State University (KSU) and Virginia-Maryland College of Veterinary Medicine (VM).
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
71139101180100%
Knowledge Area
711 - Ensure Food Products Free of Harmful Chemicals, Including Residues from Agricultural and Other Sources;

Subject Of Investigation
3910 - Cross-commodity research--multiple animal species;

Field Of Science
1180 - Pharmacology;
Goals / Objectives
The 2019-2020 FARAD project year will be focused on the essential call centers tasks including answering extra-label withdrawal requests, updating and expanding the resources available to call responders, maintaining the call center database and index page, extracting and cataloging pharmacokinetic data from published literature and updating and developing educational tools for veterinarians and the public posted on the FARAD web site. Specific to this year, topic pages will continue to expand, pages will also be made available in Spanish, bibkin finder, PBPK and antique sections will be converted to an SQL format. We will work with KSU on the development of laying hen PBPK models and with NCSU with the development of an interface for the non-linear mixed effect models that FARAD has developed for answering call based inquires. Other tasks will include working closely with the team at Virginia Maryland College of Veterinary Medicine regarding uniformity in answering calls at the three call centers. In addition to the call center activities, we will expand our efforts on educating small animal veterinarians regarding extra label drug use in backyard poultry, continue to assist veterinarians nationwide to understand the new veterinary feed directive rules, and provide California veterinarians with resources to confirm with the new Senate Bill 27. For backyard poultry, we will be summarizing the conducted survey to understand how drugs are being used in an extra-label manner.
Project Methods
FARAD performs a broad array of programmatic functions, but key among these are the collection, evaluation, analysis, interpretation and dissemination of information related to the depletion of drugs and other chemicals in edible products derived from food-producing animal species. The underlying activities that support these functions are carried out through multi-layered and complimentary approaches that are coordinated by the FARAD centers located at UCD, NCSU, UF, KSU and VM. At UCD, FARAD personnel search the peer-reviewed scientific literature plus numerous other information resources for data pertaining to the depletion or elimination from food producing animals of all classes of small molecule entities. Relevant information is extracted, modeled, and entered into a computer-based archival databank that is readily searchable for customized information retrieval. Because there are many factors that can influence how rapidly an animal eliminates a chemical residue; information about diet, age, gender, breed and disease status are taken into consideration.

Progress 09/01/19 to 08/31/22

Outputs
Target Audience:The Food Animal Residue Avoidance and Depletion (FARAD) program has a human food safety focus with services to veterinarians. The target audience for this program is livestock owners, producers, regulators, and veterinarians (private practice and state). The goal of the program is residue avoidance in human food products by providing livestock owners, producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products that are intended for human consumption. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?A graduate student (Marta Guitez), food animal residents, and a pharmacy fellow (Dr. Emily Toney; maiden name Dr. Emily Richards) have learned about the rules and regulations surrounding extra-label drug use and the pharmacokinetic distribution of veterinary drugs from a residue standpoint. Dr. Emily Toney (maiden name, Dr. Emily Richards; PharmD) completed her food animal pharmacy fellowship during this period. She is not employed as a PharmD for the UC Davis Veterinary Medical Teaching Hospital. She is one of three PharmD's that are in academia and trained specifically in food animal medicine drug use. How have the results been disseminated to communities of interest?Information is shared with communities of interest via answers to ELDU questions, journal publications, information posted on the FARAD web site, and scientific presentations. What do you plan to do during the next reporting period to accomplish the goals?Continue to provide service to producers and veterinarians regarding on label and extra label drug use. Maximize availability of educational materials regarding residue avoidance.

Impacts
What was accomplished under these goals? The main programmatic accomplishments during this period were answering drug residue inquiries (9/1/2021-8/31/2022: 4,372 specific inquiries directly impacting 3.1 million animals) and updating and maintaining the pharmacokinetic, bibliographic, and call submission databases. FARAD telephone, email and web-based inquiries were answered on a rotating basis between UC Davis, North Carolina State University and Virginia Tech University. UC Davis continued collecting bibliographic citations that contain pharmacokinetic data from live animal studies. There was an ongoing process of adding new citations to the end note library. Between 9/1/2021-8/31/2022, 254 citation and 1,009 kinetic records were added, and 1,594 kinetic records were modified to expand the recorded data. Other extraction efforts included going back into the database and modifying kinetic records for accuracy and completeness focusing on small ruminants. For all citation and kinetic records, active ingredients and species were targeted for which FARAD gets the most submissions and for active ingredients that are being used extensively for ELDU. Citations were assigned a designation of importance then extracted and the pharmacokinetic data added to the database. The data extraction that UC Davis performs is crucial for developing residue avoidance algorithms and for responders to estimate withdrawal interval recommendations. Accomplishments for modifications of the on-line applications and the databases themselves during this review period included the following: New or redesigned biblio features Create a biblio record from XML data and upload the associated PDF file. Edit existing biblio records. View records by extraction status Mass upload PDF documents for biblio records. New or redesigned kin entry features Create/edit kin entry records. Edited/modified related features such as entering new species, breed, route, matrix, drug, and disease names. Added conversion dropdown/boxes for the data that needs unit conversions. Re-designed table data for compartmental/non-compartmental data. For the analytical laboratory standpoint, the number and types of samples analyzed included: OTC Milk - 96; Bupivacaine Goat- 205; Florfenicol Goat- 383; Ivermectin Chicken- 585; Total - 1269.

Publications

  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Tell LA, Srisapoome P, Chou CC. Editorial: Aquatic Pharmacology-Temperature Sensitive Medication. Front Vet Sci. 2021 Sep 28;8:755585. doi: 10.3389/fvets.2021.755585. PMID: 34651036; PMCID: PMC8505992.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Richards ED, Tell LA, Davis JL, Baynes RE, Lin Z, Maunsell FP, Riviere JE, Jaberi-Douraki M, Martin KL, Davidson G. Honey bee medicine for veterinarians and guidance for avoiding violative chemical residues in honey. J Am Vet Med Assoc. 2021 Oct 15;259(8):860-873. doi: 10.2460/javma.259.8.860. PMID: 34609191.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Depenbrock S, Urbano T, Ziegler J, Wetzlich S, Clapham MO, Tell LA. Pharmacokinetic Parameters and Tissue Withdrawal Intervals for Sheep Administered Multiple Oral Doses of Meloxicam. Animals (Basel). 2021 Sep 25;11(10):2797. doi: 10.3390/ani11102797. PMID: 34679818; PMCID: PMC8532701.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Srisapoome P, Tell LA, Chou CC. Editorial: Aquatic Pharmacology, Volume II: Pharmacokinetics for Aquatic Species. Front Vet Sci. 2022 Oct 17;9:1039868. doi: 10.3389/fvets.2022.1039868. PMID: 36325098; PMCID: PMC9620798.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and Application of an Interactive Physiologically Based Pharmacokinetic (iPBPK) Model to Predict Oxytetracycline Tissue Distribution and Withdrawal Intervals in Market-Age Sheep and Goats. Toxicol Sci. 2021 Sep 28;183(2):253-268. doi: 10.1093/toxsci/kfab095. PMID: 34329480.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Mercer MA, Davis JL, Riviere JE, Baynes RE, Tell LA, Jaberi-Douraki M, Maunsell FP, Lin Z. Mechanisms of toxicity and residue considerations of rodenticide exposure in food Animals-a FARAD perspective. J Am Vet Med Assoc. 2022 Jan 28;260(5):514-523. doi: 10.2460/javma.21.08.0364. PMID: 35092661.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yuan L, Chou WC, Richards ED, Tell LA, Baynes RE, Davis JL, Riviere JE, Lin Z. A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens. Food Chem Toxicol. 2022 Oct;168:113332. doi: 10.1016/j.fct.2022.113332. Epub 2022 Aug 5. PMID: 35940329.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Yuan L, Lin Z, Dutch RS, Richards ED, Clapham MO, Burmas N, Wetzlich SE, Tell LA. Residue depletion profiles and withdrawal interval estimations of meloxicam in eggs and ovarian follicles following intravenous (Meloxicam solution for injection) and oral (Meloxidyl®) administration in domestic chickens (Gallus domesticus). Regul Toxicol Pharmacol. 2022 Jul;132:105170. doi: 10.1016/j.yrtph.2022.105170. Epub 2022 Apr 20. PMID: 35460801.
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Cadena MM, Kelman T, Pitesky M, Dutch RS, Tell LA. Assessing Backyard Poultry versus Small Animal Knowledge of Veterinary Students regarding Husbandry, Prescription Drug Use, and Antimicrobial Resistance. J Vet Med Educ. 2022 Aug;49(4):531-536. doi: 10.3138/jvme-2021-0044. Epub 2021 Aug 10. PMID: 34375165.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Rattanapanadda P, Kuo HC, Chang SK, Tell LA, Shia WY, Chou CC. Effect of Carbonyl Cyanide Chlorophenylhydrazone on Intrabacterial Concentration and Antimicrobial Activity of Amphenicols against Swine Resistant Actinobacillus pleuropneumoniae and Pasteurella multocida. Vet Res Commun. 2022 Sep;46(3):903-916. doi: 10.1007/s11259-022-09917-4. Epub 2022 Mar 23. PMID: 35322371.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G. Toxicol Sci. 2022 Jul 28;188(2):180-197. doi: 10.1093/toxsci/kfac056. PMID: 35642931; PMCID: PMC9333411.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Richards ED, Pereira RV, Davis JL, Rowe JD, Clapham MO, Wetzlich SE, Rupchis BA, Tell LA. Comparison of florfenicol depletion in dairy goat milk using ultra- performance liquid chromatography with tandem mass spectrometry and a commercial on-farm test. Front Vet Sci. 2022 Aug 29;9:991772. doi: 10.3389/fvets.2022.991772. PMID: 36105005; PMCID: PMC9465015.
  • Type: Journal Articles Status: Published Year Published: 2022 Citation: Richards ED, Dutch RS, Burmas NC, Davis JL, Lin Z, Clapham MO, Wetzlich SE, Tell LA. Pharmacokinetic Parameters and Estimating Extra-Label Tissue Withdrawal Intervals Using Three Approaches and Various Matrices for Domestic Laying Chickens Following Meloxicam Administration. Front Vet Sci. 2022 Mar 3;9:826367. doi: 10.3389/fvets.2022.826367. PMID: 35310412; PMCID: PMC8927936.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Maunsell FP, Baynes RE, Davis JL, Foster D, Jaberi-Douraki M, Lin Z, Riviere JE, Tell LA. FARAD: How we respond to withdrawal inquiries. American Association of Bovine Practitioners 50th Annual Conference, Salt Lake City, UT (October 7-9).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Mastorakis AN, McNabb B, Lima F, Urbano T, Watson K, Tell L, Rumbeiha W. Inorganic bromide in-utero causes locomotor and behavioral abnormalities in newborn calves. The American Association of Veterinary Laboratory Diagnosticians/US Animal Health Association Meeting, Aurora, CO (October 22-26).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Yuan L, Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in domestic chickens. Annual Meeting of Southeastern Society of Toxicology (SESOT), Virtual (November 18-19).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Chou WC, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. A web-based platform based on a generic physiologically based pharmacokinetic (PBPK) model to predict withdrawal intervals of flunixin, florfenicol, and penicillin G in cattle and swine. Annual Meeting of Southeastern Society of Toxicology (SESOT), Virtual (November 18-19).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Riad MH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Developing a web-based iPBPK interface to estimate withdrawal intervals for florfenicol and florfenicol amine in sheep and goats. Annual Meeting of Southeastern Society of Toxicology (SESOT), Virtual (November 18-19).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Carreño Gútiez M, Martinez-Lopez B, Tell LA. Statistical approaches for establishing withdrawal interval recommendations for fenbendazole in pheasants. Conference of Research Workers in Animal Diseases, Chicago, IL (December 4-7).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: January 29, Richards ED, Pereira RV, Clapham, MO Wetzlich SE and Tell LA. Extra-label use of florfenicol (Nuflor) in does. UC Davis Department of Animal Science and UC Davis School of Veterinary Medicine Goat Day 2022, Davis, CA (Virtual).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: February 10, Tell, LA. Extra-label drug use in free-ranging wildlife: rules, regulations, & realities. National Academies of Sciences, Engineering, and Medicine: Animal Welfare Challenges in Research and Education on Wildlife, Non-Model Animal Species and Biodiversity Workshop, Washington, DC (Virtual).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: March 2, Tell, LA. Drug residue study approaches for poultry and small ruminants. International Atomic Energy Agency Depletion of Veterinary Pharmaceuticals and Radiometric Analysis of their Residues in Animal Matrices, Vienna, Austria (Virtual).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Rumbeiha WK, Tell L, McNabb B, Lima F, Urbano T, Watson K, Flaws J. Characterizing a large animal model to study neonatal effects of bromide in humans. The Society of Toxicology (SOT) Meeting, San Diego, CA (March 27-31).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Richards ED, Pereira RV, Davis JL, Clapham MO, Wetzlich SE, Tell LA. Florfenicol milk and tissue depletion profiles following subcutaneous administration to goats. American Academy of Veterinary Pharmacology and Therapeutics Student Research Symposium (May 20).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Riad MH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Predicting florfenicol and florfenicol amine tissue distribution and estimating withdrawal intervals in market-age sheep and goats using a physiologically based pharmacokinetic model. Proceedings for the 61st Annual Meeting of Society of Toxicology, San Diego, CA. The Toxicologist, Supplement to Toxicological Sciences (March 27-31), 186(S1): 293.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Yuan L, Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens. The 61st Annual Meeting of Society of Toxicology, San Diego, CA. The Toxicologist, Supplement to Toxicological Sciences (March 27-31), 186(S1): 292.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Chou WC, Cheng YH, Tell LA, Baynes RE, Maunsell FP, Davis JL, Riviere JE, Lin Z. Development of an interactive physiologically based pharmacokinetic (iPBPK) modeling platform to predict meat and milk residues and withdrawal intervals for perfluorooctane sulfonate (PFOS) in beef and dairy cattle. The 61st Annual Meeting of Society of Toxicology, San Diego, CA. The Toxicologist, Supplement to Toxicological Sciences (March 27-31), 186(S1): 304.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Tell, LA. Insights on How WDI Recommendations are Established for Backyard Poultry Following Extra-Label Drug Use. Pac Vet Conference, San Francisco, CA (June 2).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Tell, LA. Extra-label drug use in backyard poultry: specific examples and cases. Pac Vet Conference, San Francisco, CA (June 2).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: The ins and outs of extra-label drug use in small ruminants (Invited). Pac Vet Conference, San Francisco, CA (June 3).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Tell, LA. Extra-label drug use in small ruminants: specific examples and cases (Invited). Pac Vet Conference, San Francisco, CA (June 3).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Richards ED, Pereira RV, Davis JL, Rowe JD, Clapham MO, Wetzlich SE, Angelos JA, and Tell LA. Comparison for florfenicol detection in dairy goat milk samples using UPLC-MS/MS and a rapid residue test, Society of Veterinary Hospital Pharmacists Annual Conference, Rohnert Park, CA (June 13).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2022 Citation: Extra-label drug use in food producing animals: FARAD and FAQ, Society of Veterinary Hospital Pharmacists Annual Conference, Rohnert Park, CA (June 14)
  • Type: Websites Status: Published Year Published: 2022 Citation: Updated: https://cafarad.ucdavis.edu/RapidAssay/rapidassay.aspx


Progress 09/01/20 to 08/31/21

Outputs
Target Audience:The Food Animal Residue Avoidance and Depletion (FARAD) program has a human food safety focus with services to veterinarians. The target audience for this program is livestock owners, producers, regulators, and veterinarians (private practice and state). The goal of the program is residue avoidance in human food products by providing livestock owners, producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products that are intended for human consumption. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?Undergraduate students have learned about human food safety and residue avoidance. Graduate students (veterinary students) and food animal and pharmacy residents have learned about the rules and regulations surrounding extra-label drug use and the pharmacokinetic distribution of veterinary drugs from a residue standpoint. Veterinarians are consistently being advised about drug residue avoidance. How have the results been disseminated to communities of interest?Information is shared with communities of interest via answers to ELDU questions, journal publications, information posted on the FARAD web site, and scientific presentations. What do you plan to do during the next reporting period to accomplish the goals?Continue to provide service to producers and veterinarians regarding on label and extra label drug use. Maximize availability of educational materials regarding residue avoidance.

Impacts
What was accomplished under these goals? The main program accomplishments were answering drug residue inquiries (2020: 3926 specific inquiries impacting 10.8 million animals) and updating and maintaining the pharmacokinetic, bibliographic, and call submission databases. FARAD telephone, email and web-based inquiries were answered on a rotating basis between UC Davis, North Carolina State University and Virginia Tech University. UC Davis continued collecting bibliographic citations that contain pharmacokinetic data from live animal studies. There was an ongoing process of adding new citations to the end note library. Citation and kinetic records (2020: 4243 kinetic records) were added, targeting active ingredients and species for which FARAD gets the most submissions and for active ingredients that are being used extensively for ELDU. Citations were assigned a designation of importance then extracted and the pharmacokinetic data added to the database. The data extraction that UC Davis performs is crucial for developing residue avoidance algorithms and for responders to estimate withdrawal interval recommendations. Other extraction efforts included identifying antique records and converting them to full PK extractions (including expanded animal subject information, analytical method, non-compartmental and compartmental PK data, and WDI estimations). From a programming standpoint, the kinentry interface was updated and modified. The pages were expanded to include individual animal data, co-administered drugs, non-compartmental and compartmental PK parameters, average data and high animal data values from unscanned figures (and subject numbers per point), FDA and EMA withdrawal interval calculations. NLME and PBPK withdrawal estimate modules were initially started and will be expanded upon at a later date. A newly designed web-based interface for responders to run queries for calls and data dumping was also developed. This web-based interface was also modified so that data extractors can find records based on priority, extractor, date extracted, and whether the entry remains as an antique or updated kinentry record. Modifications and improvements for logging and tracking questions submitted to FARAD (FARM Calls) continued. Methods for WDI estimations were explored using tissue data from two meloxicam (chicken and sheep). Multiple approaches were investigated (FDA and EMA). A tissue residue study for meloxicam in sheep was performed and a tissue residue study for florfenicol in goats was completed.

Publications

  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat. Li M, Wang YS, Elwell-Cuddy T, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. J Vet Pharmacol Ther. 2021 Jul;44(4):456-477. doi: 10.1111/jvp.12938. Epub 2020 Dec 22. PMID: 33350478
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Risk Assessment of Human Consumption of Meat From Fenbendazole-Treated Pheasants. Carre�o G�tiez M, Tell LA, Mart�nez-L�pez B. Front Vet Sci. 2021 Jun 4;8:665357. doi: 10.3389/fvets.2021.665357. eCollection 2021. PMID: 34150886
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Large-Scale Data Mining of Rapid Residue Detection Assay Data From HTML and PDF Documents: Improving Data Access and Visualization for Veterinarians. Jaberi-Douraki M, Taghian Dinani S, Millagaha Gedara NI, Xu X, Richards E, Maunsell F, Zad N, Tell LA. Front Vet Sci. 2021 Jul 21;8:674730. doi: 10.3389/fvets.2021.674730. PMID: 34368270; PMCID: PMC8334182.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Veterinary Emergency Response Considerations for Pharmacists: with an emphasis on food-animals and medication use. (Emily D. Richards and Lisa A. Tell); SVHP Annual Meeting; June 27, 2020; Virtual Telecast.
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey. Wang YS, Li M, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE, Lin Z. J Vet Pharmacol Ther. 2020 Dec 2;44(4):423-55. doi: 10.1111/jvp.12931. Online ahead of print. PMID: 33289178
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: FARAD: New Techniques for establishing Withdrawal interval recommendations. (Lisa A. Tell) US Animal Health Association; October 15, 2020; Virtual Oral Presentation
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Food Animal Therapeutics (Krysta Martin and Emily Toney); Veterinary Pharmacy Elective SPPS 266, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences; October 29, 2020; Virtual Learning.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Evaluation of heat and pH treatments on degradation of ceftiofur in whole milk (Adriana Garzon, Pramod Pandey, Lisa A. Tell, Sharif Aly, Richard Pereira); NIAMRRE Knowledge Exchange; 2020; Virtual Poster Sessions.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Extra-Label Drug Use in Backyard Poultry (Lisa A. Tell); Association of Avian Veterinarians Annual Conference; 2020; Virtual Oral Presentation.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Li M, Wang Y, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE, Lin Z. Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine. The 59th Annual Meeting of Society of Toxicology. Anaheim, CA. The Toxicologist, Supplement to Toxicological Sciences, 174(1), p. 461, abstract #2943. (March 15-19, 2020)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Lin Z, Li M, Baynes RE, Tell LA, Davis JL, Vickroy TW, Riviere JE. Development and application of an interactive physiologically based pharmacokinetic (iPBPK) model interface to estimate withdrawal intervals for penicillin G in cattle and swine. The 59th Annual Meeting of Society of Toxicology. Anaheim, CA. The Toxicologist, Supplement to Toxicological Sciences, 174(1), p. 458, abstract #2932. (March 15-19, 2020)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a physiologically based pharmacokinetic model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 158, abstract/poster board #: 2364/P102. (March 12-26, 2021)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Chou WC, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of an interactive generic physiologically based pharmacokinetic (igPBPK) modelling platform to predict drug withdrawal intervals in food animals. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences180(S1), p. 161, abstract/poster board #: 2375/P113. (March 12-26, 2021)
  • Type: Websites Status: Published Year Published: 2021 Citation: https://cafarad.ucdavis.edu/RapidAssay/rapidassay.aspx
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Yuan L, Chou WC, Riad MH, Cheng YH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 201, abstract/poster board #: 2539/P277. (March 12-26, 2021)


Progress 09/01/19 to 08/31/20

Outputs
Target Audience:The target audience for this program is mostly livestock producers, regulators, and veterinarians (private practice and state). The goal of the program is to provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? At this time no programmatic accomplishments associated with this specific funding have been achieved since no charges have been applied to this grant yet. The program will start using this funding shortly. The grant has a one year no-cost extension.

Publications