Progress 09/01/19 to 08/19/22
Outputs
Target Audience:FARAD's immediate clients are practicing veterinarians, regulators, extension officers, producers, and researchers, but it ultimately protects the food consuming public and contributes to human Public Health by equipping these professionals with the best science available. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?This is a list of estimated FTE. One undergraduate student: 0.1 FTE One DVM student: 0.1 FTE Two graduate students: 0.25 FTE each Three postdocs: 1.0 FTE each Dr. Zhoumeng Lin: 0.2 How have the results been disseminated to communities of interest?See data above on call center and internet access which is the primary route for information dissemination for FARAD. Upon completion of a specific project, we also publish the research findings in peer-reviewed journals. Please refer to the publications listed in the Products page. Also, we present our research findings in local and national conferences, such as the Annual Meeting of Society of Toxicology in 2020, 2021, and 2022 (listed in the Products page). What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
We have completed a Physiological Parameter Database for PBPK modeling in six food animal species, including cattle, swine, sheep, goats, chickens, and turkey. This database has been linked to the FARAD website. We have built a new web-based PBPK interface for oxytetracycline in sheep and goats. We have built a new web-based PBPK interface for meloxicam in broiler chickens and laying hens. We have built a generic PBPK interface that can perform simulations for multiple drugs (i.e., penicillin G, flunixin, and florfenicol) in two major food animal species (cattle and swine). We have expandedFARAD databases to develop global connection using navigation systems from HTML, XML, or pdf files and started developing artificial intelligence system for global FARAD program.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Richards ED, Dutch RS, Burmas NC, Davis JL, Lin Z, Clapham MO, Wetzlich SE, Tell LA. (2022). Pharmacokinetic parameters and estimating extra-label tissue withdrawal intervals using three approaches and various matrices for domestic laying chickens following meloxicam administration. Frontiers in Veterinary Science, 9:826367. [PMID: 35310412] [PMCID: PMC8927936] https://doi.org/10.3389/fvets.2022.826367
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Yuan L, Lin Z, Dutch RS, Richards ED, Clapham MO, Burmas N, Wetzlich SE, Tell LA. (2022). Residue depletion profiles and withdrawal interval estimations of meloxicam in eggs and ovarian follicles following intravenous (Meloxicam Solution for Injection) and oral (Meloxidyl�) administration in domestic chickens (Gallus domesticus). Regulatory Toxicology and Pharmacology, 132, 105170. [PMID: 35460801] https://doi.org/10.1016/j.yrtph.2022.105170
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Halleran JL, Papich MG, Li M, Lin Z, Davis J, Maunsell P, Riviere J, Baynes R, Foster DM. (2022). Update on Withdrawal Intervals following Extralabel Use of Procaine Penicillin G in Cattle and Swine. Journal of the American Veterinary Medical Association, 260(1):50-55. [PMID: 34793323] https://doi.org/10.2460/javma.21.05.0268
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Richards ED, Tell LA, Davis JL, Baynes RE, Lin Z, Maunsell FP, Riviere JE, Jaberi-Douraki M, Martin KL, Davidson G. (2021). Honey bee medicine for veterinarians and guidance for avoiding violative chemical residues in honey. Journal of the American Veterinary Medical Association, 259(8):860-873. [PMID: 34609191] https://doi.org/10.2460/javma.259.8.860
- Type:
Journal Articles
Status:
Published
Year Published:
2022
Citation:
Mercer MA, Davis JL, Riviere JE, Baynes RE, Tell LA, Jaberi-Douraki M, Maunsell FP, Lin Z. (2022). Mechanisms of Toxicity and Residue Considerations of Rodenticide Exposure in Food Animals: a FARAD Perspective. Journal of the American Veterinary Medical Association, 260(5):514-523. [PMID: 35092661] https://doi.org/10.2460/javma.21.08.0364
- Type:
Conference Papers and Presentations
Status:
Other
Year Published:
2022
Citation:
Yuan L, Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens. The 61st Annual Meeting of Society of Toxicology, San Diego, CA. The Toxicologist, Supplement to Toxicological Sciences, 186, (S1), p. 292, abstract/poster board #: 3998/P696. (March 27-31, 2022)
- Type:
Conference Papers and Presentations
Status:
Other
Year Published:
2022
Citation:
Maunsell F, Baynes R, Davis J, Foster D, Jaberi-Douraki M, Lin Z, Riviere J, Tell L. FARAD: How we respond to withdrawal inquiries. American Association of Bovine Practitioners (AABP) Proceedings, 54(2), 9-11. (Salt Lake City, Utah. October 7-9, 2021).
- Type:
Conference Papers and Presentations
Status:
Other
Year Published:
2022
Citation:
Sidharth, Lisa Tell, Majid Jaberi-Douraki. Automatic Data Curation and Extraction from Scientific Publications. 2022 Nexus Informatics Conference.(Kansas City, MO, April 7-8, 2022).
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Progress 09/01/20 to 08/31/21
Outputs
Target Audience:FARAD's immediate clients are practicing veterinarians, regulators, extension officers, producers, and researchers, but it ultimately protects the food consuming public and contributes to human Public Health by equipping these professionals with the best science available. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?This is a list of estimated FTE. One undergraduate student: 0.1 FTE One DVM student: 0.1 FTE One graduate students from Computer Science:0.25 FTE One graduate students from Math and Stat:0.25 FTE Three postdocs: 0.25 FTE each PI and Co-PI efforts: 0.1 How have the results been disseminated to communities of interest?As we normally do, upon completion of a specific project, we publish the research findings in peer-reviewed journals. Please refer to the publications listed in the Products page. Also, we present our research findings in local and national conferences, such as the Annual Meeting of Society of Toxicology (also listed in the Products page). What do you plan to do during the next reporting period to accomplish the goals?Dr. Zhoumeng Lin and all his lab members moved from Kansas State University to University of Florida in May 2021. Dr. Lin and his lab members will continue to complete this project at UF. Based on the advice from USDA Program Director, Dr. Lin has been working to subaward the PBPK component of this project from KSU to UF. UF sent all subaward documents to KSU Grant Office several months ago. Unfortunately, there is a delay at the KSU Grant Office, and UF has not received this subaward yet. In order not to delay the project, Dr. Lin and his lab members have been continuing working on this project, and Dr. Lin's lab members are now paid by departmental funds with the permission of his departmental chair. Dr. Lin will keep sending reminders to KSU Grant Office to request their help to process the subaward request. Dr Jaberi-Douraki is currentlyworking on three papers to be submitted early next year. 1. Data extraction: Designing a web crawling/navigating system 2. Prediction of missing/unavailable MRLs for veterinary drugs 3. Global trends in antimicrobial use in food animals
Impacts
What was accomplished under these goals?
We have completed the literature review project on physiological parameters for PBPK modeling of drugs in six food animal species, including cattle, swine, sheep, goats, chickens, and turkeys. We have developed a Physiological Parameter Database for these six food animal species. This database has been linked to the FARAD website. We have built a new PBPK model for flunixin in finishing-age swine. We have finalized a data collecting framework/agreement for global database including Taiwan Drug Data related to the drug's withdrawal time. We are also working on the development of the HTML webpage and artificial intelligence system for global FARAD program (https://1data.life/gFARAD/gFARAD.php).?
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2020
Citation:
Salas JR, Jaberi-Douraki M, Wen X, Volkova VV. (2020). Mathematical modeling of the inoculum effect': six applicable models and the MIC advancement point concept. FEMS Microbiology Letters, 367(5), fnaa012.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Jaberi-Douraki M, Dinani ST, Millagaha Gedara NI, Xu X, Richards E, Maunsell F, Zad N, Tell LA. (2021) Large-scale data mining of rapid residue detection assay data from HTML and PDF documents: improving data access and visualization for veterinarians. Frontiers in veterinary science. 8:787.
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z*. (2021). Development and application of an interactive physiologically based pharmacokinetic (iPBPK) model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep and goats. Toxicological Sciences, 183(2):253-268. [PMID: 34329480] https://doi.org/10.1093/toxsci/kfab095
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Li M, Wang YS, Elwell-Cuddy T, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z*. (2021). Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat. Journal of Veterinary Pharmacology and Therapeutics, 44(4), 456-477. [PMID: 33350478] https://doi.org/10.1111/jvp.12938
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Wang YS, Li M, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE, Lin Z*. (2021). Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey. Journal of Veterinary Pharmacology and Therapeutics, 44(4), 423-455. [PMID: 33289178] https://doi.org/10.1111/jvp.12931
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Bates JL, Karriker LA, Rajewski SM, Lin Z*, Ronette G, Li M, Riviere JE, Coetzee JF*. (2020). A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing age swine. BMC Veterinary Research, 16, 211. [PMID: 32571315] https://doi.org/10.1186/s12917-020-02429-w
- Type:
Conference Papers and Presentations
Status:
Other
Year Published:
2021
Citation:
Yuan L, Chou WC, Riad MH, Cheng YH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 201, abstract/poster board #: 2539/P277. (March 12-26, 2021)
- Type:
Conference Papers and Presentations
Status:
Other
Year Published:
2021
Citation:
Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a physiologically based pharmacokinetic model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 158, abstract/poster board #: 2364/P102. (March 12-26, 2021)
- Type:
Conference Papers and Presentations
Status:
Other
Year Published:
2020
Citation:
Oct 2020, Majid Jaberi-Douraki, Progress on the Intelligent Medicine Recommender System. CTSA One Health Alliance (COHA) 2020 Data Sharing Workshop. Organized by Tufts, UC Davis and Colorado State. Zoom.
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Progress 09/01/19 to 08/31/20
Outputs
Target Audience:FARAD's immediate clients are practicing veterinarians, regulators, extension officers, producers, and researchers, but it ultimately protects the food consuming public and contributes to human Public Health by equipping these professionals with the best science available. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?This project has provided opportunities for training and professional development for one graduate student. How have the results been disseminated to communities of interest?See data above on call center and internet access which is the primary route for information dissemination for FARAD. We also published our research in peer-reviewed journals (see the Products page). After the COVID-19 pandemic is over, we will continue to present our research findings in local, regional, and national meetings, including the Annual Meeting of Society of Toxicology as we normally do. In addition, we have been developing an Intelligent Medicine Recommender System (IMRS) named 1DrugAssist (www.1data.life and https://1data.olathe.ksu.edu/drugassist/) for humans and animals to reduce the risk level associated with commonly used drugs. 1DrugAssist, partly supported by the USDA FARAD grant, is built via multiple machine learning predictive models regarding different targets such as death, hospitalization, and disability records. The IMRS database has been curated with the FDA Adverse Event Reports for Animal Drugs and Devices and Adverse Events Reporting System (FAERS) for Human Drugs and empowered by DrugBank database, PubChem, and MedDRA (Internationally standardized medical terminology). This has received considerable media coverageincluding Brakke Consulting (The Experts in Animal Health), BioNexus KC, J. Harvey, and One Health Commission. What do you plan to do during the next reporting period to accomplish the goals?We plan to continue working on the literature review on physiological parameters in food-producing animals, including the sheep, goat, chicken, and turkey. We will try to finish the Physiological Parameter Databases for six commonly used food animal species, including cattle, swine, sheep, goat, chicken, and turkey. We will also develop a centralized PBPK model platform that can be used to run PBPK simulations for different drugs in different food animal species. Regarding gFARAD, we are planning to develop AI tools for building the global database. It is in our expectation that this task may take time as it is not a defined analysis.
Impacts
What was accomplished under these goals?
Accomplishments of the overall FARAD Program: The overall use of FARAD program services has demonstrated remarkable growth throughout the past five years in terms of both the number of residue-related questions received via our telephone hotline plus our internet-based portal as well as the number of visits to our web-based information resources at www.farad.org. FARAD has continued to operate its telephone hot-line and e-mail access systems throughout the past year, which produced continued growth in the number of calls compared to the previous year. During 2019, the regional access centers answered 3,765 specific inquiries (entailing multiple drugs/contaminants) that directly involved approximately 6.1 million animals. Given the amount of list-serve sharing of FARAD's answers, these calls most likely indirectly impacted other sets of animals, which are unquantifiable. The majority of these inquiries were submitted via the World Wide Web and remain focused on small production poultry (34%) followed by dairy and beef cattle (20%), then small ruminants (28%), swine (13%), rabbits (1%) and other (2%). Depending on species, each request may impact either a single animal or large herds or flocks. In addition to specific cases that were submitted via the hot-line, users sought general information on drug and residue avoidance. The reasons for calls are very diverse and range from "ordinary requests" for drug withdrawal recommendations (related to extra-label drug use or accidental drug overdoses) to "extraordinary requests", which include pesticide and contaminant exposures. Use of the web-based resources at www.farad.org grew tremendously in 2019, with 72,096 users making 111,783 visits (daily average of 306 visits), representing a more than 43% increase over the previous year. Of these visitors, 53,828 (75%) originated from IP addresses located within the United States, up 44% from 37,363 in the previous year. The proportion of visitors originating from outside the US (25%) increased marginally from 22% in 2018, a trend observed for the first time in the previous reporting period. In total, website visits originated from a total of 174 countries, with the top ten numbers of non-US visitors being from (high to low) Canada, India, United Kingdom, Australia, China, Philippines, Japan, France and Mexico. One continued trend in 2019 was a high demand for the internet-based VetGRAM platform (352 visits per day). Other highly viewed pages on the FARAD website included the Withdrawal Interval (WDI) Recommendation Lookup, the Withdrawal Date Calculator, the Restricted and Prohibited Drugs page and Extra-Label Drug Use information pages. During 2019, new installs of our free VetGRAM apps continued at similar levels to 2018 for both Android phones (502 active installs) and the iOS-based app for iPhones (460 active installs). Although most interaction with FARAD occurs via the modalities described above, FARAD users also followed us on Facebook (119) and Twitter (73). Several species- or topic-specific web pages added in recent years provide resources for users with specific interests. A Spanish language option was added to the FARAD website in 2018; in 2019, there were 1,334 visits to the translated pages. Accomplishments of the KSU component of the FARAD Program: Under the goals and specific objectives of the KSU component of the FARAD program described above, the following projects have been completed, including (1) we have completed the Physiological Parameter Databases for PBPK modeling in cattle and swine, (2) we are working on the Physiological Parameter Databases for PBPK modeling in chickens, turkeys, sheep, and goats, (3) we have completed the PBPK model for flunixin in swine and cattle, and (4) We are developing a centralized PBPK modeling platform for drugs in various food-producing animals. In addition, we have been working on the technology development to clean and parse the global FARAD database. A task was partly performed to scan pdf documents to extract sensitivity information of bio-assay test related to matrix and tolerance data. We also finalized a data collecting framework/agreement for Taiwan Drug Data related to the drug's withdrawal time. This agreement comprises of several fields for the data collection including Drug's Unique Approval, drug's registered or trademarked name (not the active ingredient), drug form (tablet, solution, powder, etc.), drug name (Active Ingredient), formulation (details of the amount of each active ingredient in the drug), species, indications (what disease, parasite or condition the drug is used to control, treat, or prevent), directions (specifically how, when and where to administer the drug), dose, frequency, duration, further information (further warnings specific to the species such as "Do not administer to lactating cattle."), route name (Route of Administration: Intravenous, Conjunctival, Subcutaneous, Nasogastic, etc.), withdrawal time, milk withdrawal time, and label data source (URL for label information, if found), as well as MRL information such as, ADI (Acceptable Daily Intake)), target tissue, tissue marker residue, milk marker residue, and MRL data source.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2020
Citation:
Lin Z, Li M, Wang YS, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE. (2020). Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and Swine. Journal of Veterinary Pharmacology and Therapeutics, in press. [PMID: 32270548] https://doi.org/10.1111/jvp.12861
- Type:
Journal Articles
Status:
Published
Year Published:
2020
Citation:
Salas JR, Jaberi-Douraki M, Wen X, Volkova VV. (2020). Mathematical modeling of the inoculum effect': six applicable models and the MIC advancement point concept. FEMS Microbiology Letters, 367(5), fnaa012.
- Type:
Journal Articles
Status:
Published
Year Published:
2020
Citation:
Bates JL, Karriker LA, Rajewski SM, Lin Z, Ronette G, Li M, Riviere JE, Coetzee JF*. (2020). A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing age swine. BMC Veterinary Research, 16, 211. https://doi.org/10.1186/s12917-020-02429-w
- Type:
Journal Articles
Status:
Published
Year Published:
2020
Citation:
Smith JS, Marmulak TL, Angelos JA, Lin Z, Rowe JD, Carlson JL, Shelver WL, Lee EA, Tell LA*. (2020). Pharmacokinetic parameters and estimated milk withdrawal intervals for domestic goats (Capra aegagrus hircus) after administration of single and multiple intravenous and subcutaneous doses of flunixin meglumine. Frontiers in Veterinary Science, 7:213. [PMID: 32509803] https://doi.org/10.3389/fvets.2020.00213
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