Source: TUFTS UNIVERSITY submitted to NRP
ONE-HANDED DISPLACED ABOMASUM CORRECTION DEVICE -PRE-CLINICAL STUDY
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1020354
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Sep 1, 2019
Project End Date
Feb 28, 2021
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
TUFTS UNIVERSITY
200 WESTBORO ROAD
N. GRAFTON,MA 01536
Performing Department
Environmental & Population Health
Non Technical Summary
When cows calve, they are at risk for several diseases including displaced abomasums (DA's) in which their abomasum (their "fourth stomach") moves from its normal location on the bottom of the abdomen to the upper left side of their abdomen. Unless corrected, DA's are fatal to cattle. Typically, DA corrections aredone by open surgery or by toggling. Toggling is performed by placing a fixation device through the skin of the cow into the abomasum after the abomasum has been returned to its correct location by rolling the cow onto her back. Surgery is expensive and requires a high level of expertise. Toggling is less expensive than surgery but does not allow for visualizaton of the abomasum before the toggle is inserted into the abdomen of the cow. Since the abomasum is not visualized prior to toggle placement, use of toggles can lead to penetration of organs other than the abomasum which can be fatal to cattle.This project would lead to the development of a tool that would allow for correction of DA's by a method which would be less expensive and require less expertise than surgery while at the same time allowing for visualization of the DA before insertion of a toggle. The tool would be a spring loaded device which would allow for one-handed placement of toggles into the abomasum of cows affected with DA's. Since the device could be used with one hand, the other hand couldbe used to operate an ultrasound which wouldbe used to confirm abomasum location prior to insertion of the toggle. By visualizing the abomasum ultrasonically priorto toggle placement, the risk of penetrating an organ other than the abomasum would be greatly reduced as can occur with the toggle device currently in use.This project would consist of two phases. In the first phase, a device and toggles would be developed to allow for one-handed correction of DA's. In the second phase, the prototypes developed would be used in cadaver cows to ensure reliable penetration into the abdomen ofcattle. If the tool were successful, a patent would be sought for the tool and the tool would be marketed to farmers and veterinarians as an alternate means of correcting DA's.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
100%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
31134101060100%
Knowledge Area
311 - Animal Diseases;

Subject Of Investigation
3410 - Dairy cattle, live animal;

Field Of Science
1060 - Biology (whole systems);
Goals / Objectives
The most common surgical intervention performed on dairy cattle is fixation of a displaced abomasum (DA). With over 9,000,000 dairy cattle in the Unites States and an estimated disease incidence of 3%, up to 270,000 dairy cows are affected with DA's each year in the United States. Currently, there are two methods commonly used for fixation of DA's: laparotomy with fixation of the DA or percutaneous (Surgical fixation), blind fixation of the DA using the Grymer-Sterner technique (toggling). Surgical fixation of DA's requires expertise and a large investment in equipment and consumable materials. Toggling requires less technical expertise and a lower investment in equipment but risks failure as the abomasum is not visualized at the time of fixation leading to the potential to miss the abomasum or insert the toggle into an organ other than the abomasum. The goal of this project would be to develop a device which corrects DA's using a different approach.The proposed device, the toggle gun, bypasses the limitations of both performing a laparotomy, namely cost and expertise, and using the Grymer-Sterner technique, namely uncertainty about accurate placement of the toggle. The toggle gun would require less expertise and cost than performing surgery while allowing precise placement of toggles which is not currently possible with the Grymer-Sterner technique. The chief advantage of the toggle gun is that it allows one-handed placement of toggles while the Grymer-Sterner Technique requires two hands. One-handed insertion of toggles will give the operator the opportunity to use the other hand to ensure proper placement of the toggle using an inexpensive, portable ultrasound that are routinely used in dairy practice. The project will consist of two parts: (1) engineering an instrument for toggle insertion, the toggle gun, and a novel design for the toggle itself which will allow for one-handed insertion along with simultaneous ultrasonic imaging for confirmation of proper insertion; and (2) test the implementation of the one-handed device toggle system in bovine cadavers.
Project Methods
The study to show proof of concept will be run in two phases. Phase one will involve the completion of engineering and production of the final insertion device (toggle gun). Completion of engineering will include final testing of the toggles and testing of the final toggle gun on cow cadaver(s). Phase two will be a short production run of:four toggle guns and100 toggles. The aims of this study are to show that the toggle can be effectively delivered to the abomasum and the toggle gun approach is superior than the Grymer-Sterner method.

Progress 09/01/19 to 02/28/21

Outputs
Target Audience:Farmers and cattle owners Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals?No progress has been made on this project. We are electing to terminate the project ahead of the scheduled end date.

Impacts
What was accomplished under these goals? No progress has been made on this project. We are electing to terminate the project ahead of the scheduled end date.

Publications


    Progress 09/01/19 to 09/30/19

    Outputs
    Target Audience:The target audience for this project is dairy veterinarians and dairy farmers. DA's have a significant finanicial impact on dairyfarmers and developing a less expensive, more reliable means of correcting them will have a direct, positive effect on thesefarmers. The end users of the tool, which may be veterinarians or farmers, will have a means of fixing DA's that is reliable,inexpensive, and requires less expertise than performing surgery. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest?The product is not yet at the stage to distribute for testing. What do you plan to do during the next reporting period to accomplish the goals?Continued development by engineers and testing of force requirements and how to integrate those requirements safely into the instrument.

    Impacts
    What was accomplished under these goals? Some progress has been made in determining the force necessay for the instrument to penietrate bovine skin. The device is still in an early development stage.

    Publications