Source: UNIVERSITY OF ILLINOIS submitted to NRP
COMMUNITY PARTICIPATION AND GENOMIC INTEGRATION FOR HEALTH
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1018628
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Feb 11, 2019
Project End Date
Sep 30, 2023
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIVERSITY OF ILLINOIS
2001 S. Lincoln Ave.
URBANA,IL 61801
Performing Department
Human Devel & Family Studies
Non Technical Summary
The Community Participation & Genomic Integration for Health (CPgI4H) proposal provides a unique research opportunity as studies addressing gene-environment interactions in the pathogenesis of obesity or weight gain trajectories are lacking. The CPgI4H project will provide data for subsequent proposals aimed at developing personalized interventions to optimize child health outcomes. The wealth of information already acquired on Social Determinants of Health (SDOH) that affect a wide range of health, function and quality-of-life risk and outcomes will be integrated. The operative framework of SDOH from the Healthy People 2020 encompasses five key domains: a) economic stability; b) education; c) health and health care; d) neighborhood and built environment; and e) social and community context. Three ongoing projects that address SODH and underline diet as one of the main amendable components in the environment, will be specifically investigated. Previous projects on ABRIENDO CAMINOS and STRONG Kids (SK1-Cohort 1) have provided evidence of collaboration, standardization on procedures and proof of feasibility. We are well positioned to evaluate if our community intervention has positive associations between the neighborhood characteristics, home food environment, and familial biological and behavioral outcomes at all stages of evaluation. Therefore, the CPgI4H proposal will be contextualized and integrate data from: 1) The STRONG kids 2 cohort, SK2; 2) The ABC of Abriendo Caminos; and 3) GET-UP KIDS.
Animal Health Component
40%
Research Effort Categories
Basic
40%
Applied
40%
Developmental
20%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7036020101050%
7036020108050%
Goals / Objectives
The overaching Objectives of this project are:Objective 1:To determine if the relationships between genetic and environmental factors (nutrition, dietary patterns) among children and families have common elements that are amenable to intervention.Objective 2:To identify the frequency of high-risk alleles on genes related to the early onset obesity phenotype using data from ongoing research cohorts.Objective 3:To identify novel genetic markers for excessive weight gain trajectories.Objective 4:To analyze the impact of gene-environment interactions on longitudinal weight gain trajectories.Objective 5:To translate evidence-based information gathered from Objectives 1 to 4 into training/educational materials. Those materials will enable Extension specialists and community members to communicate evidence-based-tailored recommendations as simplified messages, effective and impactful, for healthy nutrition and wellness.
Project Methods
We propose to bring together expertise in nutrition, kinesiology and genetic epidemiology to identify the most appropriate interventions to prevent obesity. The idea is to integrate phenotype and genotype data variables first to describe and then evaluate the longitudinal effects of environmental interventions, nutrition and/or exercise, in preventing obesity and related diseases. Phenotypic data will be collected by validated questionnaires accessing family history, food intake and/or eating behavior as well as physical activity. Data on basic data of anthropometric measurements will be collected.Other body composition and energy expenditure measurements will be later incorporated during the follow-up of the study (including DXA and BIA for measuring body composition). Increased food intake is one of the critical factors leading to the onset of obesity. Regulation of food intake is a complex trait resulting from the interaction of physiological, psychological, socio-environmental elements, and an individual's genetic profile. Self-reported (or UP AMIGOS) and parent-reported (STRONG Kids) surveys will be used to evaluate diet, physiological, psychological, and other socio-environmental elements according to our proposed, integrative, 6'Cs model.Genomic DNA for genotype studies will be obtained from saliva or blood samples. Genetic material has been collected with the vision to build an invaluable resource to answer additional questions related to nutrition and nutrition-related diseases such as obesity. In the long term, other biological materials (blood, serum, urine) might be assembled to feed new projects derived from the main project. This project would provide a great resource to identify and test novel biomarkers related to metabolic disease. Careful attention to ethical, legal, and social issues surrounding the availability of genetic information will be considered to protect individual identity.Statistical Analyses. Allele frequencies were estimated by the gene counting method. Chi-square tests were used to identify significant departures from Hardy-Weinberg equilibrium. The selected individual genetic variations (SNPs) will be tested for additive genotype effect on BMI percentile, WAZ, HAZ, and BMIZ values in general linear models using SAS 9.4 (SAS Institute Inc., Cary, NC). The effect of environmental covariates in the genetic associations will be tested as a categorical covariate under different integral approaches. The general linear models will be used to examine the association of the SNPs investigated with BMI percentile, CDC z-scores, assuming an additive effect, without adjustment for BF duration. Genotype-phenotype associations were tested using the publically available Plink software and other genetic epidemiology tools. When appropriate genetic predisposition scores (GPS) will be calculated and tested for association with the obesity-related phenotypes according to an additive risk allele model.

Progress 10/01/19 to 09/30/20

Outputs
Target Audience:Target audiences included nutrition educators and Extension specialists, undergraduate and graduate students in the areas of nutrition and health, low-income and low-literacy families will be informed of evidence-based information generated, Hispanic/LatinX populations will also be targeted with bilingual/bicultural educative materials, and public and scientists in the areas of nutrition, health, and wellness for children and families. Changes/Problems:During the last quarter of 2019, three Hurricanes and an earthquake made it more challenging to address the community families and leadership. During 2020 a systematic pandemic affected all the world, and particularly our target audiences. The regions where we implement our programs are confronting additional problems. To keep our community engagement, we had implemented a continuous zoom video conference with several community members. The collaboration with families of low-income, low-literacy builds on trust and respect. Thus, our work together facilitates resource optimization to the communities with their leadership. We have constructed rapport over the years with a common goal of health and wellness for children and families. We will continue this work, developing additional strategies and partnerships. What opportunities for training and professional development has the project provided?We have provided education to undergraduate students with seminars on "Global Biosecurity and Social Determinants of Health and Health Equity" during the last twoyears with an audience of 50 to 75 students. Attended professional meetings to disseminate the impact of ongoing projects. Attended the annual meeting of the Society of Nutrition Education and Behavior, and "Obesity Weekfrom The Obesity Society". This year, presentations were virtual. How have the results been disseminated to communities of interest?As an invited speaker to community and campus groups. What do you plan to do during the next reporting period to accomplish the goals?Continue collection and analyses of data. The next year will be heavy on bioinformatics and analytical tasks with the goal of completing a publication before the end of the fiscal year. Continue dissemination of materials for health and wellness to families. We provide strategies to low-income, low-literacy audiences on how to prepare healthy meals according to USDA recommendations. Disseminate resources to communities and families for developing plans for better access to nutritive and affordable food. Maintain relationships in our community to reduce the proportion of children and families affected by overweight or obesity problems. Contribute to sustained changes in healthy eating habits in youth and their families and decrease the burden of inadequate nutrition-related problems.

Impacts
What was accomplished under these goals? The data to complete Objectives 1 through4 is almost completed. DNA has been extracted from 150 selected samples and quality analyses are underway to investigate genetic-environment influences on health and wellness. Several documents were developed under Objective 5 in order to work closely with Extension specialists and community members. We are communicating evidence-based-tailored recommendations with simplified messages, effective and impactful, to promote healthy nutrition and wellness.

Publications

  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2019 Citation: Howard, D., Namara G., Teran-Garcia, M. and the Abriendo Caminos Research Team. 2019, April. Methods of Nutrition Education: Translations of Literal to Visual Approaches in the Afro-Centered Abriendo Caminos Immigrant Program. College of Applied Health Sciences, School of Molecular and Cellular Biology, Department of Human Development and Family Studies, Cooperative Extension, Division of Nutritional Sciences, College of ACES, University of Illinois at Urbana-Champaign. Poster presentation at the UIUC Undergraduate Research Symposium and at the 5th International Food Security Symposium, Urbana-Champaign, Illinois.
  • Type: Conference Papers and Presentations Status: Accepted Year Published: 2019 Citation: Inclusion session: Best Practices to Engage Communities for Health Equity. November 19, 2019. Annual Meeting of Cooperative Extension U of I. Champaign, Illinois.


Progress 02/11/19 to 09/30/19

Outputs
Target Audience:Target audiences included nutrition educators and Extension specialists, undergraduate and graduate students in the areas of nutrition and health, low-income and low-literacy families will be informed of evidence-based information generated, Hispanic populations will also be targeted with bilingual/bicultural educative materials, and general public and scientists in the area sof nutrition, health, and wellness for children and families. Changes/Problems:The objectives related to gene-environment interactions are ongoing but require long-term data collection. To investigate the relations of trajectories of excessive weight gain in critical periods of the life-cycle (early childhood and late adolescence/young adulthood) with increased frequencies of risk alleles in candidate genes commonly associated with obesity it will be necessary to complete a larger data collection. We expect to make more progress in the next report. The collaboration with families of low-income, low-literacy represent challenges on building trust and facilitating resources to communities and their leadership, We have worked in building a rapport over years with a common goal of health and wellness for children and families. We will continue this work, developing additional strategies and partnerships. What opportunities for training and professional development has the project provided?We have provided education to undergraduate students with seminars on"Global Biosecurity and Social Determinants of Health and Health Equity" Attended professional meetings to disseminate the impact of ongoing projects. Attended the annual meeting of the Society of Nutrition Education and Behavior, the Obesity week. How have the results been disseminated to communities of interest?Invited Speaker: San Francisco University School of Medicine in Quito, Ecuador. "Community Strategies for a Healthy Family Life" / Escuela de Medicina Universidad San Francisco de Quito, Ecuador. "Estrategias Comunitarias para una Vida Saludable en Familia." Public Health School San Francisco de Quito University, Ecuador. "Genetics and the Environment: its Impact on Overweight and Obesity." / Escuela de Salud Pública Universidad San Francisco de Quito, Ecuador. "Genética y Ambiente: Su Impacto en el Sobrepeso y Obesidad." What do you plan to do during the next reporting period to accomplish the goals?Continue collection and analyses of data. Continue dissemination of materials for health and wellness to families. We provide strategies to low-income, low literacy audiences on how to prepare healthy meals according to USDA recommendations. Disseminate resources to communities and families for developing plans for better access to nutritive and affordable food. Maintain relationships in our community to reduce the proportion of children and families affected by overweight or obesity problems. Contribute to sustained changes in healthy eating habits in youth and their families and decrease the burden of inadequate nutrition-related problems.

Impacts
What was accomplished under these goals? The data to complete Objectives 1 to 4 is still under collection and analyses. More than 100 samples were collected to investigate genetic-environment influences on health and wellness.However, several documents were developed under Objective 5.

Publications

  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: Maribel Barragan, Viridiana Luna, Juan Manuel Vargas-Morales, Celia Aradillas-Garcia and Margarita Teran-Garcia. 2019. Uric Acid: An Overlooked, Inexpensive Biomarker of Metabolic Syndrome (P10-068-19), Current Developments in Nutrition, Volume 3, Issue Supplement_1, June 2019, nzz034.P1006819, https://doi.org/10.1093/cdn/nzz034.P10-068-19.
  • Type: Journal Articles Status: Accepted Year Published: 2019 Citation: Gonzalez-Cortes, C.A., Teran-Garcia, M., Luevano-Contreras, C., Portales-Perez, D.P., Vargas-Morales, J.M., Cubillas-Tejeda, A.C., Cossio-Torres, P.E. and Aradillas-Garcia, C. 2019. Neck Circumference and Its Association with Cardiometabolic Risk Factors in Pediatric Population. Medicina (Kaunas), 55(5). https://doi.org/10.3390/medicina55050183.