Source: KANSAS STATE UNIV submitted to NRP
NUTRIENT BIOAVAILABILITY--PHYTONUTRIENTS AND BEYOND
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1018057
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
W-4002
Project Start Date
Nov 28, 2018
Project End Date
Sep 30, 2023
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
KANSAS STATE UNIV
(N/A)
MANHATTAN,KS 66506
Performing Department
Human Nutrition & Foods
Non Technical Summary
Each year the U.S. government through the USDA, USAID and World Food Program provide food aid in the form of fortified blended foods (FBFs). Fortified blended foods (FBFs) are micronutrient-fortified blends of milled cereals and pulses that represent the most commonly distributed micronutrient-fortified food aid. The most common types of FBF, is a vitamin and mineral fortified mixture of corn and soy, known as corn-soy blend (CSB). Processed foods make up 26% of the share of food aid products from the United States, and CSB is the most widely used FBF (Webb et al. 2011). Similarly, FBFs make up 25% of the food aid volume at the WFP, which aims to increase the use of FBFs to 80% (Webb et al. 2011). These FBFs have been criticized due to lack of efficacy in treating malnutrition, and it has suggested that alternative commodities, such as sorghum and cowpea, be investigated instead of only corn and soybean. A study commissioned by USAID encouraged the development of new cereal-bases FBFs and specifically pointed out that sorghum "could be well suited, given its acceptability in Africa, relatively low price, and its acceptability among host governments. A sorghum-soy (or indeed sorghum-pea or other pulse) blend could be envisaged (Webb et al. 2011)."One of our first activities will be a baseline assessment of the implementing country to help us understand the local context and are implementing partners. The local context will inform what food aid productsare developed through research and development at K-State. Raw materials locally and regionally for the food aid productsalong with selecting facilities with extrusion, processing and manufacturing procedures to produce the product.Food aid prodcuts will be produced and their nutritional effectiveness will be assessed at K-State as well as through a study of food aid recipients.Economic feasibility will assessed considering local context and to incorporate efficacy study findings. We will then make final recommendations, report, and publish articles based on this work. Our final step will be to apply to add the newly developed FBFs to the food basket for food aid producers to request.Webb, P., Rogers, B., Rosenberg, I., Schlossman, N., Wanke, C., Bagriansky, J., Sadler, K., Johnson, Q., Tilahun, J., Reese Masterson, A., and Narayan, A. (2011). Delivering Improved Nutrition: Recommendations for Changes to U.S. Food Aid Products and Programs. Boston, MA: Tufts University.
Animal Health Component
30%
Research Effort Categories
Basic
40%
Applied
30%
Developmental
30%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
70250101010100%
Goals / Objectives
Determine the bioavailability (absorption, distribution, metabolism, elimination) of nutrients and bioactive food components. Determine the efficacy and mechanisms of action of nutrients and dietary bioactive compounds towards improved health.
Project Methods
Research at K-State would focus on optimizing FBFs for the efficacy study collaboratively with partners in the target country or countries to ensure that they are a good fit for local and regional procurement. The research activities will include processing and physiochemicalproperty determination, animal efficacy and shelf-lifestudies. Some brief method explanations for this work are:Physiochemical property determinationWill include Bostwick consistometer determination to ensure the flow rate of porridges meets USDA specifications.Rat studies20-23 days of age Sprague-Dawley rats (n = 10) will be purchased and randomized into different study groups, where they will consume their diets for 4 weeks. Four weeks is the recommended duration for determining the protein efficiency ratio (PER) and for the prophylactic-preventive method. Iron bioavailability in prophylactic-preventive method will be assessed through hemoglobin and hepatic iron concentrations as we have done previously.Shelf-lifeAccelerated and real time shelf life studies will be conducted to study the time dependent changes occurring in FBFs. The tests would follow standard methods certified by the Association of Official Analytical Chemists (now AOAC International) and commonly used by the North American food industry and the United States Department of Agriculture (USDA) Official Testing laboratories.ReferenceDelimont NM, Fiorentino NM, Opoku-Acheampong AB, Joseph MV, Guo Q, Alavi S, Lindshield BL. Newly formulated, extruded sorghum, cowpea, corn, and soy containing fortified-blended foods lead to adequate vitamin A, iron outcomes and improved growth compared with CSB+ in rats. J Nutr Sci. 6: e18, 2017 https://doi.org/10.1017/jns.2017.15

Progress 10/01/19 to 09/30/20

Outputs
Target Audience:Nutritionists, food aid producers, food aid policy makers, food aid distributers, international agriculture development officers Changes/Problems:The pandemic has been a huge change/problem. My new graduate research assistant that was supposed to come in the fall was not able to do so since he is from outside the US. The limitations on time and the conditions have not been conducive to conduct research. What opportunities for training and professional development has the project provided?My graduate student used research to successfully defend her thesis and graduate with her MS in December 2019. How have the results been disseminated to communities of interest?Yes there have been published. What do you plan to do during the next reporting period to accomplish the goals?Restart research activities as we move to a stage of the pandemic where that can happen.

Impacts
What was accomplished under these goals? Published the manuscript reported.

Publications

  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Ward EJ, Suleria HAR, Joseph M, Chambers IV E, Alavi S, Lindshield BL. Soy Protein is and Efficacious Alternative to Whey Protein in Sorghum-Soy Fortified Blended Food in Rats. Curr Dev Nutr. 4(8): 2020. https://doi.org/10.1093/cdn/nzaa115
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Ward EJ, Lindshield BL. Performance, behavior, and perceptions of an open educational resource derived interactive educational resource by online and campus university students. Res Learn Technol. 28: 2020. 2386. http://dx.doi.org/10.25304/rlt.v28.2386


Progress 11/28/18 to 09/30/19

Outputs
Target Audience:Nutritionists, food aid producers, food aid policy makers, food aid distributers, international agriculture development officers Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?My graduate student and I both attended the Nutrition 2019 conference in June partly for professional development purposes. How have the results been disseminated to communities of interest?My graduate student was 2018 Research and the State Winner (1 of 10 at University), which meant that she had the opportunity to present her research at the Capitol in 2019. She also was a 2019 Kansas State University 3 Minute Thesis Finalist (1 of 9 at University). This competition challenges researchers to describe their research in an engaging, approachable manner. What do you plan to do during the next reporting period to accomplish the goals?We plan to complete the study described above to determine whether saliva can be used to assess iron bioavailability and status as a less invasive measure than blood. We also plan to complete the follow-up study fortified rice study alluded to above.

Impacts
What was accomplished under these goals? 1. We completed analysis and write up of results from rat fortified blended foods and fortified rice studies. We plan to submit the rat FBF article for publication in the near future. We plan to do a follow-up study with the rice before submitting a combined manuscript for both for publication. 2. We have plans in place for a study to determine whether saliva can be used to assess iron bioavailability and status as a less invasive measure than blood.

Publications

  • Type: Journal Articles Status: Published Year Published: 2018 Citation: Fiorentino NM, Kimmel KA, Suleria HAR, Joseph M, Alavi S, Beyer RS, Lindshield BL. Novel Formulated Fortified Blended Foods Result in Improved Protein Efficiency and Hepatic Iron Levels Compared to CSB+ in Broiler Chickens. Curr Dev Nutr. 2(12): 2018 https://doi.org/10.1093/cdn/nzy073
  • Type: Journal Articles Status: Published Year Published: 2019 Citation: Delimont NM, Vahl CI, Kayanda R, Msuya W, Mulford M, Alberghine P, Praygo G, Mngara J, Alavi S, Lindshield BL. Complementary Feeding of Sorghum-Based and Corn-Based Fortified Blended Foods Results in Similar Iron, Vitamin A and Anthropometric Outcomes in the MFFAPP Tanzania Efficacy Study. Curr Dev Nutr. 3(6): 2019. https://doi.org/10.1093/cdn/nzz027
  • Type: Journal Articles Status: Published Year Published: 2019 Citation: Delimont NM, Katz, BB, Fiorentino NM, Kimmel KA, Haub MD, Rosenkranz SK, Tomich JM, Lindshield BL. Salivary cystatin SN binds to phytic acid and is a predictor of non-heme iron bioavailability with phytic acid supplementation. Curr Dev Nutr. 3(7): 2019. https://doi.org/10.1093/cdn/nzz057
  • Type: Journal Articles Status: Published Year Published: 2019 Citation: Regier GK, Lilja N, Lindshield BL. Nutrient Cost Effectiveness of Fortified Blended Food Aid Products. Food Nutr Bull. 2019. https://doi.org/10.1177/0379572119846331
  • Type: Journal Articles Status: Published Year Published: 2019 Citation: Miller M, Middendorf G, Wood S, Lutter S, Jones S, Lindshield B. Food Insecurity and Assistance on Campus: A Survey of the Student Body. Online Journal of Rural Research and Policy 14(2): 2019. https://doi.org/10.4148/1936-0487.1097
  • Type: Book Chapters Status: Published Year Published: 2019 Citation: Alavi S, Ruan S, Adapa SS, Joseph M, Lindshield B, and Chilukuri S. 2019. Use of grain sorghum in extruded products developed for gluten-free and food aid applications. In Sorghum: State of the Art and Future Perspectives. Eds. Ciampitti, I., and Prasad, V. Agronomy Monograph 58. ASA and CSSA, Madison, WI.