Progress 09/26/18 to 06/30/20
Outputs
Target Audience:Target audiences include the scientific and medical communities, educators, students and the public. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?The project has provided great research training opportunities for postdocs, graduate students and undergraduate students. The researchers who have been carrying out this research project have gained tremendous experience with research techniques and scientific thinking. How have the results been disseminated to communities of interest?The research data have been presented by a PhD student, Nick Robl, at the annual ADVS Student Research Symposium. A manuscript is being prepared to publish the data in a peer-reviewed scientific journal. What do you plan to do during the next reporting period to accomplish the goals?Similar to last year's report, as planned, long term effects of diets and loss of CETP function on the development of hyperlipidemia and atherosclerosis will be investigated.
Impacts
What was accomplished under these goals?
Since the last report, we have validated the finding that loss of CETP function leads to elevated triglycerides and triglyceride-rich lipoproteins. We have also discovered that the hyperlipidemia caused by loss of CETP function may contribute to atherosclerosis. As it takes time to develop atherosclerosis, we are carrying out long term studies on the interplay between diets and CETP function and their effects on health.
Publications
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Progress 09/26/18 to 09/30/18
Outputs
Target Audience:The target audience for this report is the directors and coordinator of Utah Agricultural Experiment Station. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?The project has been providing great research training opportunities for the postdocs, graduate students and undergraduate students who have been involved in the research. This is mainly reflected by the research techniques and scientific thinking they have learned. How have the results been disseminated to communities of interest?We are planning to present/publish the scientific discoveries in conferences and peer-reviewed journals. What do you plan to do during the next reporting period to accomplish the goals?As outlined in the proposal, long term observations on the effects of diets and loss of CETP function on the development of hyperlipidemia are being made.
Impacts
What was accomplished under these goals?
Groups of hamsters of each sex from each genotype (CETP+/+, CETP+/-, CETP-/-) have been randomly assigned to either a purified maintenance diet or a modified high-fat diet beginning at six weeks of age. We are investigating if increased fat content in the diets will induce hypertriglyceridemia differently (to different extents) among the three genotypes. We are following the four, six, eight, ten, and twelve weeks schedule as proposed in the proposal for blood collection and analysis. Preliminary data so far have shown that loss of CETP function leads to elevated triglycerides and triglyceride-rich lipoproteins. As planned, we are making long term observations on the interplay between diets and CETP function.
Publications
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