Source: UNIVERSITY OF CALIFORNIA, DAVIS submitted to NRP
FOOD ANIMAL RESIDUE AVOIDANCE DEPLETION PROGRAM (FARAD, AKA HISTORICALLY FOOD ANIMAL RESIDUE AVOIDANCE DATABANK, 7 USC 7642)
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
OTHER GRANTS
Reporting Frequency
Annual
Accession No.
1017250
Grant No.
2018-41480-28806
Cumulative Award Amt.
$825,000.00
Proposal No.
2018-05987
Multistate No.
(N/A)
Project Start Date
Sep 1, 2018
Project End Date
Aug 31, 2021
Grant Year
2018
Program Code
[FARAD]- Food An. Res. Avoidance Database,FARAD
Recipient Organization
UNIVERSITY OF CALIFORNIA, DAVIS
410 MRAK HALL
DAVIS,CA 95616-8671
Performing Department
Vm: Medicine & Epidemiology
Non Technical Summary
The Food Animal Residue Avoidance Databank (FARAD) is a collaborative university-based food safety program that is coordinated and delivered by veterinary faculty and staff at several US colleges of veterinary medicine. Throughout its 36 year existence, FARAD has continued to evolve to meet the ever changing demands of providing accurate, timely and reliable service to both the veterinary profession and food animal industry stakeholders. At present, the program is managed through a very close collaboration of personnel at the University of California-Davis (UCD), University of Florida (UF), North Carolina State University (NCSU), Kansas State University (KSU) and Virginia-Maryland College of Veterinary Medicine (VM).
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
71139101180100%
Knowledge Area
711 - Ensure Food Products Free of Harmful Chemicals, Including Residues from Agricultural and Other Sources;

Subject Of Investigation
3910 - Cross-commodity research--multiple animal species;

Field Of Science
1180 - Pharmacology;
Goals / Objectives
The 2018-2019 FARAD project year will be focused on the essential call centers tasks including answering extra-label withdrawal requests, updating and expanding the resources available to call responders, maintaining the call center database and index page, extracting and cataloging pharmacokinetic data from published literature and updating and developing educational tools for veterinarians and the public posted on the FARAD web site. Specific to this year, the species pages will also be made available in Spanish, the conversion of the KinEntry portion of the database to an SQL format will be completed, a new portal system for veterinarians to look up their submissions of and current and historical answers will be developed, and an interface for extracting pharmacokinetic parameters from studies where physiologically based or population based models have been fit to data . We will also assist KSU with the development of an interface for the physiological based pharmacokinetic models (with the help of a post-doctoral fellow at UC Davis) and NCSU with the development of an interface for the non-linear mixed effect models that FARAD has developed for answering call based inquires. Other tasks will include working closely with the new responder at Virginia Maryland College of Veterinary Medicine to get that individual trained on answering calls. This will help with uniformity of answers from the three different call centers. Lastly, we will develop an on-line portal system that will allow veterinarians to log into a secure portal where they can follow inquiry submissions and review historical FARAD answers to their submissions. Given that Virginia-Maryland College of Veterinary Medicine will be a new responding center, UC Davis will also play a key role in training the new responder.In addition to the call center activities, we will expand our efforts on educating small animal veterinarians regarding extra label drug use in backyard poultry, continue to assist veterinarians nationwide to understand the new veterinary feed directive rules, and provide California veterinarians with resources to confirm with the new Senate Bill 27. For backyard poultry, we will be designing and conducting a survey (Dr. Evan Adler and Masters Graduate students, Myrna Cadena and Rachel Dutch) to understand how drugs are being used in an extra-label manner. In addition, we plan to develop (in both English and Spanish) an educational video that will allow both owners and small animal veterinarians understand the issues related to drug use in backyard poultry and how to avoid residues that could pose risks to human health.
Project Methods
FARAD performs a broad array of programmatic functions, but key among these are the collection, evaluation, analysis, interpretation and dissemination of information related to the depletion of drugs and other chemicals in edible products derived from food-producing animal species. The underlying activities that support these functions are carried out through multi-layered and complimentary approaches that are coordinated by the FARAD centers located at UCD, NCSU, UF, KSU and VM. At UCD, FARAD personnel search the peer-reviewed scientific literature plus numerous other information resources for data pertaining to the depletion or elimination from food producing animals of all classes of small molecule entities. Relevant information is extracted, modeled, and entered into a computer-based archival databank that is readily searchable for customized information retrieval. Because there are many factors that can influence how rapidly an animal eliminates a chemical residue; information about diet, age, gender, breed and disease status are taken into consideration.

Progress 09/01/18 to 08/31/21

Outputs
Target Audience:The Food Animal Residue Avoidance and Depletion (FARAD) program has a human food safety focus with services to veterinarians. The target audience for this program is livestock owners, producers, regulators, and veterinarians (private practice and state). The goal of the program is residue avoidance in human food products by providing livestock owners, producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products that are intended for human consumption. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?Undergraduate students have learned about human food safety and residue avoidance. Graduate students (veterinary students) and food animal and pharmacy residents have learned about the rules and regulations surrounding extra-label drug use and the pharmacokinetic distribution of veterinary drugs from a residue standpoint. Veterinarians are consistently being advised about drug residue avoidance. How have the results been disseminated to communities of interest?Information is shared with communities of interest via answers to ELDU questions, journal publications, information posted on the FARAD web site, and scientific presentations. What do you plan to do during the next reporting period to accomplish the goals?Continue to provide service to producers and veterinarians regarding on label and extra label drug use. Maximize availability of educational materials regarding residue avoidance.

Impacts
What was accomplished under these goals? The main program accomplishments were answering drug residue inquiries (2020: 3926 specific inquiries impacting 10.8 million animals) and updating and maintaining the pharmacokinetic, bibliographic, and call submission databases. FARAD telephone, email and web-based inquiries were answered on a rotating basis between UC Davis, North Carolina State University and Virginia Tech University. UC Davis continued collecting bibliographic citations that contain pharmacokinetic data from live animal studies. There was an ongoing process of adding new citations to the end note library. Citation and kinetic records (2020: 4243 kinetic records) were added, targeting active ingredients and species for which FARAD gets the most submissions and for active ingredients that are being used extensively for ELDU. Citations were assigned a designation of importance then extracted and the pharmacokinetic data added to the database. The data extraction that UC Davis performs is crucial for developing residue avoidance algorithms and for responders to estimate withdrawal interval recommendations. Other extraction efforts included identifying antique records and converting them to full PK extractions (including expanded animal subject information, analytical method, non-compartmental and compartmental PK data, and WDI estimations). From a programming standpoint, the kinentry interface was updated and modified. The pages were expanded to include individual animal data, co-administered drugs, non-compartmental and compartmental PK parameters, average data and high animal data values from unscanned figures (and subject numbers per point), FDA and EMA withdrawal interval calculations. NLME and PBPK withdrawal estimate modules were initially started and will be expanded upon at a later date. A newly designed web-based interface for responders to run queries for calls and data dumping was also developed. This web-based interface was also modified so that data extractors can find records based on priority, extractor, date extracted, and whether the entry remains as an antique or updated kinentry record. Modifications and improvements for logging and tracking questions submitted to FARAD (FARM Calls) continued. Methods for WDI estimations were explored using tissue data from two meloxicam (chicken and sheep). Multiple approaches were investigated (FDA and EMA). A tissue residue study for meloxicam in sheep was performed and a tissue residues study for florfenicol use in goats was completed.

Publications

  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey. Wang YS, Li M, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE, Lin Z. J Vet Pharmacol Ther. 2020 Dec 2;44(4):423-55. doi: 10.1111/jvp.12931. Online ahead of print. PMID: 33289178
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat. Li M, Wang YS, Elwell-Cuddy T, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. J Vet Pharmacol Ther. 2021 Jul;44(4):456-477. doi: 10.1111/jvp.12938. Epub 2020 Dec 22. PMID: 33350478
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Risk Assessment of Human Consumption of Meat From Fenbendazole-Treated Pheasants. Carre�o G�tiez M, Tell LA, Mart�nez-L�pez B. Front Vet Sci. 2021 Jun 4;8:665357. doi: 10.3389/fvets.2021.665357. eCollection 2021. PMID: 34150886
  • Type: Journal Articles Status: Published Year Published: 2021 Citation: Large-Scale Data Mining of Rapid Residue Detection Assay Data From HTML and PDF Documents: Improving Data Access and Visualization for Veterinarians. Jaberi-Douraki M, Taghian Dinani S, Millagaha Gedara NI, Xu X, Richards E, Maunsell F, Zad N, Tell LA. Front Vet Sci. 2021 Jul 21;8:674730. doi: 10.3389/fvets.2021.674730. PMID: 34368270; PMCID: PMC8334182.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Veterinary Emergency Response Considerations for Pharmacists: with an emphasis on food-animals and medication use. (Emily D. Richards and Lisa A. Tell); SVHP Annual Meeting; June 27, 2020; Virtual Telecast.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: FARAD: New Techniques for establishing Withdrawal interval recommendations. (Lisa A. Tell) US Animal Health Association; October 15, 2020; Virtual Oral Presentation.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Food Animal Therapeutics (Krysta Martin and Emily Toney); Veterinary Pharmacy Elective SPPS 266, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences; October 29, 2020; Virtual Learning.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Evaluation of heat and pH treatments on degradation of ceftiofur in whole milk (Adriana Garzon, Pramod Pandey, Lisa A. Tell, Sharif Aly, Richard Pereira); NIAMRRE Knowledge Exchange; 2020; Virtual Poster Sessions.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Extra-Label Drug Use in Backyard Poultry (Lisa A. Tell); Association of Avian Veterinarians Annual Conference; 2020; Virtual Oral Presentation
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Li M, Wang Y, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE, Lin Z. Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine. The 59th Annual Meeting of Society of Toxicology. Anaheim, CA. The Toxicologist, Supplement to Toxicological Sciences, 174(1), p. 461, abstract #2943. (March 15-19, 2020)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: Lin Z, Li M, Baynes RE, Tell LA, Davis JL, Vickroy TW, Riviere JE. Development and application of an interactive physiologically based pharmacokinetic (iPBPK) model interface to estimate withdrawal intervals for penicillin G in cattle and swine. The 59th Annual Meeting of Society of Toxicology. Anaheim, CA. The Toxicologist, Supplement to Toxicological Sciences, 174(1), p. 458, abstract #2932. (March 15-19, 2020)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Yuan L, Chou WC, Riad MH, Cheng YH, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 201, abstract/poster board #: 2539/P277. (March 12-26, 2021)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development and application of a physiologically based pharmacokinetic model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences, 180(S1), p. 158, abstract/poster board #: 2364/P102. (March 12-26, 2021)
  • Type: Conference Papers and Presentations Status: Published Year Published: 2021 Citation: Chou WC, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. Development of an interactive generic physiologically based pharmacokinetic (igPBPK) modelling platform to predict drug withdrawal intervals in food animals. The 60th Annual Meeting of Society of Toxicology (Virtual). The Toxicologist, Supplement to Toxicological Sciences180(S1), p. 161, abstract/poster board #: 2375/P113. (March 12-26, 2021)
  • Type: Websites Status: Published Year Published: 2021 Citation: https://cafarad.ucdavis.edu/RapidAssay/rapidassay.aspx


Progress 09/01/19 to 08/31/20

Outputs
Target Audience:The target audience for this program is mostly livestock producers, regulators, and veterinarians (private practice and state). The goal of the program is to provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?Undergraduate students have learned about human food safety and residue avoidance. Graduate students (veterinary students) and food animal and pharmacy residents have learned about the rules and regulations surrounding extra-label drug use and the pharmacokinetic distribution of veterinary drugs from a residue standpoint. Veterinarians are consistently being advised about drug residue avoidance. How have the results been disseminated to communities of interest?Information is shared with communities of interest via answers to ELDU questions, journal publications, information posted on the FARAD web site, and scientific presentations. What do you plan to do during the next reporting period to accomplish the goals?Continue to provide service to producers and veterinarians regarding on label and extra label drug use. Maximize availability of educational materials regarding residue avoidance.

Impacts
What was accomplished under these goals? The main program accomplishments were answering drug residue inquiries (2019: 3765 inquiries) and updating and maintaining the pharmacokinetic, bibliographic, and call submission databases. FARAD telephone, email and web-based inquiries were answered on a rotating basis between UC Davis, North Carolina State University and Virginia Tech University. UC Davis continued collecting bibliographic citations that contain pharmacokinetic data from live animal studies. There was an ongoing process of adding new citations to the end note library. Citation and kinetic records (2019: 2,337 kinetic records) were added, targeting active ingredients and species for which FARAD gets the most submissions and for active ingredients that are being used extensively for ELDU. Citations were assigned a designation of importance then extracted and the pharmacokinetic data added to the database. The data extraction that UC Davis performs is crucial for developing residue avoidance algorithms and for responders to estimate withdrawal interval recommendations. Other extraction efforts included identifying antique records and converting them to full PK extractions (including expanded animal subject information, analytical method, non-compartmental and compartmental PK data, and WDI estimations). From a programming standpoint, the kinentry interface was updated and modified. The pages were expanded to include individual animal data, co-administered drugs, non-compartmental and compartmental PK parameters, average data and high animal data values from unscanned figures (and subject numbers per point), FDA and EMA withdrawal interval calculations. NLME and PBPK withdrawal estimate modules were initially started and will be expanded upon at a later date. A newly designed web-based interface for responders to run queries for calls and data dumping was also developed. This web-based interface was also modified so that data extractors can find records based on priority, extractor, date extracted, and whether the entry remains as an antique or updated kinentry record. Modifications and improvements for logging and tracking questions submitted to FARAD (FARM Calls) continued. Methods for WDI estimations were explored using tissue data from two meloxicam (chicken and sheep). Multiple approaches were investigated (FDA and EMA). A tissue residue study for meloxicam in sheep was performed.

Publications

  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Smith, J.S., Marmulak, T.L., Angelos, J.A., Lin Z., Rowe, J.D., Carlson, J.L., Shelver W.L., Lee E.A., and Tell, L.A. Pharmacokinetic parameters and estimated milk withdrawal intervals for domestic goats (Capra aegagrus hircus) after administration of single and multiple intravenous and subcutaneous doses of flunixin meglumine. Front Vet Sci. 7(213), 2020. [DOI:10.3389/fvets.2020.00213].
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Garzon A., Pandey P., Tell L, Aly S., Poppenga R., Pereira R. Evaluation of heat and pH treatments on degradation of ceftiofur in whole milk. Front Vet Sci. 7 (288), 2020. [DOI=10.3389/fvets.2020.00288]
  • Type: Journal Articles Status: Published Year Published: 2019 Citation: Clapham, M. O., Martin, K. L., Davis, J. L., Baynes, R. E., Lin, Z., Vickroy, T. W., Riviere, J. E., & Tell, L. A. (2019). Extralabel drug use in wildlife and game animals. J Am Vet Med Assoc. 255(5), 555-568. [DOI: 10.2460/ javma.255.5.555]
  • Type: Journal Articles Status: Published Year Published: 2020 Citation: Lin Z, Li M, Wang YS, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE. Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine. J Vet Pharmacol Ther. 2020. [DOI: 10.1111/ jvp.12861; PMID: 32270548].
  • Type: Conference Papers and Presentations Status: Published Year Published: 2020 Citation: 2020 Adriana Garzon, Pramod Pandey, Lisa Tell, Sharif Aly, Richard Pereira. Evaluation of heat and pH treatments on degradation of ceftiofur in whole milk. NIAMRRE Knowledge Exchange - Virtual Poster Sessions.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 2019 Garzon A, Woo G, Pandey P, Tell L, Wetzlich S, Aly SS, Pereira RV. Evaluation of heat and pH treatments on degradation of ceftiofur in whole milk. 2019 American Association of Bovine Practitioners Conference.


Progress 09/01/18 to 08/31/19

Outputs
Target Audience:The target audience for this program is mostly livestock producers, regulators, and veterinarians (private practice and state). The goal of the program is to provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?Undergraduate students have learned about human food safety and residue avoidance. Graduate students (veterinary students) and food animal and pharmacy residents have learned about the rules and regulations surrounding extra-label drug use and the pharmacokinetic distribution of veterinary drugs from a residue standpoint. During the time duration of this project we had three visiting professors from Nanjing Agriculture University that were trained for a week regarding the FARAD program and the importance of mitigating drug residues. How have the results been disseminated to communities of interest?Lectures, publications, web site presence and ongoing FARAD service (information is disseminated by direct answering of cases and by posting information on the web site) have helped to educate people about on label and extra label drug use. Educational Aid Brochure: FARAD: Resources for Veterinarians Treating Bees Bibliographic citation look-up and export for public users: (http://cafarad.ucdavis.edu/citationsearch/) Presentations: Extra-label drug use in backyard poultry. Wildlife and Exotic Animal Symposium, March 10, 2019, Davis, CA The ins and outs of ELDU in food producing animals. PacVet Veterinary Conference, June 22, 2019, Long Beach, CA Insights on how withdrawal interval recommendations are established: Overview of the FARAD program. PacVet Veterinary Conference, June 22, 2019, Long Beach, CA Extra-label drug use in backyard poultry: The dos and don'ts, June 22, 2019, Long Beach, CA Poster Presentations: Evaluation of heat and pH treatments on degradation of ceftiofur and oxytetracycline in whole milk.Boehringer Ingelheim Veterinary Scholars Conference (NVSS)", July 25-28,Tufts University,Medford, MA and UC Davis Student Training Advanced Research Symposium, August 23, 2019, Davis, CA Published Web Sites: 2018: California Senate Bill 27 (http://www.usfarad.org/ca-sb-27.html) 2018: Compounding (http://www.usfarad.org/compounding.html) 2019: Pharmacists (http://www.usfarad.org/for-pharmacists.html) 2019: Spanish Versions of All Species/Topics Pages (http://www.usfarad.org/spanish-farad.html) What do you plan to do during the next reporting period to accomplish the goals?Continue to provide service to producers and veterinarians regarding on label and extra label drug use. Maximize availability of educational materials regarding residue avoidance.

Impacts
What was accomplished under these goals? The main program accomplishments were answering drug residue inquiries (2017: 3,607 and 2018: 3,645) and updating and maintaining the pharmacokinetic, bibliographic, and call submission databases. FARAD telephone, email and web-based inquiries were answered on a rotating basis between UC Davis, North Carolina State University and more recently (starting 2018) Virginia Tech University. We continued collecting bibliographic citations that contain pharmacokinetic data from live animal studies. There was an ongoing process of adding new citations to the end note library. Citation and kinetic records are added, targeting active ingredients and species for which FARAD gets the most submissions and for active ingredients that are being used extensively for ELDU (2017: 4230 kinetic records and 2018: 1815 kinetic records). Citations are assigned a designation of importance then extracted and the pharmacokinetic data added to the database. The data extraction that UC Davis performs is crucial for developing residue avoidance algorithms and for responders to estimate withdrawal interval recommendations. A web-based interface was used by responders to access the pharmacokinetic data (KINWEB) and for logging and tracking questions submitted to FARAD (FARM Calls). The UC Davis FARAD site collaborates with North Carolina State University, Kansas State University, Virginia Tech University, and the University of Florida personnel on pharmacokinetic research for food animal applications that can be used to develop and validate models that will estimate withdrawal intervals. In addition to the call based center and kinetic data extraction, the need to keep databases current and secure was of upmost priority so we continued to upgrade the existing system. During this period, conversion of older Microsoft "Active Server Pages" code to newer Microsoft .NET framework and open frameworks and technologies (AJAX, serialized JSON, bootstrap) was achieved for the call center web-based interface and the kinetic data entry web-based interface.

Publications

  • Type: Journal Articles Status: Published Year Published: 2019 Citation: Li M, Cheng YH, Chittenden JT, Baynes RE, Tell LA, Davis JL, Vickroy TW, Riviere JE, Lin Z. Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration. Arch Toxicol. 2019 Jul;93(7):1865-1880. doi: 10.1007/s00204-019-02464-z. Epub 2019 Apr 25. PubMed PMID: 31025081.
  • Type: Journal Articles Status: Published Year Published: 2018 Citation: Patel T, Marmulak T, Gehring R, Pitesky M, Clapham MO, Tell LA. Drug residues in poultry meat: A literature review of commonly used veterinary antibacterials and anthelmintics used in poultry. J Vet Pharmacol Ther. 2018 Dec;41(6):761-789. doi: 10.1111/jvp.12700. Epub 2018 Aug 3. Review. PubMed PMID: 30076635.
  • Type: Journal Articles Status: Published Year Published: 2018 Citation: 2018 Martin KL, Clapham MO, Davis JL, Baynes RE, Lin Z, Vickroy TW, Riviere JE, Tell LA. Extralabel drug use in small ruminants. J Am Vet Med Assoc. 2018 Oct 15;253(8):1001-1009. doi: 10.2460/javma.253.8.1001. PubMed PMID: 30272520.
  • Type: Journal Articles Status: Published Year Published: 2019 Citation: 2019 Li M, Cheng YH, Chittenden JT, Baynes RE, Tell LA, Davis JL, Vickroy TW, Riviere JE, Lin Z. Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration. Arch Toxicol. 2019 Jul;93(7):1865-1880. doi: 10.1007/s00204-019-02464-z. Epub 2019 Apr 25. PubMed PMID: 31025081.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 2019 Tell, LA and Martin K. Extra-label drug use in backyard poultry. 2019 Wildlife and Exotic Animal Symposium, March 10, 2019, Davis, CA (abstract and presentation).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 2019 Martin, K and Tell, LA. The ins and outs of ELDU in food producing animals. PacVet Veterinary Conference, June 22, 2019, Long Beach, CA (abstract and presentation).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 2019 Martin, K and Tell, LA. Insights on how withdrawal interval recommendations are established: Overview of the FARAD program. PacVet Veterinary Conference, June 22, 2019, Long Beach, CA (abstract and presentation).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 2019 Martin, K and Tell, LA. Extra-label drug use in backyard poultry: The dos and donts, June 22, 2019, Long Beach, CA (abstract and presentation).
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 2019 Woo, G., Pereira, R., and Tell, LA. Evaluation of heat and pH treatments on degradation of ceftiofur and oxytetracycline in whole milk. Boehringer Ingelheim Veterinary Scholars Conference (NVSS)", July 25-28, Tufts University, Medford, MA (poster)
  • Type: Theses/Dissertations Status: Published Year Published: 2019 Citation: Tissue Residue Depletion in Domestic Chickens after Multiple Oral and Single Intravenous Dosing of Meloxicam (Masters Student, Rachel Dutch, 2019, UC Davis)
  • Type: Websites Status: Published Year Published: 2018 Citation: 2018: California Senate Bill 27 (http://www.usfarad.org/ca-sb-27.html)
  • Type: Websites Status: Published Year Published: 2018 Citation: 2018: Compounding (http://www.usfarad.org/compounding.html)
  • Type: Websites Status: Published Year Published: 2019 Citation: 2019: Pharmacists (http://www.usfarad.org/for-pharmacists.html)
  • Type: Websites Status: Published Year Published: 2019 Citation: 2019: Spanish Versions of All Species/Topics Pages (http://www.usfarad.org/spanish-farad.html)