Progress 11/01/18 to 10/02/23
Outputs
Target Audience:Our Fellows continue to hone their skillsets in research and professional development. With the progressive relaxing of Covid-19 restrictions our Fellows have been able to expand their target audiences at the University of Arizona and beyond. These audiences have included internal (Data Science Research Bazaar, Annual Reimagine Health Research Symposium, Frontiers in Immunobiology and Immunopathogenesis Symposium, Cancer Research: Present and Future) and external (EPI Lifestyle, American College of Sports Medicine, International Society of Exercise Immunology, Cold Springs Harbor Laboratory Network Biology, International Electronic Conference on Nutrients - Precision Nutrition and Nutrigenomics, American Society of Nutrition) conferences both in person and virtual formats. We dedicated significant effort to assist trainees in alternative strategies to reach our intended target audiences. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Training activities: Each year, the progress of the Fellows was completed by the individual dissertation committees as a mechanism to progress toward graduation. The Fellows worked with individual Executive Committee members on specific competencies within their development plan. In check-in meetings with Dr. Limesand (PD of proposal), each Fellow was asked to reflect on their progress and future plans. These 1:1 sessions discussed creating precision nutrition and leadership goals in relationship to the research project and career trajectory. Professional development activities: The Fellows have increased their knowledge through the completion of core coursework and participation in hands-on workshops related to precision nutrition, mentorship, leadership and science communication. In addition, they have engaged with experts in Precision Nutrition and Wellness through seminars hosted by the Department of Nutritional Sciences and the BIO5 institute (e.g. see https://precisionwellness.arizona.edu/). In some cases, students received additional mentorship from individuals in industry to broaden their career development options. How have the results been disseminated to communities of interest?The Fellows disseminated their work through publications and conference presentations. Two Fellows completed training on speaking to the media and lay audience. They are currently evaluating options on how to incorporate these skills in the future. What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
Non-technical/Lay audience paragraph: Personalized approaches to diet and lifestyle are more efficacious than "one-size-fits-all"; however, the potential to tailor these approaches using an individual's genetic information has raised challenging questions. Among them, how variations in how the body processes the energy from nutrients or the composition of microbes in the gut interact with genotype, lifestyle behaviors, and environmental exposures to influence the efficacy of nutrition therapies. The application of personalized information to interventions designed to improve health is highly dependent on successful integration of diverse sources of "big data". The impact of this proposal lies within the training of a cohort of the next generation of scientists who will affect future outcomes of disease prevention and health promotion. The goal of this proposal is to train three Fellows to work across disciplines to establish research and education programs targeting precision nutrition. In the first year of the grant period, the grant executive committee (EC) evaluated 1st year PhD students of the Nutritional Sciences Graduate Program and selected three outstanding candidates to support. In the remaining years of the grant period, the trainees have made progress on their research projects and participated in professional development activities (highlights below). Outcomes during the current progress report period: Conference abstracts presented: Our Fellows have been involved in 15 conference abstracts during the current reporting period. The impact involved dissemination of foundational work critical to a Fellow's research project and critical teamwork skills to complete the project. Completion of Impact Leader professional development program by three Fellows: This 5-day training program selects the premier graduate students across the diverse disciplines of the College of Agriculture and Life Sciences. As a cohort, Fellows gain knowledge in developing effective teams, communicating with diverse individuals and navigating their careers. Additionally, Fellows were matched with industry coaches who can give them industry perspectives, help to build a professional network, and highlight the skillsets required to be successful. The impact is an understanding of the leadership traits of an individual, the development of communication pieces (e.g. 30 sec elevator speech, speaking to the media) and how to harness the entrepreneurial mindset in their research endeavors. Manuscript submissions and acceptances: Collectively there have been 11 manuscripts published as lead author or co-author by our Fellows. An additional five manuscripts are in preparation by our Fellows. Mentoring: All three Fellows have committed time to honing their mentorship skills through participation in national and regional webinars and active training of graduate, undergraduate and high school students. Efforts to increase diversity and inclusion: One Fellow was selected to serve on the UArizona Division of Agriculture, Life and Veterinary, Sciences and Cooperative Extension (ALVSCE) Diversity and Inclusion Committee. The impact of this work is to promote a culture of inclusion and to ensure diverse voices are heard within our Division. NIH F31 Predoctoral Fellowship Grants: Allow Fellows submitted an NIH F31 fellowship as part of their professional development. One of our Fellows was awarded a two-year grant to support her dissertation studies from the NIH. The impact includes an expanded analysis of her third dissertation Specific Aim and successfully navigating the grant submission process.
Publications
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2023
Citation:
Blomquist, S.A. (2023) Impact of FADS and ELOVL2/5 Genetic Variation on Fatty Acid and Cardiometabolic Endpoints in Mexican American Individuals. Poster presentation at ASNs NUTRITION 2023 conference in Boston, MA
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2023
Citation:
Gunning, J, K. Gilman, T Zuniga, RJ Simpson and KH Limesand. Parotid glands have a dysregulated immune response following radiation therapy, Salivary Gland Gordon Conference, Feb 2023
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2023
Citation:
Meeks-Buss and KH Limesand. Radiation-Induced Changes in Energy Metabolism Result in Mitochondrial Dysfunction in Salivary Glands, Salivary Gland Gordon Conference, Feb 2023
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2023
Citation:
Blomquist, SA. (2023) Impact of FADS and ELOVL2/5 Genetic Variation on Fatty Acid and Cardiometabolic Endpoints in Mexican American Individuals. Poster presentation at The 3rd International Electronic Conference on Nutrients Precision Nutrition and Nutrigenomics
- Type:
Journal Articles
Status:
Awaiting Publication
Year Published:
2023
Citation:
Gunning, J, K. Gilman, T Zuniga, RJ Simpson and KH Limesand. Parotid glands have a dysregulated immune response following radiation therapy, PLoS One
- Type:
Journal Articles
Status:
Awaiting Publication
Year Published:
2023
Citation:
Meeks-Buss, L, DDO Pessoa, J Snider, M Padi, JA Martinez and KH Limesand. Temporal Metabolomics Analysis of Pathways Underlying Radiation-Induced Salivary Gland Dysfunction, PLoS One
- Type:
Journal Articles
Status:
Under Review
Year Published:
2023
Citation:
Meeks-Buss and KH Limesand. Radiation-Induced Changes in Energy Metabolism Result in Mitochondrial Dysfunction in Salivary Glands, Scientific Reports
|
Progress 11/01/21 to 10/31/22
Outputs
Target Audience:Our Fellows continue to hone their skillsets in research and professional development. With the progressive relaxing of Covid-19 restrictions our Fellows have been able to expand their target audiences at the University of Arizona and beyond. These audiences have included internal (Data Science Research Bazaar, Annual Reimagine Health Research Symposium, Frontiers in Immunobiology and Immunopathogenesis Symposium) and external (EPI Lifestyle, American College of Sports Medicine, International Society of Exercise Immunology) conferences. We continue to assist trainees in alternative strategies to reach our intended target audiences. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Training activities: In past year, the progress of the Fellows was completed by the individual dissertation committees as a mechanism to progress toward graduation. The Fellows worked with individual Executive Committee members on specific competencies within their development plan. In check-in meetings with Dr. Limesand (PD of proposal), each Fellow was asked to reflect on their progress and future plans. In addition, Dr. Limesand onboarded one new Fellow due to a prior trainee receiving an NIH fellowship. These 1:1 sessions discussed creating precision nutrition and leadership goals in relationship to the research project and career trajectory. Professional development activities: The Fellows have increased their knowledge through the completion of core coursework and participation in hands-on workshops related to precision nutrition, mentorship, leadership and science communication. In addition, they have engaged with experts in Precision Nutrition and Wellness through seminars hosted by the Department of Nutritional Sciences and the BIO5 institute (e.g. see https://precisionwellness.arizona.edu/). One student is receiving training from an industry mentor who works for Genentech. How have the results been disseminated to communities of interest?The Fellows disseminated their work through publications and conference presentations. Two Fellows have completed training on speaking to the media and lay audience. They are currently evaluating options on how to incorporate these skills in the future What do you plan to do during the next reporting period to accomplish the goals? The Fellows will continue to work toward submission of manuscripts related to their independent research project. Re-establishment of many conferences will provide more opportunities to disseminate their work. Fellows will continue to meet regularly with Dr. Limesand for guidance and clarification on requirements for the Fellowship.
Impacts
What was accomplished under these goals?
Non-technical/Lay audience paragraph: Personalized approaches to diet and lifestyle are more efficacious than "one-size-fits-all"; however, the potential to tailor these approaches using an individual's genetic information has raised challenging questions. Among them, how variations in how the body processes the energy from nutrients or the composition of microbes in the gut interact with genotype, lifestyle behaviors, and environmental exposures to influence the efficacy of nutrition therapies. The application of personalized information to interventions designed to improve health is highly dependent on successful integration of diverse sources of "big data". The impact of this proposal lies within the training of a cohort of the next generation of scientists who will affect future outcomes of disease prevention and health promotion. The goal of this proposal is to train three Fellows to work across disciplines to establish research and education programs targeting precision nutrition. In the first year of the grant period, the grant executive committee (EC) evaluated 1st year PhD students of the Nutritional Sciences Graduate Program and selected three outstanding candidates to support. In the remaining years of the grant period, the trainees have made progress on their research projects and participated in professional development activities. One prior trainee received an NIH fellowship, so another trainee was selected from five nominations. Outcomes during the current progress report period: Re-submission of one NIH F31 predoctoral fellowship: One Fellow submitted a revised fellowship application detailing her project. The impacts included engaging with her committee members for feedback on the research plan, mapping out career goals and strategies to accomplish, and communicating effectively on how the proposal was improved based on reviewers' comments. Conference abstracts presented: Our Fellows have been involved in six conference abstracts during the current reporting period. The impact involved dissemination of foundational work critical to a Fellow's research project and critical teamwork skills to complete the project. All details are noted in the products section below. Completion of Impact Leader professional development program by one Fellow: This 5-day training program selects the premier graduate students across the diverse disciplines of the College of Agriculture and Life Sciences. As a cohort, Fellows will gain knowledge in developing effective teams, communicating with diverse individuals and navigating their careers. Additionally, Fellows will be matched with industry coaches who can give them industry perspectives, help to build a professional network, and highlight the skillsets required to be successful. The impact is an understanding of the leadership traits of an individual, the development of communication pieces (e.g. 30 sec elevator speech, speaking to the media) and how to harness the entrepreneurial mindset in their research endeavors. Manuscript submissions and acceptances: Collectively there have been two manuscripts published as lead author or co-author by our Fellows. An additional five manuscripts have been submitted by our Fellows. All details are noted in the products section below. Mentoring: All three Fellows have committed time to honing their mentorship skills through participation in national and regional webinars and active training of graduate, undergraduate and high school students. Efforts to increase diversity and inclusion: One Fellow was selected to serve on the UArizona Division of Agriculture, Life and Veterinary, Sciences and Cooperative Extension (ALVSCE) Diversity and Inclusion Committee. The impact of this work is to promote a culture of inclusion and to ensure diverse voices are heard within our Division
Publications
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2022
Citation:
Z��iga TM, Baker FL, Smith KA, Batatinha H, Lau B, Burgess SC, Gustafson MP, Katsanis, E, Simpson RJ. The effects of acute exercise on T-cell clonal diversity and function. American College of Sports Medicine Annual Meeting (2022), San Diego CA. **Oral Presentation: Immunology Section June 5th, 2022
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2022
Citation:
Z��iga TM, Baker FL, Smith KA, Batatinha H, Lau B, Burgess SC, Gustafson MP, Katsanis, E, Simpson RJ. Acute exercise preferentially mobilizes the most dominant T-cell clones within the repertoire, that display transcriptomic profiles associated with cytotoxicity, activation, and apoptosis. International Society of Exercise Immunology (2022), Tucson AZ.
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2022
Citation:
Z��iga TM, Baker FL, Smith KA, Lau, BM, Batatinha H, Gustafson MP, Katsanis E, Simpson RJ. 2022. Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptome signature but does not augment the potency of cytokine-induced killer (CIK) cells. International Society of Exercise Immunology (2022), Tucson AZ
- Type:
Journal Articles
Status:
Submitted
Year Published:
2022
Citation:
Gunning, J, K. Gilman, T Zuniga, RJ Simpson and KH Limesand. Salivary gland acute response to radiation in involves marked decreases in immune cell populations
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2022
Citation:
Fourth Annual Reimagine Health Research Symposium The Immune Phenotype of Radiation Damaged Salivary Glands , The University of Arizona College of Medicine, Phoenix, AZ
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2022
Citation:
Frontiers in Immunobiology and Immunopathogenesis Symposium The Immune Phenotype of Radiation Damaged Salivary Glands , The University of Arizona College of Medicine, Phoenix, AZ
- Type:
Journal Articles
Status:
Accepted
Year Published:
2022
Citation:
Chilton FH, Manichaikul A, Yang C, O'Connor TD, Johnstone LM, Blomquist S, Schembre SM, Sergeant S, Zec M, Tsai MY, Rich SS, Bridgewater SJ, Mathias RA, Hallmark B. Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and FADS Genetic Variation. Front Nutr. 2022 Feb 8;8:808054. doi: 10.3389/fnut.2021.808054. PMID: 35211495; PMCID: PMC8861490
- Type:
Journal Articles
Status:
Accepted
Year Published:
2022
Citation:
Z��iga TM, Baker FL, Smith KA, Lau, BM, Batatinha H, Gustafson MP, Katsanis E, Simpson RJ. 2022. Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptome signature but does not augment the potency of cytokine-induced killer (CIK) cells. doi: 0.3389/fimmu.2022.938106
|
Progress 11/01/20 to 10/31/21
Outputs
Target Audience:Our Fellows continue to hone their skillsets in research and professional development. With the progressive relaxing of Covid-19 restrictions our Fellows have been able to expand their target audiences beyond the University of Arizona. These audiences have included virtual conferences (College of Sports Medicine Annual Meeting, Cold Springs Harbor Laboratory Network Biology conference, and Cancer Research: Present and Future conference) due the COVID-19 pandemic and some local in person University of Arizona events. We continue to assist trainees in alternative strategies to reach our intended target audiences Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Training activities: The annual progress meeting was held in April 2021 with members of the grant executive committee (EC), experts in precision nutrition, the three selected Fellows and their mentors. The Fellows were allowed to select an aspect of their training that they wanted feedback on, design the pertinent aspects to present and solicit input from the attendees. This was a valuable experience for each Fellow as their approaches were quite different. In a follow-up meeting with Dr. Limesand (PD of proposal), each Fellow was asked to reflect on what went well and what might be improved. Dr. Limesand also met with the three Fellows in September 2021 to discuss our current understanding on the implementation of IRTA opportunities and to clarify any questions from the Fellows. The Fellows are currently refining their research projects and continuing to make progress on their precision nutrition and leadership goals. Professional development activities: The Fellows have increased their knowledge through the completion of core coursework and participation in hands-on workshops related to precision nutrition, mentorship, leadership and science communication. In addition, they have engaged with experts in Precision Nutrition and Wellness through seminars hosted by the Department of Nutritional Sciences and the BIO5 institute (e.g. see https://precisionwellness.arizona.edu/). Dr. Mars has met with the students extensively to hone their leadership competencies. How have the results been disseminated to communities of interest?The Fellows disseminating their work through publications and conference presentations. Two Fellows have completed training on speaking to the media and lay audience presentations with the third Fellow currently applying to these programs. They are currently evaluating options on how to incorporate these skills in the future. What do you plan to do during the next reporting period to accomplish the goals? The Fellows will continue to work toward submission of manuscripts related to their independent research project. Participation in conferences will depend on travel restrictions and transitions to virtual modes. Annual progress meeting: We will continue to hold the annual progress meeting in the Spring where the Fellows will present their research and training progress to EC and precision nutrition experts. Fellows will continue to meet regularly with Dr. Limesand for guidance and clarification on requirements for the Fellowship.
Impacts
What was accomplished under these goals?
Non-technical/Lay audience paragraph: Personalized approaches to diet and lifestyle are more efficacious than "one-size-fits-all"; however, the potential to tailor these approaches using an individual's genetic information has raised challenging questions. Among them, how variations in how the body processes the energy from nutrients or the composition of microbes in the gut interact with genotype, lifestyle behaviors, and environmental exposures to influence the efficacy of nutrition therapies. The application of personalized information to interventions designed to improve health is highly dependent on successful integration of diverse sources of "big data". The impact of this proposal lies within the training of a cohort of the next generation of scientists who will affect future outcomes of disease prevention and health promotion. The goal of this proposal is to train three Fellows to work across disciplines to establish research and education programs targeting precision nutrition. In the first year of the grant period, the grant executive committee (EC) evaluated 1st year PhD students of the Nutritional Sciences Graduate Program and selected three outstanding candidates to support. In the remaining years of the grant period, the trainees have made progress on their research projects and participated in professional development activities. Outcomes during the current progress report period: NIH F31 Predoctoral Fellowship Grant awarded: One Fellow submitted and was awarded a two-year grant to support her dissertation studies from the NIH. The impact includes an expanded analysis of her third dissertation Specific Aim and successfully navigating the grant submission process. Submission of one NIH F31 predoctoral fellowship: One Fellow submitted a fellowship application detailing her project. This impact includes engaging with her committee members for feedback on the research plan, mapping out career goals and strategies to accomplish, and communicating effectively with the pre-award submission team to ensure completion by the deadline. Conference abstracts presented: Our Fellows have been involved in five conference abstracts during the current reporting period. The impact involves dissemination of foundational work critical to a Fellow's research project and critical teamwork skills to complete the project. All details are noted in the products section below. Completion of Impact Leader professional development program by one Fellow: This 5-day training program selects the premier graduate students across the diverse disciplines of the College of Agriculture and Life Sciences. As a cohort, Fellows will gain knowledge in developing effective teams, communicating with diverse individuals and navigating their careers. Additionally, Fellows will be matched with industry coaches who can give them industry perspectives, help to build a professional network, and highlight the skillsets required to be successful. The impact is an understanding of the leadership traits of an individual, the development of communication pieces (e.g. 30 sec elevator speech, speaking to the media) and how to harness the entrepreneurial mindset in their research endeavors. Manuscript submissions and acceptances: Collectively there have been three manuscripts published as lead author or co-author by our Fellows. An additional two manuscripts have been submitted by our Fellows. All details are noted in the products section below. Mentoring: All three Fellows have committed time to honing their mentorship skills through participation in national and regional webinars (e.g. Science of Effective Mentorship) and active training of undergraduate and high school students (e.g. Women in STEM Mentor, Keeping Engaged Youth in STEM, Arizona's Science, Engineering, and Math Scholars). Efforts to increase diversity and inclusion: One Fellow has been selected to service on the UArizona Division of Agriculture, Life and Veterinary, Sciences and Cooperative Extension (ALVSCE) Diversity and Inclusion Committee. The impact of this work is to promote a culture of inclusion and to ensure diverse voices are heard within our Division.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Baker FL, Smith KA, Z��iga TM, Batatinha H, Niemiro GM, Pedlar CR, Burges SC, Katsanis E, Simpson RJ. Acute exercise increases immune responses to SARS CoV-2 in a previously infected man. Brain Behav Immun
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Molina MS, Hoffman EA, Stokes J, Kummet N, Smith KA, Baker FL, Z��iga TM, Simpson RJ, Katsanis E. Regulatory dendritic cells induced by bendamustine are associated with enhanced Flt3 expression and alloreactive T-cell death. Front Immunol. doi: 10.3389/fimmu.2021.699128
- Type:
Journal Articles
Status:
Submitted
Year Published:
2021
Citation:
Batatinha H, Smith KA, Z��iga TM, Baker FL, Pedlar CR, Burgess SC, Katsanis E, Simpson RJ. Recent COVID-19 vaccination is associated with modest increase in the physiological demands to graded exercise. J Appl Phys.
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Z��iga TM, Baker FL, Smith KA, Gufstafson MP, Katsanis E, Simpson RJ. Acute Exercise Enhances The Ex Vivo Expansion And Cytolytic Phenotype Of Cytokine Induced Killer Cells. College of Sports Medicine Annual Meeting (2021), Virtual Meeting
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Batatinha H, Diak DM, Niemiro GM, Myabathula PL, Baker FL, Smith KA, Z��iga TM, Park Y, LaVoy EC, Katsanis E, Simpson RJ. Human Lymphocytes Mobilized With Exercise Extend Survival And Lower Leukemic Burden in Xenogeneic Mice. College of Sports Medicine Annual Meeting (2021), Virtual Meeting
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
: Baker FL, Mylabathula PL, Smith KA, Z��iga TM, Diak, DM, Niemiro GM, Markofski MM, Pedlar CR, OConnor DP, Katsanis E, Simpson RJ. Exercise Enhances the Anti-leukemia Activity of Expanded ?? T-cells Via DNAM-1 Upregulation and PVR/Nectin-2 Recognition. College of Sports Medicine Annual Meeting (2021), Virtual Meeting
- Type:
Journal Articles
Status:
Published
Year Published:
2021
Citation:
Meeks, L., De Oliveira Pessoa, D., Martinez, J.A., Limesand, K.H., Padi, M. (2021). Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction. Physiological Genomics, 53(3), 85-98
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Meeks, L. De Oliveira Pessoa, D., Martinez, J.A., Limesand, K.H., Padi, M. Title: Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction. Poster session at the Cold Springs Harbor Laboratory Network Biology virtual conference
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2021
Citation:
Meeks, L. Title: Data integration to understand radiation-induced salivary gland dysfunction. Data blitz presentation at the Women in Data Science conference in Tucson, AZ
- Type:
Journal Articles
Status:
Submitted
Year Published:
2021
Citation:
Gunning, J, K. Gilman, T Zuniga, RJ Simpson and KH Limesand. Salivary gland acute response to radiation in involves marked decreases in immune cell populations
|
Progress 11/01/19 to 10/31/20
Outputs
Target Audience:Our Fellows continue to hone their skillsets in research and professional development. The target audiences have been focused on University of Arizona audiences due in part to cancellations of conferences and events stemming from the COVID-19 pandemic. We continue to assist trainees in alternative strategies to reach our intended target audiences Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Training activities: The annual progress meeting was held in April 2020 with members of the grant executive committee (EC), experts in precision nutrition, the three selected Fellows and their mentors. The Fellows presented an overview of their fellowship specific aims page and submitted a progress report on their accomplishments within precision nutrition and leadership competencies. Each Fellow received considerable feedback from the faculty members present, which was written up and distributed to the Fellows. Dr. Limesand (PD of proposal) met with the three Fellows in September 2020 to follow-up on the plans for precision nutrition and leadership trainings, present our current understanding on the implementation of IRTA opportunities and to clarify any questions from the Fellows. The Fellows are currently refining their research projects and continuing to make progress on their precision nutrition and leadership goals. Professional development activities: The Fellows have increased their knowledge through the completion of core coursework and participation in hands-on workshops related to precision nutrition, mentorship, and science communication. In addition, they have engaged with experts in Precision Nutrition and Wellness through seminars hosted by the Department of Nutritional Sciences and the BIO5 institute (e.g. see https://precisionwellness.arizona.edu/). Dr. Mars has met with the students extensively to hone their leadership competencies. How have the results been disseminated to communities of interest?This is the second year of funding and the Fellows are making progress on their independent research directions. They are reaching a stage where they are beginning to present work at scientific conferences and publishing research papers. What do you plan to do during the next reporting period to accomplish the goals? The Fellows will complete their preliminary exams and submit fellowships as part of their grant writing training. The Fellows will work toward submission of manuscripts related to their independent research project. Participation in conferences will depend on travel restrictions and transitions to virtual modes. Annual progress meeting: We will continue to hold the annual progress meeting in the Spring where the Fellows will present their research and training progress to EC and precision nutrition experts. Fellows will continue to meet regularly with Dr. Limesand for guidance and clarification on requirements for the Fellowship.
Impacts
What was accomplished under these goals?
Non-technical/Lay audience paragraph: Personalized approaches to diet and lifestyle are more efficacious than "one-size-fits-all"; however, the potential to tailor these approaches using an individual's genetic information has raised challenging questions. Among them, how variations in how the body processes the energy from nutrients or the composition of microbes in the gut interact with genotype, lifestyle behaviors, and environmental exposures to influence the efficacy of nutrition therapies. The application of personalized information to interventions designed to improve health is highly dependent on successful integration of diverse sources of "big data". The impact of this proposal lies within the training of a cohort of the next generation of scientists who will affect future outcomes of disease prevention and health promotion. The goal of this proposal is to train three Fellows to work across disciplines to establish research and education programs targeting precision nutrition. In the first year of the grant period, the grant executive committee (EC) evaluated 1st year PhD students of the Nutritional Sciences Graduate Program and selected three outstanding candidates to support. In the 2nd year of the grant period, the trainees made progress on their research projects and participated in professional development activities. Outcomes during the progress report period: American College of Sports Medicine (ACSM) Doctoral Student Fellowship Grant: One Fellow submitted and was awarded a one-year grant to support her dissertation studies from ACSM. The impact includes an expanded analysis of her first Specific Aim and successfully navigating the grant submission process. Submission of one F31 fellowship: One Fellow submitted a fellowship application detailing her project details. This impact includes engaging with her committee members for feedback on the research plan, mapping out career goals and strategies to accomplish, and communicating effectively with the pre-award submission team to ensure completion by the deadline. Co-author on 2 conference abstracts presented: One Fellow assisted her team in the completion of two conference abstracts that were presented Fall 2019. The impact involves dissemination of foundational work critical to a Fellow's research project and critical teamwork skills to complete the project. Completion of Alan Alda Science Communication workshop by 2 Fellows: This 2-day workshop uses improvisation techniques to facilitate communication to a lay audience. The impact is the development of brief communication pieces (e.g. 30 sec elevator speech) that can be used to describe the importance of the Fellow's research project. Submission of a 1st author manuscript: One Fellow has submitted a 1st author manuscript to Physiological Genomics. The impact includes working collaboratively with her co-authors to disseminate the initial findings of her research project.
Publications
- Type:
Journal Articles
Status:
Under Review
Year Published:
2020
Citation:
Meeks, L, DDO Pessoa, JA Martinez, KH Limesand and M Padi. Integrating metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction. Physiological Genomics
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2019
Citation:
Niemiro GM, Diak DM, Mylabathula PL, Baker FL, Durazo G, Smith KA, Z��iga TM, Seckeler M, Katsanis E, Simpson RJ. Isoproterenol infusion mimics the preferential mobilization of effector lymphocytes in response to steady state exercise in healthy humans. International Society of Exercise and Immunology (2019), Shanghai, China
- Type:
Conference Papers and Presentations
Status:
Accepted
Year Published:
2019
Citation:
Diak DM, Niemiro GM, Baker FL, Mylabathula PL, Smith KA, Z��iga TM, Stokes J, Hoffman EA, Katsanis E, Simpson RJ. Developing a xenotransplantation mouse model to determine the alloreactivity and anti-tumor effects of human lymphocytes mobilized with exercise: Implications for allogeneic hematopoietic stem cell transplantation and immunotherapy. International Society of Exercise and Immunology (2019), Shanghai, China.
|
Progress 11/01/18 to 10/31/19
Outputs
Target Audience:This is the first year of funding and the Fellows are developing their skillsets to reach the intended target audiences. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?Training activities: The annual progress meeting was held in April 2019 with members of the grant executive committee (EC), experts in precision nutrition, the three selected Fellows and their mentors. The Fellows presented an overview of their proposed project and a draft of their precision nutrition and leadership trainings. Each Fellow received considerable feedback from the faculty members present. Dr. Limesand (PD of proposal) met with the three Fellows in September 2019 to follow-up on the plans for precision nutrition and leadership trainings and to clarify any questions from the Fellows. The Fellows are currently refining their precision nutrition and leadership trainings as it relates to their research project and career path goals. Professional development activities: The Fellows have increased their knowledge through the completion of core coursework, participation in hands-on workshops related to precision nutrition and engaged with experts in Precision Nutrition and Wellness through seminars hosted by the Department of Nutritional Sciences and the BIO5 institute (e.g. see https://precisionwellness.arizona.edu/). How have the results been disseminated to communities of interest?This is the first year of funding and the Fellows are early in their programs and are developing their independent research directions. They are reaching a stage where they are beginning to present work at scientific conferences and publishing research papers. What do you plan to do during the next reporting period to accomplish the goals? Finalize precision nutrition and leadership training plans: Drs. Limesand and Mars will continue to meet with the Fellows during the Fall semester to finalize their training plans. Annual progress meeting: We will continue to hold the annual progress meeting in the Spring where the Fellows will present their research and training progress to EC and precision nutrition experts. The Fellows will complete a majority of their coursework and will transition to preparations for the preliminary exam and grant writing development. Fellows will continue to meet regularly with Dr. Limesand for guidance and clarification on requirements for the Fellowship.
Impacts
What was accomplished under these goals?
Personalized approaches to diet and lifestyle are more efficacious than "one-size-fits-all"; however, the potential to tailor these approaches using an individual's genetic information has raised challenging questions. Among them, how variations in how the body processes the energy from nutrients or the composition of microbes in the gut interact with genotype, lifestyle behaviors, and environmental exposures to influence the efficacy of nutrition therapies. The application of personalized information to interventions designed to improve health is highly dependent on successful integration of diverse sources of "big data". The impact of this proposal lies within the training of a cohort of the next generation of scientists who will affect future outcomes of disease prevention and health promotion. The goal of this proposal is to train three Fellows to work across disciplines to establish research and education programs targeting precision nutrition. In the first year of the grant period, the grant executive committee (EC) evaluated 1st year PhD students of the Nutritional Sciences Graduate Program and selected three outstanding candidates to support.
Publications
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2019
Citation:
1. Niemiro GM, Diak DM, Mylabathula PL, Baker FL, Durazo G, Smith KA, Z��iga TM, Seckeler M, Katsanis E, Simpson RJ. Isoproterenol infusion mimics the preferential mobilization of effector lymphocytes in response to steady state exercise in healthy humans. International Society of Exercise and Immunology (2019), Shanghai, China
- Type:
Conference Papers and Presentations
Status:
Published
Year Published:
2019
Citation:
2. Diak DM, Niemiro GM, Baker FL, Mylabathula PL, Smith KA, Z��iga TM, Stokes J, Hoffman EA, Katsanis E, Simpson RJ. Developing a xenotransplantation mouse model to determine the alloreactivity and anti-tumor effects of human lymphocytes mobilized with exercise: Implications for allogeneic hematopoietic stem cell transplantation and immunotherapy. International Society of Exercise and Immunology (2019), Shanghai, China
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