Source: UNIVERSITY OF MISSOURI EXTENSION submitted to NRP
THE NATIONAL CENTER FOR APPLIED REPRODUCTION AND GENOMICS (NCARG) IN BEEF CATTLE
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
1015094
Grant No.
2018-68008-27891
Cumulative Award Amt.
$299,440.00
Proposal No.
2017-08692
Multistate No.
(N/A)
Project Start Date
Mar 15, 2018
Project End Date
Mar 14, 2023
Grant Year
2018
Program Code
[A1701]- Critical Agricultural Research and Extension: CARE
Recipient Organization
UNIVERSITY OF MISSOURI EXTENSION
(N/A)
COLUMBIA,MO 65211
Performing Department
Animal Sciences
Non Technical Summary
This proposal describes an integrated program addressing Program Area Code - A1701 "Critical Agricultural Research and Extension as it relates to Animal Health and Production and Animal Products." The project uses a multidisciplinary integrated approach to address the high priority, economically relevant problem of technology transfer in the US beef industry, which stymies profitability and sustainability of cattle production. Advances in reproduction and genomics afford beef producers the opportunity to make rapid improvements. These technologies add significant value through improved whole herd reproductive management and accelerated genetic improvement. Combining these technologies into production and marketing systems to maximize their economic impact on beef operations must be assessed to stimulate their wide-scale adoption. The Specific Aims of this project are to: 1) Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies; 2) Develop comprehensive curricula and training programs that will enable the various sectors of the beef industry to acquire new knowledge and skills; and 3) Implement comprehensive Extension programs that focus on the effective transfer of reproductive and genomic technologies to industry stakeholders. The overall goal and resulting outcomes from this project will definitively quantify farm-level economic effects resulting from implementation of reproductive and genomic technologies in US beef herds; at the same time, the National Center for Applied Reproduction and Genomics (NCARG) will serve as our nation's training site to enable all segments of the beef cattle sector to acquire new knowledge and skills aiding in the successful adoption and long-term use of these technologies.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
30833101060100%
Goals / Objectives
This proposal describes an integrated program addressing Program Area Code - A1701 "Critical Agricultural Research and Extension as it relates to Animal Health and Production and Animal Products." The project uses a multidisciplinary integrated approach to address the high priority, economically relevant problem of technology transfer in the US beef industry, which stymies profitability and sustainability of cattle production. Advances in reproduction and genomics afford beef producers the opportunity to make rapid improvements. These technologies add significant value through improved whole herd reproductive management and accelerated genetic improvement. Combining these technologies into production and marketing systems to maximize their economic impact on beef operations must be assessed to stimulate their wide-scale adoption. The Specific Aims of this project are to: 1) Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies; 2) Develop comprehensive curricula and training programs that will enable the various sectors of the beef industry to acquire new knowledge and skills; and 3) Implement comprehensive Extension programs that focus on the effective transfer of reproductive and genomic technologies to industry stakeholders. The overall goal and resulting outcomes from this project will definitively quantify farm-level economic effects resulting from implementation of reproductive and genomic technologies in US beef herds; at the same time, the National Center for Applied Reproduction and Genomics (NCARG) will serve as our nation's training site to enable all segments of the beef cattle sector to acquire new knowledge and skills aiding in the successful adoption and long-term use of these technologies.
Project Methods
Specific Aim 1): Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. As previously described in the project narrative, our team has been highly productive in the areas of bovine reproduction and genomics research, from basic to applied approaches. In this project, our research efforts will be focused on economic questions. This strategy is chosen for three reasons: 1) economic analyses will guide the education efforts regarding the situations and market conditions in which these technologies should be deployed, 2) economic results will be used to inform and persuade adoption of these technologies, and 3) we have pre-existing data sets for which we simply need support to analyze from an economic perspective.Specific Aim 2) Develop comprehensive educational curricula and training programs for veterinarians, extension livestock specialists, allied industry personnel, producers, and veterinary and animal science students to enable all segments of the beef cattle sector to acquire new knowledge and skills that will aid in the successful adoption of reproductive and genomic technologies to support beef cattle reproductive and breeding management decision-making.Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences.?

Progress 03/15/22 to 03/14/23

Outputs
Target Audience:The National Center for Applied Reproduction and Genomics (NCARG) for Beef Cattle will develop a comprehensive educational training program for practicing veterinarians, extension livestock specialists, allied industry, producers, and students that will enable the various segments of the beef cattle sector to acquire (through face-to-face and distance-learning applications) new knowledge, skills, and attitudes that will aid in the successful adoption of existing reproductive procedures/ biotechnologies and genomic selection. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020, however efforts were delayed because of Covid-19 related concerns. After consideration of those delays and the need for targeted programming related to the topics outlined in the proposal, the decision was made to conduct two intensive webinar series focused on veterinary practitioners. Each of the two webinar series was offered with one hour of continuing education per week for eight and five consecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection. The first webinar series was titled "Establishing Consistency in Beef Heifer Development Programs". The series began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021. The first webinar series was offered with one hour of continuing education per week for eight consecutive weeks. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection. By the end of the series participants were expected to be able to:1. Describe how to identify high potential return on investment females. 2. Discuss factors necessary to ensure heifers grow at a rate to achieve puberty before breeding. 3. Explain the benefits of expected progeny difference (EPD) in the beef herd. 4. Identify elements of a successful low-cost heifer development system. 5. Summarize how data points collected at pre-breeding exams and ultrasound pregnancy checks can allow for additional revenue streams for veterinarians and increase profitability for producers. 6. Discuss strategies for incorporating genomic testing into the beef herd. 7. Discuss the incorporation of beef heifer reproductive management programs in veterinary practice. Participants included 143 veterinarians from 28 states, including: Arkansas, California, Colorado, Florida, Idaho, Illinois, Indiana, Iowa, Hawaii, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, and Virginia. In addition, of the 143 participants enrolled in the webinar series, 8 included veterinarians from two Canadian provinces, including Alberta and Saskatchewan. Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series was titled "Strategies for Control of Estrous Cycles of Beef Heifers and Cows". The series began on Thursday, September 2, 2021 and ran for five consecutive weeks, concluding on Thursday, September 30, 2021. The five topics included:1. Physiology and endocrinology of the bovine estrous cycle and products approved for use in estrous cycle control. The purpose of this webinar was to review basic principles that underlie current estrous synchronization protocols as well as products that are used. Understanding these principles supports individuals in making the right decision concerning the application of a specific synchronization protocol for groups of heifers or cows. The webinar emphasized the importance of administering protocols exactly as described, and reviewed situations wherein a problem develops when implementing an estrous synchronization protocol that users are equipped with basic knowledge to figure out what went wrong and how to correct it. 2. Estrous synchronization programs for replacement beef heifers. Lifetime reproductive performance, longevity in the herd, and cumulative pounds of calf weaned over a heifer's productive lifespan are highly correlated with the date on which a heifer conceives during the first breeding season. The investment in time and resources in heifers from weaning to breeding requires that management efforts be made to facilitate puberty onset and maximize the likelihood of early pregnancy. Estrous synchronization programs create an opportunity for heifers to conceive early in the breeding period, which is a significant opportunity given the relationship between early conception and long-term reproductive success. Beef producers are now able to utilize treatments that offer the potential to effectively synchronize estrus in pubertal heifers, while at the same time induce puberty among pre- or peripubertal heifers. This webinar reviewed protocols designed to synchronize estrus and ovulation in replacement beef heifers and factors that contribute to successful breeding programs. 3. Estrous synchronization programs for postpartum beef cows. Estrous synchronization is a powerful technology for reproductive management of the mature cow herd. Given the potential return-on-investment, synchronization is underutilized by commercial producers. This session addressed considerations related to implementation of synchronization programs prior to AI or natural service of mature cows, with special emphasis on multi-year improvements in commercial cow-calf profitability that can be realized with these technologies. 4. Estrous synchronization programs for recipient females prior to embryo transfer (ET). Embryo transfer programs offer the potential to add value in commercial beef herds. The webinar reviewed potential opportunities to capture added value from use of embryo transfer and the most effective strategies to synchronize recipient females prior to ET. 5. Assessing synchronization programs: Goals and troubleshooting results. Thewebinar also reviewed ways in which data generated from an estrous synchronization program can be analyzed, determination of what should be considered as appropriate results, and what areas should be investigated if/when results from the synchronization program are below expectation. Participants included 180 veterinarians from 32 states, including: Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Virginia, Wisconsin, and Wyoming. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces, including Alberta, Ontario, and Saskatchewan.Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. Given the feedback from these webinars, interest was generated and requests were received toconducta similar webinar series for dairy cattle focused on reproductive management. The webinar series began on June 9, 2022, and ran for five consecutive weeks, concluding on July 7, 2022. There were 138 participants in the webinar series, including: 126 from the U.S., 2 from Japan, 1 from Trinidad and Tobago, 8 from Canada, and 1 from Mexico. Participants included 115veterinary practitioners, 14 academics, 3 technical service veterinarians, 3 veterinary technicians, 1 field technician in the AI industry, 1 extension professional, and 1 engineer. The five-part series included the following topics: Physiology and endocrinology of the bovine estrous cycle and products, estrus synchronization programs for replacement dairy heifers, the use of sensors in reproductive management, estrus synchronizatin programs for dairy cows, and assessing synchronization programs and troubleshooting results. How have the results been disseminated to communities of interest?Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020 and again in 2021, however efforts were delayed because of Covid-19 related concerns. After consideration of these delays and the need for targeted programming related to the topics outlined in the proposal, the decision was made to conduct two intensive webinar series focused on veterinary practitioners. Each of the two webinar series was offered with one hour of continuing education per week for eight and five consecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection, in addition to breeding management strategies for replacement beef heifers and postpartum beef cows. The first webinar series was titled "Establishing Consistency in Beef Heifer Development Programs". The series began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021. Participants included 143 veterinarians from 28 states, including: Arkansas, California, Colorado, Florida, Idaho, Illinois, Indiana, Iowa, Hawaii, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, and Virginia. In addition, of the 143 participants enrolled in the webinar series, 8 included veterinarians from two Canadian provinces, including Alberta and Saskatchewan. Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series was titled "Strategies for Control of Estrous Cycles of Beef Heifers and Cows". The series began on Thursday, September 2, 2021 and ran for five consecutive weeks, concluding on Thursday, September 30, 2021. A brief summary of each of the five topics/webinars is provided below.Participants included 180 veterinarians from 32 states, including: Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Virginia, Wisconsin, and Wyoming. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces, including Alberta, Ontario, and Saskatchewan. Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. A significant outcome related to industry acceptance and adoption of reproductive and genomic technologies supported through NCARG was recently adopted by the Red Angus Association of America. The Red Angus Association of America launched the "Red Choice" program to promote improved heifer development, increase marketing opportunities for Red Angus females, and create reliable sources of high-quality replacement heifers for cattle producers. The "Red Choice" program embraces proven reproductive and genetic management practices which, in turn, lead to high-quality replacement females entering commercial herds. The "Red Choice" program follows requirements and guidelines fromthe University of Missouri Show-Me-Select® Replacement Heifer Program that are demonstrated toincrease the overall quality and resulting value of enrolled females. The "Red Choice" program was initiated based on success of Missouri's Show-Me-Select® Replacement Heifer Programand the significant impact the program has had on the cattle industry state-wide. A review of the "Red Choice" Program and its potential for the industry was reviewed at the Red Angus Association of America National Convention in September, 2022, in Kalispell, Montana. A pilot program was established by the University of Missouri in collaboration with the Missouri Junior Cattlemen's Association to offer a replacement heifer show and sale for youth seeking to expand their knowledge of beef cattle production, reproductive management, genetic selection and genomics, in addition to marketing. The youth program is patterned after and being developed through collaboration with the Missouri Show-Me-Select Replacement Heifer Program. The first junior show and sale for the program was held in June, 2022 in Sedalia, MO. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? Specific Aim 1) Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. Research quantified farm-level economic effects resulting from implementation of reproductive and genomic technologies using data from the University of Missouri Thompson Research Center. A graduate student in Agricultural Economics at MU completed a Master's degree with a thesis entitled "Analysis of the Economic Value Associated with the Adoption of Beef Reproductive Technologies". The results from this study provided needed evidence that has encouraged producers to invest in reproductive and genetic technologies that support and sustain their operations over the long-term. Additionally, research conducted in support of this project highlighted the importance of genomic predictions in commercial Angus cattle using the GeneMax Advantage test to accurately rank animals based on their genetic merit. These findings clearly demonstrate the value in usingthe GeneMax Advantage test asan effective selection tool in commercial cowherds. A manuscript resulting from this work is awaiting publication in a refereed journal. Specific Aim 2) Develop comprehensive educational curricula and training programs. These curricula are designed to support veterinarians, extension livestock specialists, allied industry personnel, producers, and veterinary and animal science students. Curricula will enable various segments of the beef cattle sector to acquire new knowledge and skills to aid in successful adoption of reproductive and genomic technologies, and ultimately support beef cattle breeding management decision making. The mission of NCARG is to provide education and training for active participants in the beef industry. Programs are designed to supply introductory material through online courses followed by more advanced, in-person practicums. Development of comprehensive educational curricula and training programs is currently underway and will be on-going. Educational curriculaare intended to supporta Graduate Certificate program in support of Specific Aim 3D. Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences. 3A) Veterinary practitioner education. Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020 and again in 2021, however efforts were delayed because of Covid-19 related concerns. After consideration of these delays and the need for targeted programming related to the topics outlined in the proposal, the decision was made to conduct an intensive webinar series focused on veterinary practitioners. Two webinar series wereoffered with one hour of continuing education per week for eight and five consecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection, in addition to breeding management strategies for beef cows and heifers. The first webinar series was titled "Establishing Consistency in Beef Heifer Development Programs". The series began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021.The second webinar series was titled "Strategies for Control of Estrous Cycles of Beef Heifers and Cows". The series began on Thursday, September 2, 2021 and ran for five consecutive weeks, concluding on Thursday, September 30, 2021. Given the feedback from these webinars, interest was generated and requests were received toconducta similar webinar series for dairy cattle focused on reproductive management. The webinar series began on June 9, 2022, and ran for five consecutive weeks, concluding on July 7, 2022. The webinar series attracted138 participants, including: 126 from the U.S., 2 from Japan, 1 from Trinidad and Tobago, 8 from Canada, and 1 from Mexico.3B) Training for extension livestock specialists, allied industry representatives, and beef producers. A significant outcome related to industry acceptance and adoption of reproductive and genomic technologies supported through NCARG was recently adopted by the Red Angus Association of America. The Red Angus Association of America launched the "Red Choice" program to promote improved heifer development, increase marketing opportunities for Red Angus females, and create reliable sources of high-quality replacement heifers for cattle producers. The "Red Choice" program embraces proven reproductive and genetic management practices which, in turn, lead to high-quality replacement females entering commercial herds. The "Red Choice" program follows requirements and guidelines fromthe University of Missouri Show-Me-Select® Replacement Heifer Program that are demonstrated toincrease the overall quality and resulting value of enrolled females. The "Red Choice" program was initiated based on success of Missouri's Show-Me-Select® Replacement Heifer Programand the significant impact the program has had on the cattle industry state-wide. A review of the "Red Choice" Program and its potential for the industry was reviewed at the Red Angus Association of America national convention in September, 2022, in Kalispell, Montana. 3D) Develop a Graduate Certificate programfor veterinarians, veterinary students, extension specialists, allied industry personnel, and graduate students. A proposal for the graduate certificate program was prepared and submitted to the Academic Affairs and Graduate committees in the Division of Animal Sciences.The proposalreceived approval through the University of Missouri System and is awaiting final approval from the Missouri Department of Higher Education & Workforce Development.The graduate certificate program, "Reproductive and Genomic Technologies for Livestock", is designed to support creation of a new operational model to transfer complex technologies in reproduction and genomics to U.S. livestock producers. The graduate certificate program will support the unmet need for advanced training in these disciplines for students and industry professionals. The program, with support from veterinary schools and allied industry across the nation, will be an avenue for students from the University of Missouri and beyond to receive training that is otherwise unavailable. The certificate may stand-alone orbe earned as part of an approved animal science or veterinary training program. For example: A student enrolled in an accredited College of Veterinary Medicine at a partnering university could earn a graduate certificate as part of their elective curriculum, in addition to graduate students in Animal Science programs at other Universities. 3E) 4-H and Vocational Education Youth Pilot Program. Development of a pilot youth program for studentsfocuses on the development, management, breeding and marketing of replacement beef heifers, and emphasizes use of reproductive and genomic technologies recommended for heifer selection, development and breeding. A pilot program was established by the University of Missouri in collaboration with the Missouri Junior Cattlemen's Association to offer a replacement heifer show and sale for youth seeking to expand their knowledge of beef cattle production, reproductive management, genetic selection and genomics, in addition to marketing. The youth program is patterned after and being developed through collaboration with the Missouri Show-Me-Select Replacement Heifer Program. The first junior show and sale for the program was held in June, 2022 in Sedalia, MO.

Publications

  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Physiology/endocrinology of the bovine estrous cycle and products. June 9, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Estrus synchronization programs for replacement dairy heifers. June 16, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: The use of sensors in reproductive management. June 23, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Estrus synchronization programs for dairy cows. June 30, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Assessing synchronization programs: Troubleshooting results. July 7, 2022.
  • Type: Journal Articles Status: Awaiting Publication Year Published: 2023 Citation: Arisman, BC, TN Rowan, JM Thomas, HJ Durbin, WR Lamberson, DJ Patterson, and JE Decker. 2022. Evaluation of Zoetis GeneMax Advantage genomic predictions in commercial Bos taurus Angus cattle. Livestock Science.


Progress 03/15/18 to 02/27/23

Outputs
Target Audience:The National Center for Applied Reproduction and Genomics (NCARG) for Beef Cattle will develop a comprehensive educational training program for practicing veterinarians, extension livestock specialists, allied industry, producers, and students that will enable the various segments of the beef cattle sector to acquire (through face-to-face and distance-learning applications) new knowledge, skills, and attitudes that will aid in the successful adoption of existing reproductive procedures/ biotechnologies and genomic selection. Changes/Problems:Progress on this NIFA funded project was delayed because ofCovid-19 related issues and resulting concerns. Travel and campus related restrictions in many cases hampered progress on theproject, necessitatingan initial one-year no cost extension, followed by a second. The challenges posed by Covid-19 weresignificant. In the face of these challenges, however, and consideringbudgetary concernsfacing higher education, which in part were accelerated because of Covid-19, institutionsmust consider new working modelsto sustain their land grant missions. The United States leads the world in fundamental research and development of reproductive and genomic technologies in support of animal agriculture;however, limited funding has been directed to translation andimplementation of these technologies to industry stakeholders. Global competitorsare outpacing the United States in utilizing existing and emerging technologies to support improvements in livestock production in their countries. The U.S. cannot expect to continue to lead without investing in the necessary infrastructure to transfer use of these technologies to our own livestock producers. For this reason, we remain committed to the NCARG model. What opportunities for training and professional development has the project provided?A listing of abstracts, publications and presentations resulting from this project award are summarized in the Products section of this final report. A two-day pre-conference symposium was offered at the annual meeting of the American Association of Bovine Practitioners in St. Louis, Missouri, in2019. The symposium entitled, "The National Center for Applied Reproduction and Genomics in Beef Cattle", attracted attendees from veterinary colleges and practitioners from across the U.S. and Canada. Two intensive webinar series for veterinary practitioners wereoffered with one hour of continuing education per week for eight and five consecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection. The first webinar series, "Establishing Consistency in Beef Heifer Development Programs", began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021.The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection. By the end of the series participants were expected to be able to: 1)Describe how to identify high potential return on investment females;2)Discuss factors necessary to ensure heifers grow at a rate to achieve puberty before breeding;3)Explain the benefits of expected progeny difference (EPD) in the beef herd;4)Identify elements of a successful low-cost heifer development system; 5)Summarizedata points collected at pre-breeding exams and ultrasound pregnancy checks to determine fetal age and sexto create additional revenue streams for veterinarians and increase profitability for producers;6)Discuss strategies for incorporating genomic testing into the beef herd; and7)Discuss incorporation of beef heifer reproductive management programs into a veterinary practice. Participants included 143 veterinarians from 28 states, including: Arkansas, California, Colorado, Florida, Idaho, Illinois, Indiana, Iowa, Hawaii, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, and Virginia. Of the 143 participants enrolled in the webinar series, 8 included veterinarians from two Canadian provinces, including Alberta and Saskatchewan. Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series,"Strategies for Control of Estrous Cycles of Beef Heifers and Cows", began on Thursday, September 2, 2021, and ran for five consecutive weeks, concluding on Thursday, September 30, 2021. The five topics/webinars included:1)Physiology and endocrinology of the bovine estrous cycle and products approved for use in estrous cycle control. The purpose of this webinar was to review basic principles that underlie current estrus synchronization protocols as well as products that are used. Understanding these principles supports individuals in makingdecisions concerningapplication of a specificprotocol for groups of heifers or cows. The webinar emphasized the importance of administering protocols exactly as described, and reviewed situations wherein a problem develops when implementing an estrus synchronization protocol so that users are equipped with basic knowledge to determinewhat went wrong and how to correct it. 2)Estrus synchronization programs for replacement beef heifers. Lifetime reproductive performance, longevity in the herd, and cumulative pounds of calf weaned over a heifer's productive lifespan are highly correlated with the date on which a heifer conceives during the first breeding season. The investment in time and resources in heifers from weaning to breeding requires that management efforts be made to facilitate puberty onset and maximize the likelihood of early pregnancy. Estrus synchronization programs create an opportunity for heifers to conceive early in the breeding period, a significant opportunity given the relationship between early conception and long-term reproductive success. Beef producers are now able to utilize treatments that offer the potential to effectively synchronize estrus in pubertal heifers, while at the same time induce puberty among pre- or peripubertal heifers. Thewebinar reviewed protocols designed to synchronize estrus and ovulation in replacement beef heifers and factors that contribute to successful breeding programs. 3)Estrus synchronization programs for postpartum beef cows. Estrus synchronization is a powerful technology for reproductive management of the mature cow herd. Given the potential return-on-investment, estrus synchronization is underutilized by commercial producers. This session addressed considerations related to implementation of synchronization programs prior to AI or natural service of mature cows, with special emphasis on multi-year improvements in commercial cow-calf profitability that can be realized using these technologies. 4)Estrus synchronization programs for recipient females prior to embryo transfer (ET). Embryo transfer programs offer the potential to add value in commercial beef herds. The webinar reviewed potential opportunities to capture added value from use of embryo transfer and the most effective strategies to synchronize recipient females prior to ET. 5)Assessing synchronization programs: Goals and troubleshooting results. This webinar reviewed ways in which data generated from an estrus synchronization program can be analyzed, determination of what should be considered as appropriate results, and what areas should be investigated if/when results from a synchronization program are below expectation. Participants included 180 veterinarians from 32 states, including: Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Virginia, Wisconsin, and Wyoming. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces, including Alberta, Ontario, and Saskatchewan. Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. Given the feedback from these webinars,requests were received to conduct a similar webinar series for dairy cattle focused on reproductive management. The webinar series began on June 9, 2022, and ran for five consecutive weeks, concluding on July 7, 2022. There were 138 participants in the webinar series, including: 126 from the U.S., 2 from Japan, 1 from Trinidad and Tobago, 8 from Canada, and 1 from Mexico. Participants included 115 veterinary practitioners, 14 academics, 3 technical service veterinarians, 3 veterinary technicians, 1 field technician in the AI industry, 1 extension professional, and 1 engineer. The five-part series included the following topics: 1) Physiology and endocrinology of the bovine estrous cycle and products; 2)estrus synchronization programs for replacement dairy heifers; 3)use of sensors in reproductive management: 4)estrus synchronization programs for dairy cows; and 5)assessing synchronization programs and troubleshooting results. How have the results been disseminated to communities of interest?A listing of abstracts, publications and presentations resulting from this project award are summarized in the Products section of this final report. A two-day pre-conference symposium entititled, "The National Center for Applied Reproduction and Genomics in Beef Cattle", was offered at the annual meeting of the American Association of Bovine Practitionersin St. Louis, MO, in 2019. Attendees representedveterinary colleges and practitioners from across the U.S. and Canada. Two intensive webinar series for veterinary practitioners wereoffered with one hour of continuing education per week for eight and five consecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development,genetic selection, and estrous cycle control. The first webinar series, "Establishing Consistency in Beef Heifer Development Programs", provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection. Participants included 143 veterinarians from 28 states and two Canadian provinces.Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series, "Strategies for Control of Estrous Cycles of Beef Heifers and Cows", attracted180 veterinarians from 32 states,Ukraine, South Africa, and 3 Canadian provinces. Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. Given the feedback from these webinars, requests were received to conduct a similar webinar series for dairy cattle focused on reproductive management. The webinar series began on June 9, 2022, and ran for five consecutive weeks, concluding on July 7, 2022. There were 138 participants, including: 126 from the U.S., 2 from Japan, 1 from Trinidad and Tobago, 8 from Canada, and 1 from Mexico. Participants included 115 veterinary practitioners, 14 academics, 3 technical service veterinarians, 3 veterinary technicians, 1 field technician in the AI industry, 1 extension professional, and 1 engineer. The five-part series included the following topics: Physiology and endocrinology of the bovine estrous cycle and products, estrus synchronization programs for replacement dairy heifers,use of sensors in reproductive management, estrus synchronization programs for dairy cows, and assessing synchronization programs and troubleshooting results. Additionally, in February 2023, faculty from the University of Missouri worked collaboratively with faculty at the University of Florida to provide hands-on training for veterinary practitioners in FL related to reproductive tract scoring of heifers.Trainings of this type are planned in the coming months and years through theCenter. A significant outcome related to industry acceptance and adoption of reproductive and genomic technologies supported through NCARG wasadopted by the Red Angus Association of America with launch of the "Red Choice" program;a program designedto promote practices that support improvements in beef heifer development, resulting creation ofreliable sources of high-quality replacement females, and enhancedmarketing opportunities for participating ranches.The "Red Choice" program embraces proven reproductive and genetic management practices which, in turn, lead to high-quality replacement females entering commercial herds. The "Red Choice" program followsguidelines from the University of Missouri'sShow-Me-Select Replacement Heifer Program. The"Red Choice" Programwas reviewed at the Red Angus Association of America national convention in Kalispell, Montana, in September, 2022. The University of Missouri system approved aGraduate Certificate programfor veterinarians, veterinary students, extension specialists, allied industry personnel, and graduate students and is awaiting final approval from the Missouri Department of Higher Education & Workforce Development. The certificate program, "Reproductive and Genomic Technologies for Livestock",supportscreation of a new operational model to transfer complex technologies in reproduction and genomics to U.S. livestock producers.The certificate may stand-alone or be earned as part of an approved animal science or veterinary training program. Finally, apilot program was established by the University of Missouri in collaboration with the Missouri Junior Cattlemen's Association to offer a replacement heifer show and sale for youth seeking to expand knowledge of beef cattle production, reproductive management, genetic selection and genomics, in addition to marketing. The youth program is patterned after and being developed through collaboration with the Missouri Show-Me-Select Replacement Heifer Program. The first junior show and sale for the program was held in June, 2022 in Sedalia, MO. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? Specific Aim 1)Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds.This project quantified farm-level economic effects resulting from implementation of reproductive and genomic technologies using data from the University of Missouri Thompson Research Center. Adatabase spanning a20-plus-year time frame was condenseddetailinginformation on over 4,000 calves. Sale values werecompared to U.S. average values specific to offspring marketing channels, controlling for variability in cattle prices since 2002. A graduate student in Agricultural Economics completed a M.S. degree supported from this projectwith a thesis entitled "Analysis of the Economic Value Associated with the Adoption of Beef Reproductive Technologies". Summary of these dataconsidered values of offspringbased on use of reproductive and genetic technologies in a commercial beef herd used over time. Findings from these analyses were instrumental in supporting technology adoption. Additionally,this project highlighted the importance of genomic predictions in commercial Angus cattle using the GeneMax Advantage test to accurately rank animals based on genetic merit. Findings from this researchdemonstratevalue in using the GeneMax Advantage test as an effective selection tool in commercial cowherds. A manuscript resulting from this work is awaiting publication in a refereed journal. Finally, sales data from the Missouri Show-Me-Select (SMS) Replacement Heifer Program were summarized from 2010 through 2021 to compare value of bred heifers based on improvements in genetic merit and reproductive potential. Since 1997, nearly 1000 farmsenrolled over 180,000 heifers in the SMSprogram. The SMS Program created a Tier Two classification in 2010distinguishingheifers from genetically superior high accuracy AIsires due tothe increased use of fixed-time artificial insemination in beef herdsacross Missouri.Usingthe average sales price of SMSqualified heifers carrying natural-service sired pregnanciesas a baselineaverage value,the relative added value was determined that results from improvements in genetics of the heifer and/or the pregnancy aheifer was carrying: 1) SMS qualified heifers carrying natural-service sired pregnancies (n=7,524 heifers) sold for an average price per heifer of $1,938;2) SMS qualified heifers carrying AI-sired pregnancies (n=9,789 heifers) sold for an averageprice per heifer of $2,053, an increase of $115 over the baseline; and 3) Tier Two SMS qualified heifers carrying AI-sired pregnancies (n=1,355) sold for an average price per heifer of $2,168, a value difference of $230 per heifer over the baseline. Price differentials realized from the program increased adoption and continued use of new and emerging reproductive and genetic technologies across Missouri with a resultingeconomic impact now exceeding $200M. Specific Aim 2) Develop comprehensive educational curricula and training programs for veterinarians, extension livestock specialists, allied industry personnel, producers,veterinary and animal science students to enable all segments of the beef cattle sector to acquire new knowledge and skills that will aid in the successful adoption of reproductive and genomic technologies to support beef cattle reproductive and breeding management decision-making. Development of educational curricula has been on-going. Maria Haag, Ph.D. (Consultant/ Instructional Designer, Adjunct faculty) was hired to design, develop, and evaluate online modules and assist in coordination and evaluation of practicums and webinars. Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences. Delivery of these programs wasscheduled to beginduring the spring of 2020, however delivery efforts were delayed because of Covid-19 related concerns.3A) Veterinary practitioner education.Two intensive webinar series targetedveterinary practitioners and were offered with one hour of continuing education per week for eight and five consecutive weeks, respectively. Topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection, in addition to breeding management strategies for beef cows and heifers. The first webinar series,"Establishing Consistency in Beef Heifer Development Programs" attracted143 veterinarians from 28 states and two Canadian provinces. The second webinar series,"Strategies for Control of Estrous Cycles of Beef Heifers and Cows", attracted180 veterinarians from 32 states. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces. Asimilar webinar series for dairy cattle focused on reproductive management thatran for five consecutive weeksattracting138 participants, including: 126 from the U.S., 2 from Japan, 1 from Trinidad and Tobago, 8 from Canada, and 1 from Mexico. 3B) Training for extension livestock specialists, allied industry representatives, and beef producers. A significant outcome supported through NCARG was launched by the Red Angus Association of America with the "Red Choice" program;a program designedto promote improved heifer development practices, the resulting creation ofreliable sources of high-quality replacement females, and enhancedmarketing opportunities for participating herds.The "Red Choice" program followsguidelines from the University of Missouri SMS Replacement Heifer Program, a program demonstrated to increase quality and resulting value of enrolled females. A review of the "Red Choice" Program and its potential for the industry was reviewed at the Red Angus Association of America national convention in Kalispell, Montana, in September, 2022.3C) Higher education internships.The reproductive management internship at MU is designed to: 1) provide students with practical training in the development and execution of estrus synchronization and AI programs; and 2) provide extensive hands-on experience in estrus synchronization, estrus detection, semen handling, and AI. To date roughly 275students participated in the internshipgaininghands-on experience in reproductive management procedures. These students were involved with breeding programs involving over 300,000 heifers and cows on farms and ranches in twelve states.3D) Develop a Graduate Certificate program for veterinarians, veterinary students, extension specialists, allied industry personnel, and graduate students. A graduate certificate programreceived approval from the University of Missouri System and is awaiting final approval from the Missouri Department of Higher Education & Workforce Development. The certificate program, "Reproductive and Genomic Technologies for Livestock", is designed to support creation of a new operational model to transfer complex technologies in reproduction and genomics to U.S. livestock producers.The certificate may stand-alone or be earned as part of an approved animal science or veterinary training program. 3E) 4-H and Vocational Education Youth Pilot Program. A pilot program was established by the University of Missouri in collaboration with the Missouri Junior Cattlemen's Association to offer a replacement heifer show and sale for youth seeking to expandknowledge of beef cattle production, reproductive management, genetic selection and genomics, in addition to marketing. The youth program was patterned after anddeveloped through collaboration with the Missouri Show-Me-Select Replacement Heifer Program. The first junior show and sale for the program was held in June, 2022 in Sedalia, MO.

Publications

  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Intensive versus extensive heifer development systems Part I: Intensive. July 8, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. EPD Basics and sire selection. July 15,2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Intensive versus extensive heifer development systems Part I: Extensive. July 22, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Prebreeding evaluation of beef replacement heifers. July 29, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Heifer phenotyping as a service for genetic evaluations. August 5, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Does genomic prediction work? Results from a NCARG field demonstration. August 12, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Incorporating reproductive management of beef heifers into veterinary practice. August 19,2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Physiology and endocrinology of the bovine estrous cycle and products approved for use in estrous cycle control. September 2, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Estrous synchronization programs for replacement beef heifers. September 9, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Estrous synchronization programs for postpartum beef cows. September 16, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Estrous synchronization programs for recipient females prior to embryo transfer (ET). September 23, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Assessing synchronization programs - goals and troubleshooting results. September 30, 2021.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Physiology/endocrinology of the bovine estrous cycle and products. June 9, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Estrus synchronization programs for replacement dairy heifers. June 16, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: The use of sensors in reproductive management. June 23, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Estrus synchronization programs for dairy cows. June 30, 2022.
  • Type: Other Status: Other Year Published: 2022 Citation: Webinar Series: Assessing synchronization programs: Troubleshooting results. July 7, 2022.
  • Type: Journal Articles Status: Awaiting Publication Year Published: 2023 Citation: 2023 Arisman, BC, TN Rowan, JM Thomas, HJ Durbin, WR Lamberson, DJ Patterson, and JE Decker. Evaluation of Zoetis GeneMax Advantage genomic predictions in commercial Bos taurus Angus cattle. Livestock Science.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2018 Citation: Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, and JE Decker. 2018. The National Center for Applied Reproduction and Genomics (NCARG) in beef cattle. American Society of Animal Science Annual Meeting. Vancouver, BC. No. 260.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. American Society of Animal Science Annual Meeting. Austin, TX. No. 102.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: Decker, JE, DJ Patterson, B Arisman, TN Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, and JF Taylor. 2019. The National Center for Applied Reproduction and Genomics (NCARG) evaluates accuracy of genomic prediction in commercial Angus cattle. American Society of Animal Science Annual Meeting. Austin, TX. No. 101.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: Haag, M, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and DJ Patterson. 2019. The National Center for Applied Reproduction and Genomics (NCARG): Developing high-impact educational programs for beef industry participants. American Society of Animal Science Annual Meeting. Austin, TX. No. 109.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle. American Society of Animal Science Annual Meeting. Austin, TX. No. 110.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: The National Center for Applied Reproduction and Genomics. American Association of Bovine Practitioners. September 10-11, 2019. St. Louis, MO.
  • Type: Theses/Dissertations Status: Published Year Published: 2019 Citation: Analysis of the Economic Value Associated with the Adoption of Beef Reproductive Technologies. M.S. Thesis. Emma Downing. University of Missouri.
  • Type: Other Status: Published Year Published: 2020 Citation: MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 1. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle. DJ Patterson, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, JE Decker.
  • Type: Other Status: Published Year Published: 2020 Citation: MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 2. The National Center for Applied Reproduction and Genomics (NCARG): Developing High Impact Educational Programs for Beef Industry Participants. M Haag, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, DJ Patterson.
  • Type: Other Status: Published Year Published: 2020 Citation: MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 3. The National Center for Applied Reproduction and Genomics (NCARG) Evaluates Accuracy of Genomic Prediction in Commercial Angus Cattle. JE Decker, DJ Patterson, B Arisman, T Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, JF Taylor.
  • Type: Other Status: Published Year Published: 2020 Citation: MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 4. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. DJ Patterson, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, JE Decker.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Selection of profitable commercial beef heifers. July 1, 2021.


Progress 03/15/21 to 03/14/22

Outputs
Target Audience:The National Center for Applied Reproduction and Genomics (NCARG) for Beef Cattle will develop a comprehensive educational training program for practicing veterinarians, extension livestock specialists, allied industry, producers, and students that will enable the various segments of the beef cattle sector to acquire (through face-to-face and distance-learning applications) new knowledge, skills, and attitudes that will aid in the successful adoption of existing reproductive procedures/ biotechnologies and genomic selection. Changes/Problems:Progress on this NIFA funded project was delayed because of issues and concerns related to Covid-19. Travel and campus-related restrictions in many cases hampered progress on this project. Progress related to the NCARG project was notably delayed, requiring an initial one-year no cost extension, and now a second. I have been fortunate over the course of my career to have received funding from NIFA to support my research and extension efforts. The challenges posed by Covid-19 were and are significant. However, as we consider larger budgetary challenges facing higher education moving forward, which in part were accelerated because of Covid-19, land grant institutions must consider new working models in order to sustain their missions. The United States leads the world in fundamental research and development of reproductive and genomic technologies in support of animal agriculture, however, limited funding has been directed toward effective implementation of these technologies because of inadequate resources to support their transfer to industry stakeholders. Global competitors including Brazil, Argentina, Australia, China, and Russia are outpacing the United States in utilizing existing and emerging technologies to support improvements in livestock production in their countries. The U.S. cannot continue to lead without investing in the necessary infrastructure to transfer use of these technologies to our own livestock producers. For this reason, we remain committed to the NCARG model. What opportunities for training and professional development has the project provided?Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020, however efforts were delayed because of Covid-19 related concerns. After consideration of these delays and the need for targeted programming related to the topics outlined in the proposal, the decision was made to conduct two intensive webinar series focused on veterinary practitioners. Each of the two webinar series was offered with one hour of continuing education per week for eight and fiveconsecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection.The first webinar series was titled "Establishing Consistency in Beef Heifer Development Programs".The series began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021. The first webinar series was offered with one hour of continuing education per week for eight consecutive weeks. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection. By the end of the series participants were expected to be able to: Describe how to identify high potential return on investment females. Discuss factors necessary to ensure heifers grow at a rate to achieve puberty before breeding. Explain the benefits of expected progeny difference (EPD) in the beef herd. Identify elements of a successful low-cost heifer development system. Summarize how data points collected at pre-breeding exams and ultrasound pregnancy checks can allow for additional revenue streams for veterinarians and increase profitability for producers. Discuss strategies for incorporating genomic testing into the beef herd. Discuss the incorporation of beef heifer reproductive management programs in veterinary practice. Participants included 143 veterinarians from 28 states, including: Arkansas, California, Colorado, Florida, Idaho, Illinois, Indiana, Iowa, Hawaii, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, and Virginia. In addition, of the 143 participants enrolled in the webinar series, 8 included veterinarians from two Canadian provinces, including Alberta and Saskatchewan. Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series was titled "Strategies for Control of Estrous Cycles of Beef Heifers and Cows".The series began on Thursday, September 2, 2021 and ran for five consecutive weeks, concluding on Thursday, September 30, 2021.A brief summary of each of the five topics/webinars is provided below. Physiology and endocrinology of the bovine estrous cycle and products approved for use in estrous cycle control. The purpose of this webinar was to review basic principles that underlie current estrous synchronization protocols as well as products that are used. Understanding these principles supports individuals in making the right decision concerning the application of a specific synchronization protocol for groups of heifers or cows. The webinar emphasized the importance of administering protocols exactly as described, and reviewed situations wherein a problem develops when implementing an estrous synchronization protocol that users are equipped with basic knowledge to figure out what went wrong and how to correct it. Estrous synchronization programs for replacement beef heifers.Lifetime reproductive performance, longevity in the herd, and cumulative pounds of calf weaned over a heifer's productive lifespan are highly correlated with the date on which a heifer conceives during the first breeding season. The investment in time and resources in heifers from weaning to breeding requires that management efforts be made to facilitate puberty onset and maximize the likelihood of early pregnancy. Estrous synchronization programs create an opportunity for heifers to conceive early in the breeding period, which is a significant opportunity given the relationship between early conception and long-term reproductive success. Beef producers are now able to utilize treatments that offer the potential to effectively synchronize estrus in pubertal heifers, while at the same time induce puberty among pre- or peripubertal heifers. This webinar reviewed protocols designed to synchronize estrus and ovulation in replacement beef heifers and factors that contribute to successful breeding programs. Estrous synchronization programs for postpartum beef cows.Estrous synchronization is a powerful technology for reproductive management of the mature cow herd. Given the potential return-on-investment, synchronization is underutilized by commercial producers. This session addressed considerations related to implementation of synchronization programs prior to AI or natural service of mature cows, with special emphasis on multi-year improvements in commercial cow-calf profitability that can be realized with these technologies. Estrous synchronization programs for recipient females prior to embryo transfer (ET). Embryo transfer programs offer the potential to add value in commercial beef herds. The webinar reviewed potential opportunities to capture added value from use of embryo transfer and the most effective strategies to synchronize recipient females prior to ET. Assessing synchronization programs: Goals and troubleshooting results.This webinar reviewed ways in which data generated from an estrous synchronization program can be analyzed, determination of what should be considered as appropriate results, and what areas should be investigated if/when results from the synchronization program are below expectation. Participants included 180 veterinarians from 32 states, including: Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Virginia, Wisconsin, and Wyoming. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces, including Alberta, Ontario, and Saskatchewan. Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. How have the results been disseminated to communities of interest?Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020 and again in 2021, however efforts were delayed because of Covid-19 related concerns. After consideration of these delays and the need for targeted programming related to the topics outlined in the proposal, the decision was made to conduct two intensive webinar series focused on veterinary practitioners. Each of the two webinar series was offered with one hour of continuing education per week for eight and fiveconsecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection, in addition to breeding management strategies for replacement beef heifers and postpartum beef cows.The first webinar series was titled "Establishing Consistency in Beef Heifer Development Programs".The series began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021. Participants included 143 veterinarians from 28 states, including: Arkansas, California, Colorado, Florida, Idaho, Illinois, Indiana, Iowa, Hawaii, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, and Virginia. In addition, of the 143 participants enrolled in the webinar series, 8 included veterinarians from two Canadian provinces, including Alberta and Saskatchewan. Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series was titled "Strategies for Control of Estrous Cycles of Beef Heifers and Cows".The series began on Thursday, September 2, 2021 and ran for five consecutive weeks, concluding on Thursday, September 30, 2021.A brief summary of each of the five topics/webinars is provided below.?? Participants included 180 veterinarians from 32 states, including: Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Virginia, Wisconsin, and Wyoming. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces, including Alberta, Ontario, and Saskatchewan. Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. What do you plan to do during the next reporting period to accomplish the goals?Research related to Specific Aim 1 will continue, quantifying farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds, and finalize manuscripts fo publication. In addition, development of curriculum modules and course development detailed in Specific Aim 2 will continue. Efforts related to Specific Aim 3 involving transfer of technology to the various target audiences using educational modules completed under Specific Aim 2 will begin, along with final approval of the Graduate Certificate Program within the MU System and eventual acceptance of students into the program.

Impacts
What was accomplished under these goals? Specific Aim 1) Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. Research quantified farm-level economic effects resulting from implementation of reproductive and genomic technologies using data from the University of Missouri Thompson Research Center. A graduate student in Agricultural Economics at MU completed a Master's degree with a thesis entitled "Analysis of the Economic Value Associated with the Adoption of Beef Reproductive Technologies". Two manuscripts resulting from this work are in preparation for submission to refereed journals. The results from this study provide needed evidence that will encourage producers to invest in reproductive and genetic technologies that will support and sustain their operations over the long-term. Usinggenomic predictions in commercial Angus cattle. From research conducted in support of this project The GeneMax Advantage test was shown to accurately rankanimals based on their genetic merit and is an effective selection tool in commercial cowherds. A manuscript resulting from this work is now under review in arefereed journal. Specific Aim 2) Develop comprehensive educational curricula and training programs. These curricula are designed to supportveterinarians, extension livestock specialists, allied industry personnel, producers, and veterinary and animal science students. Curricula will enable varioussegments of the beef cattle sector to acquire new knowledge and skills to aid insuccessful adoption of reproductive and genomic technologies, andultimately supportbeef cattle breeding management decisionmaking. The mission of NCARGis to provide education and training for active participants in the beef industry. Programs are designed to supply introductory material through online courses followed by more advanced, in-person practicums. Development of comprehensive educational curricula and training programs is currently underway, but was delayed because of Covid-19. Educational curricula currently being developed are intended to support the development of a Graduate Certificate program in support of Specific Aim 3D. Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences. 3A) Veterinary practitioner education. Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020 and again in 2021, however efforts were delayed because of Covid-19 related concerns. After consideration of these delays and the need for targeted programming related to the topics outlined in the proposal, the decision was made to conduct two intensive webinar series focused on veterinary practitioners. Each of the two webinar series was offered with one hour of continuing education per week for eight and fiveconsecutive weeks, respectively. The topics provided veterinary practitioners with an introduction to principles of beef heifer development and genetic selection, in addition to breeding management strategies for beef cows and heifers.The first webinar series was titled "Establishing Consistency in Beef Heifer Development Programs". The series began on Thursday, July 1, 2021 and ran for eight consecutive weeks, concluding on Thursday, August 19, 2021. Participants included 143 veterinarians from 28 states, including: Arkansas, California, Colorado, Florida, Idaho, Illinois, Indiana, Iowa, Hawaii, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Carolina, North Dakota, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, and Virginia. In addition, of the 143 participants enrolled in the webinar series, 8 included veterinarians from two Canadian provinces, including Alberta and Saskatchewan. Participants included 116 veterinary practitioners, 16 academics, 9 pharmaceutical technical service veterinarians, and 2 USDA-Government employed veterinarians. The second webinar series was titled "Strategies for Control of Estrous Cycles of Beef Heifers and Cows". The series began on Thursday, September 2, 2021 and ran for five consecutive weeks, concluding on Thursday, September 30, 2021. Participants included 180 veterinarians from 32 states, including: Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Virginia, Wisconsin, and Wyoming. In addition, 8 of the 180 participants enrolled in the webinar series included veterinarians from Ukraine, South Africa, and 3 Canadian provinces, including Alberta, Ontario, and Saskatchewan. Participants included 139 veterinary practitioners, 28 academics, 10 pharmaceutical technical service veterinarians, and 3 USDA-Government employed veterinarians. 3B) Training for extension livestock specialists, allied industry representatives, and beef producers.A significant outcome related to industry acceptance and adoption of reproductive and genomic technologies supported through NCARG was recently announced by the Red Angus Association of America. To promote improved heifer development, increase marketing opportunities for Red Angus females and create reliable sources of high-quality replacement heifers for cattle producers, the Red Angus Association of America launched the "Red Choice" program. The program embraces proven reproductive and genetic management practices which, in turn, lead to high-quality replacement females entering commercial herds. "Red Choice" is based on the University of Missouri Show-Me-Select® Replacement Heifer Program and follows guidelines and requirements set forth in the program that increase the overall quality of enrolled females.The "Red Choice" program was initiated based on success of the Show-Me-Select® program in Missouri and the significant impact the program has had on the cattle industry in the state. 3D) Develop a Graduate Certificate program entitled "Bovine Reproductive Management and Genomic Technologies" for veterinarians, veterinary students, extension specialists, allied industry personnel, and graduate students. A proposal for the graduate certificate program was prepared and submitted to the Academic Affairs and Graduate committees in the Division of Animal Sciences. The proposal in support of a Graduate Certificate was accepted and approved by both committees and is now awaiting approval from the MU Provost's office. 3E) 4-H and Vocational Education Youth Pilot Program. Development of a pilot youth program for students will focus on the development, management, breeding and marketing of replacement beef heifers, and emphasize use of reproductive and genomic technologies recommended for heifer selection, development and breeding. A pilot program has been established by the University of Missouri in collaboration with the Missouri Junior Cattlemen's Association to offer a replacement heifer show and sale for youth seeking to expand their knowledge of beef cattle production, reproductive management, genetic selection and genomics, in addition to marketing. The youth program is patterned after and is being developed through collaboration with the Missouri Show-Me-Select Replacement Heifer Program.

Publications

  • Type: Journal Articles Status: Under Review Year Published: 2022 Citation: Arisman BC, Rowan TN, Thomas JM, Durbin HJ, Patterson DJ, Decker JE. Evaluation of Zoetis GeneMax Advantage genomic predictions in commercial Bos taurus Angus cattle. Preprint available through BioRxiv https://doi.org/10.1101/2020.10.23.353144.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Selection of profitable commercial beef heifers. July 1, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Intensive versus extensive heifer development systems Part I: Intensive. July 8, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. EPD Basics and sire selection. July 15,2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Intensive versus extensive heifer development systems Part I: Extensive. July 22, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Prebreeding evaluation of beef replacement heifers. July 29, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Heifer phenotyping as a service for genetic evaluations. August 5, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Does genomic prediction work? Results from a NCARG field demonstration. August 12, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Physiology and endocrinology of the bovine estrous cycle and products approved for use in estrous cycle control. September 2, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Estrous synchronization programs for replacement beef heifers. September 9, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Estrous synchronization programs for postpartum beef cows. September 16,2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Estrous synchronization programs for recipient females prior to embryo transfer (ET). September 23, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Strategies for control of estrous cycles of beef heifers and cows. Assessing synchronization programs - goals and troubleshooting results. September 30, 2021.
  • Type: Other Status: Other Year Published: 2021 Citation: Webinar series: Establishing Consistency in Beef Heifer Development Programs. Incorporating reproductive management of beef heifers into veterinary practice. August 19,2021.


Progress 03/15/20 to 03/14/21

Outputs
Target Audience:The National Center for Applied Reproduction and Genomics (NCARG) for Beef Cattle will develop a comprehensive educational training program for practicing veterinarians, extension livestock specialists, allied industry, producers, and students that will enable the various segments of the beef cattle sector to acquire (through face-to-face and distance-learning applications) new knowledge, skills, and attitudes that will aid in the successful adoption of existing reproductive procedures/ biotechnologies and genomic selection. Changes/Problems:Covid related challenges during the past year. Progress on this NIFA funded projectwas delayed because of concerns related to Covid-19. Travel restrictions in many cases hampered progress on thisprojectand will in all likelihood continue to be an issue in the near term. Progress related to the NCARG project was notably delayed, requiring a one-year no cost extension. I have been fortunate over the course of my career to have received funding from NIFA to support my research and extension efforts. The challenges posed by Covid in the near term have been and will continue to be significant. However as we consider larger budgetary challenges facing higher educationmoving forward, which in part were accelerated because of Covid,land grant institutions must consider new working models in order to sustain their missions. The United States leads the world in fundamental research and development of reproductive and genomic technologies in support of animal agriculture, however, limited funding has been directed toward effective implementation of these technologies because of inadequate resources to support their transfer to industry stakeholders. Global competitors including Brazil, Argentina, Australia, China, and Russia are outpacing the United States in utilizing existing and emerging technologies to support improvements in livestock production in their countries. The U.S. cannot continue to lead without investing in the necessary infrastructure to transfer use of these technologies to our own livestock producers. For this reason, we remain committed to the NCARG model. What opportunities for training and professional development has the project provided?Progress and results generated from the project were shared with members of the NC-1201 MULTI-STATEPROJECT(METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE) and are detailed below. OBJECTIVE 3. DISSEMINATE REPRODUCTIVE MANAGEMENT INFORMATION TO STAKEHOLDERS TO IMPROVE SUSTAINABILITY OF CATTLE ENTERPRISES. STUDY 1. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle. DJ Patterson, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. As budgets to support research and transfer of technology via Extension have dwindled, many states lack the necessary critical mass to support research and transfer of new technologies in reproduction and genomics to industry stakeholders. In many cases, land grant universities in states across the US are categorized as "have and have-nots" when it comes to research infrastructure and qualified extension personnel in these disciplines. Further, there are a limited number of Veterinarians that specialize in these disciplines and veterinary student training and continuing education offerings for veterinary practitioners in the field is limited. These considerations formed the rationale for thisUSDA-NIFA funded project to create a new working model for research and technology transfer. STUDY 2. The National Center for Applied Reproduction and Genomics (NCARG): Developing High Impact Educational Programs for Beef Industry Participants. M Haag, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and DJ Patterson. The mission of the National Center for Applied Reproduction and Genomics (NCARG) is to provide education and training for active participants in the beef industry. Programs are designed to supply introductory material through online courses followed by more advanced, in-person practicums. Development of comprehensive educational curricula and training programs is currently underway beginning with the reproduction modules. Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020, however these efforts were delayed because of Cov id-19 related concerns. STUDY 3. The National Center for Applied Reproduction and Genomics (NCARG) Evaluates Accuracy ofGenomic Prediction in Commercial Angus Cattle. JE Decker, DJ Patterson, B Arisman, T Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, and JF Taylor. One goal of the National Center for Applied Reproduction and Genomics (NCARG) is to demonstrate in real-world settings the potential of new technologies. To this end, we evaluated the predictive ability of the Zoetis GeneMax Advantage genomic prediction. Data from commercial Angus females and their progeny at the MU Thompson Research Center were utilized to analyze Weaning Weight, Milk, Marbling, Fat Thickness, Ribeye Area and Carcass Weight. Progeny phenotypic data was matched to the respective dam, and the genomic predictions were compared to phenotypic data. All genomic predictions had correlations with progeny phenotypes that were different from zero (p-value < 0.05). Genomic predictions for all analyzed traits were significantly associated with calf performance. This evaluation demonstrates that GeneMax Advantage genomic predictions can be used reliably in commercial Angus cattle. STUDY 4. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. DJ Patterson, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. Comprehensive educational training programs in support of the National Center for Applied Reproduction and Genomics will include curriculum modules designed to support improvements in reproductive management, and will be comprised of the following: 1) Heifer development programs including reproductive tract scoring, fetal aging and sexing; 2) Breeding management, including estrus synchronization, artificial insemination, sex-sorted semen, and embryo transfer; 3) higher education student internships in reproductive management; and 4) on-farm beef heifer development and marketing programs patterned after the Missouri Show-Me-Select® Replacement Heifer Program. In addition, a graduate certificate program will be offered. How have the results been disseminated to communities of interest?Progress on the NIFA funded projectlisted in this report was delayed because of concerns related to Covid. Travel restrictions in many cases hampered progress on theprojectand will in all likelihood continue to be an issue at least for the short term. However, progress and results generated from the project were shared with members of theNC-1201 MULTI-STATEPROJECT(METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE)and are detailed in the preceding section of this report. What do you plan to do during the next reporting period to accomplish the goals?Research related to Specific Aim 1 will continue, quantifying farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. In addition, development of curriculum modules and course development detailed in Specific Aim 2 will continue. Efforts related to Specific Aim 3 involving transfer of technology to the various target audiences using educational modules completed under Specific Aim 2 will begin, along with acceptance of students into the Graduate Certificate Program.

Impacts
What was accomplished under these goals? Specific Aim 1): Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds.Research quantified farm-level economic effects resulting from implementation of reproductive and genomic technologies using data from the University of Missouri Thompson Research Center. A useable database including, animal identification, birth dates and weights, weaning weights, sale prices, marketing outlets, carcass grades, offspring associated with dams and sires, etc., throughout a 20+ year span was condensed for analyses. Over 13,000 pages of data were processed, formatted, and organized to create a database involving detailed information on over 4,000 calves. This process led to the creation of electronically accessible information available to update and use by Thompson Research Center interested parties, including, economists, farm managers, reproductive physiologists, and geneticists. Analyses of the data included changes in birth weights, weaning weights,death loss, dam longevity, offspring values, carcass grade, and carcass value over the long term. Sale values were then compared to US average values specific to offspring marketing channels, controlling for variability in cattle prices since 2002. Emma Downing, a graduate student in Agricultural Economics at MU completed a Master's degree with a thesis entitled "Analysis of the Economic Value Associated with the Adoption of Beef Reproductive Technologies". Two manuscripts resulting from this work are now in process. These data afforded the opportunity to consider values of offspring in the long term based on use of reproductive and genetic technologies in a commercial beef herd. Therefore, findings from this analysis will be instrumental in supporting the case for technology adoption. As demand for high-quality beef continues to grow, consumers of beef, domestic and abroad, are willing to pay a premium for superior quality. For the US beef industry to supply that demand, it is vital that producers, regardless of size, recognize these market signals. Heifers retained within US beef herds provide opportunities to expand quality beef markets through enhanced genetic merit. The results from this study provide needed evidence that will encourage producers to invest in reproductive and genetic technologies that will support and sustain their operations over the long term. Specific Aim 2) Develop comprehensive educational curricula and training programs for veterinarians, extension livestock specialists, allied industry personnel, producers, and veterinary and animal science students to enable all segments of the beef cattle sector to acquire new knowledge and skills that will aid in the successful adoption of reproductive and genomic technologies to support beef cattle reproductive and breeding management decisionmaking.The mission of the National Center for Applied Reproduction and Genomics (NCARG) is to provide education and training for active participants in the beef industry. Programs are designed to supply introductory material through online courses followed by more advanced, in-person practicums. Development of comprehensive educational curricula and training programs is currently underway beginning with the reproduction modules. Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020, however these efforts were delayed because of Covid-19 related concerns. Educational curricula currently being developedare intended to support the development of undergraduate and graduate certificate programs. Proposals for these certificate programs were prepared and submitted to the Academic Affairs committe in the Division of Animal Sciences and are currently under review.These certificate programs will support the unmet need for advanced training in these disciplines for students and industry professionals. The program, with support from veterinary schools and allied industry across the nation, will be an avenue for students from the University of Missouri and beyond to receive training that is otherwise often unavailable. The certificates may stand-alone or earned as part of an approved animal science or veterinary training program. For example: A student enrolled in an accredited College of Veterinary Medicine at a partnering university could earn a graduate certificate as part of their elective curriculum, in addition to graduate students in Animal Science programs at other Universities. The certificate programs will be administered through the Division of Animal Sciences with an initial focus on beef cattle. The intent is to provide further training and expertise in the area of beef cattle reproduction and genomics for animal science undergraduate and graduate students, post-baccalaureate students, veterinary students and professionals. The certificate programs will be supported through the National Center for Applied Reproduction and Genomics (NCARG). Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences.Implementation of comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences was scheduled to begin during the spring of 2020, however these efforts were delayed because of Covid-19 related concerns.

Publications

  • Type: Other Status: Published Year Published: 2020 Citation: MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 1. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle. DJ Patterson, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, JE Decker.
  • Type: Other Status: Published Year Published: 2020 Citation: 2020 MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 2. The National Center for Applied Reproduction and Genomics (NCARG): Developing High Impact Educational Programs for Beef Industry Participants. M Haag, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, DJ Patterson.
  • Type: Other Status: Published Year Published: 2020 Citation: 2020 MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 3. The National Center for Applied Reproduction and Genomics (NCARG) Evaluates Accuracy of Genomic Prediction in Commercial Angus Cattle. JE Decker, DJ Patterson, B Arisman, T Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, JF Taylor.
  • Type: Other Status: Published Year Published: 2020 Citation: 2020 MULTISTATE PROJECT NC-1201 REPORT: METHODS TO INCREASE REPRODUCTIVE EFFICIENCY IN CATTLE. OBJECTIVE 3. Disseminate Reproductive Management Information to Stakeholders to Improve Sustainability of Cattle Enterprises. STUDY 4. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. DJ Patterson, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, JE Decker.


Progress 03/15/19 to 03/14/20

Outputs
Target Audience:The National Center for Applied Reproduction and Genomics (NCARG) for Beef Cattle will develop a comprehensive educational training program for practicing veterinarians, extension livestock specialists, allied industry, producers, and students that will enable the various segments of the beef cattle sector to acquire (through face-to-face and distance-learning applications) new knowledge, skills, and attitudes that will aid in the successful adoption of existing reproductive procedures/ biotechnologies and genomic selection. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?A two day pre-conference symposium was offered at the recent annual meeting of th Amercian Association of Bovine Practitioners. The symposium was entitled "The National Center for Applied Reproduction and Genomics" and was presentedSeptember 10-11, 2019 inSt. Louis, MO. Attendees included veterinary students and practitioners from the U.S. and Canada. In addition, four presentations were made in support of the National Center for Applied Reproduction and Genomics at the 2019 American Society of Animal Science meetings in Austin, TX. A listing of those presentations is provided below. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. American Society of Animal Science Annual Meeting. Austin, TX. No. 102. Decker, JE, DJ Patterson, B Arisman, TN Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, and JF Taylor. 2019. The National Center for Applied Reproduction and Genomics (NCARG) evaluates accuracy of genomic prediction in commercial Angus cattle. American Society of Animal Science Annual Meeting. Austin, TX. No. 101. Haag, M, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and DJ Patterson. 2019. The National Center for Applied Reproduction and Genomics (NCARG): Developing high-impact educational programs for beef industry participants. American Society of Animal Science Annual Meeting. Austin, TX. No. 109. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle.merican Society of Animal Science Annual Meeting. Austin, TX. No. 110. How have the results been disseminated to communities of interest?A two day pre-conference symposium was offered at the recent annual meeting of th Amercian Association of Bovine Practitioners. The symposium was entitled "The National Center for Applied Reproduction and Genomics" and was presentedSeptember 10-11, 2019 inSt. Louis, MO. Attendees included veterinary students and practitioners from the U.S. and Canada. In addition, four presentations were made in support of the National Center for Applied Reproduction and Genomics at the 2019 American Society of Animal Science meetings in Austin, TX. A listing of those presentations is provided below. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. American Society of Animal Science Annual Meeting. Austin, TX. No. 102. Decker, JE, DJ Patterson, B Arisman, TN Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, and JF Taylor. 2019. The National Center for Applied Reproduction and Genomics (NCARG) evaluates accuracy of genomic prediction in commercial Angus cattle. American Society of Animal Science Annual Meeting. Austin, TX. No. 101. Haag, M, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and DJ Patterson. 2019. The National Center for Applied Reproduction and Genomics (NCARG): Developing high-impact educational programs for beef industry participants. American Society of Animal Science Annual Meeting. Austin, TX. No. 109. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle.merican Society of Animal Science Annual Meeting. Austin, TX. No. 110. What do you plan to do during the next reporting period to accomplish the goals?Research related to Specific Aim 1 will continue, quantifying farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. In addition, development of curriculum modules and course development detailed in SpecificAim 2 will continue. Effortsrelated to Specific Aim 3 involving transfer of technology to the various target audiences using educational modules completed under Specific Aim 2 will begin, along with acceptance of students into the Graduate Certificate Program.

Impacts
What was accomplished under these goals? Specific Aim 1): Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. Over the past year results from research quantifiedfarm-level economic effects resulting from implementation of reproductive and genomic technologies using data from the University of Missouri Thompson Research Center. A useable database including, animal identification, birth dates and weights, weaning weights, sale prices, marketing outlets, carcass grades, offspring associated with dam and sires, etc.-throughout a 20-plus-year span was condensed for analyses. Over 13,000 pages of data were processed, formatted, and organized to create a database involving detailed information on over 4,000 calves. This process led to the creation of electronically accessible information available to update and use by Thompson Research Center interested parties, including, economists, farm managers, and reproductive physiologists and geneticists. Analyses of the data included changes in birth weights, weaning weights, death loss, dam longevity, offspring values, carcass grade, and carcass value over the long term. Sale values were then compared to US average values specific to offspring marketing channels, controlling for variability in cattle prices since 2002. Emma Downing,a graduate student in Agricultural Economics atthe University ofMissouri completed a Master's degree with a thesis entitled "AnalysisoftheEconomicValueAssociated withtheAdoption ofBeefReproductiveTechnologies". This research was supported from this project award. Data collected and analyzed in support of this thesisaffordedthe opportunity to consider values of offspring in the long term based on use of reproductive and genetic technologies in a commercial beef herd. Therefore, findings from this analysis will be instrumental in supporting the case for technology adoption. As demand for high-quality beef continues to grow, consumers of beef, domestic and abroad, are willing to pay a premium for superior quality. For the US beef industry to supply that demand, it is vital that producers, regardless of size, recognize these market signals. Heifers retained within US beef herds provide opportunities to expand quality beef markets through enhanced genetic merit. The results from this study provide needed evidence that willencourage producers to invest in reproductive and genetic technologies that will support and sustain their operations over the long term. Specific Aim 2) Develop comprehensive educational curricula and training programs for veterinarians, extension livestock specialists, allied industry personnel, producers, and veterinary and animal science students to enable all segments of the beef cattle sector to acquire new knowledge and skills that will aid in the successful adoption of reproductive and genomic technologies to support beef cattle reproductive and breeding management decision-making. Development of educational curricla is currently underway beginning with the reproduction modules which will be tested during the spring of 2020. Maria Haag, Ph.D. (Consultant/ Instructional Designer) has been hired to design, develop, and evaluate online modules and assist incoordination and evaluation of practicums and webinars. Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences. These programs are scheduled tobegin during the spring of 2020.

Publications

  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 4. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle: Supporting improvements in reproductive management. American Society of Animal Science Annual Meeting. Austin, TX. No. 102.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 5. Decker, JE, DJ Patterson, B Arisman, TN Rowan, JM Thomas, DS Brown, WR Lamberson, SE Poock, MF Smith, TE Spencer, and JF Taylor. 2019. The National Center for Applied Reproduction and Genomics (NCARG) evaluates accuracy of genomic prediction in commercial Angus cattle. American Society of Animal Science Annual Meeting. Austin, TX. No. 101.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 6. Haag, M, JE Decker, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and DJ Patterson. 2019. The National Center for Applied Reproduction and Genomics (NCARG): Developing high-impact educational programs for beef industry participants. American Society of Animal Science Annual Meeting. Austin, TX. No. 109.
  • Type: Conference Papers and Presentations Status: Published Year Published: 2019 Citation: 7. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, JM Thomas, and JE Decker. 2019. The National Center for Applied Reproduction and Genomics (NCARG) in Beef Cattle. American Society of Animal Science Annual Meeting. Austin, TX. No. 110.
  • Type: Conference Papers and Presentations Status: Other Year Published: 2019 Citation: The National Center for Applied Reproduction and Genomics. American Association of Bovine Practitioners. September 10-11, 2019. St. Louis, MO.
  • Type: Theses/Dissertations Status: Published Year Published: 2019 Citation: Analysis of the Economic Value Associated with the Adoption of Beef Reproductive Technologies. M.S. Thesis. Emma Downing. University of Missouri. 2019.


Progress 03/15/18 to 03/14/19

Outputs
Target Audience:The National Center for Applied Reproduction and Genomics (NCARG) for Beef Cattle will develop acomprehensive educational training program for practicing veterinarians, extension livestock specialists, allied industry, producers, and students that will enable the various segments of the beef cattle sector to acquire (through face-to-face and distance-learning applications) new knowledge, skills, and attitudes that will aid in the successful adoption of existing reproductive procedures/ biotechnologies and genomic selection. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?Training and professional development will begin in Years 2 and 3 of the project. How have the results been disseminated to communities of interest?The abstract listed below was presented at the 2018 American Society of Animal Science meetings in Vancouver, BC. Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, and JE Decker. 2018. The National Center for Applied Reproduction and Genomics (NCARG) in beef cattle. American Society of Animal Science Annual Meeting. Vancouver, BC. No. 260. In addition, press releases and popular press articles have been disseminated over the past year since the grant was awarded. What do you plan to do during the next reporting period to accomplish the goals?Work will continue related toSpecific Aim 1, quantifying farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds. In addition, development of curriculum modules and course development detailed in Specific Aim 2 will continue. Initial efforts will begin related to Specific Aim 3involving transfer of technology to the various target audiences using educational modules completed under Specific Aim 2.

Impacts
What was accomplished under these goals? Specific Aim 1): Quantify farm-level economic effects resulting from implementation of combinations of reproductive and genomic technologies in US beef herds.Over the past year research began to quantify farm-level economic effects resulting from implementation of reproductive and genomic technologies using data from the University ofMissouri Thompson Research Center. Auseable database including, animal identification, birth dates and weights, weaning weights, sale prices, marketing outlets, carcass grades, offspring associated with dam and sires, etc.-throughout a 20-plus-year span was condensed for analyses. Over 13,000 pages of data were processed, formatted, and organized to create a database involving detailed information on over 4,000 calves. This process led to the creation of electronically accessible information available to update and use byThompson Research Center interested parties, including, economists, farm managers, and reproductive physiologists and geneticists.Analyses of the data included changes in birth weights, weaning weights, death loss, dam longevity, offspring values, carcass grade, and carcass valueover the long term. Sale values were then compared to US average values specific to offspring marketing channels, controlling for variability in cattle prices since 2002. Specific Aim 2) Develop comprehensive educational curricula and training programs for veterinarians, extension livestock specialists, allied industry personnel, producers, and veterinary and animal science students to enable all segments of the beef cattle sector to acquire new knowledge and skills that will aid in the successful adoption of reproductive and genomic technologies to support beef cattle reproductive and breeding management decision-making.Development of educational curricla is currently underway beginning with the reproduction modules.Maria Haag, Ph.D. (Consultant/ Instructional Designer) has been hired to design, develop, and evaluate online modules and assist in the coordination and evaluation of practicums and webinars. Specific Aim 3) Implement comprehensive Extension and Education programs that focus on the effective transfer of reproductive and genomic technologies to the various target audiences. These programs will begin during Year 2 of the project.

Publications

  • Type: Conference Papers and Presentations Status: Published Year Published: 2018 Citation: Patterson, DJ, DS Brown, MF Smith, WR Lamberson, JF Taylor, TE Spencer, SE Poock, and JE Decker. 2018. The National Center for Applied Reproduction and Genomics (NCARG) in beef cattle. American Society of Animal Science Annual Meeting. Vancouver, BC. No. 260.