Source: UNIV OF MARYLAND submitted to
SWINE IN BIOMEDICAL RESEARCH CONFERENCE
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
TERMINATED
Funding Source
AFRI COMPETITIVE GRANT
Reporting Frequency
Annual
Accession No.
1008555
Grant No.
2016-67015-24626
Project No.
MD-ANSC-9991
Proposal No.
2015-07161
Multistate No.
(N/A)
Program Code
A1201
Project Start Date
May 1, 2016
Project End Date
Apr 30, 2018
Grant Year
2016
Project Director
Telugu, B.
Recipient Organization
UNIV OF MARYLAND
(N/A)
COLLEGE PARK,MD 20742
Performing Department
AGNR-Animal & Avian Sciences
Non Technical Summary
The Swine in Biomedical Research Conference 2016 will highlight the growing utility of swine models in biomedical research. In the toolbox category, the transformational nature of meganucleases such as Tal effector nucleases and CRISPR-cas are just beginning to be appreciated, and will allow the generation of relevant swine models for use in agriculture and biomedical research. These models will have impact on human and animal health, reproduction, and nutrition. Similarly, advances in cellular reprogramming of somatic cells into pluripotent cells continues to advance at a rapid pace and will provide novel applications in both agriculture, and human and animal health. In the applications category, there is still much to explore in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are also warranted in zoonotic diseases, bioengineering and regenerative medicine. This conference will provide an excellent platform for discussion of these models. Recent workshops have focused on utilizing animal sciences expertise traditionally supported by the USDA in support of NIH funded investigators that utilize pig models. The joint USDA and NIH discussions identified cultural differences and a lack of in-depth knowledge of needs and opportunities as major rate limiting issues. Hence, this conference has been organized to directly address these acknowledged limitations.
Animal Health Component
25%
Research Effort Categories
Basic
50%
Applied
25%
Developmental
25%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
30435101080100%
Knowledge Area
304 - Animal Genome;

Subject Of Investigation
3510 - Swine, live animal;

Field Of Science
1080 - Genetics;
Goals / Objectives
This proposal is in response to FY 2015 Foundational Animal Reproduction A1211 request for applications. The conference is to be held at the Loews Annapolis Hotel, in Annapolis, MD from 06/05/2016-06/07/2016. The Swine in Biomedical Research Conference 2016 will highlight the growing utility of swine models in biomedical research. In the toolbox category, the transformational nature of meganucleases such as Tal effector nucleases and CRISPR-cas are just beginning to be appreciated, and will allow the generation of relevant swine models for use in agriculture and biomedical research. These models will have impact on human and animal health, reproduction, and nutrition. Similarly, advances in cellular reprogramming of somatic cells into pluripotent cells continues to advance at a rapid pace and will provide novel applications in both agriculture, and human and animal health. In the applications category, there is still much to explore in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are also warranted in zoonotic diseases, bioengineering and regenerative medicine. This conference will provide an excellent platform for discussion of these models. Recent workshops have focused on utilizing animal sciences expertise traditionally supported by the USDA in support of NIH funded investigators that utilize pig models. The joint USDA and NIH discussions identified cultural differences and a lack of in-depth knowledge of needs and opportunities as major rate limiting issues. Hence, this conference has been organized to directly address these acknowledged limitations.
Project Methods
In order to achieve the defined outcomes and deliverables, the conference has been organized to provide significant discussion among the participants. Each of the sessions will have invited speakers selected with respect to their individual expertise and who will provide a summary of the topic or identify opportunities and needs. Poster sessions will provide additional opportunities to showcase existing models, methodologies and experimental approaches. Session Chairs will be responsible for leading discussion towards defined deliverables, ensuring that existing resources are adequately recognized and to assess priorities within the community. Each poster session will have a Moderator (selected from participants to provide diversity representation) who will be responsible for selecting oral presentations from the submitted abstracts. The planned Poster Sessions are: (1) Immunology and Infectious Diseases; 2) Nutrition (Obesity and Diabetes; (3) Genomics; (4) Physiology; (5) Transgenesis and Cloning; (6) Bioengineering and Regenerative Medicine; (7) Transplantation (allo and xeno); (8) Cardiovascular; (9) Cancer; (10) Drug development (Pharmaceutical); and (11) Clinical Models (applications and regulations).

Progress 05/01/16 to 04/30/18

Outputs
Target Audience:The target audience for the workshop were: A. Academia: 1) Trainees : Graduate students and postdoctoral fellows 2) Research scientists and academic faculty 3) Physicians and medical practioners B. Private sector 4) Research institutes 5) Contract Research Organizations C. Federal agencies: 6) Regulatory agencies 7) Federal funding agencies Changes/Problems:Close to 30 registrants failed to join the conference. These were students mostly from China, who couldn't obtain a visa, or those students within USA, who did not have sufficient funds to travel. Future conferences should consider raising additional revenue to cover the costs/ defray the registration costs of students to encourage participation. Additionally, advertising the meeting at least one year in advance could facilitate the travel plans of foreign attendees What opportunities for training and professional development has the project provided?The trainees had the opportunity to: 1) Present their research and obtain first-hand feedback from scientists 2) exposed to cutting-edge research presentations by leading scientists in the field 3) opportunity to network with leading scientists in the fied How have the results been disseminated to communities of interest?Yes. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? The meeting was organized in Baltimore from September 23-25, 2017( www.swinebiomed.org). The three day sessions included talks from notable scientists in the medical and agricultural community including physicians and bench scientists from both academia and industry. The meeting brought together researchers at various stages of career progression from graduate students to senior scientists. The speakers were selected based on their outstanding contributions towards the utilization of the pig in biomedical research. The conference participants were provided with a brief status report of the topic areas. Every attempt was made to ensure ethnic and gender, as well as career stage, and diversity, while making the selection. There were a total of 153 registrants, among which 101 are from within USA and another 52 from outside. The meeting highlighted recent advances in genome editing, xenotransplantation, disease modeling, and dual-purpose applications where the pig is a coveted animal model. The conference highlighted the ever increasing relevance of existing pig models for human diseases and the emerging ability to capture genomic information to create novel models. The conference: (1) distributed a summary of the discussions that address the conference goals in the concluding sessiond; (2) created a website and web app to disseminate information as well as distributed a memory stick that contains the abstracts; (3) provided a summary of potential new models that should be developed; (4) summarized potential funding needs and agency support; and (5) highlighted several publications that reaches a broader target audience interested in the use of swine for biomedical research will be published The two day conference was a success. Key Outcomes:The conference highlighted the ever increasing relevance of existing pig models for human diseases and the emerging ability to capture genomic information to create novel models. The conference: (1) distributed a summary of the discussions that address the conference goals in the concluding sessiond; (2) created a website and web app to disseminate information as well as distributed a memory stick that contains the abstracts; (3) provided a summary of potential new models that should be developed; (4) summarized potential funding needs and agency support; and (5) highlighted several publications that reaches a broader target audience interested in the use of swine for biomedical research will be published Atotal of 153 registrants participated in the conference: The breakdown is shown below. Number of Registrants (Total 153): United States Alabama 3 California 6 Colarado 1 DC 6 Florida 5 Georgia 2 Illinois 8 Iowa 5 Maryland 16 Massachusettes 2 Michigan 1 Minnesota 2 Missouri 6 Missouri 6 New York 4 North Carolina 4 Pennsylvania 2 Texas 3 Virginia 8 Washington 1 Wisconsin 10 101 Foreign registrants China 21 Colombia 1 Germany 7 Italy 1 Japan 2 Korea 15 Spain 1 Switzerland 2 UK 2 52 Total registrants 153

Publications


    Progress 05/01/16 to 04/30/17

    Outputs
    Target Audience: Nothing Reported Changes/Problems:The conference was postponed to September of this 2017. A no-cost extension was submitted to accommodate the change. What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

    Impacts
    What was accomplished under these goals? The conference was rescheduled for September of 2017. A no-cost extension was submitted to accommodate the change.

    Publications