Progress 12/01/15 to 11/30/19
Outputs
Target Audience:This research proposal seeks to better understand the mechanisms by which omega-3 fatty acids modulate eicosanoid signaling pathways to reduce the risks of colon cancer, therefore, the obtained results could benefit the general public, the food industry which works on omega-3 fatty acids, as well as the researchers who work on lipid chemistry and biochemistry. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?In the last 5 years, my students have won ~20 campus, national, and international awards, including Best Poster Awards, Best Publication Awards, and Travel Awards. They have performed >30 poster and oral presentations at academic conferences. Some highlighted awards are shown below: Weicang Wang, PhD student, 2014-19: Alumni Fellowship (2013), Graduate Travel Award of American Society for Pharmacology and Experimental Therapeutics (ASPET) (2017), Micha Peleg International Travel Award (2017), Institute of Food Technologists (IFT) Feeding Tomorrow Graduate Scholarship (2017), Phi Tau Sigma Founders Award (2018), Outstanding Poster Award of the 17th International Winter Eicosanoid Meeting (2018), and Travel Award of the Honor Society of Phi Kappa Phi (2018). Katherine Z. Sanidad, PhD student, 2014-19: Best Student Oral Presentation Award of Northeast Chapter of Society of Toxicology (NESOT) (2017), Graduate Travel Award of NESOT (2017), Travel Award of the 24th Annual Meeting of North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry (NACSETAC), (2018), and Best Poster Award of the 24th Annual Meeting of NACSETAC (2018). Elvira Sukamtoh, undergraduate researcher and MS student, 2013-18: Travel Award of IFT (2015), 2nd Place Award of IFT Undergraduate Research Competition (2015), Rising Researcher Award, UMass-Amherst (2015), Travel Award of American Chemical Society (ACS) (2016), 1st Place Award of ACS Undergraduate Student Research Symposium (2016), and Alumni Fellowship (2016). Haixia Yang, postdoctoral fellow, 2016-18: Postdoctoral Poster Award of NESOT (2017), and Best Postdoctoral Publication Award of Society of Toxicology (SOT) (2018). How have the results been disseminated to communities of interest?We have collaborated with ω-3 food industry, notably DSM Nutritional Products (Columbia, MD), to study the effects of ω-3 PUFAs on colon cancer development in mouse models (see our publication Journal of Nutritional Biochemistry 2017, 48:29-35). These resutls showed health benefits of DSM-derived ω-3 products and therefore could help to promote the ω-3 market. What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
We have accomplished the three aims proposed in this application: (1) determine the effects of ω-3 PUFAs on colon carcinogenesis-associated inflammation and immune responses. We have shown that dietary feeding of a diet rich in ω-3 PUFAs reduce the development of colon cancer in C57BL/6 mice (Journal of Nutritional Biochemistry 2017, 48:29-35); (2) determine the effects of ω-3 PUFAs on tissue profiles of lipid metabolites. Using LC-MS/MS-based lipidomics, we have shown that dietary feeding of a diet rich in ω-3 PUFAs increases tissue concentrations of ω-3-series lipid metabolites and reduces the concentrations of ω-6-series lipid metabolites (Journal of Nutritional Biochemistry 2017, 48:29-35); and (3) determine the molecular mechanisms for the anti-cancer and immune-modulating effects of ω-3 PUFAs. We have shown that the P450 monooxygenase pathway plays critical role in mediating the anti-colon cancer effects of ω-3 PUFAs. Indeed, the ω-3-series P450 metabolites, termed epoxydocosapentaenoic acids (EDPs), inhibit colon tumor growth in mice (Journal of Nutritional Biochemistry 2017, 48:29-35), in contrast, the ω-6-series P450 metabolites, termed epoxyoctadecenoic acids (EpOMEs), increase colon tumor growth and upregulate tumor inflammation in mice (Cancer Research, 2019 Doi: 10.1158/0008-5472.CAN-18-3221). Together, these research support our hypothesis regarding the molecular mechanism for the anti-colon cancer effects of ω-3 PUFAs.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Wang W., Zhang J., and Zhang G. Cytochrome P450 monooxygenase eicosanoid pathway: a potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk? Food Science and Human Wellness, Doi: 10.1016/j.fshw.2019.11.002.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Wang Y., Dattmore D.A., Wang W., Pohnert G., Wolfram S., Zhang J., Yang R., Decker E.A., Lee K.S.S., and Zhang G. (2019) trans, trans-2,4-decadienal, a lipid peroxidation product, induc-es inflammatory responses via Hsp90- or 14-3-3?-dependent mechanisms. Journal of Nutri-tional Biochemistry, Doi: 10.1016/j.jnutbio.2019.108286.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Zhang J., Chen X., Yang R., Ma Q., Qi W., Park Y., Sanidad K.Z., Kim D., Decker E.A., and Zhang G. (2019) Thermally processed oil exaggerates colonic inflammation and colitis-associated colon tumorigenesis in mice. Cancer Prevention Research. Doi: 10.1158/1940-6207.CAPR-19-0226
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Zhang J., Sanidad K.Z., and Zhang G. (2019) Role of cytochrome P450 monooxygenase eico-sanoid pathway in pathogenesis of colorectal cancer. Oncoscience, 6:371-375.
- Type:
Book Chapters
Status:
Published
Year Published:
2019
Citation:
Wang W., Sanidad K.Z., and Zhang G. (2019) Cytochrome P450 eicosanoid signaling pathway in colorectal tumorigenesis. Advances in Experimental Medicine and Biology, 1161:115-123. doi: 10.1007/978-3-030-21735-8_11.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Sanidad K.Z., Song M., Bisbee A.H., Bradbury J.A., Nan G., Zhang J., Shih B., Lee K.S.S., Minter L.M., Kim D., Xiao H., Liu J., Hammock B.D., Zeldin D.C., and Zhang G. (2019) Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tu-morigenesis. Cancer Research, Doi: 10.1158/0008-5472.CAN-18-3221.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Wang Y., Wang W., Yang H., Shao D., Zhao X., and Zhang G. (2019) Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling. Free Radical Biology & Medicine, 131:237-242.
- Type:
Journal Articles
Status:
Published
Year Published:
2018
Citation:
Wang Y., Wang W., Sanidad K., Shih P., Zhao X., and Zhang G. (2018) Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Review 37:257-267.
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Progress 12/01/17 to 11/30/18
Outputs
Target Audience: This research proposal seeks to better understand the mechanisms by which omega-3 fatty acids modulate eicosanoid signaling pathways to reduce the risks of colon cancer, therefore, the obtained results could benefit the general public, the food industry which works on omega-3 fatty acids, as well as the researchers who work on lipid chemistry and biochemistry. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?With the grant support from this USDA grant, my students have won ~20 campus, national, and international awards, including Best Poster Awards, Best Publication Awards, and Travel Awards. They have performed >30 poster and oral presentations at academic conferences. Some highlighted awards are shown below: Weicang Wang, PhD student, 2014-present: Alumni Fellowship (2013), Graduate Travel Award of American Society for Pharmacology and Experimental Therapeutics (ASPET) (2017), Micha Peleg International Travel Award (2017), Institute of Food Technologists (IFT) Feeding Tomorrow Graduate Scholarship (2017), Phi Tau Sigma Founders Award (2018), Outstanding Poster Award of the 17th International Winter Eicosanoid Meeting (2018), and Travel Award of the Honor Society of Phi Kappa Phi (2018). Katherine Z. Sanidad, PhD student, 2014-present: Best Student Oral Presentation Award of Northeast Chapter of Society of Toxicology (NESOT) (2017), Graduate Travel Award of NESOT (2017), Travel Award of the 24th Annual Meeting of North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry (NACSETAC), (2018), and Best Poster Award of the 24th Annual Meeting of NACSETAC (2018). Elvira Sukamtoh, undergraduate researcher and MS student, 2013-18: Travel Award of IFT (2015), 2nd Place Award of IFT Undergraduate Research Competition (2015), Rising Researcher Award, UMass-Amherst (2015), Travel Award of American Chemical Society (ACS) (2016), 1st Place Award of ACS Undergraduate Student Research Symposium (2016), and Alumni Fellowship (2016). Haixia Yang, postdoctoral fellow, 2016-18: Postdoctoral Poster Award of NESOT (2017), and Best Postdoctoral Publication Award of Society of Toxicology (SOT) (2018). How have the results been disseminated to communities of interest?We have published our findings in academic journals and presented our findings in academic conferences, these activities help the public and the scientific field to know our research activities. What do you plan to do during the next reporting period to accomplish the goals?Our research has shown: (1) omega-3 fatty acids suppress colon tumorigenesis in mouse models (J. Nutr. Biochem. 2-17 48:29-35), and modulated the tissue concentrations of cytochrome P450 (CYP)-derived fatty acid metabolites, and (2) we have shown that the CYP pathway and the CYP-produced fatty acid metabolites play critical roles in regulating colon tumorigenesis (Cancer Research, 2019, in press). In the next stage, we propose to use genetically engineered mouse models to better understand the roles of the CYP pathway in the anti-cancer effects of omega-3 fatty acids.
Impacts
What was accomplished under these goals?
We have made substantial research progress toward Aim 2 and Aim 3, regarding the roles of cytochrome P450 (CYP)-derived fatty acid metabolites in colon cancer. Using a LC-MS/MS-based metabolomics approach, we report that epoxygenated fatty acids (EpFA), which are eicosanoid metabolites produced by CYP monooxygenases, were increased in both the plasma and colon of azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer mice. CYP monooxygenases were overexpressed in colon tumor tissues and colon cancer cells. Pharmacological inhibition or genetic ablation of CYP monooxygenases suppressed AOM/DSS-induced colon tumorigenesis in vivo. In addition, treatment with 12,13- epoxyoctadecenoic acid (EpOME), which is a metabolite of CYP monooxygenase produced from linoleic acid (the most abundant omega-6 fatty acid in human diets), increased cytokine production and JNK phosphorylation in vitro and exacerbated AOM/DSS-induced colon tumorigenesis in vivo. Together these results demonstrate that the previously unappreciated CYP monooxygenase pathway is upregulated in colon cancer, contributes to its pathogenesis, and could be therapeutically explored for preventing or treating colon cancer.
Publications
- Type:
Journal Articles
Status:
Accepted
Year Published:
2019
Citation:
Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Sanidad K.Z., Song M., Bisbee A.H., Bradbury J.A., Nan G., Zhang J., Shih B., Lee K., Minter L.M., Kim D., Xiao H., Liu J., Hammock B.D., Zeldin D.C., and Zhang G. (2019) Targeted metabolomics identifies cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tumorigenesis. Cancer Research, in press
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Sanidad K.Z., Sukamtoh E., Xiao H., McClements D. and Zhang G. (2019) Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability. Annual Review of Food Science and Technology, doi: 10.1146/annurev-food-032818-121738.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Wang Y., Wang W., Yang H., Shao D., Zhao X., and Zhang G. (2019) Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling. Free Radical Biology & Medicine, 131:237-242.
- Type:
Journal Articles
Status:
Published
Year Published:
2019
Citation:
Yang H., Wang W., and Zhang G. (2019) Consumer antimicrobials on gut microbiota and gut health. DNA and Cell Biology, 38:7-9
- Type:
Journal Articles
Status:
Published
Year Published:
2018
Citation:
Wang Y., Wang W., Sanidad K., Shih P., Zhao X., and Zhang G. (2018) Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Review 37:257-267.
- Type:
Journal Articles
Status:
Published
Year Published:
2018
Citation:
Wang W., Yang J., Zhang J., Wang Y., Hwang S., Qi W., Wan D., Kim D., Sun J., Sanidad K.Z., Yang H., Park Y., Liu J., Liu Z., Hammock B.D. and Zhang G. (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proceedings of the National Academy of Sciences 115:5283-5288.
- Type:
Book Chapters
Status:
Under Review
Year Published:
2019
Citation:
Wang W., Sanidad K.Z., and Zhang G. Cytochrome P450 eicosanoid signaling pathway in colorectal tumorigenesis. Submitted (invited contribution for book chapter of Bioactive Lipids).
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Progress 12/01/16 to 11/30/17
Outputs
Target Audience:This research proposal seeks to better understand the mehchanimsms by which omega-3 fatty acids have benecial effects (reducing the risks of colon cancer), therefore, the obtained results could benefit the general public, and the food industry which works on omega-3 fatty acids. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?With the support of the NIFA grant, the graduate students in my laboratory have won several national and international awards, including American Society for Pharmacology and Experimental Therapeutics (ASPET) Graduate Student Travel Award, Micha Peleg International Travel Award, IFT Feeding Tomorrow Graduate Scholarship, and NEIFT scholarship. In addition, with the supports of the NIFA grant, my graduate students have attended several national and international meetings with poster and oral presentations, including: 1.Wang W., Yang J., Song M, Wan D., Yang H., Sanidad K., Hammock B.D., Xiao H, Liu Z, and Zhang G. Lipidomic profiling identifies cytochrome P450 as a therapeutic target for colitis-associated colorectal cancer. Experimental Biology National Meeting, Chicago, IL, 22-26 April, 2017 (oral and poster presentation) 2.Sanidad K.Z., Wang W., Zhu J., Nimiya Y., Sukamtoh E., Du Z., and Zhang G. Manipulation of curcumin degradation to enhance its stability and biological activity.Experimental Biology National Meeting, Chicago, IL, 22-26 April, 2017 (poster) 3.Wang W., Yang H., Johnson D. Sanidad K., Sukamtoh E., Xiao H., Decker E., Zhang G. Oxidized corn oil increases colon inflammation and colon cancer. 2017 SRA conference, Amherst, MA, April, 2017 (oral finalistand poster presentation). How have the results been disseminated to communities of interest?We have (1) published our findings in peer-reviewed journals, (2) presented our findings in national adn international meetings, and (3) applied patents of our technology. In addiiton, we have intensive collaboration with food industry, for example, our recent publish(Wang W., Yang J., Nimiya Y., Lee K., Sanidad K., Qi W., Sukamtoh E., Park Y., Liu, Z., and Zhang G.(2017) ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.J. Nutr. Biochem.48:29-35) was through a close collaboration with DSM Inc (one of the largest omega-3 fatty acid producers in US and the world). What do you plan to do during the next reporting period to accomplish the goals?In this proposal, we seek to understand the roles of cytochrome P450 epoxygenases in the anti-colon cancer effects of omega-3 fatty acids. Through our research, we discovered that P450 epoxygenases play a central andessnetial roles in the pathology of colon cancer. This research is within our NIFA proposal, and in the future, we seek to better understand the mechanisms by which P450 epoxygenases contribute to colon cancer, and the roles of P450 epoxygenase pathway in the anti-colon cancer effects of omega-3 fatty acids.
Impacts
What was accomplished under these goals?
Our recent publication (Wang W., Yang J., Nimiya Y., Lee K., Sanidad K., Qi W., Sukamtoh E., Park Y., Liu, Z., and Zhang G.(2017) ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.J. Nutr. Biochem.48:29-35) showed that: (1) dietary feeding of omega-3 fatty acids suppressed colon tumor growth in mice (Aim 1), (2) dietary feeding of omega-3 fatty acids suppressed levels of omega-6-series lipid metabolites and increased levels of omega-3 series of lipid metabolites in the plasma and tissues of mice (Aim 2), and (3)the P450 metabolite of omega-3 fatty acids, termed EDPs, suppressed colon tumor growth and reduced expressions of pro-tumorigenic genes in mice (Aim 3).Together, the findings presented in this published manuscript investigate the three specific aims proposed in our project, and successfully get the expected results. In addition, in 2017 we have filed a US patent "Zhang G., Hammock B.D., Hwang S. and Wang W. (2017) SYNTHESIS AND USE OF OMEGA-HYDROXYLATED POLYUNSATURATED FATTY ACIDS, PCTPatentApplication No. PCT/US2017/047113". In this patent, we discovered that P450 metabolites of omega-3 fatty acids have potent effects to suppress angiogenesis and colon tumor growth in mice.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2017
Citation:
Wang W., Yang J., Nimiya Y., Lee K., Sanidad K., Qi W., Sukamtoh E., Park Y., Liu, Z., and Zhang G.(2017) ?-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. J. Nutr. Biochem. 48:29-35.
- Type:
Journal Articles
Status:
Published
Year Published:
2017
Citation:
Wang W., Yang J., Qi W., Yang H., Wang C., Tan B., Hammock B.D., Park Y., Kim D., and Zhang G.(2017) Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity, 25, 132-140.
- Type:
Journal Articles
Status:
Published
Year Published:
2017
Citation:
Wang W., Yang H., Johnson D., Gensler C., Decker E., and Zhang G. (2017) Chemistry and biology of ?-3 PUFA peroxidation-derived compounds. Prostaglandins Other Lipid Mediat. https://doi.org/10.1016/j.prostaglandins.2016.12.004.
- Type:
Journal Articles
Status:
Published
Year Published:
2017
Citation:
Zhu J., Sanidad K., Sukamtoh E., and Zhang G. (2017) Potential roles of chemical degradation in biological activities of curcumin. Food Funct. 8, 907-914
- Type:
Journal Articles
Status:
Published
Year Published:
2017
Citation:
Yang H., Du Z., Wang W., Sukamtoh E., Zheng J., Sanidad K., and Zhang G. (2017) Structure and activity relationship of curucmin: role of methoxy groups in its anti-inflammatory and anti-colitis effects. J. Agric. Food Chem. 65:45094515.
- Type:
Journal Articles
Status:
Published
Year Published:
2016
Citation:
Wang W., Yang J., Yang H., Sanidad K., Hammock B.D., Kim D., and Zhang G.(#). (2016) Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice. Prostaglandins Other Lipid Mediat. 127:9-13.
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Progress 12/01/15 to 11/30/16
Outputs
Target Audience:(1) Food industry: we are collaborating with several major ω-3 PUFA companies in US and in Europe, such as DSM and Solutex Inc. Our research to demonstrate the beneficial effects and mechanisms of ω-3 PUFAs will help the ω-3 PUFA industry. (2) Generla public: we will publish our results in peer-reviewed publicaitons, since ω-3 PUFAs are among the most widely food supplements in US and are being added into various food products, the published results could impact the general public. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?The NIFA funding supports graduate student (Weicang Wang) to present his research of lipidomics analysis at several international meetings, including the 16th International Winter Eicosanoid Conference, Baltimore, MD, and Experimental Biology National Meeting, San Diego, CA, 2-6 April, 2016. These meeting presentations will help the students to advance their career development. How have the results been disseminated to communities of interest?We are collaborating with several major ω-3 PUFA companies in US and in Europe, such as DSM and Solutex Inc. Our research to demonstrate the beneficial effects and mechanisms of ω-3 PUFAs will help the ω-3 PUFA industry. What do you plan to do during the next reporting period to accomplish the goals?Our research so far has shown that cytochrome P450 epoxygenase pathway is essential for the progression of AOM/DSS-induced colon cancer. Our next step is to study the roles of this pathway in the anti-cancer effects of ω-3 PUFAs, as we proposed in the research proposal. We will use transgenic mice to modulate the P450-epoxygenase-mediated metabolism of ω-3 PUFAs, in order to elucidate the roles of P450 epoxygenase pathway in the anti-cancer effect of ω-3 PUFAs.
Impacts
What was accomplished under these goals?
Our recent research showed that: (1) dietary feeding of ω-3 PUFA-rich diet inhibited colon tumor growth in C57BL/6 mice, with reduced tumor angiogenesis and inflammation (Specific Aim 1 of the proposal), (2) dietary feeding of ω-3 PUFA-rich diets modulated tissue levels of lipid metabolites, with enhanced ω-3-series fatty acid epoxides and decreased ω-6-series fatty acid epoxides (Spefici Aim 2 of the proposal), (3) systematic treatment with ω-3-series fatty acid epoxides, termed epoxydocosapentaenoic acids (EDPs, cytochrome P450 metabolites of ω-3 PUFAs), inhibited colon tumor growth in C57BL/6 mice, and reduced immune cell infiltration into tumors (Specific Aim 3 of the proposal). We are preparing a manuscript for submission. In addition, For Aim 3, we hypothesize that cytochrome P450 epoxygenase pathway plays critical roles in colon cancer. Our recent research showed that: (1) in AOM/DSS-induced colon cancer model in C57BL/6 mice, only cytochrome P450 epoxygenase-derived lipid metabolites were significantly increased in both plasma and colon tissues of AOM/DSS-treated mice, and (2) inhibition of P450 epoxygenases suppressed AOM/DSS-induced colon cancer. These results strongly support our hypothesis for Aim 3 that cytochrome P450 epoxygenase pathway is essential for colon cancer progression. We have submitted this manuscript to Cancer Research and it is currently under review.
Publications
- Type:
Journal Articles
Status:
Accepted
Year Published:
2016
Citation:
Wang W., Yang J., Qi W., Yang H., Wang C., Tan B., Hammock B.D., Park Y., Kim D., and Zhang G.(#) (2016) Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity, in press.
- Type:
Journal Articles
Status:
Published
Year Published:
2016
Citation:
8. Sanidad K.*, Sukamtoh E.*, Wang W., Du Z., Florio E., He L., Xiao H., Decker E. and Zhang G.(#) (2016) Oxidative conversion mediates anti-proliferative effects of tert-butylhydroquinone (TBHQ): structure and activity relationship study. J. Agric. Food Chem. 64:3743-8.
- Type:
Journal Articles
Status:
Under Review
Year Published:
2016
Citation:
Wang W., Yang H., Johnson D., Gensler C., Decker E., and Zhang G.(#) (2016) Chemistry and biology of ?-3 PUFA peroxidation-derived compounds. Submitted to Prostaglandins Other Lipid Mediat.
- Type:
Journal Articles
Status:
Under Review
Year Published:
2016
Citation:
Wang W., Yang J., Song M., Wan D., Yang H., Sanidad K., Hammock B.D., Xiao H., Liu Z., and Zhang G.(#). Lipidomic profiling identifies cytochrome P450 as a therapeutic target for colitis-associated colorectal cancer. Submitted to Cancer Research.
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