THE CALIFORNIA FAMILIES PROJECT: UNDERSTANDING BIOLOGICAL CHANGES IN ADOLESCENCE AND EARLY ADULTHOOD

• Sponsoring Institution: National Institute of Food and Agriculture
• Project Status: COMPLETE
• Funding Source: HATCH
• Reporting Frequency: Annual
• Accession No.: 1004914
• Project Start Date: Oct 1, 2014
• Project End Date: Sep 30, 2019
• Program Code: [(N/A)]- (N/A)

Recipient Organization
UNIVERSITY OF CALIFORNIA, DAVIS
410 MRAK HALL
DAVIS,CA 95616-8671

Performing Department
Human Ecology

Non Technical Summary
Depression is a common psychiatric illness that often begins in adolescence and adds to high mental health costs in the United States. Some depression can be normal and short-lived, but having a depressive disorder in adolescence can lead to other mental illnesses such as anxiety disorders, substance abuse, and suicide in adolescence and adulthood. Thus, it is important to study depression during adolescence in order to identify risk factors for depressive disorders before functioning is impaired. The ways in which the body physiologically responds and adapts to stress has been linked with the development of depression. Little is known how these biological processes work in Mexican-origin youth, which is important given that Mexican-origin adolescents show higher rates of depression symptoms and diagnoses relative to peers of other racial/ethnic groups and suicide is the third leading cause of death among 10-20 year old Hispanics in the U.S. If it is not treated early, depression can lead to 1) repeated school absences/inability to finish school; 2) impaired peer relations; 3) low self-esteem; 4) alcohol/drug use; and 5) problems adjusting in the workforce. Despite this importance, depression in Mexican-origin youth has been understudied, particularly from a neurobiological perspective. It is only recently that non-invasive neuroimaging methods have been available for scientists to safely study neurobiology involved in depression. Using neuroimaging techniques and other methods to assess physiology in humans allows for a tighter integration between animal and clinical research on depression, provides a better understanding of the development of depression, and helps create better treatments for depression. This project will examine neurobiological data (e.g., brain function, immune function, cardiovascular physiology, and stress reactivity), psychiatric symptoms and diagnoses, and reports on family, peers, behavior and functioning in Mexican-origin adolescents who have elevated depressive symptoms. This approach will address new questions about the relationships between the brain and social contexts in the development of depression. If a specific profile of neurobiological functioning is associated with the symptoms of depression, then such assessments might be helpful for identifying youth with high risk for depression. The project's results will be analyzed, evaluated, and interpreted to provide informational sessions and workshops for parents, teachers, and clinicians as well as local mental health service providers and schools about depression and associated risk factors in youth.

Animal Health Component

100%

Research Effort Categories

Basic

(N/A)

Applied

100%

Developmental

(N/A)

Classification

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
802	6010	3070	100%

Knowledge Area
802 - Human Development and Family Well-Being;

Subject Of Investigation
6010 - Individuals;

Field Of Science
3070 - Psychology;

Keywords

adolescence

youth

depression

mental health

brain function

neurobiology

family

stress

Goals / Objectives
The goals and objectives of this project are to serve the welfare of people in California by understanding the development of depression and associated risk factors in youth. These goals will be implemented by conducting research that examines relationships neurobiological and social contextual factors in a sample of adolescents Mexican-origin adolescents studied since childhood. The objectives are to 1) analyze, summarize, and disseminate results from this project; 2) mentor students and postdoctoral trainees in the study of depression and associated neurobiological and social contextual risk factors in youth; and 3) teach the public about depression and associated risk factors in youth.

Project Methods
From the 673 Mexican-origin families participating in the California Families Project (CFP; UC Davis, Family Research Group), 250 adolescents in Grade 11, aged 16-17 years, and their parents will participate in the current project. This will include equal numbers of male and female youths, with 125 youths recruited in 2012-13, and 125 youths recruited in 2013-14. Adolescents will be recruited based on their scores on two measures of depression symptoms that are administered in the CFP, the Major Depressive Disorder (MDD) symptom count from the Diagnostic Interview Schedule for Children-IV (DISC-IV), and the Anhedonic Depression scale from the Mini Mood and Anxiety Symptom Questionnaire (Mini-MASQ). Youths above the sample median on either measure will be eligible to participate. Exclusion criteria will include factors that preclude completion of the magnetic resonance imaging (MRI) procedures. Neurobiological data collection will occur twice, two years apart. Neural, immunological, adrenocortical, and autonomic data will be collected simultaneously during lab visits. Adolescents and their parents will also complete behavioral measures of executive functioning using computer-administered tasks, and will complete questionnaires. In the final two years of the study, psychiatric interviews and questionnaire measures will be administered to the young adults (18-19 years) by telephone interview.Participants will complete MRI scans at the UC Davis Imaging Research Center (IRC) on a Tim Trio 3.0 Tesla imaging scanner (Siemens, AG) using identical parameters per assessment per task. Participants will be trained on tasks and acclimated to the MRI environment in a simulator (~30 min). Mock scanning allows participants to learn how to monitor their body movements. Prior to entering the actual scanner, youths will have electrodes applied to their body and complete a 5 minute resting baseline for psychophysiological data collection using BioPac systems. Adolescents' height, weight and blood pressure will be recorded. Actual imaging in the scanner will then begin, during which youths will complete three tasks. Adolescents also will be asked to provide 7 saliva samples before, during and after the scan, from which cortisol and interleukin-6 will be assayed. Procedures will be stopped immediately at the participant's request or any signs of significant distress. After each task, adolescents will report on their subjective task experiences (e.g., how much they liked each cue/event, how they felt during the scan) to verify they understood instructions and appropriately interpreted task stimuli.By examining these questionnaire self- and parent-reports and family observational measures obtained in childhood and in adolescence, along with fMRI data in adolescence, the PI will address new questions that have been untapped about the interplay between the brain and behavior in risk for depression in Mexican-origin adolescents. Results of the project will be analyzed, evaluated, and interpreted in order to inform parents, teachers, and clinicians as well as local mental health service providers and schools in the community through informational sessions and workshops about anxiety and associated risk factors in youth.Efforts involved in this project will include laboratory instruction, experiential learning opportunities, and outreach to the community with information about depression and associated risk factors in youth. These efforts can cause a 1) change in knowledge for scientists and trainees through new knowledge contained in publications as well as increased knowledge that affects skills of youth, parents, teachers, and clinicians and 2) change in action through new therapeutic approaches used by clinicians as well as parenting and teaching skills of parents and teachers. The success of the project for its impact on the intended audiences will be evaluated based on the presentations and publications generated from this project by the PI and the PI's students and trainees. In addition, indicators of the success of outreach activities, such as informational sessions and workshops for parents, teachers, and clinicians in the community will be collected and summarized to evaluate the project's impact on the public.

Progress 10/01/14 to 09/30/19

Outputs
Target Audience:Target audiences were adolescents, parents, educators and mental health service providers in the community reached through popular media such as social media, newspapers, magazines, and public lectures. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?The project provided opportunities for high school, undergraduate, and graduate students, as well as postdoctoral research trainees to learn how to analyze, prepare and deliver data/results for public dissemination. One junior faculty member, for whom I served as a mentor, published a paper in collaboration through a career development mechanism. One graduate student completed his dissertation from this project. Two other graduate students presented findings from this project at a scientific meeting. How have the results been disseminated to communities of interest?During this project period, results were disseminated through lectures and learning objectives for mental health clinicians and educators who represented key target communities of interest for this project. In addition, results from the project were discussed with middle school youth in the community. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? The goals and objectives of this project were to serve the welfare of people in California by understanding the development of depression and associated risk factors in youth. The objectives were to 1) analyze, summarize, and disseminate results from this project; 2) mentor students and postdoctoral trainees in the study of depression and associated neurobiological and social contextual risk factors in youth; and 3) teach the public about depression and associated risk factors in youth. Objective 1 was met by publishing empirical research studies of how neurobiological and social contextual factors influence the development of depression in a sample of Mexican-origin adolescents residing in California. Adolescents completed neurobiological assessments at 16 and at 18 years old that measure brain (function and structure) and physiological (immunological, autonomic, and adrenocortical) markers of neurobiological reactivity to social and emotional challenges. This project was innovative because it combined multiple measures of neurobiology with psychosocial data using a longitudinal design within an ethnic minority sample in California, and the project advanced knowledge about an understudied population in human developmental neuroscience and mental health. We showed that brain function moderates relations between stressful and supportive social-contextual experiences and youths' adjustment and distinguished between experiences strongly related to externalizing problems versus other experiences predictive of depressive symptoms. Adverse (community crime) and advantageous (family connection) experiences predicted depression symptoms differentially depending on adolescents' hippocampal volume. The hippocampus, a brain region central to learning and regulating stress, is affected negatively by adversity. Adolescents with larger hippocampal volumes reported more depressive symptoms when family connection was low but fewer symptoms when it was high; smaller volume was not sensitive to divergent degrees of family connection in relation to symptoms. Thus, low family connection may potentiate risk for depression particularly in adolescents with larger hippocampi. Further, we showed that exposure to hostile school contexts predicted stronger subgenual anterior cingulate cortex response to a social stressor (social exclusion), which in turn predicted engaging in deviant behavior, but that youths were protected from this effect by having stronger family connections. We have also found that adolescents whose family income increased showed greater connectivity between long-range brain areas. This finding was important because it suggests having more financial resources in adolescence, especially among adolescents in poverty, may alleviate stressors thereby influencing development of large-scale brain networks. Another result was showing that adolescents' neural response is coordinated with autonomic nervous system response during emotion processing, which was also related to their depression and anxiety; this was the first study to report a dynamic link between brain activity and physiological activity in adolescents. Finally, we found that problematic alcohol use for males and females stems from different neural systems involved in reward processing and cognitive control; patterns of neural activity in males corresponded to a sensation-seeking/impulsive pathway of risk whereas in females they corresponded to a depression pathway of risk. Objective 2 was met by involving graduate students and postdoctoral trainees in the research process from start to finish. Several graduate students and postdoctoral trainees were involved in or led the publications and conference presentations generated from this project. Objective 3 was met through my outreach efforts discussing the study's findings with adolescents, parents, educators and clinicians in public and mental health face-to-face and developing new ideas about the application and translation of my results for their clients and students. Thus, overall this project led to changes in knowledge due to scientists, trainees, and citizens learning about these findings.

Publications

• Type: Journal Articles Status: Published Year Published: 2019 Citation: Weissman, D. G., Guyer, A. E., Ferrer, E., Robins, R. W., & Hastings, P. D. (2019). Tuning of brain-autonomic coupling by prior threat exposure: Implications for internalizing problems in Mexican-origin adolescents. Development and Psychopathology, 31, 1127-1141. doi: 10.1017 S0954579419000646
• Type: Journal Articles Status: Published Year Published: 2019 Citation: Swartz, J.R., Weissman, D.G., Ferrer, E., Beard, S.J., Fassbender, C., Robins, R.W., Hastings, P.D., & Guyer A.E. (2019). Reward-related brain activity prospectively predicts increases in alcohol use in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. doi: 10.1016/j.jaac.2019.05.022
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2019 Citation: Beard, S., Chahal, R., Weissman, D., Robins, R., Hastings, P., & Guyer, A. E. (March, 2019). Neural response to social exclusion, depressive symptoms, and substance use in Mexican-origin adolescents. Poster presented at the Biennial Meeting of the Society for Research in Child Development, Baltimore, MD.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2019 Citation: Manning, R. A., Parra, L.A., Weissman, D.G. Robins, R. W., Guyer, A. E., & Hastings, P.D. (March, 2019). Rumination mediates associations between family relationship quality and depressive symptoms in a sample of Mexican-origin adolescents. Poster presented at the Biennial Meeting of the Society for Research in Child Development, Baltimore, MD.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2019 Citation: Hastings, P.D., Parra, L.A., Johnson, E., Weissman, D.G. Robins, R., W., & Guyer, A. E. (March, 2019). Poverty potentiates the association of parental conflict with elevated cytokines and depression in Mexican-origin adolescents. Paper presented at the Biennial Meeting of the Society for Research in Child Development, Baltimore, MD.

Progress 10/01/17 to 09/30/18

Outputs
Target Audience:Target audiences continue to be adolescents, parents, educators and mental health service providers through popular media such as television, radio, magazines, and public lectures. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?The project has provided opportunities for high school, undergraduate, and graduate students, as well as postdoctoral research trainees to learn how to analyze, prepare and deliver data/results for public dissemination. One graduate student completed his dissertation from this project. How have the results been disseminated to communities of interest?During this project year, the results were disseminated through lectures and learning objectives for mental health clinicians and educators who represent key target communities of interest for this project. In addition, results were discussed with middle school youth in the community. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period, plans to accomplish the goals include development of publications, conference presentations, student training and mentoring, and dissemination of results through schools and to parents.

Impacts
What was accomplished under these goals? Under the major goals of this project an outcome through my outreach efforts was discussing my findings with educators and clinicians in public and mental health face-to-face and developing new ideas about the application and translation of my results for their clients and students. We produced some new publications and conference presentations, which has been another major goal.

Publications

• Type: Conference Papers and Presentations Status: Accepted Year Published: 2018 Citation: Guyer, A. E. (April, 2018). Risk and resilience mechanisms underlying dimensions of psychopathology during adolescence. In M. Sheridan (chair), RDoC: A lens for understanding changes in adolescent brain and behavior. Invited paper symposium presented at the Biennial Meeting for the Society of Research on Adolescence, Minneapolis, Minnesota.
• Type: Journal Articles Status: Published Year Published: 2018 Citation: Weissman, D. G., Conger, R. D., Robins, R. W., Hastings, P.D., & Guyer, A. E. (2018). Income change alters default mode network connectivity for adolescents in poverty. Developmental Cognitive Neuroscience, 30, 93-99. doi: 10.1016/j.dcn.2018.01.008
• Type: Journal Articles Status: Published Year Published: 2018 Citation: Weissman, D. G., Gelardi, K. L., Conger, R. D., Robins, R. W., Hastings, P.D., & Guyer, A. E. (2018). Adolescent externalizing problems: Contributions of community crime exposure and neural function during emotion introspection in Mexican-Origin Youth. Journal of Research on Adolescence, 28, 551-563. doi: 10.1111/jora.12358
• Type: Journal Articles Status: Under Review Year Published: 2018 Citation: Weissman, D. G., Guyer, A. E., Ferrer, E., Robins, R. W., & Hastings, P. D. (In review). Tuning of brain-autonomic coupling by prior threat exposure: Implications for internalizing problems in Mexican-origin adolescents. Development and Psychopathology.
• Type: Journal Articles Status: Under Review Year Published: 2018 Citation: Swartz, J.R., Weissman, D.G., Ferrer, E., Beard, S.J., Fassbender, C., Robins, R.W., Hastings, P.D., & Guyer A.E. (In review). Reward-related brain activity prospectively predicts increases in alcohol use in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2018 Citation: Johnson, L., Parra, L.A., Weissman, D.G., Ugarte, E., Robins, R., Guyer, A. E., & Hastings, P. D. (September, 2018). Poverty and family conflict impact cortisol reactivity, differentially by timing of stressor. International Society of Psychoneuroendocrinology, Newport Beach, California.
• Type: Journal Articles Status: Published Year Published: 2018 Citation: Weissman, D. G., Guyer, A. E., Ferrer, E., Robins, R. W., & Hastings, P. D. (2018). Adolescents brain-autonomic coupling during emotion processing. NeuroImage, 183, 818-827. doi: 10.1016/j.neuroimage.2018.08.069
• Type: Journal Articles Status: Published Year Published: 2018 Citation: Schriber, R. A., Rogers, C. R., Ferrer, E., Conger, R. D., Robins, R. W., Hastings, P. D., & Guyer, A. E. (2018). Do hostile school environments promote social deviance by shaping neural responses to social exclusion? Journal of Research on Adolescence, 28, 103-120. doi: 10.1111/jora.12340
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2018 Citation: Swartz, J. R., Weissman, D. G., Robins, R. W., Hastings, P. D., & Guyer, A. E. (May, 2018). Developmental patterns of life stress predict reward-related brain function in adolescence. Paper presented at the Annual Meeting for the Association for Psychological Science, San Francisco, California.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2018 Citation: Guyer, A. E. (April, 2018). Considering the future of developmental science. Panelist for invited roundtable presented at the Biennial Meeting for the Society of Research on Adolescence, Minneapolis, Minnesota.

Progress 10/01/16 to 09/30/17

Outputs
Target Audience:Target audiences continue to be adolescents, parents, educators and mental health service providers through popular media such as television, radio, magazines, and public lectures. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?The project has provided opportunities for high school, undergraduate, and graduate students, as well as postdoctoral research trainees to learn how to analyze, prepare and deliver data/results for public dissemination. How have the results been disseminated to communities of interest?During this project year, the results were disseminated through lectures and learning objectives for mental health clinicians and educators who represent key target communities of interest for this project. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period, plans to accomplish the goals include development of publications, conference presentations, student training and mentoring, and dissemination of results through schools and to parents.

Impacts
What was accomplished under these goals? Under the major goals of this project an outcome through my outreach efforts was discussing my findings with educators and clinicians in public and mental health face-to-face and developing new ideas about the application and translation of my results for their clients and students. We produced some new publications and conference presentations, which has been another major goal.

Publications

• Type: Journal Articles Status: Published Year Published: 2017 Citation: Weissman, D. G., Gelardi, K. L., Conger, R. D., Robins, R. W., Hastings, P.D., & Guyer, A. E. (2017). Adolescent externalizing problems: Contributions of community crime exposure and neural function during emotion introspection in Mexican-Origin Youth. Journal of Research on Adolescence. doi: 10.1111/jora.12358
• Type: Journal Articles Status: Published Year Published: 2017 Citation: Schriber, R. A., Anbari, Z., Robins, R. W., Conger, R. D., Hastings, P. D., & Guyer, A. E. (2017). Hippocampal volume as an amplifier of the effect of social context on adolescent depression. Clinical Psychological Science, 5, 632 -649. doi: 10.1177/2167702617699277
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2017 Citation: Weissman, D. G., Robins, R. W., Guyer, A. E., & Hastings, P. D. (April, 2017). Effects of depression on neurovisceral integration during emotion processing in Mexican-origin youth. In N. Tottenham & M. VanTiegham (Co-chairs), Developmental psychopathology and neuroscience: Emotion dysregulation at multiple levels of analysis. Symposium paper presented at the Biennial Meeting of the Society for Research in Child Development, Austin, Texas.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2017 Citation: Weissman, D. G., Robins, R. W., Hastings, P. D., & Guyer, A. E. (April, 2017). Income improvement across adolescence predicts increased default network connectivity in Mexican-origin youth. In C. E. Hostinar (chair), What promotes better outcomes for children experiencing poverty? Multilevel investigations of resilience. Symposium paper presented at the Biennial Meeting of the Society for Research in Child Development, Austin, Texas.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2017 Citation: Schriber, R. A., Rogers, C. R., Ferrer, E., Conger, R. D., Robins, R. W., Hastings, P. D., & Guyer, A. E. (March, 2017). Do hostile school environments promote social deviance by shaping neural response to social exclusion? An fMRI study in Mexican-origin adolescents. Poster presented at the Tenth Annual Meeting of the Social and Affective Neuroscience Society, Los Angeles, California.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Guyer, A. E. (November, 2016). Depression and the changing adolescent brain. Invited talk presented at the Neuroscience of Youth Depression at the University of North Carolina, Chapel Hill, Chapel Hill, North Carolina.
• Type: Journal Articles Status: Awaiting Publication Year Published: 2017 Citation: Schriber, R. A., Rogers, C. R., Ferrer, E., Conger, R. D., Robins, R. W., Hastings, P. D., & Guyer, A. E. (In press). Do hostile school environments promote social deviance by shaping neural responses to social exclusion? Journal of Research on Adolescence.

Progress 10/01/15 to 09/30/16

Outputs
Target Audience:Target audiences continue to be adolescents, parents, educators and mental health service providers through popular media such as television, radio, magazines, and public lectures. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?The project has provided opportunities for high school, undergraduate, and graduate students, as well as postdoctoral research trainees to learn how to analyze, prepare and deliver data/results for public dissemination. How have the results been disseminated to communities of interest?During this project year, the results were disseminated through lectures and learning objectives for mental health clinicians and educators who represent key target communities of interest for this project. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period, plans to accomplish the goals include development of publications, conference presentations, student training and mentoring, and dissemination of results through schools and to parents.

Impacts
What was accomplished under these goals? Under the major goals of this project an outcome through my outreach efforts was discussing my findings with educators and clinicians in public and mental health face-to-face and developing new ideas about the application and translation of my results for their clients and students. Another outcome was the invitation to present at the John D. Wiley Seminar Series, Waisman Center, University of Wisconsin, Madison, which had an impact on knowledge about contextual influences, brain development and depression for mental health clinicians and practitioners, as well as educators. We produced some new publications and conference presentations, which has been another major goal.

Publications

• Type: Journal Articles Status: Published Year Published: 2016 Citation: Schriber, R. A. & Guyer, A. E. (2016). Adolescent neurobiological susceptibility to social context. Developmental Cognitive Neuroscience, 19, 1-18.
• Type: Journal Articles Status: Published Year Published: 2016 Citation: Guyer, A. E., Nelson, E. E., & Silk, J. S. (2016). The neurobiology of the emotional adolescent: From the inside out. Neuroscience and Biobehavioral Reviews.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Guyer, A. E. (April, 2016). The adolescent brain within a sociocultural context. In A. Fuligni (chair), Sociocultural processes, brain, and biology during adolescence. Invited symposium paper presented at the Biennial Meeting of the Society for Research on Adolescence, Baltimore, Maryland.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Weissman, D. G., Hastings, P.D., Robins, R. W., Guyer, A. E. (April, 2016). Exposure to community crime and Mexican-origin adolescents' neural processing of emotional faces. Poster presentation at the Biennial Meeting of the Society for Research in Adolescence, Baltimore, Maryland.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Guyer, A. E. (June, 2016). Stress, affect, and the teenage brain. In B. Giesbrecht and M. de Vos (co-organizers), The stressed brain. Invited talk for the Kavli Summer Institute in Cognitive Neuroscience, Santa Barbara, California.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Weissman, D. G., Guyer, A. E., Gelardi, K. L., Hastings, P.D., Robins, R. W. (September, 2016). Community crime exposure, neural response to sad faces, and adolescent externalizing problems. Poster presentation at the 4th Annual Flux Congress, St. Louis, Missouri.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Schriber, R. A., Anbari, Z., Hastings, P. D., & Guyer, A. E. (September, 2016). Hippocampal volume and sensitivity to social context in the emergence of depression in adolescence. Poster presentation at the 4th Annual Flux Congress, St. Louis, Missouri.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Miller, J. G., Weissman, D. G., Hastings, P. D., & Guyer, A. E. (September, 2016). Cognitive reappraisal interacts with motivation-related neural responses to sad faces to predict individual differences in adolescent prosociality. Poster presentation at the Fifty-sixth Annual Meeting of the Society for Psychophysiological Research, Minneapolis, Minnesota.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2016 Citation: Guyer, A. E. (February, 2016). Integrating developmental neuroscience and psychosocial context to better understand adolescent psychopathology. Invited talk for the John D. Wiley Seminar Series, Waisman Center, University of Wisconsin, Madison, Wisconsin.

Progress 10/01/14 to 09/30/15

Outputs
Target Audience:Target audiences continue to be adolescents, parents, educators and mental health service providers through popular media such as television, radio, magazines, and public lectures. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?The project has provided opportunities for undergraduate and graduate students, as well as research trainees to learn how to analyze, prepare and deliver data/results for public dissemination. How have the results been disseminated to communities of interest?During this project year, the results were disseminated through lectures and learning objectives for mental health clinicians and educators who represent key target communities of interest for this project. What do you plan to do during the next reporting period to accomplish the goals?During the next reporting period, plans to accomplish the goals include development of publications, conference presentations, student training and mentoring, and dissemination of results through schools and to parents.

Impacts
What was accomplished under these goals? Under the major goals of this project an outcome through my outreach efforts was discussing my findings with educators and clinicians in public and mental health face-to-face and developing new ideas about the application and translation of my results for their clients and students. Another outcome was the invitation to present at the Frontiers of Innovation Initiative at the Harvard University Center for the Developing Child as well as the Symposium on Advances in Adolescent Neurodevelopment: Context, Brain and Behavior at UCLA which had an impact on knowledge about brain development and depression for mental health clinicians and practitioners, as well as educators. Finally, even though this was the first year of the project, we produced many new conference presentations, which has been another major goal.

Publications

• Type: Conference Papers and Presentations Status: Accepted Year Published: 2014 Citation: Guyer, A. E. (November, 2014). Peers and parents in the brain: The neurobiology of social behavior. Invited talk for the School of Education Brown Bag Series, Harvard University, Boston, Massachusetts.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2014 Citation: Guyer, A. E. (November, 2014). Translating research on self-regulation to achieve breakthrough outcomes for young children and families facing adversity. Invited talk for the Frontiers of Innovation Initiative, Center for the Developing Child at Harvard University, Boston, Massachusetts.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2014 Citation: Guyer, A. E., Anbari, Z., Schriber, R. A., & Hastings, P. D. (December, 2014). Hippocampal volume and gender differentially predict rumination in adolescents at-risk for depression. Poster presented at the Annual Meeting of the American College of Neuropsychopharmacology, Phoenix, Arizona.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2015 Citation: Lee, C. C., Helm, J., Schofield, T., Robins, R. W., & Guyer, A. E. Perception of neighborhood disorder and risk-taking among Mexican-origin adolescents (March, 2015). In A. E. Guyer & C. C. Lee (chairs), Empirical tests of neighborhoods to neurons in the development of risky behaviors among Mexican-origin adolescents. Symposium paper presented at the Biennial Meeting of the Society for Research in Child Development, Philadelphia, Pennsylvania.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2015 Citation: Schriber, R. A., Fassbender, C., Ferrer, E., Conger, R. D., Robins, R. W., Hastings, P. D., & Guyer, A. E. (April, 2015). How does ethnic discrimination relate to risk for depression through neural reactivity to social exclusion? Poster presented at the 2nd Annual Meeting of the Society for Affective Science,�Oakland, California.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2015 Citation: Guyer, A. E. (May, 2015). Tracking changes in the brain, psychosocial contexts, and outcomes across adolescence. Invited talk for the Symposium on Advances in Adolescent Neurodevelopment: Context, Brain and Behavior, University of California, Los Angeles, California.
• Type: Conference Papers and Presentations Status: Accepted Year Published: 2015 Citation: Hastings, P. D., Gonzales, J., Schriber, R., Weissman, D., & Guyer, A. E. (October, 2015). What do person-centered approaches to examining multi-system biobehavioral relations buy us? In K. Buss (chair), Using biobehavioral profiles to decrease heterogeneity, improve specificity and prediction of risk. Symposium paper presented at the 55th Annual Meeting of the Society for Psychophysiological Research, Seattle, Washington.