Recipient Organization
Federation of American Societies for Experimental Biology
9650 ROCKVILLE PIKE
BETHESDA,MD 20814-3998
Performing Department
OSMC
Non Technical Summary
This application is for a conference grant to bring together scientists to advance knowledge of the function and efficacy of nutrients and/or other dietary bioactive components in promoting health. This science research conference (SRC), entitled "Nutrient Sensing and Metabolic Signaling", is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will be held in Big Sky, MT on August 10-15, 2014. Invited speakers consist of internationally-respected experts who are opinion leaders in the fields of nutrition, metabolism, immunity, microbiology, endocrinology, biochemistry and molecular biology. We expect the scope of this meeting will attract a significant and cross-disciplinary audience of attendees. This conference is highly responsive to the USDA program "Function and Efficacy of Foods - Priority Code - A1341", prioritizing studies on the role of bioactive components in food in preventing inflammation or promoting gastrointestinal health.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Goals / Objectives
The major goals/learning objectives for this meeting are:Define nutrient sensing mechanisms and their involvement in the regulation of interorgan metabolism.Describe nutrient actions in the regulation of gene transcription, epigenetics, signal transduction events, and microbiome diversity.Explore the role of nutrients in promoting dyslipidemia and inflammation.Identify mechanisms by which nutrients or bioactive food components influence insulin resistance, dyslipidemia and metabolic syndrome.
Project Methods
The meeting will commence on Sunday, August 10, 2014, with a keynote address. Then on each of the following 4 days (August 11-14), two daily sessions 2 hrs long will typically consist of 4 regular talks (20 minutes, 5 minutes discussion) followed by one short talk (15 minutes, 5 minutes discussion) from a junior investigator. Talks will emphasize the use of multiple experimental approaches and model systems, including cell and molecular biology, epigenetics and gene expression profiling, diverse animal models, advanced imaging techniques and discussion of how the microbiome interfaces with metabolism. One or more poster sessions will be spread throughout the week based on number of submissions, and an abstract/ poster competition for trainees will be scheduled. The meeting ends on Friday, August 15, 2014.Keynote Presentation: Gerald I. Shulman, M.D., Ph.D., Yale University School of Medicine, "Cellular Mechanisms of Lipid-Induced Insulin Resistance: Implications for Obesity, Lipodystrophy and Type 2 Diabetes"Session 1: Regulation of Chromatin Structure and Transcription by Nutrients1. Michael Kilberg, Ph.D. (Chair), University of Florida, "Transcription Factor Networks Associated with Amino Acid Limitation"2. Joan Conaway, Ph.D., Stowers Institute, "ATF6 Recruits Multiple Chromatin-Associated Complexes"3. Steven Zeisel, Ph.D., University of North Carolina Chapel Hill, "Choline, Metabolic Signaling and Gene Expression/Epigenetics"4. Lanlan Shen, M.D., Ph.D., Baylor College of Medicine, "Nutritional and Environmental Influences on Intestinal Developmental Epigenetics."5. Junior Investigator AbstractSession 2: Insulin, mTOR and AMPK in Metabolic Control1. Brendan Manning, Ph.D. (Chair), Harvard University, "Metabolic Control of Cell Growth by mTOR"2. David Sabatini, M.D., Ph.D., Whitehead Institute for Biomedical Research, "Amino Acid Sensing by mTOR"3. Reuben Shaw, Ph.D., Salk Institute, "AMPK Signaling Controls Acute and Prolonged Metabolic Reprogramming"4. Nada Kalaany, Ph.D., Boston Children's Hospital/Harvard Medical School, "Differential Sensitivity of Tumors to Dietary Restriction"5. Junior Investigator AbstractSession 3: Nutrient Stress Signals and the Unfolded Protein Response1. Ronald C. Wek, Ph.D. (Chair), Indiana University School of Medicine, "Nutrient Stress Signals and Translational Control"2. Tracy G. Anthony, Ph.D., Rutgers University, "Targeting eIF2 Kinase Signaling to Improve Treatment of Disease"3. Fumihiko Urano, MD, PhD, Washington University School of Medicine, "Endoplasmic Reticulum: An Interface between the Immune System and Metabolism"4. Ira Tabas, M.D., Ph.D., Columbia University, "Calcium Signaling and ER Stress in Obesity and Type 2 Diabetes"5. Junior Investigator AbstractSession 4: Nutrient Sensing and Metabolic Signaling - Liver Lipid Metabolism1. Timothy Osborne, Ph.D., Sanford-Burnham Medical Research Institute, "New Roles and Regulation for SREBPs in Growth and Metabolism"2. Morris Birnbaum, M.D., Ph.D., University of Pennsylvania, "The Regulation of Hepatic Lipid Metabolism by Insulin"3. Kasey Vickers, PhD, Vanderbilt University School of Medicine,"MicroRNAs in Atherosclerosis and Lipoprotein Metabolism"4. Jay Horton, M.D., University of Texas Southwestern, "Characterization of New Post-Transcriptional Regulators of Fatty Acid Synthesis"5. Junior Investigator AbstractSession 5: Nutrient Sensing and Metabolic Signaling in Adipose Tissue1. Naima Moustaid-Moussa, Ph.D. (Chair), Texas Tech University, "Omega 3 Fatty Acids Regulation of White and Brown Fat Metabolism"2. Nishan Kalupahana, Ph.D., University of Peradeniya School of Medicine, Sri Lanka, "At the Cross Roads of Obesity and Immunology"3. Steven Clarke, PhD, Oklahoma State University, "MicroRNA Profiling Reveals the Potential for miR-181d to Contribute to the Metabolic Adaptation to Iron Deficiency"4. Alyssa H. Hasty, Ph.D., Vanderbilt University School of Medicine, "A Role for the Micronutrient, Iron, in Adipose Tissue Homeostasis"5. Junior Investigator AbstractSession 6: Nutrient Sensing and Metabolic Signaling in Skeletal Muscle1. Blake Rasmussen, Ph.D. (Chair), University of Texas Medical Branch at Galveston, "Protein/Amino Acid Sensing and Metabolic Signaling in Human Skeletal Muscle."2. Scot Kimball, Ph.D., Penn State College of Medicine, "Macronutrient Regulation of Alternative Pre-mRNA Splicing in Muscle."3. Debbie Muoio, Ph.D., Duke University, "Lipid-Induced Mitochondrial Stress and Glucose Transport in Skeletal Muscle."4. Christopher Adams, M.D., Ph.D., University of Iowa, "Role of ATF4 in Skeletal Muscle Atrophy."5. Junior Investigator AbstractSession 7: Nutrient Sensing and Metabolic Signaling in the Central Nervous System and Beyond1. Susan Hutson, Ph.D. (Chair), Virginia Tech University, "Branched Chain Amino Acid and α-Keto Acids Regulate mTOR Signaling in Brain"2. Christopher Morrison, Ph.D., Pennington Biomedical Research Center, "Molecular Detectors Linking Dietary Protein to Behavior and Metabolism"3. Steve Simpson, Ph.D., University of Sydney, Australia, "The Geometry of Macronutrient Balance and Protein Leverage4. Gary J. Schwartz, Ph.D., Albert Einstein College of Medicine, "Distributed Nutrient Sensing in the Integrated Control of Energy Balance"5. Junior Investigator AbstractSession 8: Nutrient Sensing and Metabolic Signaling in the GI Tract1. Judy Storch, Ph.D. (Chair), Rutgers University, "Differential Regulation of Whole Body Energy Homeostasis by Enterocyte Fatty Acid-Binding Proteins"2. Nada Aburmrad, Ph.D., Washington University in St. Louis, "Dietary Lipid Signals the Arrival of a Meal via CD36-Mediated Signaling"3. Liping Zhao, Ph.D., Shanghai Jiao Tong University, "Nutritional Modulation of Gut Microbiota for Metabolic Health."4. Sarah Campbell, Ph.D., Rutgers University, "Impact of Exercise on Gut Microbiota"5. Junior Investigator Abstract