Progress 08/01/14 to 07/31/16
Outputs
Target Audience:The target audience for FARAD includes veterinarians, extension specialists, government and industry regulators as well as producers throughout all parts of the food animal industries. Veterinarians may submit questions for expert-mediated consultations by FARAD via a nationwide toll-free hotline (1-888-USFARAD or 1-888-873-2723) or through a Web-based online submission portal. The databank, which is updated and maintained regularly, is readily searchable and allows for curated information to be accessed and considered by trained FARAD experts who provide guidance in response to inquiries from veterinarians about potential residue problems associated with situations involving contaminant exposure or legal extralabel drug therapy in food-producing animals. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided?
Nothing Reported
How have the results been disseminated to communities of interest?See above for detailed information onweb-based platforms and smartphone apps What do you plan to do during the next reporting period to accomplish the goals?
Nothing Reported
Impacts
What was accomplished under these goals?
A. A major programmaticaccomplishment of FARAD was the collection, updating and dissemination of regulatory information pertaining to FDA-approved animal drugs. The FARAD center at UF is responsible for collecting and entering data for the US Approved Animal Drugs Database (US-AADD), maintaining and updating the publicly-accessible FARAD website (www.farad.org) as well as development and maintenance of associated web-based interactive databases and mobile platforms, including the Veterinarian's Guide to Residue Avoidance Management (VetGRAM) and apps for smartphones and other mobile devices. These FARAD products provide complete information about approved animal drugs, including dosing information, disease indications, species and use-class restrictions as well as the associated withholding times for meat, milk, eggs, honey and other products following label?approved drug treatments. A calendar function has been integrated into these programs to aid veterinarians in the determination of proper withholding times and dates following drug treatments that are consistent with approved regulations. All of this information is openly accessible and free of charge to users who seek information about labeled uses of food animal drugs. As an addendum, it is worthwhile to note that within the drug approval process, estimations for safe withdrawal times are based upon determinations in healthy animals. However, for certain drugs and/or certain disease states, it has been discovered that drug disposition may be altered by the disease or abnormal condition, especially in situations where drug metabolism is involved. In view of these specific situations that are now recognized as well as the likelihood of additional situations that are still unrecognized, it may not always be safe to assume that use of an approved drug in accordance with label instructions will be sufficient to avoid violative residues. B. Based on usage patterns as described above, the FARAD web site (www.farad.org) continued to be a highly-used resource for domestic and international users. Our fully searchable databases were accessed by more than 1000 users each week by the end of the report period and the annual growth in this usecontinued at double digit percentages year over year. Every week, the UF component of FARAD conducted detailed reviews of the Federal Register to extract the latest information pertaining to drug approvals in food animal species, both major (cattle, pigs, turkeys and chickens) and minor (goats, sheep, game birds, bison, etc.) species. During the 2016 calendar year, more than 2,000 revisions were incorporated into the FARAD databases in response to newly released or updated regulatory information as well as newlypublished research reports. C. Workcontinued on the development of web pages for several minor use species, such as sheep and gamebird industries. D. Our program's first mobile app was developed and launched in 2013 and a second major new app for use on iPhones was released in 2015. One significant advantage of these apps is that all data and resources are "native" insofar as data is fully accessible and usable even in the absence of internet access to other live mobile platforms. New products are currently under development with the goal to increase accessibility by smartphones to a up-to-date and complete drug residue information. An increasing number of smartphone app installs have been made on devices associated with foreign-based wireless carriers, including Australia, Bolivia, Canada, China, Germany, Great Britain, Hungary, Italy, Mexico, Netherlands, New Zealand and the Philippines.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2104
Citation:
Baynes RE, Riviere JE (eds): Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing. New York: Wiley, 2014.
Li M, Gehring R, Tell L, Baynes R, Huang Q, Riviere JE: Interspecies mixed effect pharmacokinetic modeling of penicillin G in cattle and swine. Antimicrob. Agents Chemother. 58: 4495-4503, 2014. [24867969]
Huang Q, Riviere JE: The application of allometric scaling principles to predict pharmacokinetic parameters across species. Expert Opinion Drug Metab. Toxicol. 10: 1241-1253, 2014. [24984569]
Kissel LW, Leavens TL, Baynes RE, Riviere JE, Smith G. Comparison of flunixin pharmacokinetics and milk elimination in healthy cows and cows with mastitis. J.Am.Vet.Med.Assoc. 246: 118-125, 2015 [25517334]
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