Source: UNIVERSITY OF TEXAS AT SAN ANTONIO submitted to NRP
EFFICACY AND SAFETY STUDIES USING A 1% DORAMECTIN PRODUCT AND BM86-BASED ANTI-CATTLE FEVER TICK VACCINE AGAINST CATTLE FEVER TICKS
Sponsoring Institution
Agricultural Research Service/USDA
Project Status
ACTIVE
Funding Source
Reporting Frequency
Annual
Accession No.
0435026
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Jul 1, 2018
Project End Date
Sep 30, 2019
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIVERSITY OF TEXAS AT SAN ANTONIO
1 UTSA CIRCLE
SAN ANTONIO,TX 78249
Performing Department
(N/A)
Non Technical Summary
(N/A)
Animal Health Component
80%
Research Effort Categories
Basic
10%
Applied
80%
Developmental
10%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
3123120113050%
7213310113050%
Goals / Objectives
Complete concentration analysis of dormectin in animal serum collected as part of efficacy and safety studies using a 1% doramectin product against cattle fever ticks.
Project Methods
The amended project will consist of two studies. One will be a standard barn stall trial in which stanchioned cattle will be infested with known amounts of tick larvae at regular intervals. The animals will be treated at the label rate with 1% doramectin, Bm86-based vaccine only, or the combination of 1% doramectin and Bm86-based vaccine. A fourth group will serve as untreated controls. Regular tick infestations will occur, and the number of engorged females will be collected and counted each day. A sub-sample of the daily collected ticks will be held for fertility and fecundity measurements. The study will terminate when the level of control drops below 90% for three consecutive days. The second study will have the identical experimental design except that the cattle will be held outside in a pasture under natural conditions. Cattle will be infested at regular intervals. Tick counts will be made weekly. Up to 10 engorged females will be collected from each animal and held in the incubator for fecundity and fertility determinations. The study will terminate when efficacy reaches below 90% for three consecutive days.