Recipient Organization
MICHIGAN STATE UNIV
(N/A)
EAST LANSING,MI 48824
Performing Department
(N/A)
Non Technical Summary
(N/A)
Animal Health Component
30%
Research Effort Categories
Basic
50%
Applied
30%
Developmental
20%
Goals / Objectives
Refine the chicken genome assembly and annotation, and in turn, identify chicken genes and causative polymorphisms for Marek's disease resistance and specific developmental mutations associated with MDV.
Project Methods
To identify genes and the underlying causative mutation, employ next generation sequencing on chickens of known phenotype and analyze the data to reveal polymorphisms that are linked or associated with the trait. Validate using standard molecular genetic techniques. For improving the genome sequence, continue collaborative efforts with Washington U. at St. Louis to obtain sequences and contigs that will fill gaps or missing microchromosomes.