Progress 10/01/10 to 09/30/11
Outputs
Progress Report Objectives (from AD-416) Determine the antimicrobial resistance of E. coli from cattle reared with various antibiotic usage regimens. Are these intervention strategies that can reverse antimicrobial resistance? Approach (from AD-416) 1. Will culture approximately 1000 cattle fecal samples for E. coli. 2. E. coli will be tested for antibiotic sensitivities. 3. Resistant bacteria will be genotypically characterized. 4. Antibiotic usage practices will be altered and cattle populations re- distributed to reduce antibiotic resistance. The goal of this project is to develop new intervention strategies that can be used to manage/minimize the development of antimicrobial resistance in food-producing animals so as to assure ongoing access by livestock and poultry producers to critically important antimicrobial drugs used in animal production agriculture. In FY 2011, project work established the transmission dynamics of antimicrobial sensitive and antimicrobial resistant pathogenic bacteria between different groups of feedlot cattle. The work showed that sensitive bacterial populations were oftentimes able to displace resistant bacterial populations; work by the parent project is ongoing to define the causes of this preferential colonization. Work under this project, overall, has facilitated identification of best use practices for appropriate agricultural utilization of antibiotics that are fully sensitive to human public health concerns. This project was scheduled to expire in FY 2012, but was terminated in FY 2011 because the cooperating scientist has left the cooperating institution.
Impacts
(N/A)
Publications
|
Progress 10/01/09 to 09/30/10
Outputs
Progress Report Objectives (from AD-416) Determine the antimicrobial resistance of E. coli from cattle reared with various antibiotic usage regimens. Are these intervention strategies that can reverse antimicrobial resistance? Approach (from AD-416) 1. Will culture approximately 1000 cattle fecal samples for E. coli. 2. E. coli will be tested for antibiotic sensitivities. 3. Resistant bacteria will be genotypically characterized. 4. Antibiotic usage practices will be altered and cattle populations re- distributed to reduce antibiotic resistance. In an attempt to reduce the burden of antimicrobial resistance in public health settings, regulatory agencies have proposed rules that could limit the ability of food animal producers to control pathogens of importance to both animal and human health. The goal of this project is to develop new intervention strategies that can be used to manage/minimize the development of antimicrobial resistance so as to assure ongoing access by livestock and poultry producers to critically important antimicrobial drugs used in animal production agriculture. Project work in FY 2010 developed important new information on the genetic aspects of how E. coli develops resistance to a member (ceftiofur) of an important class of antibiotics used both in agriculture and in human medicine. The work developed new insights on the bacterial/chemical interactions as related to practical antibiotic treatment protocols.
Impacts
(N/A)
Publications
|
Progress 10/01/08 to 09/30/09
Outputs
Progress Report Objectives (from AD-416) Determine the antimicrobial resistance of E. coli from cattle reared with various antibiotic usage regimens. Are these intervention strategies that can reverse antimicrobial resistance? Approach (from AD-416) 1. Will culture approximately 1000 cattle fecal samples for E. coli. 2. E. coli will be tested for antibiotic sensitivities. 3. Resistant bacteria will be genotypically characterized. 4. Antibiotic usage practices will be altered and cattle populations re- distributed to reduce antibiotic resistance. Significant Activities that Support Special Target Populations This is a new project. The use of antibiotics in animal agriculture may increase the risk of harmful microorganisms developing resistance and thus being harder to control. In the U.S., regulatory agencies such as the Food and Drug Administration have proposed rules on antibiotic use that could limit the ability of food animal producers to control bacteria that cause animal sickness or death, and also those that can directly impact on human health as the result of food poisoning associated with contaminated meat products. The goal of this project is to develop intervention strategies that will not contribute to the development of antimicrobial resistance, and which will maintain producer access to important antimicrobial drugs. Work in FY 2009 focused on the important antibiotic ceftiofur and how different animal treatment regimes affected certain pathogenic bacteria both in physical characteristics and also genetically. Ongoing work by this project will provide information of value in development of new treatment approaches and protocols that will help ensure that antimicrobial drugs remain available to food animal production industries while protecting public health.
Impacts
(N/A)
Publications
|
|