Progress 10/01/08 to 09/30/09
Outputs
Progress Report Objectives (from AD-416) To evaluate recombinant DNA technology against avian coccidiosis. Approach (from AD-416) Develop in vitro and in vivo immunoassays to evaluate recombinant DNA vaccines against coccidiosis. Significant Activities that Support Special Target Populations This will be a final report for this agreement. It was established to develop a recombinant vaccination strategy against avian coccidiosis in broiler birds. A purified recombinant protein from Eimeria maxima gametocyte was used to vaccinate chickens against avian coccidiosis. Vaccination induced significantly decreased oocyst shedding, enhanced body weight gains and enhanced cell-mediated immune response against vaccinating protein. These results demonstrate that vaccination with the recombinant Gam82 protein induces protective immunity against coccidiosis. In addition, these results suggest that the recombinant gamete protein is a potential vaccine candidate.
Impacts
(N/A)
Publications
|
Progress 06/01/07 to 05/31/09
Outputs
Progress Report Objectives (from AD-416) To evaluate recombinant DNA technology against avian coccidiosis. Approach (from AD-416) Develop in vitro and in vivo immunoassays to evaluate recombinant DNA vaccines against coccidiosis. Significant Activities that Support Special Target Populations This trust agreement was established to evaluate cell-mediated immunity against recombinant Eimeria vaccines which were developed by the Indian Immunologicals Limited. ARS and Indian Immunologicals Limited scientists will work together to develop recombinant coccidiosis vaccine. Work progress is monitored by regular teleconferences, meetings and formal written progress reports.
Impacts
(N/A)
Publications
|
Progress 10/01/06 to 09/30/07
Outputs
Progress Report Objectives (from AD-416) To evaluate recombinant DNA technology against avian coccidiosis. Approach (from AD-416) Develop in vitro and in vivo immunoassays to evaluate recombinant DNA vaccines against coccidiosis. Significant Activities that Support Special Target Populations This report documents research conducted under a Trust Fund Agreement between ARS and Indian Immunologicals, Ltd. Additional details of the research can be found in the report for the associated in-house project 1265-31320-072-00D, �Development of Functional Genomic and Immunologic Approaches to Control Avian Mucosal Pathogens�. This is a new trust agreement which is being established to develop new immunological assays to evaluate cytokine response to DNA vaccination. This work will start when the paperwork is finalized. Disseminating progress to date has been primarily phone conversations.
Impacts
(N/A)
Publications
|
|