Recipient Organization
YALE UNIVERSITY
105 WALL ST
NEW HAVEN,CT 06511-6614
Performing Department
EPIDEMIOLOGY & COMMUNITY HLTH
Non Technical Summary
(N/A)
Animal Health Component
50%
Research Effort Categories
Basic
0%
Applied
50%
Developmental
50%
Goals / Objectives
The objective of this project is to develop the tools necessary to create local, integrated disease management programs for the reduction of Lyme disease and other illnesses caused by tick-borne pathogens.
Project Methods
Current efforts to develop a human anti-tick vaccine at Yale University will be leveraged to develop a deer anti-tick vaccine. The first step will be screening of candidate recombinant antigens in laboratory models to determine which ones induce antibodies that affect Ixodes scapularis ticks. Developmental (e.g., reduction in fecundity) as well as lethal effects will be measured. Promising recombinant antigens will be tested on deer in a paddock environment where controlled tests with ticks can be conducted. This work will produce criteria for selection of the best antigen or combination of antigens. In parallel with development of antigens, work will be conducted on the means of delivery of injectables, acaricidal collars, and baits. Methods other than vaccination will also be developed as opportunity and resources allow. This will include development of IDM trial locations, testing of deer handling equipment, development of better acaricidal collars, etc.