Progress 10/01/09 to 09/30/10
Outputs
Progress Report Objectives (from AD-416) The objective of this cooperative research project is to conduct an intervention study to determine if the consumption of whey protein, compared to soy protein or an isocaloric control product, in free-living adults, decreases body weight and fat, and if there are concomitant improvements in risk factors of cardiovascular disease and diabetes. Approach (from AD-416) Briefly, a free-living study will be conducted in which subjects will be provided one of three products to be incorporated into their meals. Subjects will be recruited who are overweight or obese. At the beginning and throughout the 6 month study, body weight and composition will be measured as well as dietary intake and physical activity. Blood and urine samples will be collected and will be used to measure factors, such as hormones, associated with food intake and risk factors of diabetes and cardiovascular disease. A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation, and biomarkers of cardiovascular disease, diabetes and obesity. There is a significant benefit of dietary protein supplementation with respect to body weight and fat. Protein intake also improves insulin response. These results suggest that dietary protein is associated with improving body composition and that whey protein may help improve some risk factors for chronic diseases. Manuscripts describing the findings of this study have been submitted for publication. Activities and progress of this Agreement were monitored through site visits and conference calls.
Impacts
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Progress 10/01/08 to 09/30/09
Outputs
Progress Report Objectives (from AD-416) The objective of this cooperative research project is to conduct an intervention study to determine if the consumption of whey protein, compared to soy protein or an isocaloric control product, in free-living adults, decreases body weight and fat, and if there are concomitant improvements in risk factors of cardiovascular disease and diabetes. Approach (from AD-416) Briefly, a free-living study will be conducted in which subjects will be provided one of three products to be incorporated into their meals. Subjects will be recruited who are overweight or obese. At the beginning and throughout the 6 month study, body weight and composition will be measured as well as dietary intake and physical activity. Blood and urine samples will be collected and will be used to measure factors, such as hormones, associated with food intake and risk factors of diabetes and cardiovascular disease. Significant Activities that Support Special Target Populations A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation, and biomarkers of cardiovascular disease, diabetes, and obesity. There is a significant benefit of dietary protein supplementation with respect to body weight and fat. Protein intake also improves insulin response. These results suggest that dietary protein is associated with improving body composition and that whey protein may help improve some risk factors for chronic diseases. Manuscripts describing the findings of this study have been submitted for publication. Activities and progress of this agreement were monitored through site visits and conference calls.
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Progress 08/01/04 to 07/30/09
Outputs
Progress Report Objectives (from AD-416) The objective of this cooperative research project is to conduct an intervention study to determine if the consumption of whey protein, compared to soy protein or an isocaloric control product, in free-living adults, decreases body weight and fat, and if there are concomitant improvements in risk factors of cardiovascular disease and diabetes. Approach (from AD-416) Briefly, a free-living study will be conducted in which subjects will be provided one of three products to be incorporated into their meals. Subjects will be recruited who are overweight or obese. At the beginning and throughout the 6 month study, body weight and composition will be measured as well as dietary intake and physical activity. Blood and urine samples will be collected and will be used to measure factors, such as hormones, associated with food intake and risk factors of diabetes and cardiovascular disease. A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation, and biomarkers of cardiovascular disease, diabetes and obesity. There is a significant benefit of dietary protein supplementation with respect to body weight and fat. A double-blind randomized clinical trial was conducted to determine the effect of consumption of supplemental whey protein (WP), soy protein (SP) and an isoenergetic amount of carbohydrate (CHO), on body weight and composition in free-living overweight and obese but otherwise healthy participants. Ninety overweight and obese participants were randomly assigned to 1 of 3 treatment groups for 23 wk: 1) WP, 2) SP, (each providing ~56g/d of protein and 1670 kJ/d), or 3) an isoenergetic amount of CHO. Supplements were consumed as a beverage twice daily. Participants were provided no dietary advice and continued to consume their free-choice diets. Participants� body weight and composition data were obtained monthly. Dietary intake was determined by 24-h dietary recalls collected every 10 days. After 23 wk, body weight and composition did not differ between the groups consuming the SP and WP or between SP and CHO; however, body weight and fat mass of the group consuming the WP were lower by 1.8 kg (P<0.006) and 2.3 kg (P<0.005), respectively, than the group consuming CHO. Lean body mass did not differ among any of the groups. Waist circumference was smaller in the participants consuming WP than in the other groups (P<0.05). Fasting ghrelin was lower in participants consuming WP compared to SP or CHO. Through yet unknown mechanisms, different sources of dietary protein may differentially facilitate weight loss and affect body composition. These results suggest that dietary protein is associated with improving body composition and that whey protein may help improve some risk factors for chronic diseases. Manuscripts describing the findings of this study have been published. Activities and progress of this Agreement were monitored through site visits and conference calls.
Impacts
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Progress 10/01/07 to 09/30/08
Outputs
Progress Report Objectives (from AD-416) The objective of this cooperative research project is to conduct an intervention study to determine if the consumption of whey protein, compared to soy protein or an isocaloric control product, in free-living adults, decreases body weight and fat, and if there are concomitant improvements in risk factors of cardiovascular disease and diabetes. Approach (from AD-416) Briefly, a free-living study will be conducted in which subjects will be provided one of three products to be incorporated into their meals. Subjects will be recruited who are overweight or obese. At the beginning and throughout the 6 month study, body weight and composition will be measured as well as dietary intake and physical activity. Blood and urine samples will be collected and will be used to measure factors, such as hormones, associated with food intake and risk factors of diabetes and cardiovascular disease. Significant Activities that Support Special Target Populations A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation, and biomarkers of cardiovascular disease, diabetes and obesity. There is a significant benefit of dietary protein supplementation with respect to body weight and fat. Protein intake also improves insulin response. These results suggest that dietary protein is associated with improving body composition and that whey protein may help improve some risk factors for chronic diseases. Manuscripts describing the findings of this study have been submitted for publication. Activities and progress of this Agreement were monitored through site visits and conference calls.
Impacts
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Progress 10/01/06 to 09/30/07
Outputs
Progress Report Objectives (from AD-416) The objective of this cooperative research project is to conduct an intervention study to determine if the consumption of whey protein, compared to soy protein or an isocaloric control product, in free-living adults, decreases body weight and fat, and if there are concomitant improvements in risk factors of cardiovascular disease and diabetes. Approach (from AD-416) Briefly, a free-living study will be conducted in which subjects will be provided one of three products to be incorporated into their meals. Subjects will be recruited who are overweight or obese. At the beginning and throughout the 6 month study, body weight and composition will be measured as well as dietary intake and physical activity. Blood and urine samples will be collected and will be used to measure factors, such as hormones, associated with food intake and risk factors of diabetes and cardiovascular disease. Significant Activities that Support Special Target Populations This report documents research conducted under a reimbursable agreement between ARS and Dairy Management, Inc. Additional details of research can be found in the report for the in-house associated project, 1235- 51530-008-00D, "Dietary Modulation of Markers of Inflammation and Oxidation as Risk Factors of Chronic, Degenerative Diseases." A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation, and biomarkers of cardiovascular disease, diabetes and obesity. There is a significant benefit of dietary protein supplementation with respect to body weight and fat. Protein intake also improves insulin response. These results suggest that dietary protein is associated with improving body composition and that whey protein may help improve some risk factors for chronic diseases. Four manuscripts describing the findings of this study are being prepared. Activities and progress of this agreement were monitored through site visits and conference calls.
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Progress 10/01/05 to 09/30/06
Outputs
Progress Report 4d Progress report. This report serves to document research conducted under a Reimbursable Agreement between ARS and Dairy Management, Inc. Additional details of research can be found in the report for the parent project 1235-51530-008- 00D, "Dietary Modulation of markers of inflammation and oxidation as risk factors of chronic, degenerative diseases." A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation and biomarkers of cardiovascular disease, diabetes and obesity. There is a significant benefit of dietary protein supplementation with respect to body weight and fat. Protein intake also improves insulin response. These results suggest that dietary protein is associated with improving body composition and that whey protein may help improve some risk factors for chronic diseases.
Impacts
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Progress 10/01/04 to 09/30/05
Outputs
4d Progress report. This report serves to document research conducted under a Reimbursable Agreement between ARS and Dairy Management, Inc. Additional details of research can be found in the report for the project, 1235-51530-008-00D, "Dietary Modulation of markers of inflammation and oxidation as risk factors of chronic, degenerative diseases." A dietary intervention study was conducted to determine the effect of whey protein on body weight, body fat, markers of inflammation and biomarkers of cardiovascular disease, diabetes and obesity. The intervention component of the project has been completed and data and sample analyses have begun.
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