Source: UNIVERSITY OF CALIFORNIA, BERKELEY submitted to NRP
ZINC METABOLISM, STATUS AND REQUIREMENTS
Sponsoring Institution
Agricultural Research Service/USDA
Project Status
ACTIVE
Funding Source
Reporting Frequency
Annual
Accession No.
0403380
Grant No.
58-5306-0-076
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Mar 31, 2000
Project End Date
Mar 30, 2005
Grant Year
2000
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIVERSITY OF CALIFORNIA, BERKELEY
(N/A)
BERKELEY,CA 94720
Performing Department
(N/A)
Non Technical Summary
(N/A)
Animal Health Component
0%
Research Effort Categories
Basic
100%
Applied
0%
Developmental
0%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
70260101010100%
Goals / Objectives
Most pregnant women are given iron supplements. A preliminary study done in our lab showed that supplemental iron interferred with zinc absorption during lactation. The practice of supplementing women with iron during pregnancy and lactation may reduce the zinc health of the mother and child.
Project Methods
Conduct clinical study using stable isotopes of zinc and iron to measure their absorption and interaction in two groups of pregnant women, one of which is suplemented with iron and the other group is not. Documents SCA with UC Berkeley.

Progress 10/01/00 to 09/30/01

Outputs
1. What major problem or issue is being resolved and how are you resolving it? 2. How serious is the problem? Why does it matter? 3. How does it relate to the National Program(s) and National Component(s)? 4. What were the most significant accomplishments this past year? This report serves to document research conducted under this cooperative agreement between ARS and the University of California Berkeley. Additional details of this research can be found in the report for the parent CRIS 5306-51520-004-00D, Influence of Dietary Intervention on Mineral Homeostasis. Zinc absorption and endogenous fecal excretion change promptly with changes in zinc intake. Since it is thought that the size of exchangeable zinc pools dictate changes in zinc homeostasis, we compared the zinc absorptive and excretory response to oral and intravenous zinc in men who were previously zinc-depleted. Oral, but not intravenous, zinc altered zinc absorption and endogenous excretion. Thus, the sensor that modulates zinc homeostasis must be in the gastrointestinal tract rather than an endogenous pool. 5. Describe the major accomplishments over the life of the project including their predicted or actual impact. 6. What do you expect to accomplish, year by year, over the next 3 years? 7. What science and/or technologies have been transferred and to whom? When is the science and/or technology likely to become available to the end user (industry, farmer, other scientists)? What are the constraints if known, to the adoption & durability of the technology product? 8. List your most important publications in the popular press (no abstracts) and presentations to non-scientific organizations and articles written about your work (NOTE: this does not replace your peer-reviewed publications which are listed below)

Impacts
(N/A)

Publications