Source: UNIVERSITY OF CALIFORNIA, DAVIS submitted to NRP
FOOD AN. RES AVOIDANCE DATABANK (FARAD)
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0230791
Grant No.
2012-41480-20281
Cumulative Award Amt.
$384,000.00
Proposal No.
2012-03919
Multistate No.
(N/A)
Project Start Date
Sep 1, 2012
Project End Date
Aug 31, 2015
Grant Year
2012
Program Code
[FARAD]- Food An. Res. Avoidance Database,FARAD
Recipient Organization
UNIVERSITY OF CALIFORNIA, DAVIS
410 MRAK HALL
DAVIS,CA 95616-8671
Performing Department
Medicine & Epidemology
Non Technical Summary
Regulations require that extra-label use of drugs in food animals be based on sound principles of residue avoidance. The purpose of FARAD is to provide an expert-mediated residue avoidance decision support system which is able to provide timely advice and information on a wide range of drug and chemical entities in food animals to veterinarians, regulatory agencies, extension specialists, livestock producers and scientists. This will ultimately result in a food supply that is free of harmful drug and chemical residues.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
71139101180100%
Goals / Objectives
The elemental goal of FARAD is the production of safe foods of animal origin through the prevention and mitigation of violative chemical and drug residues in food animal products. The objectives of FARAD are to identify, extract, assemble, evaluate and distribute reviewed information about residue avoidance and mitigation to people involved in residue avoidance programs throughout the United States.
Project Methods
Utilizing extracted pharmacokinetic parameters from published pharmacokinetic data, data from research trials, and newly developed mathematical algorithms, FARAD scientists will provide veterinarians, livestock producers, extension specialists and scientists with information to prevent drug, pesticide, and environmental contaminant residues in food animal products.

Progress 09/01/12 to 08/31/15

Outputs
Target Audience:The target audience for this program is mostly livestock producers and veterinarians. The goal of the program is to provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided?PhD students at other FARAD regional centers were trained by the UC Davis site regarding case calls for drug residue avoidance. How have the results been disseminated to communities of interest?FARAD has become crucial to the maintenance of a residue-free food supply to the American public. It is important to recognize that FARAD works with residues that can be either drugs used in veterinary practice, agricultural chemicals or outright environmental contaminants. FARAD has provided this guidance through use of its databank by specially trained professional staff to provide information on prevention and mitigation of violative chemical residues and supplies recommended withdrawal intervals to allow safe extralabel use of drugs in food animals based on sound principles of residue avoidance. Information is disseminated by direct answering of cases and by posting information on the web site. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? The accomplishment of the program for this term was that FARAD, at the University of California Davis, updated and maintained the pharmacokinetic and bibliographic databases. Numerous bibliographic citations and pharmacokinetic records were added to these databases. The FARAD Documentation Specialist maintained a continuous updating process and continued to work on the hundreds of original references on the library retrieval list that were awaiting evaluation for relevant data and data extraction. This data extraction was crucial for the application of the residue avoidance algorithms. Additionally, UCD continued to maintain the web-based access to the kinetic and bibliographic citation files for the global FARAD (gFARAD) partners. With FARAD Director's (Dr. Lisa Tell) guidance, the UCD FARAD programmer continued to revise the older software to allow for improved data entry into the kinetic databases and the bibliographic citation database. The new web-based interface was used in full this year for access to the pharmacokinetic data (KINWEB) and for logging and tracking questions submitted to FARAD (FARM Calls). The web-based interface (FARMWEB) for direct, on-line submission of FARAD questions was also modified slightly for improvement of case submissions. New citation and kinetic records were added, especially for the species for which we get the most submissions and for active ingredients that are being used extensively for ELDU. UC Davis worked with the University of FL to establish the "on line" look up withdrawal interval (WDI) calculator that allows constituents to look up all of the WDI recommendations that have been published in FARAD digests or for which enough data is present for modeling and establishing a WDI recommendation. The UC Davis FARAD Director will continue to collaborate with North Carolina State University, Kansas State University, and the University of Florida personnel on pharmacokinetic research for food animal applications as the FARAD pharmacokinetic database contains a vast resource of data that can be used to develop and validate such models. FARAD telephone, email and web-based inquiries will be continued to be answered on a weekly, rotating basis between UC Davis and North Carolina State University and Kansas State University.

Publications