Source: COMPACT MEMBRANE SYSTEMS, INC. submitted to NRP
ENHANCING BIOSYNTHESIS OF BIOFUELS FROM CELLULOSIC BIOMASS
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0230069
Grant No.
2012-33610-20326
Cumulative Award Amt.
$450,000.00
Proposal No.
2012-02176
Multistate No.
(N/A)
Project Start Date
Sep 1, 2012
Project End Date
Aug 31, 2017
Grant Year
2012
Program Code
[8.8]- Biofuels and Biobased Products
Recipient Organization
COMPACT MEMBRANE SYSTEMS, INC.
335 WATER STREET
WILMINGTON,DE 19804
Performing Department
(N/A)
Non Technical Summary
There continues to be a need for production of biofuels from agricultural sources. Butanol is a more attractive fuel than ethanol because it leads to better gas mileage, it achieves higher blends with gasoline than bioethanol, it has greater compatibility with existing fuel infrastructure, it is less volatile, it is more amenable to transport via pipeline due to low water absorption, there is no need for an engine retrofit, and it allows to use numerous existing agricultural feedstocks, as well as next generation feedstock including cellulosic biomass and algae. To produce butanol efficiently the fermentation process must be run continuously while maintaining low butanol concentration in the fermenter. This requires that butanol be removed from the fermenter at the same rate that it is produced. This can be done by conventional distillation, which requires that the fermentation broth be first processed for removing the microorganisms for recycle to the fermenter. The clarified broth must be heated and distilled to produce a butanol concentrate in the distillate. The bottoms product from the distillation must be cooled down and recycled to the fermenter. The conventional process requires a solids-liquid separation step and is energy intensive. If an alternate technology were developed to a) Do the butanol recovery without an extra step to do the solids-liquid separation, and b) Reduce the heating/cooling energy requirements of the distillation step It would reduce butanol production costs, save energy and reduce emissions of greenhouse gases. Thus the process for producing biobutanol from agricultural sources and its economical attractiveness would be enhanced. The objective of this program is to develop a membrane system that accomplishes the above at a cost that is at least 30% lower than the cost conventional techniques. The Phase I was extremely successful and produced the data to give high probability of success in this Phase II program. This will be run experimentally and we will use best practices and statistically designed experiments to insure the highest quality data. Anticipated Results: Overall fuel market is 150 billion gallons per year domestically. With USDA/DOE plus executive mandates projecting 30% of fuel being renewable the market potential is 45 billion gallons/yr. Given biobutanol's superior performance to bioethanol, much of this 45 billion gallons/yr market is available to biobutanol if it can be supplied economically. Potential commercial applications: In addition to butanol, many other valuable chemicals can be derived from agricultural sources, e.g., acetone, glycerol, THF, isoprene, propanediol, gluconic acid, succinic acid, etc. All of these materials, assuming biochemical or fermentation routes to produce these materials are developed, would benefit from the CMS membrane technology and the proposed product concept.
Animal Health Component
40%
Research Effort Categories
Basic
20%
Applied
40%
Developmental
40%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
5111520200030%
5111510202070%
Goals / Objectives
The goal is to scale up, optimize, pilot and field test a non-fouling membrane system that will recover butanol directly from the fermentation broth. Demonstrate the technical and economical advantage of the proposed concept over the conventional system relying entirely on distillation. The expected outputs/milestones during the 8 quarters and completion times are: 1. Produced an optimized CMS7/PDMS membrane so that it gives a butanol flux of at least 0.1 Kg/h-m2 and a butanol-water separation factor of at least 25 to 30. By end of 1st Q(Quarter). 2. Determined the fluxes and separation factors of butanol fermentation byproducts (acetone, butyric acid, acetic acid, ethanol. By end of 2nd Q 3. Produced at least 20 ft2 of membrane with butanol flux is at least 0.1 Kg/h-m2 and the butanol-water separation factor is at least 25 to 30. By end of 3d Q. 4. Fabricated at least two membrane modules. By end of 5th Q. 5. Designed, built and debugged pilot test system. By end of 4th Q. 6. Demonstrated in pilot test module initial flux of at least 0.1 Kg/h-m2, butanol-water separation factor of at least 25 to 30, and long term flux decline of no more than 20%. By end of 6th Q. 7. Demonstrated in field test a separation factor of at least 25 to 30 and initial flux of at least 0.1 kg/h/m2 under field conditions. By end of 7th Q. 8. Demonstrated that the cost of a membrane based system recovery of fermentation butanol is at least 30% less than in a conventional system based on distillation. By end of 8th Q.
Project Methods
The first 7 tasks of this program will be executed experimentally. Sufficient experiments will be run to insure reproducibility and for determining the experimental error. The data will be analyzed using statistical and graphical methods. This program will make use of the technical expertise and proprietary knowledge of the company for manufacturing novel membranes, membrane model and experimental test equipment. The chemical compositions of multicomponent samples will be determined by gas chromatography. In the case of binary samples the compositions will be analyzed by density using an acoustic density meter that is accurate to 5 decimal figures. The main output of this program will be evaluated and demonstrated in the field with a third party that would be a potential end user of the technology. Task 8, engineering design and economic analysis, will be done using the engineering models, which were developed for the Phase I economic analysis. These will be used in combination with cost estimation methods from the literature for estimating the capital and operating costs of the membrane and conventional systems. For the Phase II program, the analysis will be expanded to include an examination of the effects of important process variables, including: plant size, butanol production rate, and operating conditions.

Progress 09/01/12 to 08/31/17

Outputs
Target Audience:Fermentation processes to produce biobutanol are the goal of extensive research and development world-wide. There is a need to significantly reduce the current costs and energy required for butanol recovery from the fermentation broth. The current biobutanol recovery process of distillation and/or flash evaporation is expensive and energy-intensive. The CMS membrane biobutanol will reduce biobutanol manufacturers' operational cost by 30% compared to conventional filtration/distillation. Manufacturing energy savings is over 50% with the CMS membrane process since the biobutanol is separated from the broth with minimal heat input compared to conventional distillation. This market need may be met by the companies working on microorganisms and enzymes to improve the biobutanol process. The domestic companies that appear to be closest to commercializing their process is Gevo and Butamax. There are other companies that claim to have better microorganisms, but they are in earlier stages of the biobutanol development cycle. Gevo's location is in Englewood, Colorado and has started up its first commercial isobutanol facility in Luverne, Minn. Butamax' location is in Wilmington, Delaware. Butamax Advanced Biofuels is developing the advanced biofuel biobutanol and commissioning a technology demonstration facility in the UK. Other potential partners are not as far as these two en route to a commercial viable process and product. Changes/Problems:The planned field test with DuPont had to be postponed because on-going restructuring in DuPont and the Dow Chemical - DuPont merger. What opportunities for training and professional development has the project provided? One junior chemical engineer with an undergraduate degree is working throughout the project under the mentorship of a senior engineer. An undergraduate co-op student from Drexel University and an undergraduate summer trainee from University of Delawareis being trained Three undergraduate junior students from University of Delaware are being trained during this summer of 2017. How have the results been disseminated to communities of interest? 2017 TechConnect, Washington DC, CMS presented on "Development and Applications of Custom Amorphous Fluoropolymers" We are planning to start preliminary contacts with Butamax (DuPont), Gevo, and Cargill, limiting the discussion to the possibility of a prototype product being available during the last stages of CMS's Phase II SBIR program. We will also contact Novozymes and other enzyme suppliers for information on the recent biobutanol enzymes since the membrane process is more advantageous (with enzymes of greater biobutanol resistance) at higher butanol concentration in the broth. It should be noted that the CMS membrane process is additive and synergistic and not in competition with improved microorganisms or enzymes. Increasing the fermenter butanol concentration increases the economic advantage of the product concept relative to the conventional process. This product concept may be applied to the production of many other valuable chemicals that can be derived from agricultural sources, such as acetone, glycerol, THF, isoprene, propanediol, gluconic acid, succinic acid, etc. We will watch for significant opportunities in the production of these different chemicals. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? Accomplishments Demonstrated that the separation factor can be maximized by increasing the membrane thickness with little decrease in the butanol flux. We have demonstrated that the main byproducts (acetone and ethanol) can be recovered by the membrane as well as BuOH. We have scaled up and successfully tested the membrane. We have built a pilot demonstration unit. We have scaled up and demonstrated the optimum module design that approaches BuOH recovery from simulated fermentation broth. Four-week long term test was completed with simulated fermentation broth and demonstrated constant separation factor and flux decline of only 21%, which is close to the goal of a long term flux decline. Showed that the extra initial investment in the membrane case is recovered within only 14 months After 10 years the total cost of butanol recovery using the membrane system is about 50% less than in the conventional system, which exceeds our stated goal.

Publications