Recipient Organization
UNIVERSITY OF TENNESSEE
2621 MORGAN CIR
KNOXVILLE,TN 37996-4540
Performing Department
Biomedical & Diagnostic Sciences
Non Technical Summary
The objective of this study was to determine if a single loading dose, three times the label dose of firocoxib oral paste, followed by nine maintenance doses at the current label dose achieves and maintains near steady state concentrations. This would allow therapeutic concentrations to be achieved sooner providing relief to the animal.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Goals / Objectives
The objective of this study was to determine if a single loading dose, three times the label dose of firocoxib oral paste, followed by nine maintenance doses at the current label dose achieves and maintains near steady state concentrations.
Project Methods
Six healthy, adult mares received 0.3 mg/kg of firocoxib on Day 0, followed by 0.1 mg/kg administered at 24 hours on Day 1, and at 24 hour intervals Day 2 through Day 9, for a total of 10 doses. Blood samples were collected at 0 (prior to treatment), 0.25, 0.5, 1, 2, 4, 6, and 12 hours post treatment on Day 0, prior to treatment on Day 1, and at the same times as Day 0. Blood samples were also collected prior to each treatment on Days 2-9 and at 0.25, 0.5, 1, 2, 4, 6, 12, 24, 48, 72, 96, 120, 144, and 168 hours post treatment on Day 9. Samples were centrifuged and plasma stored frozen until analyzed by a validated HPLC-MS method.