CANINE MODELS OF OCD

• Sponsoring Institution: Cooperating Schools of Veterinary Medicine
• Project Status: COMPLETE
• Funding Source: STATE
• Reporting Frequency: Annual
• Accession No.: 0228003
• Project Start Date: Jul 1, 2011
• Project End Date: Mar 31, 2013
• Program Code: [(N/A)]- (N/A)

Recipient Organization
TUFTS UNIVERSITY
200 WESTBORO ROAD
N. GRAFTON,MA 01536

Performing Department
Clinical Sciences

Non Technical Summary
Previous studies suggest a candidate gene for Obsessive Compulsive Disorder (OCD) in Doberman Pinschers. The purpose of this project is to investigate a genetic basis of obsessive-compulsive disorder in dogs. It is hoped that the gene associated with OCD in the dog will serve as a basis for investigation of the same candidate OCD gene in humans.

Animal Health Component

(N/A)

Research Effort Categories

Basic

(N/A)

Applied

(N/A)

Developmental

(N/A)

Classification

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
703	3999	1080	100%

Knowledge Area
703 - Nutrition Education and Behavior;

Subject Of Investigation
3999 - Animal research, general;

Field Of Science
1080 - Genetics;

Keywords

ocd

obsessive-compulsive disorder

dna extraction

candidate gene

genome wide association study

canine model

Goals / Objectives
The purpose of this project is to investigate a genetic basis of obsessive-compulsive disorder in dogs.

Project Methods
We will assemble cohorts of dogs with Obsessive Compulsive Disorder (OCD) including Border collie dogs with and without light-chasing compulsion; accurately phenotyping these dogs; obtaining blood from them; and delivering said samples to a laboratory at the University of Massachusetts for DNA extraction and storage. These samples will subsequently be analyzed using either a candidate gene approach or Genome Wide Association Study.