Source: UNIVERSITY OF ILLINOIS submitted to
SWINE IN BIOMEDICAL RESEARCH CONFERENCE 2011 CREATING THE BUILDING BLOCKS: GENOMICS, TRANSGENESIS AND CLONING
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
TERMINATED
Funding Source
Reporting Frequency
Annual
Accession No.
0224913
Grant No.
2011-67015-30229
Project No.
ILLU-538-652
Proposal No.
2010-04545
Multistate No.
(N/A)
Program Code
A1201
Project Start Date
Apr 1, 2011
Project End Date
Mar 31, 2012
Grant Year
2011
Project Director
Schook, L. B.
Recipient Organization
UNIVERSITY OF ILLINOIS
2001 S. Lincoln Ave.
URBANA,IL 61801
Performing Department
Animal Sciences
Non Technical Summary
Outcomes, Deliverables and Conference Contributions for New Initiatives. The increasing relevance of existing pig models for human diseases and the emerging ability to capture genomic information to create novel models has stimulated the organization of this conference. The conference will: (1) distribute a summary of the discussions that address the conference goals; (2) submit a publication quality document that reaches a broader target audience interested in the use of swine for biomedical research; (3) distribute a memory stick or CD that contains the abstracts; (4) provide a summary of potential new models that should be developed; and (5)summarize potential funding needs and agency support.
Animal Health Component
(N/A)
Research Effort Categories
Basic
80%
Applied
(N/A)
Developmental
20%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
3043599106050%
3053510102050%
Goals / Objectives
The single goal of this project is to hold a Swine in Biomedical Research Conference with the following specific aims: Specific Aim 1. Identify areas of study or methodologies that enhance the utility of pigs as biomedical models. In particular, the conference will focus on identifying human diseases where traditional rodent models have not proven relevant, where the historical use of swine in this regard may be enhanced, or where no useful models exist today and for which pigs may be considered. Specific Aim 2. Identify resource needs and areas in which new approaches or methodologies are required. One session will be organized by the National Swine Resource and Research Center to showcase approaches proven successful in creating current models as well as present new approaches for creating transgenic pigs. Specific Aim 3. Stimulate interactions between researchers working within swine and human disciplines. To date, the majority of researchers focusing on porcine physiology and related disciplines are in separate research communities than those conducting clinically focused research. The conference will provide a forum for introductions and to identify joint programs and research targets to further facilitate the utility of the pig. Specific Aim 4. Provide an integrated discussion focusing on the regulated use of pigs and regulatory approval pathways associated with the use of pigs for biomedical research. Barriers for the full utilization of the pig as a biomedical model, e.g. are related to the development of appropriate animal protocols and housing, will be addressed.
Project Methods
This grant is for support of a scientific meeting, therefore there are no scientific methods. In order to achieve the defined outcomes and deliverables, the conference has been organized to provide significant discussion among the participants. Each of the sessions will have invited speakers selected with respect to their individual expertise and who will provide a summary of the topic or identify opportunities and needs. Poster sessions will provide additional opportunities to showcase existing models, methodologies and experimental approaches. Session Chairs will be responsible for leading discussion towards defined deliverables, ensuring that existing resources are adequately recognized and to assess priorities within the community. Each poster session will have a moderator (selected from participants to provide diversity representation) who will be responsible for selecting oral presentations from the submitted abstracts. The planned Poster Sessions are: (1) Bioengineering and Regenerative Medicine; (2) Immunology and Infectious Diseases; (3)Transplantation (allo and xeno); (4) Nutrition (Obesity and Diabetes); (5) Genomics; (6)Cardiovascular; (7) Physiology; (8) Trangenesis and Cloning; (9) Cancer; and (10) Clinical Models (applications and regulations).

Progress 04/01/11 to 03/31/12

Outputs
OUTPUTS: The Swine in Biomedical Research Conference was held in Chicago during July 2011. We had 153 registrants representing 11 countries from Asia, Europe and North America. The registrants came from various public and private sectors including industry, universities, government agencies, and not-for-profit institutions. These 5 sessions were included in the meeting with invited speakers as well as slide presentations of selected abstracts: Session 1: Building Blocks of Models: Genomics, Bioninformatics, and Metabolomics. Session 2: Clinical Implications: Lesson from Successful Models Session. 3: War of the Worlds The Academic-Regulatory-Industry Interface, a World of Models, Medicines, and Scientific Frontiers. Session 4: Emerging Models: Regenerative Medicine, Behavior and Bioengineering. Session 5: NSRRC Workshop on Developing Transgenic Pig Models. PARTICIPANTS: Dr. Schook was in charge of putting this meeting together as chair of the organizing and scientific program committee. Additional committee members are listed here: Organizing Committee: Sherrie Clark, D.V.M., Ph.D. Assistant Professor of Veterinary Clinical Sciences, University of Illinois. John Critser, Ph.D. Gilbreath McLorn Professor of Veterinary Pathobiology, University of Missouri. Randall Prather, Ph.D. Curator's Professor of Reproductive Biology, University of Missouri. Lela Riley, Ph.D. Professor of Veterinary Pathobiology, University of Missouri. Laurie Rund, Ph.D. Research Assistant Professor of Animal Sciences, University of Illinois. Lawrence B. Schook, Ph.D. (Chair) Vice President for Research (Interim), University of Illinois, Edward William and Jane Marr Gutgsell Professor, University of Illinois. Scientific Program Committee: Alan L. Archibald FRSE, Ph.D. Professor and Head of Genetics and Genomics, Chair of Mammalian Molecular Genetics The Roslin Institute and the Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, UK. Ina Dobrinksi, D.V.M., Ph.D. Professor and Head, Department of Comparative Biology and Experimental Medicine College of Veterinary Medicine, University of Calgary, Canada. Merete Fredholm, D.V.M., Ph.D. Professor, Royal Veterinary and Agricultural University, University of Copenhagen, Denmark. Jorge Piedrahita, D.V.M., Ph.D. Professor of Molecular Biomedical Sciences, North Carolina State University. Lawrence B. Schook, Ph.D. (Chair) Vice President for Research (Interim), University of Illinois, Edward William and Jane Marr Gutgsell Professor, University of Illinois. This meeting was determined to qualify for veterinary continuing education credits. TARGET AUDIENCES: We had 153 registrants representing 11 countries from Asia, Europe and North America. The registrants were from industry, universities, government agencies, and not-for-profit institutions. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
Clearly the quality of the oral presentations, the posters, and the discussions was recognized by all who attended. The platform made it very inviting for those using pigs as a model to learn from each other and to initiate new collaborations. Discussions verified the growing momentum and recognition regarding the value of the pig as a biomedical model. We need to ensure that we capture that energy as we move forward.

Publications

  • Those that attended the meeting received the program which included a copy of all the abstracts. An electronic version can be found at: http://www.dbs.illinois.edu/comparativegenomics/articles_view.aspxID =149 2011.