Source: PENNSYLVANIA STATE UNIVERSITY submitted to NRP
SUPPORT FOR THE 30TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE IMMUNOLOGY
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0223071
Grant No.
2010-67015-21496
Cumulative Award Amt.
(N/A)
Proposal No.
2010-03215
Multistate No.
(N/A)
Project Start Date
Sep 1, 2010
Project End Date
Aug 31, 2011
Grant Year
2010
Program Code
[A1211]- Animal Health and Production and Animal Products: Animal Reproduction
Recipient Organization
PENNSYLVANIA STATE UNIVERSITY
208 MUELLER LABORATORY
UNIVERSITY PARK,PA 16802
Performing Department
Dairy & Animal Science
Non Technical Summary
This Conference Proposal seeks support for the 30th Annual Meeting of the American Society for Reproductive Immunology. The overall goal for this proposal is to enhance participation of animal scientists in the ASRI meeting; particularly those from underrepresented groups and from underdeveloped countries that use domestic animal models in their research. An additional goal is to enhance participation to trainees using large animal models in the annual meeting. Reproductive immunology has a large impact on profitability of animal production systems. For example, 15-20% of dairy cows experience microbial diseases that significantly reduce fertility. Furthermore it is becoming increasingly clear that the immune system plays a role in pregnancy and delivery of a viable offspring. Vaccine strategies are currently under development that will render animals sterile or that can enhance the ovulation and embryo transfer protocols. Sexually transmitted infections continue to the be a problem in a number of farm species. Finally, successful pregnancies is increasingly recognized to depend on how the maternal immune system interacts with the developing plancenta to support its growth and function. The meeting has been organized into eight plenary sessions over 3 days and includes experts in reproductive immunology and related disciplines utilizing diverse models ranging from humans, to rodents to domestic farm animals. This proposal seeks funding to cover meeting costs for 4 plenary speakers and to provide travel grants to 4 trainees using domestic animal models in their research. This meeting will bring together international experts in reproductive immunology in a venue that is conducive to scientific exchange, development of collaborative projects and cross-fertilization of ideas between basic and clinical reproductive scientists with the goal of advancing understanding of how the immune system affects reproductive tract function and fertility.
Animal Health Component
(N/A)
Research Effort Categories
Basic
100%
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
3013310109012%
3013410109012%
3013510109012%
3013610109012%
3113310109012%
3113410109012%
3113510109012%
3113610109016%
Goals / Objectives
Support is sought for the 30th Annual Meeting of the American Society for Reproductive Immunology. The fundamental aim of the Society's annual meeting is to bring together the most recent developments in basic, clinical and translational studies in the field of reproductive immunology. These goals will be addressed with the following Specific Aims: Aim 1. Enhance cross disciplinary exchange between basic and translational research; Aim 2. Promote the field of reproductive immunology to new investigators and trainees; Aim 3. Promote the field of reproductive immunology beyond the US borders; Aim 4. Promote the field of reproductive immunology among under-represented groups; Aim 5. Promote greater participation of animal and veterinary scientists in the field of reproductive immunology. Importantly, the specific goal of this proposal is to foster the continued development of reproductive immunology based on species of agricultural importance by providing speaker and student travel support for the ASRI annual meeting. The scope of the conference is consistent the USDA Animal Reproduction Program Area (A1211) by directly addressing Program Priority area #2 Embryonic and fetal development, including interaction between the conceptus and its uterine environment and is also relevant to the Animal Health Program Area (A1221) indirectly addressing Program Priority Areas 2, 4 & 6 related to mucosal immunology.
Project Methods
The meeting will be organized to include plenary speakers using domestic animal models to answer questions of reproductive immunology. Specifically, the proposal will support travel for 4 plenary speakers and provide travel support for 4 trainees to attend the meeting. There will be a pre-conference post-graduate course that will review current techniques in reproductive immunology with a focus on the contribution of domestic animal models. This will be followed by a three day meeting organized into eight plenary sessions. Plenary session 1 will include a review of progress during the last 30 years in the field of reproductive immunology with a specific focus on the contribution of domestic animal models to the evolution and progress of the field. Plenary session 2 will focus of on the role of the immune system in contraceptive development with specific focus on domestic and feral animal models. Plenary session 3 will examine the role of epigenetics in reproductive immunology. Plenary session 4 will focus on trophoblast immunology and inflammation and the fetal-maternal interface. Plenary session 5 will address immunology of the gonad and gamete with a specific focus on the bovine corpus luteum. Plenary session 7 will focus on sexually transmitted infections. Plenary session 8 will address metabolic-endocrine-immune system interactions with specific focus on the novel lactocrine hypothesis of programming neonatal reproductive tract development in swine. There will also be a poster session and trainee abstract competition. The meeting has been organized to provide meals so that trainees will have a greater opportunity to interact with invited speakers. For example, following the post-graduate course there is a trainee-mentor dinner where trainees will have the opportunity to interact with the speakers.

Progress 09/01/10 to 08/31/11

Outputs
OUTPUTS: The primary output from this proposal was the 2010 Annual Conference for the American Society for Reproductive Immunology. The meeting was hosted by Penn State University on May 17-20th at Nemacolin Woodlands Resort in Farmington, PA. The specific aims of the 2010 Annual Conference that were supported by funds from this grant were to: 1.) review the last 30 years of progress and future needs in the field of reproductive immunology with specific emphasis on both human clinical and domestic animal models; 2.) to gain insights into immunological methods for contraception in humans and domestic and feral animals; 3.) to evaluate the latest concepts related to trophoblast immunology; 4.) to become aware of the newly described lactocrine hypothesis and the role of colostrum on reproductive tract development in domestic animals and; 5.) Promote greater participation of animal and veterinary scientists in the field of reproductive immunology. Achieving these aims resulted in enhanced understanding of the important role of reproductive immunology in fertility in domestic farm animals. The meeting had 150 registrants from around the world spanning basic and applied research in the field of reproductive immunology. Funds were used to support participation of the following experts in animal reproductive immunology who present papers at the meeting: -Peter Hansen (University of Florida): Thinking outside the mouse: Domestic animals as models for reproductive immunology research. -Juan Arroyo (University of Kansas Medical Center); The sheep as a model of intrauterine growth restriction (IUGR). -Chris Davies (Utah State University); Bovine and porcine models of IUGR/preterm birth. -Gary Killian (Penn State University & National Wildlife Research Center); Long acting, single shot contraceptive vaccines for wildlife. -Satish Gupta (National Institute of Immunology, India); Prospects of contraceptive vaccines for human and Wildlife populations. -Joy Pate (Penn State University); Location, location, location: The luteal neighborhood directs T-cell functions. -Masayuki Shimada (Hiroshima University); The innate immune functions of male and female germ cells: Expression of TLR family reduces the risk of fetal infection. -Frank Bartol (Auburn University); Programming neonatal reproductive tract development: The lactocrine hypothesis. In addition, funds were used to support meeting participation for 4 trainees using large animal models in their research. PARTICIPANTS: Funds supported the 30th Annual Meeting of the American Society for Reproductive Immunology. Participants included 150 basic and applied reproductive immunologists from across the globe; many using domestic animal models in their research. This meeting is designed to enhance training of graduate students and post-doctoral fellows by providing opportunities for them to present their research for evaluation and critique. The meeting includes a new investigator award for the top abstract present at the meeting. The meeting also provides CME credits as professional development for clinical physicians/researchers. TARGET AUDIENCES: Physicians and basic and clinical scientists working in the discipline of reproductive immunology. Abstracts of papers presented at the meeting are published as a journal supplement and made available to all members of the American Society for Reproductive Immunology and the scientific community at large. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.

Impacts
The meeting resulted in increased awareness of the role of the immune system in regulating fertility in domestic animals among attendees, members of the society and the scientific community at large. The speakers supported by funds from this grant enhanced understanding among attendees of the role of research using domestic animal models in advancing the discipline of reproductive immunology. Finally, the meeting facilitated development of collaborative studies between scientists using domestic and non-domestic animal models that should accelerate development of new knowledge in both arenas.

Publications

  • 30th Annual Meeting of the American Society for Reproductive Immunology-Meeting Abstracts. May 2010. The American Journal of Reproductive Immunology Volume 63 (Supplement 1). 57 pages.