Progress 09/01/10 to 08/31/13
Outputs
Target Audience: Veterinarians, Livestock Produces, Regulatory Agencies, Federal and State Veterinarians, Consumers, Scientists Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided? Food Animal Medicine and Veterinary Pharmacy residents have been trained through this program on residue avoidance. In addition, this program has actively trained veterinary students and undergraduate students. How have the results been disseminated to communities of interest? Web based information (FARAD web site) and inquires are answered by telephone calls or email responses. What do you plan to do during the next reporting period to accomplish the goals? Collaborations with North Carolina State University and University of Florida will continue in order to provide veterinarians, producers, and veterinary students in training with information relative to residue avoidance in animal derived food products
Impacts
What was accomplished under these goals?
The Western Region continued to answer calls on an every other week basis (shared with North Carolina State University) regarding extra label drug use. In addition, FARAD at UC Davis maintained the pharmacokinetic and bibliographic databases and during this time period all published bibliographic citations and pharmacokinetic records were added to these databases. The FARAD documentation specialist maintained continous activity of evaluating literature, retrieving necessary documents, and updating the bibliographic databse. This data extraction is crucial for the application of newer residue avoidance algorithms and for the call centers to answer the submitted questions. Addition, UCD maintained the web based access to the kietic and bibliographic citation files for global FARAD. With Dr. Lisa Tell's supervision, the programmer continued to revise the historic software to improve data entry. In conjuction with NCSU, the physiologically based pharmacokinetic database was completed. This database will be essential for future estimates for trans-species models.
Publications
- Type:
Journal Articles
Status:
Published
Year Published:
2011
Citation:
Goetting V, Lee KA, Tell LA. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. J Vet Pharmacol Therap Dec;34(6):521-56 (Published online 2011).
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Progress 09/01/11 to 08/31/12
Outputs
Target Audience: Federal regulations require that extralabel use of drugs in food animals be based on scientific principles of residue avoidance. The purpose of the FARAD program is to provide an expert mediated residue avoidance decision support system for veterinarians. The program provides timely advice and educational information on a wide range of drug and chemical entities that food animals are exposed to. Constituents include prescribing veterinarians, regulatory agencies, extension specialists, livestock prodcuers and scientists. This program ultimately reults in a food supply that is free of harmful drug and chemical residues. Changes/Problems:
Nothing Reported
What opportunities for training and professional development has the project provided? Food Animal Medicine and Veterinary Pharmacy residents have been trained through this program on residue avoidance. In addition, this program has actively trained veterinary students and undergraduate students. How have the results been disseminated to communities of interest? Web based information (FARAD web site) and inquires are answered by telephone calls or email responses. What do you plan to do during the next reporting period to accomplish the goals? Collaborations with North Carolina State University and University of Florida will continue in order to provide veterinarians, producers, and veterinary students in training with information relative to residue avoidance in animal derived food products
Impacts
What was accomplished under these goals?
The Western Region continued to answer calls on an every other week basis (shared with North Carolina State University) regarding extra label drug use. In addition, FARAD at UC Davis maintained the pharmacokinetic and bibliographic databases and during this time period all published bibliographic citations and pharmacokinetic records were added to these databases. The FARAD documentation specialist maintained continous activity of evaluating literature, retrieving necessary documents, and updating the bibliographic databse. This data extraction is crucial for the application of newer residue avoidance algorithms and for the call centers to answer the submitted questions. Addition, UCD maintained the web based access to the kietic and bibliographic citation files for global FARAD. With Dr. Lisa Tell's supervision, the programmer continued to revise the historic software to improve data entry. In conjuction with NCSU, the physiologically based pharmacokinetic database was completed. This database will be essential for future estimates for trans-species models.
Publications
- Type:
Journal Articles
Status:
Accepted
Year Published:
2011
Citation:
Leavens TL, Tell LA, Clothier KA, Griffith RW, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats. J Vet Pharmacol Therap 2012 Apr;35(2):121-31 (Published online, 2011).
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Progress 09/01/10 to 08/31/11
Outputs
OUTPUTS: The Western Region has continued to answer calls on an every other week basis (shared with North Carolina State University) regarding extralabel drug use. In addition, FARAD at the University of California Davis maintains the pharmacokinetic and bibliographic databases and during 2010-2011, numerous bibliographic citations and pharmacokinetic records were added to these databases. The FARAD Documentation Specialist maintains a continuous updating process and currently has numerous original references on the library retrieval list that await evaluation for relevant data and data extraction. This data extraction is crucial for the application of some of the newer residue avoidance algorithms. Additionally, UCD maintains the web-based access to the kinetic and bibliographic citation files for the global FARAD (gFARAD) partners. With FARAD Director's (Dr. Lisa Tell) guidance, the UCD FARAD programmer continued to revise the historic software to allow for improved data entry into the kinetic databases and the bibliographic citation database. Records continue to be entered into the pharmacokinetic database. In conjunction with North Carolina State University, the development of a physiologically based pharmacokinetic database began. In the future, the Western Region FARAD Director (Tell) will continue to collaborate with North Carolina State University and the University of Florida personnel on pharmacokinetic research for food animal applications as the FARAD pharmacokinetic database contains a vast resource of data that can be used to develop and validate such models. FARAD telephone, email and webbased inquiries will continue to be answered on a weekly, rotating basis between UC Davis and North Carolina State University. PARTICIPANTS: Nothing significant to report during this reporting period. TARGET AUDIENCES: To provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
FARAD has become crucial to the maintenance of a residue-free food supply to the American public. It is important to recognize that FARAD works with residues that can be either drugs used in veterinary practice, agricultural chemicals or outright environmental contaminants. FARAD provides this guidance through use of its databank by specially trained professional staff to provide information on prevention and mitigation of violative chemical residues and supplies recommended withdrawal intervals to allow safe extralabel use of drugs in food animals based on sound principles of residue avoidance.
Publications
- Young G, Smith GW, Leavens TL, Wetzlich SE, Baynes RE, Mason SE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats. Res Vet Sci, 90(3):477-479, 2011
- Clothier KA, Leavens T, Griffith RW, Wetzlich SE, Baynes RE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus). J Vet Pharmacol Therap (published online), 2011
- Goetting V, Lee KA, Tell LA. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. J Vet Pharmacol Therap (Published online), 2011
- Leavens TL, Tell LA, Clothier KA, Griffith RW, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats. J Vet Pharmacol Therap (Published online), 2011
- Clothier KA, Leavens T, Griffith RW, Wetzlich SE, Baynes RE, Riviere JE, Tell LA. Tulathromycin assay validation and tissue residues after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus). J Vet Pharmacol Therap (Published online), 2011
- Leavens TL, Tell LA, Clothier KA, Griffith RW, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats. J Vet Pharmacol Therap (Published online), 2011
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