Progress 02/01/09 to 01/31/14
Outputs
OUTPUTS: A recent publication this year generated a press release and intense interest. My laboratoty published the unexpected observation that fish oil enhanced colitis and tumor formation in a mouse model of experimental colitis. These tumors were observed at human equivalent doses of 3, 5 and 8 grams of DFO per day on a human 2000 kilocalorie diet. The journal Cancer Research is a top ten Cancer Journal with an impact factor of 7.5. This publication provides an important foundation for upcoming grant submissions. In addition, I was featured on Michigan Public Radio Interview (NPR-Ann Arbor) October 9, 2010, "Ebling and You" 1320 AM Radio Interview October 7, 2010, MyHealthNewsDaily.com Interview October 6, 2010, MSU News Bulletin October, 2010 and the MSU Press Release October 5th, 2010. PARTICIPANTS: Collaborators for the immunology expertise included Dr. Gardner and for the fatty acid work Dr. Pestka. In addition, the pathology was scored by the collaborator Dr. Langohr TARGET AUDIENCES: The target audience continues to be the diet and cancer prevention scientific community, the National Institute of Health and the translation to relevance in the human diet. Clearly, the project has braod interest in the larger community as evidenced by the significant interest generated by the press release. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.
Impacts
The impact of my research program is evident by my recent publications in peer reviewed journals of high quality at the national and international level. Major contributions to the state of knowledge from my laboratory in the field of diet and cancer prevention are primarily by challenging long standing dogma. I have established and continue to establish models illustrating the continuum of the transition of a normal cell to a tumor cell and how diet/nutrients can have a differential impact depending on stage and context. Discrepancies between the dogma and my experimental observations have created several opportunities to clarify the biological context in which dietary factors operate to modulate cancer risk. Dietary supplementation studies in humans have provided specific data showing both reduced and enhance disease risk. The relevance of the research generated from my laboratory is demonstrated by inclusion in the MSU News Bulletin, the front of the MSU web site, the annual Presidents' report for research accomplishments, numerous health related web sites, radio and magazine interviews along with publication in high impact cancer journals.
Publications
- Woodworth HL, McCaskey SJ, Clinthorne J, Langohr I, Duriancik D, Gardner EM, Fenton JI. Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. Cancer Res. 2010 Oct 15;70(20):7960-9.
- Fenton, JI and Birmingham, JM. Adipokines and colon carcinogenesis: Adiponectin attenuates interleukin-6-induced carcinoma cell proliferation via STAT-3. Molecular Carcinogenesis. 2010 Jul; 49(7):700-9.
- Fenton, JI, McCaskey SJ, and Woodworth HL. Molecular mechanisms of obesity, inflammation and cancer: The use of in vitro model approaches for targeted prevention strategies. Open Obesity Journal. 2010; 2:23-37. http://www.bentham.org/open/toobesj/openaccess2.htm
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Progress 01/01/09 to 12/31/09
Outputs
OUTPUTS: My laboratory group has continued to make progress with research in the area of diet and cancer prevention. This year my laboratory group has published 2 research articles in the field. A recent article was featured in the MAES bulletin and the MSU research bulletin in the summer of 2009. The press release was picked up by several national science bulletins and featured on numerous web sites. In addition, the research resulted in a recently funded RO3 from NIH and a grant from the CTSI center at MSU. PARTICIPANTS: Dr. Fenton has overseen the research, designed projects and submitted articles and grants for funding. Dr. Hord has mentored and supported the research design and effort. Dr. McCabe provided technical research support for collection of tissue and growth of bacteria. Dr. Pestka provided access to equipment in his laboratory, diet design and support as well as mentoring. Sarah McCaskey is a MS candidate that conducted much of the research. Anita Gopala, Hillary Woodworth and Andrea Coffman are undergraduates that have provided laboratory assistance for the projects. TARGET AUDIENCES: The research program is oriented towards basic discovery science. Therefore, the target audience is other cancer biologists and nutrition/cancer prevention experts. In addition, funding is targeted at NIH, ACS and AICR. However, as the projects transition to translational research, the target audience will also be community interest in cancer prevention via dietary interventions. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.
Impacts
Obesity has risen at an epidemic rate in the United States and is recognized to increase colon cancer risk. Colon cancer is the second leading cause of cancer in the US. It is anticipated that with increased obesity colon cancer cases will increase; therefore, our research regarding how obesity increases the risk of colon cancer is extremely timely, important and will affect upcoming generations. Adipose tissue secretes hormones in the body that are important modulators of obesity and subsequent cancer risk. Reducing the production of these hormones associated with obesity is a viable target for prevention of colon cancer associated with obesity. However, this hypothesis has not been investigated. The resulting research was featured at the National Obesity Meetings. I was asked to speak at the meeting and overview the research from the last five years as a plenary lecture. In addition, I have been asked to speak in Spain July of 2010 regarding the models and the research. These are evidence of strong impact in the field of diet and cancer prevention.
Publications
- Fenton, JI, McCaskey SJ, and Woodworth HL.Molecular mechanisms of obesity, inflammation and cancer: The use of in vitro model approaches for targeted prevention strategies. 2009 Open Obesity Journal. Accepted(In Press).
- Birmingham JM, Busik JV, Hansen-Smith FM and Fenton JI. Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis. 2009 Apr; 30(4):690-7.
- Fenton JI, Nunez N, Yakar S, Perkins S, Hord NG, Hursting SD. Dietary modulation of energy balance alters the serum profile of inflammation in C57BL/6N mice. 2009. Diabetes, Obesity and Metabolism (published).
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