Influence of Diet on Insulin Resistance and Cognition

Sponsoring Institution

National Institute of Food and Agriculture

Project Status

COMPLETE

Funding Source

HATCH

Reporting Frequency

Annual

Accession No.

0217347

Grant No.

(N/A)

Cumulative Award Amt.

(N/A)

Proposal No.

(N/A)

Multistate No.

(N/A)

Project Start Date

Oct 1, 2009

Project End Date

Sep 30, 2010

Grant Year

(N/A)

Program Code

[(N/A)]- (N/A)

Recipient Organization
AUBURN UNIVERSITY
108 M. WHITE SMITH HALL
AUBURN,AL 36849

Performing Department
Biological Sciences

Non Technical Summary
Various risk factors exist that enhance the probability of one developing cognitive impairment and loss of memory, Alzheimer's disease. The major risk factor is age, and the second is type 2 diabetes. We propose that an increased consumption of sugar in the diet will lead to development of insulin resistance and promote loss of cognition. This study will define the need for reduced sugar consumption, which has been on the rise since the 1950's and may play a role in the increased incidence cognitive issues.

Animal Health Component

Research Effort Categories

Basic

95%

Applied

Developmental

(N/A)

Classification

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
701	2099	1010	25%
702	2099	1010	25%
724	2099	1010	25%
805	2099	1010	25%

Knowledge Area
724 - Healthy Lifestyle; 805 - Community Institutions, Health, and Social Services; 702 - Requirements and Function of Nutrients and Other Food Components; 701 - Nutrient Composition of Food;

Subject Of Investigation
2099 - Sugar crops, general/other;

Field Of Science
1010 - Nutrition and metabolism;

Keywords

Goals / Objectives
1. Examine the influence of diet on the progression of familial and sporadic Alzheimer's disease. 2. Examine whether over expression of p62 might diminish the progression of Alzheimer's disease.

Project Methods
Mice of various genotypes will be fed a diet rich in sugar. At 3 and 7 months thereafter, the mice will be subjected to testing for insulin sensitivity, behavior testing, cytokine profiles by ELISA and various signalling pathways.

Progress 10/01/09 to 09/30/10

Outputs
OUTPUTS: Marie Wooten was killed in a car accident, so this project is terminated. PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Marie Wooten was killed in a car accident, so this project is terminated.

Impacts
Marie Wooten was killed in a car accident, so this project is terminated.

Publications

No publications reported this period

Progress 01/01/09 to 12/31/09

Outputs
OUTPUTS: During this period we generated transgenic mice that overexpress the p62 gene in the hippocampal region of BL6 mice. Currently genetic crossess are ongoing to breed the mice to homoygosity. PARTICIPANTS: Mr. Lamar Seibenhener TARGET AUDIENCES: Nothing significant to report during this reporting period. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
None as of yet. This is a new project that has not yielded outcomes nor impacts.

Publications

No publications reported this period