Source: NORTH CAROLINA STATE UNIV submitted to NRP
FOOD ANIMAL FUNCTIONAL GENOMICS FELLOWSHIP PROGRAM
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0215408
Grant No.
2009-38420-05026
Cumulative Award Amt.
(N/A)
Proposal No.
2008-03689
Multistate No.
(N/A)
Project Start Date
Dec 1, 2008
Project End Date
Nov 30, 2013
Grant Year
2009
Program Code
[KK]- National Needs Graduate Fellowships Program
Recipient Organization
NORTH CAROLINA STATE UNIV
(N/A)
RALEIGH,NC 27695
Performing Department
ANIMAL SCIENCE
Non Technical Summary
This proposal outlines an integrated program of graduate training, research, and industry outreach designed to meet the national need for academics and scientists trained in the application of functional genomics to food animal agriculture. The United States has strived to maintain a leadership role in the agricultural sciences including that for food animal agriculture. In order to maintain this role, the implementation of new technologies including those utilizing genomic science must be applied to food animal production. Therefore our goal is to increase the number of qualified academics and scientists with skills in functional genomics, food animal production, and innovative training for online learning. This proposal seeks to support two pre-doctoral students (Food Animal Fellows, FAFs) embedded in the Functional Genomics graduate curriculum at North Carolina State University focusing on research in animal and poultry science. The research of these students will involve identification, mapping, manipulation, and understanding of the function and control of genes to improve production, well-being, and health of agricultural/food animals. With the increasing globalization of world economies and the competition of countries such as China, India, and Brazil, it is vital that poultry, swine, and their allied industries in the US remain forward thinking leaders in new and emerging technologies and train a new generation of qualified academics and scientists. The core faculty involved in training the Fellows funded through this program consists of a group using integrated systems-wide molecular approaches in food animal model systems. The bulk of this research is dual-benefit in that it will have direct impacts on both animal agriculture and human health. The innovative addition of training in online instruction will provide the FAFs with valuable skills to develop and deliver information and course content outside the "bricks and mortar" classroom. By all accounts, demand for online education is expanding. About 3.2 million students took at least one online course during the fall of 2005. That is 39 percent more than the 2.3 million the previous year, according to the Sloan Consortium, which promotes standards for online learning. Online education is becoming an important long-term strategy for many postsecondary institutions. Given the rapid growth of online education and its importance for postsecondary institutions, it is imperative that institutions of higher education provide quality online programs as well as training for instructors on the proper pedagogy and technologies involved in the delivery of these courses. Literature suggests academics play a different role from that of traditional classroom instructors when they teach online courses as well as when they teach residential courses with Web enhancements. These new roles for online instructors require training and support. Some case studies of faculty development programs indicate that such programs can have positive impacts on an instructor's ability to transition from teaching face-to-face to an online setting.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
90360993020100%
Goals / Objectives
This proposal outlines an integrated program of graduate training, research, and industry outreach designed to meet the national need for academics and scientists trained in the application of functional genomics to food animal agriculture. The United States has strived to maintain a leadership role in the agricultural sciences including that for food animal agriculture. In order to maintain this role, the implementation of new technologies including those utilizing genomic science must be applied to food animal production. Therefore our goal is to increase the number of qualified academics and scientists with skills in functional genomics, food animal production, and innovative training for online learning. This proposal seeks to support two pre-doctoral students (Food Animal Fellows, FAFs) embedded in the Functional Genomics graduate curriculum at North Carolina State University focusing on research in animal and poultry science. The research of these students will involve identification, mapping, manipulation, and understanding of the function and control of genes to improve production, well-being, and health of agricultural/food animals. With the increasing globalization of world economies and the competition of countries such as China, India, and Brazil, it is vital that poultry, swine, and their allied industries in the US remain forward thinking leaders in new and emerging technologies and train a new generation of qualified academics and scientists. The core faculty involved in training the Fellows funded through this program consists of a group using integrated systems-wide molecular approaches in food animal model systems. The bulk of this research is dual-benefit in that it will have direct impacts on both animal agriculture and human health. The innovative addition of training in online instruction will provide the FAFs with valuable skills to develop and deliver information and course content outside the "bricks and mortar" classroom. By all accounts, demand for online education is expanding. About 3.2 million students took at least one online course during the fall of 2005. That is 39 percent more than the 2.3 million the previous year, according to the Sloan Consortium, which promotes standards for online learning. Online education is becoming an important long-term strategy for many postsecondary institutions. Given the rapid growth of online education and its importance for postsecondary institutions, it is imperative that institutions of higher education provide quality online programs as well as training for instructors on the proper pedagogy and technologies involved in the delivery of these courses. Literature suggests academics play a different role from that of traditional classroom instructors when they teach online courses as well as when they teach residential courses with Web enhancements. These new roles for online instructors require training and support. Some case studies of faculty development programs indicate that such programs can have positive impacts on an instructor's ability to transition from teaching face-to-face to an online setting.
Project Methods
Innovative, special features of our program that will be available to or required especially for the FAFs have been described in detail throughout the proposal and are summarized below. We will couple research training with teaching, mentoring and outreach training. Each Fellow will develop and maintain a career portfolio, including goals for PhD program in teaching, research, mentoring and service components. Fellows will continually update the portfolio, helping them and their mentors identify areas needing improvement and outlining steps that will be taken to achieve goals. This portfolio will also be used to assess students' progress and outcomes. Each Fellow will serve as teaching assistant for at least one semester. Prior to serving as TA, Fellows will complete an activity that will teach them how to be effective instructors. The 2 Fellows will learn to develop effective online content through DELTA technology instruction. Fellows will have the opportunity to mentor an undergraduate student on a research project, providing the Fellow the opportunity to learn how to mentor students. We will provide cross-disciplinary, innovative training. Each Fellow will follow the Functional Genomics curriculum, receiving in-depth training in Functional Genomics with cross-training in bioinformatics, ethics and the opportunity to minor in animal or poultry science or biotechnology. Each Fellow will have the opportunity to participate in an industry internship. These internships, sponsored by major companies involved in the production of food animals, will expose the Fellows to the workings of research and development on a commercial scale and potentially pipeline them into available food animal genomics positions upon graduation. Fellows will participate in Professional Development courses so they acquire skills to assess values and conflicts arising in a diverse and global workplace. We will respond to the academic, social, financial and cultural needs of the Fellows. Fellows from underrepresented groups will be able to participate in bridging programs to help them acquire research skills prior to starting the PhD program. Each Fellow will participate in student orientation and be encouraged to participate in student-sponsored educational and social events organized by the Functional Genomics, Animal Science, and Poultry Science Graduate Student Associations and cultural groups such as the Association for the Concerns of African-American Graduate Students. Each Fellow will receive a competitive stipend and tuition remission throughout their PhD program through funds provided by this award as well as support provided by the College. This tuition and infrastructure support illustrates the College's commitment to training Functional Genomics scientists working in animal agriculture.

Progress 12/01/12 to 11/30/13

Outputs
Target Audience: Nothing Reported Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Nothing Reported How have the results been disseminated to communities of interest? Nothing Reported What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

Impacts
What was accomplished under these goals? Two graduate students have continued to matriculate toward their degrees via conducing research projects and assisting with teaching assignments.

Publications


    Progress 12/01/08 to 11/30/13

    Outputs
    Target Audience: The primary audience reached by this project was the two graduate fellows who were trained. Other secondary audiences that were impacted include other scientists, graduate and undergraduate students with whom the fellows interacted. For example, the fellows were highly mentored and engaged as teaching assistance, with a collective impact on approximately 700 undgergraduate students. Changes/Problems: Nothing Reported What opportunities for training and professional development has the project provided? Becasue this is exclusively a student training grant, it has been completely devoted to the professional development of the two fellows recruited into the program. Accordingly, it is redundant to repeat the training activities outlined above. How have the results been disseminated to communities of interest? The results have been communicated both via the didactic classroom but also though the scientific meetings and conferences attending by the fellows. The fellows have taught courses and made multiple seminar and conference presentations related to their research projects. What do you plan to do during the next reporting period to accomplish the goals? Nothing Reported

    Impacts
    What was accomplished under these goals? After some unanticipated delay and multiple failed attempts to recruit students from neighboring 1890 institutions, two academically talented Ph.D. students were competitively recruited to fill the Food Animal Fellows positions made available via this project. Dynamic advising teams were assembled to mentor the students with Drs. Ashwell and Koci taking the lead mentoring roles for the two students. Both fellowswere housed in the Department of Poultry Science but matriculated through the Functional Genomics program at North Carolina State University. While engaged in the cross-cutting biotechnology and bioinformatic curricula, the students were mentored in proposal writing, research and teaching (both traditional and distance education) related to multiple dimensions of nutrition, functional genomicsand food animal biotechnology. Although neither student has yet graduated, their strong trajectories will lead to completeddoctorial degrees within 2014. We expect both fellows to build upon the solidfoundation provided by this training grantand to have strong careers in allied animal biotechnogly.

    Publications

    • Type: Conference Papers and Presentations Status: Published Year Published: 2013 Citation: A. L. Ballou, R. Qiu, R. A. Ali, W. J. Croom, and M. D. Koci. Direct fed microbial supplementation affects host immune function and energy consumption. April 2013. Experimental Biology 2013. Boston, MA.
    • Type: Conference Papers and Presentations Status: Published Year Published: 2012 Citation: J. Croom, C. Nash, M. D. Koci, J. Wock, A. Ballou, D. Carver, and J. Brake. Fluoxetine increases growth and feed efficiency in broilers. July 2012. Annual Meeting of the Poultry Science Association. Athens, GA.
    • Type: Journal Articles Status: Published Year Published: 2012 Citation: R. Qiu, J. Croom, R. A Ali, A. L. Ballou, C. Smith, C. M. Ashwell, H. M. Hassan, C.-C. Chiang, and M. D. Koci. Direct fed microbial supplementation repartitions host energy to the immune system. Journal of Animal Science. 90:113, 2012.
    • Type: Conference Papers and Presentations Status: Published Year Published: 2012 Citation: A. Zavelo, & C. Ashwell. (2012). Epigenetic impacts associated with early phosphorus (P) conditioning on intestinal gene expression may result from NOTCH signaling networks. Presented at ISAG 2012, Cairnes, Australia.
    • Type: Conference Papers and Presentations Status: Published Year Published: 2013 Citation: A. Zavelo, S.J.Lamont, C. Schmidt, M. Rothschild, M. Persia, and C. Ashwell (2013). MHC Diversity in Local Ugandan Birds. PSA annual meeting 2013, San Diego, CA.
    • Type: Conference Papers and Presentations Status: Awaiting Publication Year Published: 2014 Citation: R. L. Taylor, Jr., S. J. Nolin, Z. S. Lowman, A. Zavelo, and C. M. Ashwell., (2014) v-src tumor growth differs among recombinant congenic strains identical at the major histocompatibility complex. Poultry Science Association Annual Meeting, Corpus Christi, TX.


    Progress 12/01/11 to 11/30/12

    Outputs
    OUTPUTS: Ms Anne Ballou has been making progress on her training. She has continued to serve as TA for Comparative Nutrition (NTR/PO 415). She has assembled a graduate committee and will finish her course work in the spring of 2013 with expectations of taking her preliminary exams in the summer or early fall of 2013. In addition, she has been making great progress in the laboratory, and has developed several new assays for use in her research. Her progress in this area has led to her submitting an abstract the 2013 Experimental Biology meeting entitled "Direct fed microbial supplementation affects host immune function and energy expenditure". PARTICIPANTS: Nothing significant to report during this reporting period. TARGET AUDIENCES: Nothing significant to report during this reporting period. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.

    Impacts
    There is no impact of the project to date.

    Publications

    • No publications reported this period


    Progress 12/01/10 to 11/30/11

    Outputs
    OUTPUTS: We successfully recruited a panel of graduate student applicants and selected two individuals to receive Food Animal Functional Genomics Fellowships: Ms Anne Ballou and Mr Alexander Zalvo. Prior to applying to the graduate program at NC State Ms Ballou received a BS in Animal Science in 2007 (GPA 3.59) and a Masters of Science in Animal Science in 2010 (GPA 3.87) from the University of Kentucky. Ms Ballou is interested in understanding how animal health and performance is regulated through nutrition, the intestinal microbiota, and the mucosal immune system. Based on these interests Ms Ballou elected to work in the laboratory of Dr Matt Koci on a project done in collaboration with Dr Jim Croom investigating how changes in the intestinal microbiota affect the expression and function of physiological systems both in the intestine and systemically. Since joining the Functional Genomics graduate program and Dr Koci's laboratory Ms Ballou has worked to define her project as well as fulfill the expectations of her as one of the Food Animal Functional Genomics Fellows. She has begun working on developing her career portfolio, and is expected to complete the first draft of this document by the middle of her second semester. She as already served as a Teaching Assistant for Dr Jim Croom's Comparative Nutrition (NTR/PO 415). This course is offered both as a traditional classroom course as well as a Distance Education course. She served as TA in the Fall of 2011, and has agreed to serve as the TA for this course again in the Spring of 2012 with the expectation that she will continue in this role throughout her program with increasing responsibilities each term. As part of her TA responsibilities Ms Ballou has completed a series of online Distance Education training classes offered through NC State (http://delta.ncsu.edu/). Ms Ballou was also selected to participate in the Graduate Student Professional Development Workshop program offered annually through the College of Agriculture and Life Sciences (http://harvest.cals.ncsu.edu/applications/career/gspdw/). This program has been offered over the past 25 years and is a 3 day experience designed to expose graduate student participants to many professional development issues including personnel management, role of personality types, interviewing skills, stress management, ethics, and interactions with the media. Ms Ballou has also become an active participant both the Functional Genomics Graduate Student Association as well as the Poultry Science program. In addition to these activities, Ms Ballou has been very active in the laboratory trying to determine the specific focus of her PhD dissertation. As part of these efforts she has contributed to several active projects, one of which was submitted and is currently in press in the Journal of Animal Science. PARTICIPANTS: Ms Anne Ballou and Mr Alexander Zalvo and graduate student fellows recieving mentoring from Dr. Matthew Koci and Dr. Christopher Ashwell (co-PI's on the grant). Both students are being supported on the grant as they matriculate toward their professional degrees at North Carolina State University. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

    Impacts
    There is no impact of the project to date.

    Publications

    • R. Qiu, J. Croom, R. A. Ali, A. L. Ballou, C. Smith, C. M. Ashwell, H. M. Hassan, C. C. Chiang, and M. D. Koci. Direct Fed Microbial Supplementation Repartitions Host Energy to the Immune System. Journal of Animal Science. In Press. 2011.


    Progress 12/01/09 to 11/30/10

    Outputs
    We revised our recruitment brochure that outlines the training program. The brochure was re-distributed electroncially and a co-PI particiated in a minority recruitment program in Charlotte North Carolina. The PI also particpated in a distance education workshop sponsored by Michigan State University. We are actively recruting two prospective students to begin the program in the Fall of 2011. PRODUCTS: We have produced a recruitment brochure. OUTCOMES: The program will produce two well-trained scientists in the area of food animal functional genomics. DISSEMINATION ACTIVITIES: We have electronically distributed our recruitment brochure, nationally. FUTURE INITIATIVES: Our future initiative is to recruit and train two graduate students in food aninmal functional genomics.

    Impacts
    There is no impact of the project to date.

    Publications

    • No publications reported this period


    Progress 12/01/08 to 11/30/09

    Outputs
    We have developed a recruitment brochure that outlines the training program. The brochure has been distributed electroncially and the principal investigator particiated in a minority recruitment program on the North Carolina State University Campus. A co-investigator also particpated in a USDA-sponsored workshop to interact with program staff and other training grant investigators. We hope to successfully recruit two students in the coming year. PRODUCTS: We have produced a recruitment brochure. OUTCOMES: The program will produce two well-training scientists in the area of food animal functional genomics. DISSEMINATION ACTIVITIES: We have electronically distributed our recruitment brochure, nationally. FUTURE INITIATIVES: Our future initiative is to recruit and train two graduate students in food aninmal functional genomics.

    Impacts
    There is no impact to date.

    Publications

    • No publications reported this period