Progress 09/01/08 to 08/31/12
Outputs
OUTPUTS: The 2008 USDA-NIFSI support for the conference project enabled the PI and the conference organization committee accomplished the proposed objectives with the following outputs: 1. Organized the international conference on "Food Safety and Public Health: Minimizing Antibiotic Resistance Transmission through the Food Chain", April 2-3, 2009, in Crystal City, VA. The conference brought together experts from academia, industry, and federal agencies to provide a balanced and scientific review on AR. More than 20 invited senior experts shared their most up-to-date discoveries and visions on AR management through oral presentations. Close to 80 expert attendees participated in the conference discussion. It is the consensus view of the conference organization committee that systematic studies for a comprehensive understanding, both at macroscopic and microscopic levels, of AR connected to the food chain, is central to design targeted and integrated intervention strategies for effective mitigation. 2. A synthesized expert report on AR research and mitigation directions was developed by the organization committee members, keynote speaker and session moderators, submitted to USDA-ARS and NIFA food safety leaders, and shared with NARMS director. The recommendation was addressed in USDA-ARS 5-year strategic plan, NIFSI RFA, and published in ASM official journal "Microbe" (Dec, 2010). 3. The group submitted an expert input to NARMS (USDA, FDA, CDC national AR monitory network) 5-year strategic plan, during the public commenting period (March 2011). 4.The PI, assistant Lu Zhang, and several team members (Sofos, Zhang etc) traveled to China and delivered a workshop on antibiotic resistance and targeted mitigation to Chinese colleagues. 5. A special issue on Antibiotic Resistance was published by the ASM journal Appl Environ Microbiology (Oct 2011), with conference organization committee member Don Schaffner being the issue editor. Thirteen papers from the conference senior speakers were published to systematically present a comprehensive picture on AR and mitigation, for a broad impact. PARTICIPANTS: Conference organization co-chairs: Hua H. Wang Food Science, Microbiology, Human Nutrition The Ohio State University; John Sofos Center for Meat Safety & Quality Colorado State University; Thaddeus B. Stanton National Animal Disease Center USDA-ARS; Organization Committee: Timothy J. Buckley School of Public Health The Ohio State University; Michael P. Doyle Center for Food Safety University of Georgia; Donald W. Schaffner Food Science and Nutrition The State University of New Jersey-Rutgers; Thomas R. Shryock Elanco Animal Health Eli Lilly and Company; Mary E. Torrence Food Safety, National Program USDA-ARS; Qijing Zhang Veterinary Microbiology & Preventive Medicine Iowa State University; Ad Hoc Member: D. Ramkishan Rao CSREES, USDA; Conference organization program manager: Lu Zhang, the Ohio State University; Conference web page technical support: Tony Stull, The Ohio State University; Conference accounting support: Tina Gossard, The Ohio State University; Conference facility provider: Crystal City Embassy Suites Hotel. TARGET AUDIENCES: More than 80 international conference participants covered a broad range of stakeholders across food, agriculture, medicine, public health, veterinary medicine including but not limited to academic researchers and educators; government legislative, regulatory and research agencies; agricutlure,food and pharmaceutical industries; consumer groups. The conference provided the platform to facilitate discussion and knowledge dissemination to all participants. The publications and scientific recommendations further enabled effective coverage to all stakeholders worldwide. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.
Impacts
The conference and series of publication and recommendation systematically presented a much more comprehensive scientific picture regarding antibiotic resistance emergence, dissemination, persistence in humans, animals, environment and the food chain compared to previous understanding, and illustrated the success of antibiotic resistance reduction in fermented dairy products through targeted mitigation. The cutting-edge knowledge and successful example on antibiotic resistance reduction have already significantly facilitated the change of the direction of scientific investigation, policy and mitigation approaches in agriculture and human medicine, as reflected in USDA and FDA agency strategic plans and call for proposals, WHO/FAO antibiotic resistance risk assessment document, etc. As the first and only international conference so far with the focus on commensal bacteria and antibiotic resistance mitigation, USDA played a key role in recognizing the knowledge breakthrough and facilitated this landmark movement in scintific history. The project will have major and lasting impact on protecting the health of human beings, food and non-food animals, the resistance status of the global ecosystem, as well as on the multi-billion-dollar healthcare industry, as well as food and agriculture commodities towards effective problem control.
Publications
- Meeting and peer-reviewed abstracts: 1. International Conference: Food Safety and Public Health: Minimizing Antibiotic Resistance Transmission through the Food Chain, April 2-3, 2009, in Crystal City, VA. 2. 30 abstracts in the conference abstract book.
- 6. Karczmarczyk M, Walsh C, Slowey R, Leonard N, Fanning S. 2011. Molecular characterization of multidrug resistant (MDR) Escherichia coli isolates from Irish cattle farms. Appl. Environ. Microbiol. 77: 7121-7127.
- 7. Li XH, Alvarez V, Harper WJ, Wang HH. 2011. Persistent, TA-independent tetracycline resistance-encoding plasmid from a dairy Entercococcus faecium isolate. Appl. Environ. Microbiol. 77:7096-7103.
- 8. Li XH, Li YL, Alvarez V, Harper WJ, Wang HH. 2011. Antibiotic resistance mitigation in dairy fermentation. Appl. Environ. Microbiol. 77:7171-7175.
- 9. Schink A, Kadlec K, Schwarz S. 2011. Analysis of blaCTX-M-carrying plasmids from Escherichia coli isolates collected in the BfT-GermVet study. Appl. Environ. Microbiol. 77:7142-7146.
- 10. Shen Z, Pu X, Zhang Q. 2011. Salicylate functions as an efflux pump inducer and promotes the emergence of fluoroquinolone-resistant mutants in Campylobacter. Appl. Environ. Microbiol. 77:7128-7133.
- 11. Stanton TS, Humphrey SB. 2011. The persistence of antibiotic resistance: evaluation of a probiotic approach using antibiotic-sensitive M. elsdenii strains to prevent colonization of swine by antibiotic resistant strains. Appl. Environ. Microbiol. 77:7158-7166.
- 12. Stanton TS, Humphrey SB, Stoffregen WC. 2011. Chlortetracycline-resistant intestinal bacteria in organically-raised and feral swine. Appl. Environ. Microbiol. 77:7167-7170.
- Peer-reviewed papers: 1. Wang HH, Schaffner DW. 2011. Antibiotic Resistance: How Much Do We Know and Where Do We Go from Here Appl. Environ. Microbiol. 77:7093-7095
- 2. Feßler AT, Kadlec K, Hassel M, Hauschild T, Eidam C, Ehricht R, Monecke S, Schwarz S. 2011. Characterization of methicillin-resistant Staphylococcus aureus isolates from food and food products of poultry origin. Appl. Environ. Microbiol. 77:7151-7157.
- 3. Kadlec K, von Czapiewski E, Kaspar H, Wallmann J, Michael GB, Steinacker U, Schwarz S. 2011. Molecular basis of sulfonamide and trimethoprim resistance in fish-pathogenic Aeromonas isolates. Appl. Environ. Microbiol. 77:7147-7150
- 4. Karczmarczyk M, Abbott Y, Walsh C, Leonard N, Fanning S. 2011. Characterisation of multidrug resistant Escherichia coli from animals presenting at a university veterinary hospital. Appl. Environ. Microbiol. 77:7104-7112.
- 5. Karczmarczyk M, Martins M, Quinn T, Leonard N, Fanning S. 2011. Mechanisms of fluoroquinolone resistance in Escherichia coli isolates from food-producing animals. Appl. Environ. Microbiol. 77:7113-7120.
- 13.Zhang L, Kinkelarr D, Huang Y, Li Y. Li XJ, Wang HH. 2011. Antibiotic resistance: are we born with it Appl. Environ. Microbiol. 77:7134-7141.
- 14. Wang HH. 2010. Antibiotic Resistance Mitigation: a Complicated Issue Begging for Targeted Investigation. Microbe. 504-505.
|
Progress 09/01/08 to 08/31/09
Outputs
OUTPUTS: The Conference on Food Safety and Public Health Frontier:Minimizing Antibiotic Resistance Transmission through the Food Chain was delivered from April 2 to 3, 2009, in Crystal City, Virginia. Conference brochure includeing program, compiled abstracts for oral and poster presentations, and a list of attendees was delivered to conference attendees. An expert report from the scientific organization committee, conference session convenors and keynote speaker was developed and submitted to USDA-CSREES (NIFA) food safety program officers and ARS national food safety program leader. PARTICIPANTS: Hua Wang, PI, conference organizer, conference scientific organization committee co-chair, conference session convenor, speaker; John Sofos, co-PI, conference co-organizaer and scentific organization committee co-chair, conference session convenor, speaker; Thas Stanton, co-PI, conference co-organizaer and scentific organization committee co-chair, conference session convenor, speaker; Timothy Buckley,Donald W. Schaffner,Thomas R. Shryock,Mary E. Torrence, scentific organization committee member,conference session convenor; Michael P. Doyle, scentific organization committee member; Qijing Zhang, scentific organization committee member,conference session convenor, speaker; Richard Raymond, conference session moderator; Lydia Medeiros: conference session moderator and speaker; additional speakers: Colien Hefferan; Terence Whitehead; John Maurer; Karl Matthews; Jeff LeJune; Barbara E. Murray; Stefan Schwarz; Seamus Fanning; Todd R. Callaway; John R. MacMillan; Toni Poole; Steven J. Lehotay; Abigail Salyers; Paul Sundberg; David White; Jianghong Meng; Valente Alvarez;Teresa Morishita; Ann Draughon. The conference attracted more than 80 expert attendees covering all major agriculture, food and public health domains. US Congressional fellow, EU representative also attended the conference. TARGET AUDIENCES: Targted audeinces include scientists, regulators and representatives from government, industry, academia, and consumer organizations. The conference information was disseminated through AR conference webpage and listserve through IFT food microbiology and biotechnology divisions, US agriculture, food science and nutrition chair network, IAFP official journal anouncement,etc. PROJECT MODIFICATIONS: The project is still on-going. After successfully delivered the conference, an expert report was compiled and sumbitted to USDA-CSREES and ARS. Information from the report has already been incorporated into NIFSI call for proposal and ARS 5-year strategic plan. Initially we have also considered gathering papers from all speakers for a JFP supplemental issue. After discussion, the committee decided it is better to put together a review paper with synthesized opinion. This is what we will do in the following year.Meanwhile, we will also continue the effort to disseminate related scientific information to policy makers, industry, government agencies and consumers for targeted mitigation.
Impacts
Information from the conference and the expert report has already been incorporated into USDA-ARS 5-year strategic plan and NIFSI call for proposal,and we expect to see more follow ups from other food safety programs and agencies including other NIFA programs and NARMS (FDA, USDA, CDC). In addition, the package has also been delivered to Senator's office and Senator Brown is considering to have a discussion with the related group at OSU. Dr. Wang has provided input to his draft bill, basically emphasized the emerging scientific evidence, the complication of the AR issue and urged for a balanced scientific approach for strategic breakthroughs in targeted mitigation.
Publications
- A total of 30 abstracts was published in the Conference proceeding, made available to all attendees. Examples: Thad B. Stanton. 2009. Antibiotic Resistant Microbiota in the Swine Intestinal Tract. Conference on Food Safety and Public Health Frontier: Minimizing Antibiotic Resistance through the Food Chain. Abstract S1, Conference proceeding p7.
- Terence R. Whitehead. 2009. Microbial Ecology of and Antimicrobial Resistance in Stored Swine Manure. Conference on Food Safety and Public Health Frontier: Minimizing Antibiotic Resistance through the Food Chain. AbstractS2, Conference proceeding p7.
- Hua H. Wang. 2009. Antibiotic resistance in processed foods and human digestive tract. Conference on Food Safety and Public Health Frontier: Minimizing Antibiotic Resistance through the Food Chain. Abstract S3, Conference proceeding p7.
- John N. Sofos. 2009. Antibiotic Resistance in Meats and Other Foods. Abstract S4, Conference proceeding p8.
- Karl Matthews. 2009. Antibiotic Resistance in Produce. Abstract S6, Conference proceeding p8.
- Jeffrey T. LeJeune. 2009. Organic Food Production and Antibiotic Resistance: A Case of the Tail Wagging the Dog. Abstract S7, Conference proceeding p9.
- Barbara E. Murray. 2009. Antibiotic Resistance in Enterococci. Abstract S8, Conference proceeding p9.
|