DOSE TITRATION OF AN INTRAVENOUS (IV) LIPOPOLYSACCHARIDE (LPS) CHALLENGE IN CALVES

• Sponsoring Institution: Cooperating Schools of Veterinary Medicine
• Project Status: COMPLETE
• Funding Source: STATE
• Reporting Frequency: Annual
• Accession No.: 0213198
• Project Start Date: Oct 31, 2006
• Project End Date: Nov 14, 2007
• Program Code: [(N/A)]- (N/A)

Recipient Organization
UNIV OF CALIFORNIA (VET-MED)
(N/A)
DAVIS,CA 95616

Performing Department
POPULATION HEALTH AND REPRODUCTION

Non Technical Summary
Coliform mastitis is a widespread problem in the dairy industry. Rapid proliferation of coliform bacteria in the udder frequently initiates a rigorous inflammatory reaction that causes death of coliform bacteria and subsequent release of endotoxin. Resulting toxemia may cause severe local and systemic clinical signs and/or death of the animal. Endotoxin disease models in calves have demonstrated that similarities exist in systemic clinical signs of calf endotoxin disease and toxic coliform mastitis in cows. This project is a drug study to determine an optimal level of intravenous LPS challenge in calves.

Animal Health Component

(N/A)

Research Effort Categories

Basic

(N/A)

Applied

(N/A)

Developmental

100%

Classification

Knowledge Area (KA)	Subject of Investigation (SOI)	Field of Science (FOS)	Percent
311	3410	1180	50%
901	3410	1180	50%

Knowledge Area
311 - Animal Diseases; 901 - Program and Project Design, and Statistics;

Subject Of Investigation
3410 - Dairy cattle, live animal;

Field Of Science
1180 - Pharmacology;

Keywords

mastitis

dairy cattle

holstein calves

drug study;

Goals / Objectives
This project is a drug study to determine an optimal level of intravenous LPS challenge in calves.

Project Methods
The study design is a generalized randomized block design with one-way treatment structure. The blocking factor is the challenge group. Two groups of animals, 12 calves per challenge group, will be alloted to treatment groups T01, T02, T03 or NTX (no treatment) with each treatment equally represented in a challenge group.

Progress 10/31/06 to 11/14/07

Outputs
OUTPUTS: No Outputs information provided. PARTICIPANTS: No Participants Information Provided. TARGET AUDIENCES: No Target audience information provided. PROJECT MODIFICATIONS: No Project Modification information provided.

Impacts
No Outcomes information provided.

Publications

• No publications reported this period