Source: UNIV OF WISCONSIN submitted to NRP
RESEARCH AND TRAINING IN NUTRITIONAL SCIENCES
Sponsoring Institution
State Agricultural Experiment Station
Project Status
COMPLETE
Funding Source
STATE
Reporting Frequency
Annual
Accession No.
0213164
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Jul 1, 2007
Project End Date
Jun 30, 2012
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIV OF WISCONSIN
21 N PARK ST STE 6401
MADISON,WI 53715-1218
Performing Department
Nutritional Sciences
Non Technical Summary
Optimum nutrition is one of the major factors that individuals can control to prevent disease and to promote health throughout their lifespan. Even today, America as well as the World continues to suffer from poor nutrition, ranging from over nutrition (obesity, diabetes, cardiovascular disease) to poor nutrition (fast foods, snack foods, few fresh fruits and vegetables) to under nutrition (starvation, deficiencies in protein, vitamin A, iron, selenium). In research, the department is conducting original research to help solve these problems by gaining new knowledge that will help shape public policy, dietary recommendations, and treatment of disease. Specific research areas include: Community Nutrition and Epidemiology; Diabetes and Obesity Mechanisms; Molecular Mineral Nutrition; Nutrition and Intestine; Vitamin A metabolism, function, and nutrition. For graduate student training, faculty oversee our graduate students, who learn to conduct original research in the research areas listed above, as part of the path to become independent scientists and teachers. The outcome is the training of the next generation of nutritional sciences researchers and teachers. In Nutritional Sciences Extension, faculty, staff and county extension agents develop and present programs to the public that teach youth, adults and the elderly about emerging concepts in nutrition so that they can better make informed choices and adoption of nutrition recommendations in their lives and the lives of those they influence.
Animal Health Component
(N/A)
Research Effort Categories
Basic
(N/A)
Applied
(N/A)
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7246099101020%
8056099101010%
7023299100010%
7023999101010%
7023999102010%
7023999104010%
7024020104010%
7026099117010%
7036099101010%
Knowledge Area
703 - Nutrition Education and Behavior; 724 - Healthy Lifestyle; 805 - Community Institutions, Health, and Social Services; 702 - Requirements and Function of Nutrients and Other Food Components;

Subject Of Investigation
3999 - Animal research, general; 3299 - Poultry, general/other; 4020 - Fungi; 6099 - People and communities, general/other;

Field Of Science
1040 - Molecular biology; 1010 - Nutrition and metabolism; 1000 - Biochemistry and biophysics; 1020 - Physiology; 1170 - Epidemiology;
Goals / Objectives
To generate and disseminate knowledge regarding diet and nutrition to improve the health and economic development of current and future generations and foster an educated society.
Project Methods
To accomplish these goals, the Department of Nutritional Sciences: provides research labs for 12 faculty who support their research via competitive grants; the department in conjunction with the Interdepartmental Graduate Program in Nutritional Sciences trains approximately 40 graduate students in modern nutritional sciences; the department provides undergraduate training in nutritional sciences and dietetics to approximately 250 undergraduate majors by advising, by teaching formal courses, and by providing individualized training projects; the department in conjunction with UW Extension and Outreach leads state-wide programs to improve the health and nutrition knowledge of the public.

Progress 07/01/07 to 06/30/12

Outputs
OUTPUTS: Nutrition is the science in which biology, chemistry and social sciences meet to study and explain metabolic pathways for nutrients, therapies for diseases, and food habits and customs. Our Interdepartmental Graduate Program in Nutritional Sciences (IGPNS) has 7 Masters students and 26 PhD students. We conferred 5 PhD degrees in 2010 (Huebner, Gialamas, MacLeod, Frey, 1106 and Raines) and I MS degree (Joyce). Our undergraduate program had 260 students (107 in dietetics, 99 in pre-dietetics, 53 in natural sciences and 1 in international) in fall, 2010. We recently instituted a new requirement with GPA minimums for admission to our dietetics major which has enabled us to provide more focused instruction to students who are pursuing the highly competitive professional credential of "registered dietitian" (RD). In collaboration with the College of Agriculture and Life Sciences (CALS) International Programs and the Center for Global Health, the Department was awarded funds to develop a Certificate in Global Health. The directorship will be housed in Nutritional Sciences and the certificate administered by CALS. Several courses are in development including introductory core classes, international field courses and relevant public health experiences in the United States. In cooperation with UW-Extension, The UW-Madison Institute on Aging and other co-sponsors, we conducted a statewide conference on "Current Concepts in Nutrition and Aging" in September, 2010 and we collaborated with other members of WiPOD (Wisconsin Prevention of Obesity and Diabetes) and WI-PAN (Wisconsin Partnership for Physical Activity and Nutrition) to offer an interdisciplinary conference on in preventing obesity at the community level in June, 2010. PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Nothing significant to report during this reporting period. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.

Impacts
The WiPOD-WI PAN collaboration has led to four grants with Nutritional Science faculty as co-investigators. Three of the grants support IGPNS graduate student research, as follows: 1) A School of Medicine and Public health grant to study socio-economic influences on rates of obesity in Hispanic children in a charter school in Milwaukee, 2), a CDC grant to evaluate the impact of farm-to-school programs on knowledge, attitudes and consumption of fruits and vegetables, and 3) a pilot study of the influence of a 10-week summer gardening project on the fatness and fitness of overweight and obese children. As evidenced by the publications below, our Department conducted original research in community nutrition, nutritional epidemiology, diabetes/obesity prevention and treatment, mineral metabolism, nutritional interaction with intestinal function, metabolism of vitamin A and other vitamins. For example: Studies in the Yen group revealed that the triglyceride synthesis enzyme MGAT2 regulates energy expenditure in response to meals. David Nelson, an IGPNS post-doctoral trainee , has been invited to give an oral presentation of these findings at the Experimental Biology national conference in 2011. Professor Ney's research with glycomacropeptide (GMP) to improve the diet required for phenylketonuria (PKU) has resulted in the successful introduction of a commercial formula containing GMP, BetterMilk by Cambrooke Foods, for those with PKU in the United States. The Eisenstein group further elucidated how iron metabolism is controlled through selective expression of key proteins involved in iron metabolism. Professor Lai's epidemiologic research on the effects of nutrition on the onset and progression of pediatric chronic diseases began in the area of cystic fibrosis and has expanded to asthma and obesity. Professor Schoeller's group showed that when rats exercise before a meal, their amount of fat that is stored in the body's adipose tissue is reduced. This supports the value of exercising before breakfast. Awards: NUTRITIONAL SCIENCES is one of 5 doctoral programs in the UW-Madison College of Agricultural and Life Sciences that rank in the top 15 percent in their respective fields, according to the National Research Council's "Data-Based Assessment of Research-Doctorate Programs in the United States." These national rankings are based on 20 characteristics including research productivity, interdisciplinary connections, degree completion rates and student demographics. Denise Ney received the College of Agricultural and Life Sciences 2010 Spitzer Excellence in Teaching Award for her outstanding contributions to teaching and instruction. James Ntambi received the UW-Madison Chancellor's distinguished teaching Award for 2010. James Ntambi was inducted into the Uganda National Academy of Sciences. Susan Smith was elected President of the national Fetal Alcohol Spectrum Disorders Study Group. Susan Smith was awarded U.S. Patent 7,838,561, "Method for Preventing or Treating Cardiac Hypertrophy."

Publications

  • Arscott SA, Howe JA, Davis CR, Tanumihardjo SA. 2010. Carotenoid profiles in provitamin A-containing fruits and vegetables affect the bioefficacy in Mongolian gerbils. Exp Biol Med (Maywood). 235(7):839-48.
  • Dever JT, Surles RL, Davis CR, Tanumihardjo SA. 2010. alpha-Retinol is Distributed through Serum Retinol-Binding Protein-Independent Mechanisms in the Lactating Sow-Nursing Piglet Dyad. (Epub ahead of print, November 2010).
  • Ejoh RA, Dever JT, Mills JP, Tanumihardjo SA. 2010. Small quantities of carotenoid-rich tropical green leafy vegetables indigenous to Africa maintain vitamin A status in Mongolian gerbils ( Meriones unguiculatus). Br J Nutr. 103(11):1594-601.
  • Escaron AL, Tanumihardjo SA. 2010. Orally ingested (13)C(2)-retinol is incorporated into hepatic retinyl esters in a nonhuman primate (Macaca mulatta) model of hypervitaminosis A. Comp Med. 60(1):71-6.
  • Arscott SA, Simon PW, Tanumihardjo SA. 2010. Anthocyanins in purple-orange carrots (Daucus carota L.) do not influence the bioavailability of beta-carotene in young women. J Agric Food Chem. 58(5):2877-81.
  • Nuss ET, Tanumihardjo SA. 2010. Maize: A paramount staple crop in the context of global nutrition. Compr Rev Food Sci Food Saf. 9:417-436.
  • McClean M, Penniston KP, Tanumihardjo SA. 2010. Promoting dairy intake in rural Wisconsin by empowering youth. J Extension. 48(5):5IAW4.
  • Cook CM, Alvig AL, Liu YQ, Schoeller DA. 2010. The natural 13C abundance of plasma glucose is a useful biomarker of recent dietary caloric sweetener intake. J Nutr. 140(2):333-7.
  • Book chapters: Smith SM. 2010. Environmentally-induced heart malformations. In: Comprehensive Toxicology 2nd Edition. (Charlene McQueen). Oxford: Elsevier. 229-445.
  • Smith SM. 2010. Ethanol and Cell Death. In: Comprehensive Toxicology 2nd Edition. (Charlene McQueen). Oxford: Elsevier. 223-238.
  • Schoeller DA, Racine NA, Shriver T, Matthews D. Doubly labeled water method in IRMS to measure free-living energy expenditure, in: Beauchemin D and Matthews DE eds, Encyclopedia of Mass Spectrometry-Vol 5. Elemental and Isotope Ratio Mass Spectrometry. Elsevier 2010. pp 962-967.
  • Book: Nitzke S, Riley D, Ramminger A, Jacobs G. 2010. Rethinking nutrition: Connecting science and practice in early childhood settings. St. Paul, MN: Redleaf Press, ISBN: 978-1-60554-031-3.
  • Frey AG, Eide DJ. (2010) The roles of Zap1s two activation domains in the response to zinc deficiency in Saccharomyces cerevisiae. J Biol Chem (epub ahead of print, December 2010).
  • Atkinson A, Khalimonchuk O, Smith P, Sabic H, Eide D, Winge DR. 2010. Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function. J Biol Chem. 2010;285(25):19450-9.
  • Zhang AS, Anderson SA, Wang J, Yang F, Demaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. 2010. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matripatase-2 protein. Blood (epub ahead of print, November 2010).
  • Baumler MD, Koopmann MC, Thomas DD, Ney DM, Groblewski GE. 2010. Intravenous or luminal amino acids are insufficient to maintain pancreatic growth and digestive enzyme expression in the absence of intact dietary protein. Am J Physiol Gastrointest Liver Physiol. 299(2):G338-47.
  • MacLeod EL, Clayton MK, van Calcar SC, Ney DM. 2010. Breakfast with glycomacropeptide compared with amino acids suppresses plasma ghrelin levels in individuals with phenylketonuria. Mol Genet Metab. 100(4):303-8.
  • Koopmann MC, Chen X, Holst JJ, Ney DM. 2010. Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure. Am J Physiol Gastrointest Liver Physiol. 299(6):G1222-30.
  • Thomas DD, Martin CL, Weng N, Byrne JA, Groblewski GE. 2010. Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane. Am J Physiol Cell Physiol. 298(3):C725-39.
  • Falkowski MA, Thomas DD, Groblewski GE. 2010. Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini. J Biol Chem. 285(46):35558-66.
  • Thomas DD, Frey CL, Messenger SW, August BK, Groblewski GE. 2010. A role for tumor protein TPD52 phosphorylation in endo-membrane trafficking during cytokinesis. Biochem Biophys Res Commun. 402(4):583-7.
  • Sunde RA. 2010. mRNA transcripts as molecular biomarkers in medicine and nutrition. J Nutr Biochem. 21(8)665-70.
  • Sunde RA, Hadley KB. 2010. Phospholipid hydroperoxide glutathione peroxidase (Gpx4) is highly regulated in male turkey poults and can be used to determine dietary selenium requirements. Exp Biol Med (Maywood). 235(1):23-31.
  • Sunde RA. 2010. Molecular biomarker panels for assessment of selenium status in rats. Exp boil Med (Maywood). 235(9):1046-52.
  • Arscott SA, Tanumihardjo SA. 2010. Carrots of many colors provide basic nutrition and bioavailable phytochemicals acting as a functional food. Comp Rev Food Sci Food Safety. 9:223-39.
  • Chang MW, Nitzke S, Brown R, Baumann L. 2010. Predictors of Low-income, Obese Mothers' Use of Healthful Weight Management Behaviors. J Nutr Educ Behav. (Epub ahead of print, October 2010)
  • Chang MW, Nitzke S, Brown R. 2010. Design and outcomes of a Mothers In Motion behavioral intervention pilot study. J Nutr Educ Behav. 42(3 Suppl):S11-21.
  • Strable MS, Ntambi JM. 2010. Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol. 45(3):199-214.
  • Hyun CK, Kim ED, Flowers MT, Liu X, Kim E, Strable M, Ntambi JM. 2010. Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochem Biophys Res Commun. 399(4):480-6.
  • Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl M, Gorgun C, Balschi JA, Ntambi JM, Lee CH. 2010. Role of peroxisome proliferator-activated receptor delta/beta in hepatic metabolic regulation. J Biol Chem. (Epub ahead of print, November 2010).
  • Smith SM, Flentke GR, Kragtorp KA, Tessmer L. 2010. Ethanol exposure during the early first trimester equivalent impairs reflexive motor activity and heightens fearfulness in an avian model. Alcohol. (Epub ahead of print, August 2010).
  • Zhang Z, Shoff SM, Lai HJ. 2010. Incorporating genetic potential when evaluating stature in children with cystic fibrosis. J Cyst Fibros. 9(2):135-42.
  • Zhang Z, Lai HJ, Roberg KA, Gangnon RE, Evans MD, Anderson EL, Pappas TE, Dasilva DF, Tisler CJ, Salazar LP, Gern JE, Lemanske RF Jr. 2010. Early childhood weight status in relation to asthma development in high-risk children. J Allergy Clin Immunol. 126(6):1157-62.
  • Tsenkova VK, Carr D, Schoeller DA, Ryff CD. 2010. Perceived Weight Discrimination Amplifies the Link Between Central Adiposity and Nondiabetic Glycemic Control (HbA(1c)). Ann Behav Med. (Epub ahead of print, December 2010).
  • Hansen KC, Schoeller DA. 2010. Effect of prior acute exercise on trafficking of dietary fat away from adipose tissue. Int J Sport Nutr Exerc Metab. 20(6):466-74.
  • Bradley DP, Johnson LA, Zhang Z, Subar AF, Troiano RP, Schatzkin A, Schoeller DA. 2010. Effect of smoking status on total energy expenditure. Nutr Metab (Lond). 26(3):243-9.
  • Cooper JA, Watras AC, Paton CM, Wegner FH, Adams AK, Schoeller DA. 2010. Impact of exercise and dietary fatty acid composition from a high-fat diet on markers of hunger and satiety. Appetite. (Epub ahead of print, October 2010).
  • Thomas DM, Schoeller DA, Redman LA, Martin CK, Levine JA, Heymsfield SB. 2010. A computational model to determine energy intake during weight loss. Am J Clin Nutr. 92(6):1326-31.
  • Nedeltcheva AV, Kilkus JM, Imperial J, Schoeller DA, Penev PD. 2010. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med. 153(7):435-41.
  • Colbert LH, Matthews CE, Havighurst TC, Kim K, Schoeller DA. 2010. Comparative Validity of Physical Activity Measures in Older Adults. Med Sci Sports Exerc. (Epub ahead of print, September 2010).
  • Cooper JA, Watras AC, Shriver T, Adams AK, Schoeller DA. 2010. Influence of dietary fatty acid composition and exercise on changes in fat oxidation from a high-fat diet. J Appl Physiol. 109(4):1011-8.
  • Aleman-Mateo H, Rush E, Esparza-Romero J, Ferriolli E, Ramirez-Zea M, Bour A, Yuchingtat G, Ndour R, Mokhtar N, Valencia ME, Schoeller DA. 2010. Prediction of fat-free mass by bioelectrical impedance analysis in older adults from developing countries: a cross-validation study using the deuterium dilution method. J Nutr Health Aging. 14(6):418-26.
  • Racine NM, Watras AC, Carrel AL, Allen DB, McVean JJ, Clark RR, O'Brien AR, O'Shea M, Scott CE, Schoeller DA. 2010. Effect of conjugated linoleic acid on body fat accretion in overweight or obese children. Am J Clin Nutr. 91(5):1157-64.
  • Trasande L, Cronk C, Durkin M, Weiss M, Schoeller D, Gall E, Hewitt J, Carrel A, Landrigan P, Gillman M. 2010. Environment and obesity in the National Children's Study. Cien Saude Colet. 15(1):195-210.
  • Bradley DP, Kulstad R, Schoeller DA. 2010. Exenatide and weight loss. Nutrition. 26(3):243-9.
  • Yamada Y, Schoeller DA, Nakamura E, Morimoto T, Kimura M, Oda S. 2010. Extracellular water may mask actual muscle atrophy during aging. J Gerontol A Biol Sci Med Sci. 65(5):510-6.
  • Bergouignan A, Momken I, Schoeller DA, Normand S, Zahariev A, Lescure B, Simon C, Blanc S. 2010. Regulation of energy balance during long-term physical inactivity induced by bed rest with and without exercise training. J Clin Endocrinol Metab. 95(3):1045-53.


Progress 01/01/09 to 12/31/09

Outputs
OUTPUTS: OUTPUTS: Our Interdepartmental Graduate Program in Nutritional Sciences has 8 Masters students and 23 PhD students. We conferred 6 PhD degrees in 2009 and 4 MS degrees. Our undergraduate program graduates for 2009 include 60 BS degrees in dietetics and 12 in nutritional sciences. In cooperation with UW-Extension, The UW-Madison Institute on Aging and other co-sponsors, we conducted a statewide conference on "Current Concepts in Nutrition and Aging" in September, 2009 and we collaborated with other members of WiPOD (Wisconsin Prevention of Obesity and Diabetes) to offer an interdisciplinary conference on "production and consumption of whole food" in October, 2009. PARTICIPANTS: Participants include Nutritional Sciences research teams led by the following faculty members: David Eide, Rick Eisenstein, Guy Groblewski, HuiChuan Lai, Denise Ney, Susan Nitzke, James Ntambi, Dale Schoeller, Susan Smith, Roger Sunde, Sherry Tanumiahardjo and Eric Yen. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
As evidenced by the publications below, our Department conducted original research in community nutrition, nutritional epidemiology, diabetes/obesity prevention and treatment, mineral metabolism, nutritional interaction with intestinal function, metabolism of vitamin A and other vitamins. For example, David Eide's group discovered that the expression of many genes change in response to zinc status and these genes are involved in maintaining zinc levels within cells as well as allowing cells to adapt to the stresses that result from zinc deficiency. Roger Sunde's lab has used microarray analysis to identify several new highly-regulated selenoprotein mRNAs in mice that can be used as molecular biomarkers of selenium status, and used mRNA levels and selenoenzyme levels as biomarkers to report selenium status and selenium requirements in growing rats, old rats, and growing turkeys. Rick Eisenstein's lab has identified new ways in which cell adapt to iron deficiency through hierarchical control of the expression of proteins that control the uptake and metabolic fate of iron. Dr. Susan Smith's lab has isolated a protein called beta-catenin as an important target of alcohol's toxicity in the developing brain. They have also demonstrated that a moderate iron inadequacy in the mother can magnify alcohol's damage to the developing brain. The Schoeller lab has continued to investigate the relative roles of physical activity and energy intake in the increase in the rates of obesity in the US and elsewhere throughout the world. Through their work with the doubly labeled water method for measurement of total energy expenditure, they and others have demonstrated that excess energy intake is the primary driver of excess weight gain. They have also demonstrated, however, that reduced physical activity contributes to excess energy intake by reducing the accuracy of the homeostatic mechanisms controlling fat storage leading to small increases in body fat. Eric Yen and colleagues recently reported that MGAT2 is a key determinant of energy metabolism in response to dietary fat and that inhibiting this enzyme may prove to be a useful strategy for treating obesity and other metabolic diseases associated with excessive fat intake. Eric Yen's group is now studying the underlying mechanisms. Susan Nitzke's research is highlighted by a multistate research project to improve young adults' health behaviors in three key areas -- nutrition, physical activity, and stress management.

Publications

  • Manini TM, Everhart JE, Anton SD, Schoeller DA, Cummings SR, Mackey DC, Delmonico MJ, Bauer DC, Simonsick EM, Colbert LH, Visser M, Tylavsky F, Newman AB, Harris TB. Activity energy expenditure and change in body composition in late life. Am J Clin Nutr. 2009 Nov;90(5):1336-42. Epub 2009 Sep 9.
  • Savastano DM, Tanofsky-Kraff M, Han JC, Ning C, Sorg RA, Roza CA, Wolkoff LE, Anandalingam K, Jefferson-George KS, Figueroa RE, Sanford EL, Brady S, Kozlosky M, Schoeller DA, Yanovski JA. Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. Am J Clin Nutr. 2009 Oct;90(4):912-20. Epub 2009 Aug 5.
  • Cooper JA, Polonsky KS, Schoeller DA. Serum Leptin levels in obese males during over- and underfeeding. Obesity (Silver Spring). 2009 Dec;17(12):2149-54. Epub 2009 May 14.
  • Manini TM, Everhart JE, Patel KV, Schoeller DA, Cummings S, Mackey DC, Bauer DC, Simonsick EM, Colbert LH, Visser M, Tylavsky F, Newman AB, Harris TB; Health, Aging, and Body Composition Study. Activity energy expenditure and mobility limitation in older adults: differential associations by sex. Am J Epidemiol. 2009 Jun 15;169(12):1507-16. Epub 2009 Apr 21.
  • Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, Luke A, Schoeller DA, DeLany JP, Butte NF, Ravussin E. Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr. 2009 Jun;89(6):1723-8. Epub 2009 Apr 15.
  • Cooper JA, Watras AC, Adams AK, Schoeller DA. Effects of dietary fatty acid composition on 24-h energy expenditure and chronic disease risk factors in men. Am J Clin Nutr. 2009 May;89(5):1350-6. Epub 2009 Mar 25.
  • Bergouignan A, Momken I, Schoeller DA, Simon C, Blanc S. Metabolic fate of saturated and monounsaturated dietary fats: the Mediterranean diet revisited from epidemiological evidence to cellular mechanisms. Prog Lipid Res. 2009 May-Jul48(3-4):128-47. Epub 2009 Mar 9.
  • Trasande L, Cronk C, Durkin M, Weiss M, Schoeller DA, Gall EA, Hewitt JB, Carrel Al, Landrigan PJ, Gillman MW. Environment and obesity in the National Childrens Study. Environ Health Perspect. 2009 Feb;117(2):159-66. Epub 2008 Sep 12.
  • Singh R, Martin BR, Hickey Y, Teegarden D, Campbell WW, Craig BA, Schoeller DA, Kerr DA, Weaver CM. Comparison of self-reported, measured, metabolizable energy intake with total energy expenditure in overweight teens. Am J Clin Nutr. 2009 Jun;89(6):1744-50. Epub 2009 Apr 22.
  • Schoeller DA. The energy balance equation: looking back and looking forward are two very different views. Nutr Rev. 2009 May;67(5):249-54.
  • Dugas LR, Carstens MA, Ebersole K, Schoeller DA, Durazo-Arvizue RA, Lambert EV, Luke A. Energy expenditure in young adult urban informal settlement dwellers in South Africa. Eur J Clin Nutr. 2009 Jun;63(6):805-7. Epub 2009 Jan 21.
  • Cooper JA, Watras AC, OBrien MJ, Luke A, Dobratz JR, Earthman CP, Schoeller DA. Assessing validity and reliability of resting metabolic rate in six gas analysis systems. J Am Diet Assoc. 2009 Jan;109(1):128-32.
  • Nedeltcheva AV, Kilkus JM, Imperial J, Kasza K, Schoeller DA, Penev PD. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr. 2009 Jan;89(1):126-33. Epub 2008 Dec 3.
  • Tchum SK, Newton S, Tanumihardjo SA, Arthur FKN, Tetteh A, Owusu-Agyei S. Evaluation of a green leafy vegetable intervention in Ghanaian postpartum mothers. Afr J Food Agric Nutr Development. 2009;9:1294-308.
  • Dever JT, Tanumihardjo SA. Hypervitaminosis A in experimental nonhuman primates: Evidence, causes, and the road to recovery. Am J Primatol 2009;71:813-6.
  • Montagnac JA, Davis CR, Tanumihardjo SA. The nutritional value of cassava for use as a staple food and recent advances for improvement. Comp Rev Food Sci Food Safety. 2009;8:181-94.
  • Sun T, Simon PW,Tanumihardjo SA. Antioxidant phytochemicals and antioxidant capacity of biofortified carrots (Daucus carota L.) of various colors. J Ag Food Chem 2009;57:4142-7.
  • Mills JP, Tumuhimbise G, Jamil KM, Thakkar S, Failla ML, Tanumihardjo SA. Sweet potato B-carotene bioefficacy is enhanced by dietary fat and not reduced by soluble fiber intake in Mongolian gerbils. J Nutr. 2009;139:44-50.
  • Howe JA, Valentine AR, Hull AK, Tanumihardjo SA. 13C natural abundance in serum retinol acts as a biomarker for increases in dietary provitamin A. Exp Biol Med. 2009;234:140-7.
  • Montagnac JA, Davis CR, Tanumihardjo SA. Processing techniques to reduce toxicity and antinutrients of cassava for use as a staple food. Comp Rev Food Sci Food Safety. 2009;8:17-27.
  • Howe JA, Maziya-Dixon B, Tanumihardjo SA. Cassava with enhanced B-carotene maintains adequate vitamin A status in Mongolian gerbils (Meriones unguiculatus) despite substantial cis-isomer content. Br J Nutr 2009;102:342-9.
  • Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki, J, Wong JS, Hubbard B, Marmor S, Farese RV Jr. Deficiency of the intestinal enzyme acyl coA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med. 2009 Apr; 15(4):442-6. Epub 2009 Mar 15.
  • Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV Jr. Retinol Esterification by DGAT1 is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem. 2009 Feb 13;284(7)4292-9. Epub 2008 Nov 20.
  • Nelson DW and Yen C-LE Triacylglycerol synthesis and energy metabolism: a gut reaction Clin. Lipidol. 2009;4(6): 683-6.
  • Wu CY, Steffen J, Eide DJ. Cytosolic superoxide dismutase (SOD1) is critical for tolerating the oxidative stress of zinc deficiency in yeast. PLoS One. 2009 Sep 16;4(9):e7061.
  • Wu CY, Roje S, Sandoval FJ, Bird AJ, Winge DR, Eide DJ. Repression of sulfate assimilation is an adaptive response of yeast to oxidative stress of zinc deficiency. J Biol Chem. 2009 Oct 2;284(40):27544-56. Epub 2009 Aug 5.
  • Eide DJ. Homeostatic and adaptive responses to zinc deficiency in Saccharomyces cerevisiae. J Biol Chem. 2009 July 10;284(28):18565-9. Epub 2009 Apr 10.
  • Qiao W, Ellis C, Steffen J, Wu CY, Eide DJ. Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae. Mol Microbiol. 2009 Apr;72(2):320-34. Epub 2009 Mar 3.
  • Goforth JB, Anderson SA, Nizzi CP, Eisenstein RS. Multiple Determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy. RNA. 2010 Jan;16(1):154-69. Epub 2009 Nov 25.
  • Deck KM, Vasanthakumar A, Anderson SA, Goforth JB, Kennedy MC, Antholine WE, Eisenstein RS. Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling. J Biol Chem. 2009 May 8;284(19):12701-9. Epub 2009 Mar 6.
  • Koopmann MC, Baumler MD, Boehler CJ, Chang FL, Ney DM, Groblewski GE. Total Parenteral Nutrition Attenuates Cerulein-Induced Pancreatitis in Rats. Pancreas. 2009 Nov 9. [Epub ahead of print]
  • Weng N, Baumler MD, Thomas DD, Falkowski MA, Swayne LA, Braun JE, Groblewski GE. Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells. Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1030-9. Epub 2009 Mar 12.
  • Yan J, Cheng Y, Fine JP, Lai HJ. Uncovering Symptom Progression History from Disease Registry Data with Application to Young Cystic Fibrosis Patients. Biometrics. 2009 Jun 12.
  • Rufer ES, Hacker TA, Flentke GR, Drake VJ, Brody MJ, Lough J, Smith SM. Altered cardiac function and ventricular septal defect in avian embryos exposed to low-dose trichloroethylene. Toxicol Sci. 2009 Nov (epub ahead of print).
  • Tanumihardjo SA, Valentine AR, Zhang Z, Whigham LD, Lai HJ, Atkinson RL. Strategies to increase vegetable or reduce energy and fat intake induce weight loss in adults. Exp Biol Med (Maywood). 2009 May;234(5):542-52. Epub 2009 Feb 20.
  • Lai HJ, Shoff SM, Farrell PM; Wisconsin Cystic Fibrosis Neonatal Screening Group. Recovery of birth weight z score within 2 years of diagnosis is positively associated with pulmonary status at 6 years of age in children with cystic fibrosis. Pediatrics. 2009 Feb;123(2):714-22.
  • Liu X, Murali SG, Holst JJ, Ney DM. Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats. Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1554-62. Epub 2009 Sep 23.
  • Cook CM, Alvig AL, Liu YQ, Schoeller DA. The Natural 13C Abundance of Plasma Glucose Is a Useful Biomarker of Recent Dietary Caloric Intake. J Nutr. 2009 Dec 16. [Epub ahead of print]
  • Schoeller DA, Watras AC, Whigham LD. A meta-analysis of the effects of conjugated linoleic acid on fat-free mass in humans. Appl Physiol Nutr Metab. 2009 Oct;34(5):975-8.
  • Luke A, Dugas LR, Ebersole K, Durazo-Arvizue RA, Cao G, Schoeller DA, Adeyemo A, Brieger WR, Cooper RS. Energy expenditure does not predict weight change in either Nigerian or African American women. Am J Clin Nutr. 2009 Jan;89(1):169-76. Epub 2008 Dec 3.
  • Bergouignan A, Trudel G, Simon C, Chopard A, Schoeller DA, Momken I, Votruba SB, Desage M, Burdge GC, Gauquelin-Koch G, Normand S, Blanc S. Physical inactivity differentially alters dietary oleate and palmitate trafficking. Diabetes. 2009 Feb;58(2):367-76. Epub 2008 Nov 18.
  • Sunde RA, Raines AM, Barnes KM, Evenson JK. Selenium status highly-regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Biosci Rep. 2009;29: 329-338.
  • Barnes KM, Evenson JK, Raines AM, Sunde RA. Transcript analysis of the selenoproteome indicates that dietary selenium requirements in rats based on selenium-regulated selenoprotein mRNA levels are uniformly less than those based on glutathione peroxidase activity. J Nutr. 2009;139: 199-206.
  • Sunde RA, Thompson KM. Dietary selenium requirements based on tissue selenium concentration and glutathione peroxidase activities in old female rats. J. Trace Elem. Med. Biol. 2009;23: 132-137.
  • Schriever SC, Barnes KM, Evenson JK, Raines AM, Sunde RA. Selenium requirements are higher for glutathione peroxidase-1 mRNA than Gpx1 activity in rat testis. Exp. Biol. Med. 2009;234: 513-521.
  • Sunde RA, Thompson KM, Evenson JK, Thompson BM. Blood glutathione peroxidase-1 mRNA levels can be used as molecular biomarkers to determine selenium requirements in rats. Exp. Biol. Med. 2009;234: 1271-1279.
  • Tanumihardjo S. Biological issues surrounding the use of vitamin A supplements in neonates. In: World Health Organization Report of the WHO technical consultation on neonatal vitamin A supplementation research priorities. Geneva, Switzerland World Health Organization, 2009, p. 8-11.
  • Tanumihardjo SA, Ouedraogo JB, Mbacham WF, Newton S, Djimde A, Davidsson LM, Moleah T. Evaluation of vitamin A and zinc supplementation on malaria morbidity. International Atomic Energy Agency technical report, 2009.
  • Tanumihardjo SA, Horvitz MA, Porter Dosti M, Simon PW. Serum B- and a-carotene concentrations qualitatively respond to sustained carrot feeding. Exp Biol Med. 2009;234: 1250-6.
  • Tanumihardjo SA, Valentine AR, Zhang Z, Whigham LD, Lai HJ, Atkinson RL. Strategies to increase vegetable or reduce energy and fat intake induce weight loss in adults. Exp Biol Med. 2009;234:542-52.
  • Valentine AR, Whigham LD, Tanumihardjo SA. Pedometers are perceived as useful tools for weight loss. J Extension. 2009;42(2):2TOT6.
  • Permaesih D, Hardinsyah, Setiawan B, Tanumihardjo SA. Kadar sIgA dan lactoferrin air susu ibu. Gizi Indonesia. 2009;32:1-9.
  • Escaron AE, Green MH, Howe JA, Tanumihardjo SA. Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A. J. Nutr. 2009;139:2000-6.
  • Escaron AL, Green MH, Tanumihardjo SA. Plasma turnover of 3,4-didehydroretinol (vitamin A2) increases in vitamin A-deficient rats fed low versus high dietary fat. J Lipid Res 2009; 50:694-703. Epub 2008 Nov 30.
  • MacLeod El, Gleason ST, van Calcar SC, Ney DM. Reassessment of phenylalanine tolerance in adults with phenylketonuria is needed as body mass changes. Mol Genet Metab. 2009 Dec;98(4):331-7. Epub 2009 Aug 8.
  • Koopmann MC, Liu X, Boehler CJ, Murali SG, Holst JJ, Ney DM. Colonic GLP-2 is not sufficient to promote jejuna adaptation in a PN-dependent rat model of human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009 Nov-Dec;33(6):629-38; discussion 638-9. Epub Jul 30.
  • Laclair CE, Ney DM, MacLeod EL, Etzel MR. Purification and use of glycomacropeptide for nutritional management of phenylketonuria. J Food Sci. 2009 May;74(4):E199-206.
  • Ney DM, Weiss JM, Kind AJ, Robbins J. Senescent swallowing: impact, strategies, and interventions. Nutr Clin Pract. 2009 Jun-Jul;24(3):395-413.
  • van Calcar SC, MacLeod EL, Gleason ST, Etzel MR, Clayton MK, Wolff JA, Ney DM. Improved nutrtitional management of phenylketonuria by using diet containing glycomacropeptide compared with amino acids. Am J Clin Nutr. 2009 Apr;89(4):1068-77. Epub 2009 Feb 25.
  • Ney DM, Gleason ST, van Calcar SC, MacLeod EL, Nelson KL, Etzel MR, Rice GM, Wolff JA. J Inherit Metab Dis. 2009 Feb;32(1):32-9. Epub 2008 Oct 29.
  • Chang MW, Brown R, Nitzke S. Participant recruitment and retention in a pilot program to prevent weight gain in low-income overweight and obese mothers. BMC Public Health. 2009 Nov 21;9:424.
  • Liu X, Ntambi JM. Atherosclerosis: keep your macrophages in shape. Nat Med. 2009 Dec;15(12):1357-8.
  • Liu X, Miyazaki M, Flowers MT, Sampath H, Zhao M, Chu K, Paton CM, Joo DS, Ntambi JM. Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):31-8. Epub 2009 Nov 12.
  • Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J Biol Chem. 2009 Jul 24;284(30):19961-73. Epub 2009 May 8.
  • Miyazaki M, Sampath H, Flowers MT, Chu K, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun. 2009 Mar 20;380(4):818-22. Epub 2009 Feb 5.
  • Flowers MT, Ntambi JM. Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. Biochim Biophys Acta. 2009 Feb;1791(2):85-91. Epub 2009 Jan 2.
  • Paton CM, Ntambi JM. Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E28-37. Epub 2008 Dec 9.


Progress 01/01/08 to 12/31/08

Outputs
OUTPUTS: Our Interdepartmental Graduate Program in Nutritional Sciences has 5 Masters students and 26 PhD students. We conferred 9 PhD degrees in 2008 and 3 MS degrees. In cooperation with UW-Extension, The UW-Madison Institute on Aging and other co-sponsors, we conducted a statewide conference on "Current Concepts in Nutrition and Aging in September, 2008. Several faculty are involved in international programs including a public health partnership in Uganda, where James Ntambi's work (joint professor with Nutritional Sciences and Biochemistry),earned the UW-Madison College of Agriculture and Life Sciences Arhur Maurer Extra Mile award in 2008. PARTICIPANTS: Not relevant to this project. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
As evidenced by the publications below, our Department conducted original research in community nutrition, nutritional epidemiology, diabetes/obesity prevention and treatment, mineral metabolism, nutritional interaction with intestinal function, metabolism of vitamin A and other vitamins. For example, David Eide's group discovered that the expression of many genes change in respose to zinc status and these genes are involved in maintaining zinc levels within cells as well as allowing cells to adapt to the stresses that result from zinc deficiency. Denise Ney's phenylketonuria research has contributed to the development of a whey protein that expands the dietary choices of children and adults with this inborn error of metabolism. Susan Nitzke and collaborators have developed a website that helps dietetics students throughout Wisconsin find practicum experiences to help prepare them for future careers in nutrition. James Natmbi's group found that mice without a spedivic gene resist obesity, diabetes and fatty liver disease. Susan Smith's lab has discovered new roles for vitamin A in the adult heart.

Publications

  • Wu CY, Bird AJ, Chung LM, Newton MA, Winge DR, Eide DJ.Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae. BMC Genomics. 2008 Aug 1;9:370.
  • dos Santos CO, Dore LC, Valentine E, Shelat SG, Hardison RC, Ghosh M, Wang W, Eisenstein RS, Costa FF, Weiss MJ. An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA. J Biol Chem. 2008 Oct 3;283(40):26956-64.
  • Stehling O, Netz DJ, Niggemeyer B, Rosser R, Eisenstein RS, Puccio H, Pierik AJ, Lill R. Human Nbp35 is essential for both cytosolic ron-sulfur protein assembly and iron homeostasis. Mol Cell Biol. 2008 Sep;28(17):5517-28.
  • Ney DM, Gleason ST, van Calcar SC, Macleod EL, Nelson KL, Etzel MR, Rice GM, Wolff JA. Nutritional management of PKU with glycomacropeptide from cheese whey. J Inherit Metab Dis. 2008 Oct 29.
  • Liu X, Murali SG, Holst JJ, Ney DM. Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1794-802.
  • Nelson DW, Murali SG, Liu X, Koopmann MC, Holst JJ, Ney DM. Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1175-84.
  • Ney DM, Hull AK, van Calcar SC, Liu X, Etzel MR. Dietary glycomacropeptide supports growth and reduces the concentrations of phenylalanine in plasma and brain in a murine model of phenylketonuria. J Nutr. 2008 Feb;138(2):316-22.
  • Do M, Kattelmann K, Boeckner L, Greene G, White A, Hoerr S, Horacek T, Lohse B, Phillips B, Nitzke S. Low-income young adults report increased variety in fruit and vegetable intake after a stage-tailored intervention. Nutr Res. 2008 Aug;28(8):517-22.
  • Park A, Nitzke S, Kritsch K, Kattelmann K, White A, Boeckner L, Lohse B, Hoerr S, Greene G, Zhang Z. Internet-based interventions have potential to affect short-term mediators and indicators of dietary behavior of young adults. J Nutr Educ Behav. 2008 Sep-Oct;40(5):288-97.
  • Esters ON, Boeckner LS, Hubert M, Horacek T, Kritsch KR, Oakland MJ, Lohse B, Greene G, Nitzke S. Educator and participant perceptions and cost analysis of stage-tailored educational telephone calls. J Nutr Educ Behav. 2008 Jul-Aug;40(4):258-64.
  • Chang MW, Brown RL, Baumann LJ, Nitzke SA. Self-efficacy and dietary fat reduction behaviors in obese African-American and white mothers. Obesity (Silver Spring). 2008 May;16(5):992-1001. Epub 2008 Feb 21.
  • Chang MW, Brown R, Nitzke S. Scale development: factors affecting diet, exercise, and stress management (FADESM). BMC Public Health. 2008 Feb 26;8:76.
  • Chang MW, Nitzke S, Guilford E, Adair CH, Hazard DL. Motivators and barriers to healthful eating and physical activity among low-income overweight and obese mothers. J Am Diet Assoc. 2008 Jun;108(6):1023-8.
  • Kelley E, Ashley B, Getlinger MJ, Nitzke S. A lesson on "how much should I eat" helps learners understand and apply MyPyramid recommendations. J Nutr Educ Behav. 2008 Mar-Apr;40(2):116-7.
  • Bergouignan A, Schoeller DA, Votruba S, Simon C, Blanc S. The acetate recovery factor to correct tracer-derived dietary fat oxidation in humans. Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E645-53.
  • Neuhouser ML, Tinker L, Shaw PA, Schoeller D, Bingham SA, Horn LV, Beresford SA, Caan B, Thomson C, Satterfield S, Kuller L, Heiss G, Smit E, Sarto G, Ockene J, Stefanick ML, Assaf A, Runswick S, Prentice RL. Use of recovery biomarkers to calibrate nutrient consumption self-reports in the Women's Health Initiative. Am J Epidemiol. 2008 May 5;167(10):1247-59.
  • Sunde RA, Paterson E, Evenson JK, Barnes KM, Lovegrove JA, Gordon MH. Longitudinal selenium status in healthy British adults: assessment using biochemical and molecular biomarkers. Br J Nutr. 2008 Jun;99 Suppl 3:S37-47.
  • Teegarden D, White KM, Lyle RM, Zemel MB, Van Loan MD, Matkovic V, Craig BA, Schoeller DA. Calcium and dairy product modulation of lipid utilization and energy expenditure. Obesity. 2008 Jul;16(7):1566-72.
  • Dugas LR, Ebersole K, Schoeller D, Yanovski JA, Barquera S, Rivera J, Durazo-Arzivu R, Luke A. Very low levels of energy expenditure among pre-adolescent Mexican-American girls. Int J Pediatr Obes. 2008;3(2):123-6.
  • Ebersole KE, Dugas LR, Durazo-Arvizu RA, Adeyemo AA, Tayo BO, Omotade OO, Brieger WR, Schoeller DA, Cooper RS, Luke AH. Energy Expenditure and Adiposity in Nigerian and African-American Women. Obesity. 2008 Jun 26.
  • Bergouignan A, Trudel G, Simon C, Chopard A, Schoeller DA, Momken I, Votruba SB, Desage M, Burdge GC, Gauquelin-Koch G, Normand S, Blanc S. PHYSICAL INACTIVITY DIFFERENTIALLY ALTERS DIETARY OLEATE AND PALMITATE TRAFFICKING. Diabetes. 2008 Nov 18.
  • Garic-Stankovic A, Hernandez M, Flentke GR, Zile MH, Smith SM. A ryanodine receptor-dependent Ca(i)(2+) asymmetry at Hensen's node mediates avian lateral identity. Development. 2008 Oct;135(19):3271-80.
  • Sunde RA, Raines AM, Barnes KM, Evenson JK. Selenium status highly-regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Biosci Rep. 2008 Dec 12.
  • Howe JA, Valentine AR, Hull A, Tanumihardjo SA. 13C Natural Abundance in Serum Retinol Acts as a Biomarker for Increases in Dietary Provitamin A. Exp Biol Med (Maywood). 2008 Dec 30. [Epub ahead of print] PMID: 19116317 [PubMed - as supplied by publisher]
  • Cannell JJ, Vieth R, Willett W, Zasloff M, Hathcock JN, White JH, Tanumihardjo SA, Larson-Meyer DE, Bischoff-Ferrari HA, Lamberg-Allardt CJ, Lappe JM, Norman AW, Zittermann A, Whiting SJ, Grant WB, Hollis BW, Giovannucci E. Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic. Ann Otol Rhinol Laryngol. 2008 Nov;117(11):864-70.
  • Tateya T, Tateya I, Surles RL, Tanumihardjo S, Bless DM. Roles of vitamin A and macula flava in maintaining vocal folds. Ann Otol Rhinol Laryngol. 2008 Jan;117(1):65-73.
  • Davis C, Jing H, Howe JA, Rocheford T, Tanumihardjo SA. beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements. Br J Nutr. 2008 Oct;100(4):786-93.
  • Tateya I, Tateya T, Surles RL, Kanehira K, Tanumihardjo S, Bless DM. Vitamin A deficiency causes metaplasia in vocal fold epithelium: a rat study. Ann Otol Rhinol Laryngol. 2008 Feb;117(2):153-8.
  • Sun T, Surles RL, Tanumihardjo SA. Vitamin A concentrations in piglet extrahepatic tissues respond differently ten days after vitamin A treatment. J Nutr. 2008 Jun;138(6):1101-6.
  • Davis CR, Howe JA, Rocheford TR, Tanumihardjo SA. The xanthophyll composition of biofortified maize (Zea mays Sp.) does not influence the bioefficacy of provitamin a carotenoids in Mongolian gerbils (Meriones unguiculatus). J Agric Food Chem. 2008 Aug 13;56(15):6745-50.
  • Mills JP, Furr HC, Tanumihardjo SA. Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Exp Biol Med (Maywood). 2008 Oct;233(10):1255-61.
  • Mills JP, Simon PW, Tanumihardjo SA. Biofortified carrot intake enhances liver antioxidant capacity and vitamin a status in mongolian gerbils. J Nutr. 2008 Sep;138(9):1692-8.
  • Yang Z, Zhang Z, Penniston KL, Binkley N, Tanumihardjo SA. Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis. Int J Vitam Nutr Res. 2008 May;78(3):105-11.
  • Escaron AL, Green MH, Tanumihardjo SA. Plasma turnover of 3,4-didehydroretinol (vitamin A2) increases in vitamin A-deficient rats fed low versus high dietary fat1. J Lipid Res. 2008 Nov 30.
  • Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV Jr. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008 Nov;49(11):2283-301. Epub 2008 Aug 29.