Source: UNIVERSITY OF ILLINOIS submitted to NRP
OSTEOPOROSIS RISK IN TYPE TWO DIABETES
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0212109
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
Oct 1, 2010
Project End Date
Sep 30, 2011
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
UNIVERSITY OF ILLINOIS
2001 S. Lincoln Ave.
URBANA,IL 61801
Performing Department
Food Science & Human Nutrition
Non Technical Summary
The literature is not clear concerning the relationship of diabetes to bone health. Although the vasculature of bone may be effected by blood glucose similarly to other microvascular complications of diabetes (eye, kidney, nerve damage), the data published to date both support and conflict with this possiblity, probably because of the many confounding variables that can also effect bone health. We will collect more information on lifestyle, diabetes history, and other variables in hopes of finding more definitive relationships than have been published to date.
Animal Health Component
100%
Research Effort Categories
Basic
(N/A)
Applied
100%
Developmental
(N/A)
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
7036010101025%
7036010102025%
7246010101025%
7246010102025%
Goals / Objectives
The goal of this project is to determine if there is an association between bone density and diabetes-related variables. The objectives are to determine bone density through heel ultrasound in adults with diabetes, and explore the relationships between medication use, BMI, complications of diabetes, physical activity, length of disease duration, and bone mineral density.
Project Methods
Bone mineral density will be determined in adults with diabetes using a heel ultrasound, in triplicate, along with anthropometrics of hip, waist circumference, and BMI. A survey exploring the history of diabetes and any complications, medication use, gender, and lifestyle factors that may affect bone density such as supplement use, smoking, and physical acitivty will also be completed. Data will be entered into SPSS for analysis, using paremetric design if the data are normally distributed.

Progress 10/01/10 to 09/30/11

Outputs
OUTPUTS: Appropriate IRB approval has been obtained. Heel ultrasound measures in patients with type 2 diabetes has occurred. Recruitment has been completed, although short of the number needed to support significant findings with adequate power and medium effect size. PARTICIPANTS: One graduate student trained during this project. Collaborators are area hospitals, Illinois Extension education sites, and public health facilities. TARGET AUDIENCES: Target audiences are men and women with type 2 diabetes. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.

Impacts
Heel ultrasound assessment of bone density resulted in finding that t scores values ranged from -4.00 to 2.23; approximately 44.2% had low t-scores (below -1.0). Bone mineral density (BMD) as measured by heel ultrasound was significantly lower in those with a history of cancer than in those without such history (p=0.037). Age had a significant association with BMD (r= -.57, p<.0001).

Publications

  • No publications reported this period


Progress 01/01/10 to 12/31/10

Outputs
OUTPUTS: All subjects have been recruited and data collected including heel ultrasounds, surveys, and DNA analyses. PARTICIPANTS: Dr. Chapman-Novakofski (PI), and two graduate students worked on the project with collaborator Dr. Teran-Garcia. TARGET AUDIENCES: The target audience was adults with diabetes. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
New data are being analyzed so no outcomes or impacts are as of yet reportable.

Publications

  • Naseri Kouzehgarani, G., Rogers, T. and Chapman-Novakofski, K. 2010. Relationship between diabetes and bone health variables in adults with diabetes. FASEB J, 24:558.7, 2010.


Progress 01/01/09 to 12/31/09

Outputs
OUTPUTS: The project added a componenet of DNA analysis and was approved by IRB. Recruitment went through 2 phases with half of desired participants recruited. These participants completed the protocol and their data were entered into an SPSS database. PARTICIPANTS: Nothing significant to report during this reporting period. TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: The project was modified to include DNA markers for osteoporosis and diabetes.

Impacts
The results are not analyzed since only a few of the required subject number have been recuited. The remaining subjects will be recruited this Spring.

Publications

  • No publications reported this period


Progress 01/01/08 to 12/31/08

Outputs
OUTPUTS: Results have been shared with the dietetic internship preceptors. The process has been shared with Illinois Extension, Illinois Department of Public Health facilities, and academic staff at the University. PARTICIPANTS: Two graduate students have worked on this project and Extension Educators have facilitated participant recruitment. Champaign County Public Health Department personnel also facilitated recruitment. Graduate students were trained on heel ultrasound and data analyses. TARGET AUDIENCES: Adults with type 2 diabetes. PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.

Impacts
Data is still being collected and analyzed. Additional groups are interested in participating as subjects. Using Extension diabetes programs to recruit has not been as successful as anticipated because of travel difficulties and cost.

Publications

  • No publications reported this period


Progress 01/01/07 to 12/31/07

Outputs
OUTPUTS: Appropriate IRB approval haas been obtained. Heel ultrasound measures in type 2 diabetics at 2 sites has occured. Recruitment continues. PARTICIPANTS: A Master's student has worked on this project. Collaborators are area hospitals, Illinois Extension education sites, and Public Health facilities. TARGET AUDIENCES: Target audiences are men and woemn with type 2 diabetes.

Impacts
Still in the data collection stage so no evaluation is possible.

Publications

  • No publications reported this period