Progress 09/15/07 to 08/31/10
Outputs
OUTPUTS: FARAD at the University of California Davis maintains the pharmacokinetic and bibliographic databases and during 2007-2010, thousands of bibliographic citations and pharmacokinetic records were added to these databases. The FARAD Documentation Specialist maintains a continuous updating process and currently has over 500 original references on the library retrieval list that await evaluation for relevant data and data extraction. This data extraction is crucial for the application of some of the newer residue avoidance algorithms. Additionally, UCD maintains the web-based access to the kinetic and bibliographic citation files for the global FARAD (gFARAD) partners. With FARAD Director (Dr. Lisa Tell) guidance, the UCD FARAD programmer revised the older software to allow for improved data entry into the kinetic databases and the bibliographic citation database. A new web-based interface was created for access to the pharmacokinetic data (KINWEB) and for logging and tracking questions submitted to FARAD (FARM Calls). In addition, a web-based interface (FARMWEB) for direct, on-line submission of FARAD questions was brought on-line in December 2007 and remains fully functional. All of the databases and software were moved over to a new server in 2008. Due to lack of funding during 2008-2009, only a maintenance number of records were entered into the pharmacokinetic database, as we only had one data extractor. New records have been added, but there are still more than 2500 articles in the files containing residue information that await data extraction. The FARAD Director will continue to collaborate with North Carolina State University and the University of Florida personnel on pharmacokinetic research for food animal applications as the FARAD pharmacokinetic database contains a vast resource of data that can be used to develop and validate such models. FARAD telephone, email and now web-based inquiries are answered on a weekly, rotating basis between UC Davis and North Carolina State University. PARTICIPANTS: Nothing significant to report during this reporting period. TARGET AUDIENCES: To provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
FARAD has become crucial to the maintenance of a residue-free food supply to the American public. It is important to recognize that FARAD works with residues that can be either drugs used in veterinary practice, agricultural chemicals or outright environmental contaminants. FARAD provides this guidance through use of its databank by specially trained professional staff to provide information on prevention and mitigation of violative chemical residues and supplies recommended withdrawal intervals to allow safe extralabel use of drugs in food animals based on sound principles of residue avoidance.
Publications
- Young G, Smith GW, Leavens TL, Wetzlich SE, Baynes RE, Mason SE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats. Res Vet Sci, 246-252, 2010.
- Davis, JL, Smith GW, Baynes, RE, Tell LA, Webb AI, Riviere, JR. FARAD Digest: Update on drugs prohibited from extralabel use in food animals. J Am Vet Med Assoc, 235(5):528-534, 2009.
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Progress 09/15/07 to 09/14/08
Outputs
OUTPUTS: FARAD at the University of California Davis maintains the pharmacokinetic and bibliographic databases and during 2007-2008, 2292 bibliographic citations were evaluated and 692 bibliographic citations were added to the database. There were 2971 pharmacokinetic records added to the database. In addition, 734 questions were answered during a 9 month period (the phones were shut done for 3 months (Sept-Nov) due to no funding for the program). The FARAD documentation specialist maintained a continuous updating process and currently has approximately 1100 original references on the library retrieval list that await evaluation for relevant data and data extraction. This data extraction is crucial for the application of some of the newer residue avoidance algorithms. Additionally, UCD maintains the web-based access to the kinetic and bibliographic citation files for the global FARAD (gFARAD) partners. With the FARAD Director's (Dr. Lisa Tell) guidance, the UCD FARAD programmer revised the older software to allow for improved data entry into the kinetic databases and the bibliographic citation database. A new web-based interface was created for access to the pharmacokinetic data (KINWEB) and for logging and tracking questions submitted to FARAD (FARM Calls). In addition, a web-based interface (FARMWEB) for direct, on-line submission of FARAD questions was brought on-line in December 2007 and remains fully functional. All of the databases and software were moved over to a new server in 2008. Due to lack of funding, this past year resulted in a "maintenance" number of kinetic records entered into the pharmacokinetic database as we only had one data extractor. New records have been added, but there are still more than 2000 articles in the files containing residue information that await data extraction. Once more stable funding is achieved, the FARAD Director will continue to collaborate with North Carolina State University and the University of Florida personnel on pharmacokinetic research for food animal applications as the FARAD pharmacokinetic database contains a vast resource of data that can be used to develop and validate such models. FARAD telephone, email and now web-based inquiries are answered on a weekly, rotating basis between UC Davis and North Carolina State University. PARTICIPANTS: Nothing significant to report during this reporting period. TARGET AUDIENCES: To provide livestock producers, extension specialists, scientists, and veterinarians with information to prevent drug, pesticide, and environmental contaminant residues in food animal products. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
FARAD has become crucial to the maintenance of a residue-free food supply to the American public. It is important to recognize that FARAD works with residues that can be either drugs used in veterinary practice, agricultural chemicals or outright environmental contaminants. FARAD provides this guidance through use of its databank by specially trained professional staff to provide information on prevention and mitigation of violative chemical residues and supplies recommended withdrawal intervals to allow safe extralabel use of drugs in food animals based on sound principles of residue avoidance.
Publications
- Smith, Geof W., Davis, Jennifer, Tell, Lisa A., Webb, Alistair I. and Riviere, Jim E. 2008. FARAD Digest: Extralabel use of nonsteroidal anti-inflammatory drugs in cattle. Journal of the American Veterinary Medical Association, 232(5):697-701.
- Needham, Martha L., Webb, Alistair I., Baynes, Ronald E., Riviere, Jim E., Craigmill, Arthur L. and Tell, Lisa A. 2007. FARAD Digest: Current update on drugs for game bird species. Journal of the American Veterinary Medical Association, 231(10):1506-1508.
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