Progress 10/01/07 to 10/01/12
Outputs
OUTPUTS: We have been involved in disseminating our findings in the context of scientific communities at the ASN annual meetings (2012 and 2013, submitted) and a smaller meeting, the International Meeting of Cachexia held in Boston, MA in September 2012. In addition, we have published three more papers on the role of fatty acids in human health and management of diseases. From the original work of our Hatch project, two grants were funded by the NIH submitted as Co-I with Dr. Jan Kiecolt-Glaser. In addition, my work has extended to breast cancer prevention (Collaborator, Lisa Yee) and children's depression and bi-polar disorder (Mary Fristad). PARTICIPANTS: Rachel Cole is a research associate who is involved with analyzing fatty acid composition of tissues and blood specimen from all clinical studies. Dr. Lisa Yee is a medical oncologist who has designed and implemented two funded studies in collaboration with me on omega three fatty acids in women at high risk for breast cancer. Dr. Jan Kiecolt-Glaser is a collaborator on several projects involving negative mood, omega 3 fatty acids and inflammation. Dr. Mary Fristad has begun a collaboration with me on two R34 grants funded from NIH to determine effects of n3 fatty acids in children with varying degrees of depression. TARGET AUDIENCES: Peer business people, producers and scientists in the edible oil arena are the chief target audiences. Registered dietitians, nurse and doctors are also highly interested in our research. Nutritional food companies are highly interested in our work. PROJECT MODIFICATIONS: There have been no major changes in our approaches.
Impacts
We are evaluating the role of N-3 polyunsaturated fatty acids in conditions and diseases involving inflammation. Our work has provided new evidence to support that N-3 supplementation and consequently increased levels of N-3 fatty acids in the blood predict for lower cytokine levels in older adults with mild depression. We have also found that increasing levels of N-3 supplements to 9 g / day results in a dose response accumulation of EPA and DHA in breast adipose tissue and plasma. These findings are important because they will be useful to make recommendations about doses needed to achieve the benefits of N-3 fatty acids for improving health in people.
Publications
- Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R.Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial. Brain Behav Immun 2012; 26:988-95
- McDaniel JC, Belury MA. Are young adults following the dietary guidelines for Americans Nurse Pract 2012; 37(5):1-9
- Kiecolt-Glaser JK, Christian LM, Andridge R, Hwang BS, Malarkey WB, Belury MA, Emery CF, Glaser R. Adiponectin, Leptin, and Yoga Practice, Physiol Behav 2012; in press
- Orchard TS, Ing SW, Lu B, Belury MA, Johnson K, Wactawski-Wende J, Jackson RD. The association of red blood cell n-3 and n-6 fatty acids to dietary fatty acid intake, bone mineral density and hip fracture risk in the Women's Health Initiative J Bone Miner Res 2012; in press
- Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun 2012; in press
|
Progress 01/01/11 to 12/31/11
Outputs
OUTPUTS: Dietary polyunsaturated fatty acids (PUFAs) are important components of a healthy diet. It is known that n6 PUFAs reduce the risk for cardiovascular disease in men. We recently reported that n6 PUFAs attenuate risk factors for cardiovascular diseases in women in mechanisms that may be distinct from those previously proposed by other research groups. Our research of n6 PUFAs in women has now been developed in to a commercial product (SAFSLIM) and I was recently featured on the Emmy award winning syndicated television show, Dr. Oz. In addition to this media coverage, I continue to work with extension and dietetic audiences to update their education on the benefits of n6 and n3 PUFAs. Our work with n3 PUFAs also has garnered a great deal of media attention due to our work showing that n3 PUFAs reduce symptoms of anxiety in medical students. We have collaborated with world renown researchers in the area of psychology (Dr. Kiecolt-Glaser), oncology (Dr. Yee) and diabetes (Dr. Schuster and Dr. Parthasarathy) and bone health (Dr. Jackson). Due to our multi-disciplinary approach, we are poised to address important questions related to healthy oils and human health. PARTICIPANTS: Dr. Jan Kiecolt-Glaser - PI and Co-I Dr. Lisa Yee - PI and Co-I Dr. Rebecca Jackson - PI Dr. Sara Schuster - PI and CO-I Dr. Sam Parthasarathy - PI and Co-I TARGET AUDIENCES: Dietitians Extension agents Medical doctors Researchers Lay audiences PROJECT MODIFICATIONS: None that are significant
Impacts
Using dietary oils rich in n6 or n6 fatty acids is an inexpensive approach that most people can use to improve their health. Our findings related to n3 PUFAs reducing the risk for breast cancer, negative mood affect and the metabolic syndrome is important. These three diseases affect millions of people in the United States and any non-pharmacologic approach could improve the quality of people's lives and save tax dollars required to treat these debilitating illnesses. We have also identified that the n6-rich oil from the safflower reduces many attributes of the metabolic syndrome. These findings have lead to several start-up companies that now market n-6 rich safflower oil for reducing belly fat. A commercialized product in the area by Ohio could generate jobs for people in Ohio and income for the OSU and OARDC.
Publications
- Casagrande G, Belury MA, LeJeune J, Medeiros LC. Registered dietitian's personal beliefs and characteristics predict their teaching or intention to teach fresh vegetable food safety. Appetite 2011; 56(2):469-75
- Tian M, Kliewer KL, Asp ML, Stout MB, Belury MA. c9t11-CLA rich oil fails to attenuate wasting in colon-26 tumor-induced late stage cancer cachexia in male CD2F1 mice. Molecular Nutrition & Food Research 2011; 55(2):268-77
- Asp ML, Norris LE, Collene AL, Cole R, Stout MB, Yu S-Z, Hsu JC, Belury MA. Time-to-effect analyses of improvement of glycemia by dietary safflower oil in obese, post-menopausal women with type 2 diabetes. Clin Nutr 2011; 30 (4) 443-9
- Stout MB, Liu L-F, Belury MA. Hepatic steatosis by dietary conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C epsilon in mice. Mol Nutr Food Res 2011; 55(7): 1010-7
- Tian M, Asp ML, Kliewer KL, Belury MA. Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. Int J Oncol 2011; 39 (5): 1321-6
- Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 Supplementation Lowers Inflammation and Anxiety in Medical Students: A Randomized Controlled Trial. Brain Behav Immun 2011; 25(8): 1725-34
- Asp ML, Collene AL, Richardson JR, Droll KR, Belury MA. Dietary protein and beef consumption predict for markers of muscle mass and nutrition status in older adults. J Nutr Health Aging, 2012
- Asp ML, Tian M, Kliewer KL, Belury MA. Rosiglitazone delayed weight loss and anorexia while attenuating adipose depletion in mice with cancer cachexia. Cancer Biol Ther, 2012
- Janice K. Kiecolt-Glaser JK, Christian LM, Andridge R, Hwang BS, Malarkey WB, Belury MA, Emery CF, Glaser R. Adiponectin, Leptin, and Yoga Practice, Physiol Behav 2012.
|
Progress 01/01/10 to 12/31/10
Outputs
OUTPUTS: During the reporting period, I have spoken to three state dietetic association annual meetings about new and emerging findings regarding polyunsaturated fatty acids (n3, n6, conjugated linoleic acids) and saturated fatty acids on health of humans. Dietary Oils that Lower Body Fat: April 2010, New Mexico Dietetics Association, Albuquerque, NM Passport to the World of Fatty Acids Sept 2010, Dayton Dietetic Association, Dayton, OH April 2010s, Maryland Dietetic Association, Baltimore, MD We have also conducted clinical and basic science experiments to elucidate the role of fatty acids in modulating weight loss in people and adipose loss and metabolism in mice. PARTICIPANTS: Martha Belury Michelle Asp Rachel Cole Min Tian Mike Stout Sam Parthasarathy TARGET AUDIENCES: Registered dietitians Nutrition scientists Consumers PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.
Impacts
Our research continues to influence how consumers choose and consume foods that lower risk for obesity-related conditions such as breast cancer, type 2 diabetes and heart disease.
Publications
- Asp ML, Tian M, Wendel AA, Belury MA. Insulin resistance occurs early in cancer cachexia. Int J Cancer 2010; 126:756-763
- Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, Clinton SK. Omega 3 fatty acid supplements in women at high risk for breast cancer show dose dependent effects on breast adipose fatty acid composition. Am J Clin Nutr 2010; 91:1185-1194
- McDaniel JC, Ahijevych K, Belury M. Effect of n-3 oral supplements on the n-6/n-3 ratio in young adults. West J Nurs Res 2010; 32(1):64-80
- Tian M, Yoshinori N, Asp ML, Stout MB, Reiser PJ, Belury MA. Cardiac alterations in cancer-induced cachexia in mice. Int J Oncol 2010; 37(2):347-53
- Deiuliis J, Belury MA, Rimm J, Shin J, Liu L-F, Lee K. β3-Adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes. Lipids 2010; 45(6):479-89
- Tian M, Kliewer KL, Asp ML, Stout MB, Belury MA. c9t11-CLA rich oil fails to attenuate wasting in colon-26 tumor-induced late stage cancer cachexia in male CD2F1 mice. Mol Nutr Food Res 2010, in press
|
Progress 01/01/09 to 12/31/09
Outputs
OUTPUTS: During 2009, I was invited to three professional audiences to provide research and practical updates on dietary oils in a healthy diet. In February 2009, I spoke to over 200 family practice physicians at the Ohio State University Medical Canter with a 1 hr seminar entitled, Surprising Effects of Dietary Fats on Body Composition. In this seminar we discussed how n-3 and n-6 fatty acids contribute to metabolism to alter body adipose mass and composition. For two state dietetic association annual meetings (Florida and Kansas), I reached over 300 dietitians with a 1-hr seminar entitled, Fitting Dietary Fats into Your Genes: Working Genomics into Your Practice. The seminar presented evidence and case studies showing the importance of using genetic information in counseling clients. We reviewed the chemistry of n-3 PUAFs and discussed how n-3 PUFAs contribute to dietetic counseling using case study examples. PARTICIPANTS: Principal Investigator: M. A. Belury The OSU Medical Center sponsored my talk for physicians in Columbus, OH National Cattleman's Beef Association sponsored my talks in Florida and Kansas. TARGET AUDIENCES: Physicians and Registered dietitians PROJECT MODIFICATIONS: Nothing significant to report during this reporting period.
Impacts
Physicians and registered dietitians are the professionals who boil down my research findings into achievable messages for the public. Reaching so many professionals in the medical care field will likely increase the intake of n-3 rich foods such as walnuts, fatty fish, and even fish oil supplements. It is hoped that increasing the consumption of healthful oils will contribute to reduced incidence of heart disease.
Publications
- No publications reported this period
|
Progress 01/01/08 to 12/31/08
Outputs
OUTPUTS: We have used our preliminary findings to support proposals for funding to study the role of n-3 fatty acids in inflammation, negative mood symptoms and risk for diseases. PARTICIPANTS: Janice Kiecolt-Glaser Lisa Yee Julia Richardson Rachel Cole TARGET AUDIENCES: Men and women of multiple ages who are participating in n-3 intervention studies for reducing inflammation, muscle changes, obesity, metabolic syndrome, mood disorders. PROJECT MODIFICATIONS: Not relevant to this project.
Impacts
Inflammation is associated with various debilitating diseases. Muscle wasting, obesity, metabolic syndrome, and even diseases of mental health may be exacerbated by excessive inflammation. n-3 oils may attenuate a hyper-inflamed response and worsen outcomes of diseases. We have analyzed over 1000 samples over the past year from subjects who were supplemented with one of three levels of n-3 oils. Our analyses will allow for us to eventually determine the strength of association of accumulation of n-3 fatty acids with changes in muscle wasting, obesity, metabolic syndrome, and mood disorders such as depression, stress, hostility and anxiety. Further analysis will include fatty acid composition of breast adipose, plasma, serum or white blood cells from subjects supplemented with various levels of n-3 PUFAs.
Publications
- No publications reported this period
|
|