Source: CORNELL UNIVERSITY submitted to NRP
IMPROVING METHODS FOR PATIENT ACCRUAL TO CLINICAL TRIALS
Sponsoring Institution
State Agricultural Experiment Station
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0211039
Grant No.
(N/A)
Cumulative Award Amt.
(N/A)
Proposal No.
(N/A)
Multistate No.
(N/A)
Project Start Date
May 1, 2007
Project End Date
Apr 30, 2008
Grant Year
(N/A)
Program Code
[(N/A)]- (N/A)
Recipient Organization
CORNELL UNIVERSITY
(N/A)
ITHACA,NY 14853
Performing Department
COMMUNICATION
Non Technical Summary
Low enrollment in clinical trials in the United States poses a threat to the advancement of medical science. This project investigates factors that contribute to decisions to enroll in clinical trials.
Animal Health Component
40%
Research Effort Categories
Basic
20%
Applied
40%
Developmental
40%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
90360103030100%
Goals / Objectives
Low patient accrual in clinical trials poses a serious concern for the advancement of medical science in the United States. This research will apply the model of Risk Information Seeking and Processing (RISP) and the Theory of Planned Behavior to examine factors that influence communication behaviors related to information seeking and processing about clinical trials and subsequent behavioral intentions. This study intends to lay the groundwork for a multi-year research program that seeks to investigate pathways to decision making about clinical trial enrollment. The overall goal of the project is to investigate factors underlying low enrollment in clinical trials in an effort to provide data-supported recommendations for the accrual of patients in clinical trials.
Project Methods
We will conduct a random telephone survey of samples (500 adults per sample) from two populations: (a) the Leukemia and Lymphoma Society (LLS) and (b) the U.S. Having the two samples will allow us to compare the communication behaviors of LLS members to the general population. To collect the data, we will contract with the Cornell Survey Research Institute (SRI). All contact will occur via telephone, with the interviewer being at SRI and the respondent being contacted and interviewed at their home number. Interviews will average 25 minutes.

Progress 05/01/07 to 04/30/08

Outputs
OUTPUTS: In November 2007, we completed a telephone survey of 1000 individuals regarding their information seeking and processing behaviors related to clinical trial participation. 500 of these individuals were randomly selected adults from the U.S. and 500 were members of the Leukemia and Lymphoma Society. Data analysis is ongoing, but we have disseminated findings to health practitioners, physicians, risk analysts, and communication professionals via informal conversations and formal presentations. Two articles are currently under peer review. PARTICIPANTS: Principal Investigator: Dr. Katherine McComas, Assistant Professor, Department of Communication, College of Agriculture and Life Sciences; Co-PI: Dr. Geri Gay, Professor and Chair, Department of Communication, College of Agriculture and Life Sciences Co-PI (and Research Assistant): Ms. Zheng Yang, Ph.D. student, Department of Communication, College of Agriculture and Life Sciences; Co-PI: Dr. John Leonard, Associate Professor of Medicine, Associate Attending Physician, Weill Cornell Medical College; Co-PI: Dr. Andrew Dannenberg, Professor of Medicine, Attending Physician, Weill Cornell Medical College; Co-Investigator: Hildy Dillon, Leukemia and Lymphoma Society TARGET AUDIENCES: Physicians, patients with cancer, users of the services of the Leukemia and Lymphoma Society, readers of scientific and medical literature, communication scholars and practitioners. PROJECT MODIFICATIONS: There are no major changes in the approach.

Impacts
Our impacts are knowledge-oriented regarding individuals' decision making regarding clinical trial enrollment. These include knowledge about individuals' baseline receptivity to receiving further information about clinical trials, which could be used to compare results of future interventsion to increase awareness of clinical trial opportunities. We also identified factors influencing receptivitiy to information, including "information sufficiency" or the extent to which individuals already believed they had sufficient knowledge of clinical trials. We also found that "informational subjective norms" or the extent to which individuals believed people they care about would want them to know about clinical trial opportunities influenced information seeking behavior. Trust in physicians was also a significant predictor of individuals' willingness to talk to their doctor about clinical trials. Finally, we found that the positive emotion "optimism" was a signficant factor in individuals' motivation to seek and process information about clinical trial enrollment possibilities.

Publications

  • Yang, Z, McComas, K.A., Gay, G., Leonard, J. P. Leonard, Dannenberg, A. J., & Dillon, H. (2008, December) The role of positive affect in motivating risk information seeking and processing: a study on communication about clinical trial enrollment. Paper presented at the 2008 Society for Risk Analysis Annual Meeting, Boston, MA.
  • Yang, Z, McComas, K.A., Gay, G., Leonard, J. P. Leonard, Dannenberg, A. J., & Dillon, H.. (2008, November). Information seeking and processing about clinical trial enrollment. Poster presented at the 2008 American Public Health Association Annual Meeting, San Diego, CA.
  • McComas, K. A., Yang, Z., Gay, G. K., Leonard, J. P., Dannenberg, A. J., & Dillon, H. (2008, May). Talking to doctors about clinical trials. Paper presented at the International Communication Association Annual Meeting, Montreal, Canada.


Progress 10/01/06 to 09/30/07

Outputs
OUTPUTS: This project began in May 2007. In November 2007, we completed a telephone survey of 1000 individuals regarding their information seeking and processing behaviors related to clinical trial participation. 500 of these individuals were randomly selected adults from the U.S. and 500 were members of the Leukemia and Lymphoma Society. We are currently working on an initial summary report of the survey findings for January 2008. PARTICIPANTS: Principal Investigator: Dr. Katherine McComas, Assistant Professor, Department of Communication, College of Agriculture and Life Sciences; Co-PI: Dr. Geri Gay, Professor and Chair, Department of Communication, College of Agriculture and Life Sciences Co-PI (and Research Assistant): Ms. Zheng Yang, Ph.D. student, Department of Communication, College of Agriculture and Life Sciences; Co-PI: Dr. John Leonard, Associate Professor of Medicine, Associate Attending Physician, Weill Cornell Medical College; Co-PI: Dr. Andrew Dannenberg, Professor of Medicine, Attending Physician, Weill Cornell Medical College; Co-Investigator: Robin Kornhaber, Leukemia and Lymphoma Society; Co-Investigator: Hildy Dillon, Leukemia and Lymphoma Society TARGET AUDIENCES: Once the data are analyzed, we plan to reach out to physicians, patients with cancer, and members of the Leukemia and Lymphoma Society, as well as readers of the scientific and medical literature.

Impacts
At this time, we do not have any outcomes or impacts to report.

Publications

  • No publications reported this period