Source: GORDON RESEARCH CONFERENCES, INC submitted to NRP
EPIGENETICS 2007 GORDON RESEARCH CONFERENCE
Sponsoring Institution
National Institute of Food and Agriculture
Project Status
COMPLETE
Funding Source
Reporting Frequency
Annual
Accession No.
0209924
Grant No.
2007-35300-17919
Cumulative Award Amt.
(N/A)
Proposal No.
2007-02290
Multistate No.
(N/A)
Project Start Date
Jul 15, 2007
Project End Date
Jul 14, 2008
Grant Year
2007
Program Code
[52.1]- (N/A)
Recipient Organization
GORDON RESEARCH CONFERENCES, INC
512 LIBERTY LN
WEST KINGSTON,RI 02892-1502
Performing Department
(N/A)
Non Technical Summary
Started in 1995 and now meeting for the seventh time, the Gordon Research Conference on Epigenetics is the premier venue for presenting new developments in one of the most exciting areas of the biological sciences today. This conference includes a diverse group of scientists, studying many different organisms, to expand the frontiers of epigenetics research. The study of epigenetics leads to an understanding of genome function. Epigenetic modifications such as methylation of the DNA and post-translational modification of core histones affect the organization and packaging of genes, and hence gene expression. Thus, a plethora of different processes are affected by the underlying epigenetic regulation of the genome. Many early groundbreaking discoveries in epigenetics came from plant research, and roughly 30% of invited speakers work on some aspect of plant biology, including gene regulation in polyploid genomes, gene regulation during vernalization, transgene silencing, pathogen defense, transposon regulation, and RNA interference. These topics have immediate relevance to agriculture and have greatly influenced research goals in both academic and industrial settings. The research covered by this conference will therefore be relevant to several of the goals of the USDA, such as enhancing opportunities for agricultural producers, and improving the nations nutrition and health. This conference will be a worthwhile and cost-effective investment in the future of basic and applied plant research.
Animal Health Component
50%
Research Effort Categories
Basic
(N/A)
Applied
50%
Developmental
50%
Classification

Knowledge Area (KA)Subject of Investigation (SOI)Field of Science (FOS)Percent
2012499104050%
2012499108050%
Goals / Objectives
The study of epigenetics leads to an understanding of genome function. In recent years, epigenetic analysis has revealed some of the most extraordinary forms of gene regulation and quickly become one of the most exciting research areas in genetics and developmental biology. Even as genome projects are providing the complete nucleotide sequence of organism after organism, researchers are turning to the field of epigenetics to understand how that sequence is interpreted in the context of the cell or the organism. Epigenetic modifications such as methylation of the DNA and post-translational modification of core histones affect the organization and packaging of the chromosome. That these chromosomal marks are both dynamic and heritable leads to epigenetics being one of the most intriguing aspects of biology with a wide range of implications for development, disease and natural variability. It has become clear that epigenetic processes encompass an impressive diversity of mechanisms including RNA-mediated gene regulation, DNA methylation, identification of new pathways in gene control, inheritance of expression states as mediated by RNAs and proteins, cellular and nuclear organization, and response to environmental cues. The richness and versatility of these biological processes has been elucidated through the study of a wide range of diverse organisms and this conference prides itself on its inclusiveness and its respect for the exchange of ideas and value of learning from the full range of model systems. Over the past two decades, epigenetic findings have continued to surprise us and changed the way we think about gene regulation and chromosome organization. New fields, such as Epigenomics and the Role of small RNAs, have emerged that link the organization of the genome sequence to the mechanisms and pathways controlling chromosome function. As epigenetic mechanisms are found across many species, including prokaryotes, fungi, ciliates, plants, worms, insects, and mammals, it is clear that a solid grasp of epigenetic phenomena will have a broad impact on our general understanding of gene regulation, development and chromosome biology. But much remains to be done in this fast moving field. Not only is our understanding of the molecular bases of known epigenetic mechanisms in its infancy, but the great number of biological phenomena that remain mysterious indicates that many more epigenetic mechanisms are yet to be elucidated. In sum, the specific aims of the conference are to: 1) advance our understanding of epigenetic mechanisms by facilitating the exchange of information and ideas from experts working in a wide array of epigenetic systems, 2) introduce new issues and new questions that push the boundaries of epigenetics, and 3) promote the careers of young investigators, including students, postdoctoral fellows, and new principal investigators including underrepresented minorities. The success of this conference will have long-term outcomes in our efforts to understand fundamental aspects of genome function including chromosome architecture, gene regulation and developmental processes.
Project Methods
Format: The Epigenetics Gordon Research Conference will have nine platform sessions featuring ~56 speakers and four poster sessions spread over five days (see Section E for Program). Our speaker invitations have thus far met with an overwhelmingly positive response; 43 out of 48 initial invitees have accepted, and we therefore anticipate no difficulty in completing our program with compelling presentations. In order to maximize talks featuring critical discoveries made in the final months leading up to the meeting, we plan to fill the remainder of the program with ~13 speakers selected from submitted abstracts. Of particular interest will be those new to the conference and young investigators, including new principal investigators, postdoctoral fellows, and students. Platform presentations: This Gordon Conference has a superb track record for provocative and productive discussions during the platform presentations, and we will organize the morning and evening platform schedules to accommodate such high level interactions among the participants. Accordingly, two thirds of the platform presentations will be long talks of ~20 minutes to be followed by ~10 minutes of discussion, and one third will be short talks of ~13 minutes to be followed by ~7 minutes of discussion (final presentation and discussion times to be fixed when the final number of speakers has been determined). Conference time and site: The conference is scheduled to take place from the evening of Sunday, August 5 through the evening of Thursday, August 9, with Friday, August 10 reserved as a travel day. This timing avoids conflicts with other meetings relevant to invited participants, such as the Alan Wolffe EMBO Conference on Chromatin and Epigenetics, in Heidelberg, Germany held May 2007, the Keystone Symposium on Epigenetics: Regulation of Chromatin Structure in Development and Disease, to be held in Breckenridge Colorado in April 2007, and the FASEB Summer Research Conference on Chromatin and Transcription held July 2007 at Snowmass, Colorado. The conference will be held at its traditional site of the Holderness School in Holderness, New Hampshire. This site has excellent facilities for lectures (air conditioned), poster sessions, and housing plus nearby resources for outdoor activities such as hiking, swimming, and kayaking. Last year, wireless internet access was installed in the campus accommodation. The staff are very supportive and work well with us. The location of the site in rural New Hampshire fosters the intimate feel of the Conference.

Progress 07/15/07 to 07/14/08

Outputs
OUTPUTS: The Gordon Research Conferences provide a private forum for the free and open discussion of ideas at the frontiers of science and technology. Participants have the opportunity to discuss unpublished work and to explore new issues and ideas in the formative stage. The long-term agenda for research in an area is set based on these discussions and new interdisciplinary research areas often develop from the interactions and discussions at the meetings. The Gordon Research Conferences conference format provides an excellent training opportunity for younger scientists. The small size and traditional informality of the GRC format provides a unique opportunity for researchers, at all career stages, to interact closely with the more senior researchers in our field, share information, and develop long-lasting ties that often reach across disciplines. Speakers, discussion leaders, poster presenters and attendees simultaneously contributed to and benefited from the collective skills and experience shared throughout the conference. PARTICIPANTS: The 156 participants in attendance represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. Statistical Participant Demographics based on information provided by attendee: 1. Previous GRC's - None:35%, 1 to 5:28%, 6 to 10:25%, Over 10:13%; 2. Typical Annual Conferences attended - 1 to 2:50%, 3 to 5:34%, 6 to 8:10%, Over 9:6%; 3. Gender - Male:57%, Female:43%; 4. Role in Conference - Chair / V. Chair:4%, Speaker:30%, Discussion Leader 3%, Poster Presenter:58%, Conferee:5%;5. Affiliation - Academic:72%, Industry:5%, Government:5%, Research:19%; 6. Age Group - 20's:14%, 30's:29%, 40's:36%, 50's:14%, 60+:7%; 7. Number of People Was - Too Small:1%, Just Right:99%, Too Large:0%, 8. Region of Residence - N. America:59%, S. America:0%, Europe:29%, Africa:0%, Asia:4%, Australia/Oceania:7%; 9. Position - Grad Student:12%, Post Doc:22%, Professor:40%, Research Scientist:12%, Research Director:9%, Program Mgr:2%, Other:4% TARGET AUDIENCES: Not relevant to this project. PROJECT MODIFICATIONS: Not relevant to this project.

Impacts
The Gordon Research Conference on EPIGENETICS was held at Holderness School, Holderness, New Hampshire, August 5-10, 2007. The Conference was well-attended with 156 participants (attendees list available upon request). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. Thank you for your support of this Conference. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings. If you wish any further details, please feel free to contact me. Steven Jacobson, Conference Chairperson

Publications

  • No publications reported this period